{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T12:02:56Z","timestamp":1785153776061,"version":"3.55.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014472","name":"Scientific Research Foundation of Hunan Provincial Education Department","doi-asserted-by":"publisher","award":["21B0414"],"award-info":[{"award-number":["21B0414"]}],"id":[{"id":"10.13039\/100014472","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019413","name":"Yunnan Provincial Department of Education Science Research Fund Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019413","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2021JJ40476"],"award-info":[{"award-number":["2021JJ40476"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2021JJ40506"],"award-info":[{"award-number":["2021JJ40506"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.cellsig.2026.112630","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T16:28:23Z","timestamp":1780417703000},"page":"112630","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Role of homocysteine in renal tubular epithelial\u2013mesenchymal transition: N-homocysteinylation of \u03b2-catenin impairs FUNDC1-dependent autophagy and mitochondrial quality control"],"prefix":"10.1016","volume":"146","author":[{"given":"Yanping","family":"Lei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellsig.2026.112630_bb0005","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3390\/nu7010074","article-title":"Prevalence of hyperhomocysteinemia in China: a systematic review and meta-analysis","volume":"7","author":"Yang","year":"2014","journal-title":"Nutrients"},{"key":"10.1016\/j.cellsig.2026.112630_bb0010","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1093\/eurjpc\/zwae022","article-title":"Homocysteine, hyperhomocysteinemia, and H-type hypertension","volume":"31","author":"Wu","year":"2024","journal-title":"Eur. J. Prev. Cardiol."},{"key":"10.1016\/j.cellsig.2026.112630_bb0015","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26020746","article-title":"Homocysteine metabolites, endothelial dysfunction, and cardiovascular disease","volume":"26","author":"Jakubowski","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cellsig.2026.112630_bb0020","doi-asserted-by":"crossref","first-page":"6259","DOI":"10.3390\/ijms22126259","article-title":"Homocysteine and age-related central nervous system diseases: role of inflammation","volume":"22","author":"Tawfik","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cellsig.2026.112630_bb0025","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1093\/ajh\/hpaa086","article-title":"Hyperhomocysteinemia-induced oxidative stress aggravates renal damage in hypertensive rats","volume":"33","author":"Gao","year":"2020","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.cellsig.2026.112630_bb0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1476-511X-5-1","article-title":"Mining literature for a comprehensive pathway analysis: a case study for retrieval of homocysteine related genes for genetic and epigenetic studies","volume":"5","author":"Sharma","year":"2006","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.cellsig.2026.112630_bb0035","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.jhep.2022.06.033","article-title":"Vitamin B(12) and folate decrease inflammation and fibrosis in NASH by preventing syntaxin 17 homocysteinylation","volume":"77","author":"Tripathi","year":"2022","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cellsig.2026.112630_bb0040","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3109\/13813455.2011.635660","article-title":"Mitochondrial mitophagic mechanisms of myocardial matrix metabolism and remodelling","volume":"118","author":"Vacek","year":"2012","journal-title":"Arch. Physiol. Biochem."},{"key":"10.1016\/j.cellsig.2026.112630_bb0045","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.biocel.2015.06.015","article-title":"Role of S-adenosylhomocysteine in cardiovascular disease and its potential epigenetic mechanism","volume":"67","author":"Xiao","year":"2015","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.cellsig.2026.112630_bb0050","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.gene.2014.02.015","article-title":"Homocysteine contribution to DNA damage in cystathionine \u03b2-synthase-deficient patients","volume":"539","author":"Vanzin","year":"2014","journal-title":"Gene"},{"key":"10.1016\/j.cellsig.2026.112630_bb0055","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1159\/000110876","article-title":"Mechanisms of homocysteine-induced glomerular injury and sclerosis","volume":"28","author":"Yi","year":"2008","journal-title":"Am. J. Nephrol."},{"key":"10.1016\/j.cellsig.2026.112630_bb0060","article-title":"The link between homocysteine, folic acid and vitamin B12 in chronic kidney disease","volume":"38","author":"Angelini","year":"2021","journal-title":"G. Ital. Nefrol."},{"key":"10.1016\/j.cellsig.2026.112630_bb0065","article-title":"Hyperhomocysteinemia exacerbates acute kidney injury via increased mitochondrial damage","volume":"13","author":"Zhang","year":"2022","journal-title":"Front. Physiol."},{"key":"10.1016\/j.cellsig.2026.112630_bb0070","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s40662-023-00362-1","article-title":"Homocysteine and mitochondrial quality control in diabetic retinopathy","volume":"11","author":"Malaviya","year":"2024","journal-title":"Eye Vis. (Lond.)"},{"key":"10.1016\/j.cellsig.2026.112630_bb0075","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s40662-019-0167-9","article-title":"Faulty homocysteine recycling in diabetic retinopathy","volume":"7","author":"Kowluru","year":"2020","journal-title":"Eye Vis. (Lond.)"},{"key":"10.1016\/j.cellsig.2026.112630_bb0080","doi-asserted-by":"crossref","first-page":"4261","DOI":"10.1016\/j.molcel.2024.10.040","article-title":"AMPK: balancing mitochondrial quality and quantity through opposite regulation of mitophagy pathways","volume":"84","author":"Jiang","year":"2024","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cellsig.2026.112630_bb0085","article-title":"Src activation aggravates podocyte injury in diabetic nephropathy via suppression of FUNDC1-mediated mitophagy","volume":"13","author":"Zheng","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.cellsig.2026.112630_bb0090","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1080\/15548627.2024.2389474","article-title":"Role of AMBRA1 in mitophagy regulation: emerging evidence in aging-related diseases","volume":"20","author":"Di Rienzo","year":"2024","journal-title":"Autophagy"},{"key":"10.1016\/j.cellsig.2026.112630_bb0095","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/s41419-022-05395-3","article-title":"Tubular \u03b2-catenin alleviates mitochondrial dysfunction and cell death in acute kidney injury","volume":"13","author":"Li","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cellsig.2026.112630_bb0100","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/nature03319","article-title":"Wnt signalling in stem cells and cancer","volume":"434","author":"Reya","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.cellsig.2026.112630_bb0105","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.molcel.2004.08.010","article-title":"Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation","volume":"15","author":"Ha","year":"2004","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cellsig.2026.112630_bb0110","doi-asserted-by":"crossref","DOI":"10.1002\/dvg.23529","article-title":"Epithelial-mesenchymal plasticity in kidney fibrosis","volume":"62","author":"Hadpech","year":"2024","journal-title":"Genesis"},{"key":"10.1016\/j.cellsig.2026.112630_bb0115","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1253\/circj.CJ-13-0835","article-title":"Mitochondrial autophagy--an essential quality control mechanism for myocardial homeostasis","volume":"77","author":"Thomas","year":"2013","journal-title":"Circ. J."},{"key":"10.1016\/j.cellsig.2026.112630_bb0120","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020104705","article-title":"Molecular mechanisms and physiological functions of mitophagy","volume":"40","author":"Onishi","year":"2021","journal-title":"EMBO J."},{"key":"10.1016\/j.cellsig.2026.112630_bb0125","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.1016\/j.ekir.2024.08.019","article-title":"TRPC6-Calpain-1 axis promotes tubulointerstitial inflammation by inhibiting mitophagy in diabetic kidney disease","volume":"9","author":"Liu","year":"2024","journal-title":"Kidney Int. Rep."},{"key":"10.1016\/j.cellsig.2026.112630_bb0130","doi-asserted-by":"crossref","first-page":"1453365","DOI":"10.3389\/fcell.2024.1453365","article-title":"Multiple roles of mitochondrial autophagy receptor FUNDC1 in mitochondrial events and kidney disease","volume":"12","author":"Li","year":"2024","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.cellsig.2026.112630_bb0135","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1038\/emboj.2012.150","article-title":"The many faces and functions of \u03b2-catenin","volume":"31","author":"Valenta","year":"2012","journal-title":"EMBO J."},{"key":"10.1016\/j.cellsig.2026.112630_bb0140","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202201657","article-title":"Stabilization of nuclear \u03b2-catenin by inhibiting KDM2A mediates cerebral ischemic tolerance","volume":"37","author":"Zuo","year":"2023","journal-title":"FASEB J."},{"key":"10.1016\/j.cellsig.2026.112630_bb0145","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1093\/jb\/mvw072","article-title":"Context-dependent regulation of the \u03b2-catenin transcriptional complex supports diverse functions of Wnt\/\u03b2-catenin signaling","volume":"161","author":"Masuda","year":"2017","journal-title":"J. Biochem."},{"key":"10.1016\/j.cellsig.2026.112630_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102288","article-title":"Empagliflozin attenuates cardiac microvascular ischemia\/reperfusion through activating the AMPK\u03b11\/ULK1\/FUNDC1\/mitophagy pathway","volume":"52","author":"Cai","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.cellsig.2026.112630_bb0155","doi-asserted-by":"crossref","first-page":"10193","DOI":"10.1073\/pnas.1733909100","article-title":"A noncanonical sequence phosphorylated by casein kinase 1 in beta-catenin may play a role in casein kinase 1 targeting of important signaling proteins","volume":"100","author":"Marin","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cellsig.2026.112630_bb0160","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ceb.2014.08.003","article-title":"Casein kinase 1 and Wnt\/\u03b2-catenin signaling","volume":"31","author":"Cruciat","year":"2014","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.cellsig.2026.112630_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2022.101553","article-title":"Empagliflozin activates Wnt\/\u03b2-catenin to stimulate FUNDC1-dependent mitochondrial quality surveillance against type-3 cardiorenal syndrome","volume":"64","author":"Cai","year":"2022","journal-title":"Mol. Metab."},{"key":"10.1016\/j.cellsig.2026.112630_bb0170","article-title":"Emerging therapeutic strategies for attenuating tubular EMT and kidney fibrosis by targeting Wnt\/\u03b2-catenin signaling","volume":"12","author":"Hu","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.cellsig.2026.112630_bb0175","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1186\/s12967-025-06852-1","article-title":"EphrinB2 alleviates tubulointerstitial fibrosis in diabetic kidney disease","volume":"23","author":"Ni","year":"2025","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.cellsig.2026.112630_bb0180","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.semnephrol.2020.01.004","article-title":"Wnt\/\u03b2-catenin in acute kidney injury and progression to chronic kidney disease","volume":"40","author":"Huffstater","year":"2020","journal-title":"Semin. Nephrol."},{"key":"10.1016\/j.cellsig.2026.112630_bb0185","doi-asserted-by":"crossref","first-page":"23953","DOI":"10.1038\/s41598-025-09221-6","article-title":"Homocysteine induces ferroptosis in renal tubular epithelial cells via \u03b2-catenin\/GPX4 signaling pathway","volume":"15","author":"Lei","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cellsig.2026.112630_bb0190","doi-asserted-by":"crossref","first-page":"22207","DOI":"10.1038\/s41598-025-06772-6","article-title":"Homocysteine promotes cardiomyocyte hypertrophy through inhibiting \u03b2-catenin\/ FUNDC1 mediated mitophagy","volume":"15","author":"Lei","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cellsig.2026.112630_bb0195","doi-asserted-by":"crossref","first-page":"1586937","DOI":"10.3389\/fphar.2025.1586937","article-title":"Ophiopogonin D mitigates doxorubicin-induced cardiomyocyte ferroptosis through the \u03b2-catenin\/GPX4 pathway","volume":"16","author":"Lei","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.cellsig.2026.112630_bb0200","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14124","article-title":"N-homocysteinylation of DJ-1 promotes neurodegeneration in Parkinson\u2019s disease","volume":"23","author":"Guo","year":"2024","journal-title":"Aging Cell"}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826002834?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826002834?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:25:37Z","timestamp":1785151537000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656826002834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":40,"alternative-id":["S0898656826002834"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112630","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of homocysteine in renal tubular epithelial\u2013mesenchymal transition: N-homocysteinylation of \u03b2-catenin impairs FUNDC1-dependent autophagy and mitochondrial quality control","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112630","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"112630"}}