{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T12:03:44Z","timestamp":1785153824342,"version":"3.55.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003787","name":"Hebei Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["H2025101001"],"award-info":[{"award-number":["H2025101001"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023M734268"],"award-info":[{"award-number":["2023M734268"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270679"],"award-info":[{"award-number":["82270679"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82104257"],"award-info":[{"award-number":["82104257"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.cellsig.2026.112634","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T15:50:04Z","timestamp":1780415404000},"page":"112634","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Drug repurposing for pancreatic cancer: Lomitapide Mesylate as a potent HK2 inhibitor discovered via virtual screening"],"prefix":"10.1016","volume":"146","author":[{"given":"Xin","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bangwei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianguo","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijian","family":"Si","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoshen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianghao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellsig.2026.112634_bb0005","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1016\/S0140-6736(25)00261-2","article-title":"Pancreatic cancer","volume":"405","author":"Stoop","year":"2025","journal-title":"Lancet"},{"key":"10.1016\/j.cellsig.2026.112634_bb0010","first-page":"252","article-title":"Cancer treatment and survivorship statistics, 2014","volume":"64","author":"DeSantis","year":"2014","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.cellsig.2026.112634_bb0015","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1001\/jama.2021.13027","article-title":"Pancreatic cancer: a review","volume":"326","author":"Park","year":"2021","journal-title":"Jama"},{"key":"10.1016\/j.cellsig.2026.112634_bb0020","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s13046-025-03332-8","article-title":"Combining molecular characteristics and therapeutic analysis of PDOs predict clinical responses and guide PDAC personalized treatment","volume":"44","author":"Li","year":"2025","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.cellsig.2026.112634_bb0025","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1056\/NEJMoa1304369","article-title":"Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine","volume":"369","author":"Von Hoff","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cellsig.2026.112634_bb0030","doi-asserted-by":"crossref","first-page":"6049","DOI":"10.1097\/JS9.0000000000002086","article-title":"Updates on pancreatic cancer treatment - invited special issue","volume":"110","author":"Conlon","year":"2024","journal-title":"Int. J. Surg."},{"key":"10.1016\/j.cellsig.2026.112634_bb0035","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/s41571-025-01019-9","article-title":"Improving outcomes of patients with pancreatic cancer","volume":"22","author":"Dreyer","year":"2025","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.cellsig.2026.112634_bb0040","first-page":"C540","article-title":"Barriers and opportunities for gemcitabine in pancreatic cancer therapy","volume":"324","author":"Beutel","year":"2023","journal-title":"Am. J. Phys. Cell Phys."},{"key":"10.1016\/j.cellsig.2026.112634_bb0045","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nature16064","article-title":"Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer","volume":"527","author":"Zheng","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.cellsig.2026.112634_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.217809","article-title":"Paricalcitol plus hydroxychloroquine enhances gemcitabine activity and induces mesenchymal to epithelial transition in pancreatic ductal adenocarcinoma: a single cell RNA-seq analysis","volume":"625","author":"Nagaraju","year":"2025","journal-title":"Cancer Lett."},{"key":"10.1016\/j.cellsig.2026.112634_bb0055","doi-asserted-by":"crossref","first-page":"775","DOI":"10.7150\/ijbs.26077","article-title":"Atg7 inhibits Warburg effect by suppressing PKM2 phosphorylation resulting reduced epithelial-mesenchymal transition","volume":"14","author":"Feng","year":"2018","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.cellsig.2026.112634_bb0060","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13045-020-01030-w","article-title":"Targeting hypoxic tumor microenvironment in pancreatic cancer","volume":"14","author":"Tao","year":"2021","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.cellsig.2026.112634_bb0065","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.canlet.2014.04.001","article-title":"The Warburg effect in tumor progression: mitochondrial oxidative metabolism as an anti-metastasis mechanism","volume":"356","author":"Lu","year":"2015","journal-title":"Cancer Lett."},{"key":"10.1016\/j.cellsig.2026.112634_bb0070","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s00018-019-03278-z","article-title":"The enhancement of glycolysis regulates pancreatic cancer metastasis","volume":"77","author":"Yang","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.cellsig.2026.112634_bb0075","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1016\/j.cmet.2022.08.002","article-title":"Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of I\u03baB\u03b1","volume":"34","author":"Guo","year":"2022","journal-title":"Cell Metab."},{"key":"10.1016\/j.cellsig.2026.112634_bb0080","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/s41467-017-02733-4","article-title":"Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin","volume":"9","author":"DeWaal","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cellsig.2026.112634_bb0085","doi-asserted-by":"crossref","first-page":"56081","DOI":"10.18632\/oncotarget.9760","article-title":"Hexokinase 2 promotes tumor growth and metastasis by regulating lactate production in pancreatic cancer","volume":"8","author":"Anderson","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.cellsig.2026.112634_bb0090","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26123518","article-title":"Mechanistic actions between Garcinia atroviridis essential oil and 2 deoxy-d-glucose in cultured PANC-1 human pancreatic cancer cells","volume":"26","author":"Nik Mohamed Kamal","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.cellsig.2026.112634_bb0095","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1203\/00006450-198405000-00020","article-title":"The 2-deoxyglucose test as a supplement to fasting for detection of childhood hypoglycemia","volume":"18","author":"Hansen","year":"1984","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.cellsig.2026.112634_bb0100","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s00280-012-2045-1","article-title":"A phase I dose-escalation trial of 2-deoxy-D-glucose alone or combined with docetaxel in patients with advanced solid tumors","volume":"71","author":"Raez","year":"2013","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.cellsig.2026.112634_bb0105","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s11883-024-01269-5","article-title":"Homozygous familial hypercholesterolemia treatment: new developments","volume":"27","author":"Blom","year":"2025","journal-title":"Curr. Atheroscler. Rep."},{"key":"10.1016\/j.cellsig.2026.112634_bb0110","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s10822-013-9644-8","article-title":"Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments","volume":"27","author":"Sastry","year":"2013","journal-title":"J. Comput. Aided Mol. Des."},{"key":"10.1016\/j.cellsig.2026.112634_bb0115","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/s10822-007-9133-z","article-title":"Epik: a software program for pK(a) prediction and protonation state generation for drug-like molecules","volume":"21","author":"Shelley","year":"2007","journal-title":"J. Comput. Aided Mol. Des."},{"key":"10.1016\/j.cellsig.2026.112634_bb0120","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1021\/jm0306430","article-title":"Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy","volume":"47","author":"Friesner","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.cellsig.2026.112634_bb0125","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1002\/jcc.20945","article-title":"CHARMM-GUI: a web-based graphical user interface for CHARMM","volume":"29","author":"Jo","year":"2008","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.cellsig.2026.112634_bb0130","article-title":"TWIST1 regulates HK2 ubiquitination degradation to promote pancreatic cancer invasion and metastasis","volume":"25","author":"Wang","year":"2025","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.cellsig.2026.112634_bb0135","doi-asserted-by":"crossref","first-page":"790","DOI":"10.7150\/ijms.105553","article-title":"The role of HK2 in tumorigenesis and development: potential for targeted therapy with natural products","volume":"22","author":"He","year":"2025","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.cellsig.2026.112634_bb0140","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.ccr.2013.06.014","article-title":"Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer","volume":"24","author":"Patra","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cellsig.2026.112634_bb0145","doi-asserted-by":"crossref","DOI":"10.1039\/D6OB00245E","article-title":"A modular semi-synthetic approach to form a DHA-like polyunsaturated ether lipid with 15-lipoxygenase-1 substrate activity","author":"Bathen","year":"2026","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.cellsig.2026.112634_bb0150","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1093\/bib\/bbaa428","article-title":"Virtual screening and molecular dynamics simulation study of plant-derived compounds to identify potential inhibitors of main protease from SARS-CoV-2","volume":"22","author":"Mahmud","year":"2021","journal-title":"Brief. Bioinform."},{"key":"10.1016\/j.cellsig.2026.112634_bb0155","doi-asserted-by":"crossref","first-page":"3685","DOI":"10.1172\/JCI69741","article-title":"Targeting lactate metabolism for cancer therapeutics","volume":"123","author":"Doherty","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cellsig.2026.112634_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.seminoncol.2025.152351","article-title":"Hexokinases in gastrointestinal cancers: from molecular insights to therapeutic opportunities","volume":"52","author":"Liang","year":"2025","journal-title":"Semin. Oncol."},{"key":"10.1016\/j.cellsig.2026.112634_bb0165","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s13046-017-0530-4","article-title":"Benserazide, a dopadecarboxylase inhibitor, suppresses tumor growth by targeting hexokinase 2","volume":"36","author":"Li","year":"2017","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.cellsig.2026.112634_bb0170","article-title":"Benserazide-induced diarrhea - a retrospective clinical study","volume":"4","author":"Csoti","year":"2021","journal-title":"Clin. Park. Relat. Disord."},{"key":"10.1016\/j.cellsig.2026.112634_bb0175","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.parkreldis.2014.04.007","article-title":"Cardiovascular effects of levodopa in Parkinson\u2019s disease","volume":"20","author":"Noack","year":"2014","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.cellsig.2026.112634_bb0180","doi-asserted-by":"crossref","DOI":"10.3390\/molecules21121730","article-title":"The HK2 dependent \u201cWarburg effect\u201d and mitochondrial oxidative phosphorylation in cancer: targets for effective therapy with 3-Bromopyruvate","volume":"21","author":"Lis","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.cellsig.2026.112634_bb0185","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.toxlet.2019.09.024","article-title":"Rotenone and 3-bromopyruvate toxicity impacts electrical and structural cardiac remodeling in rats","volume":"318","author":"Zhan","year":"2020","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.cellsig.2026.112634_bb0190","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/s41392-024-01859-4","article-title":"Genetically programmable cell membrane-camouflaged nanoparticles for targeted combination therapy of colorectal cancer","volume":"9","author":"Yang","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.cellsig.2026.112634_bb0195","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1002\/med.21995","article-title":"Advances in machine intelligence-driven virtual screening approaches for big-data","volume":"44","author":"Kumar","year":"2024","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.cellsig.2026.112634_bb0200","doi-asserted-by":"crossref","first-page":"5749","DOI":"10.1021\/jm300338m","article-title":"Life beyond kinases: structure-based discovery of sorafenib as nanomolar antagonist of 5-HT receptors","volume":"55","author":"Lin","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.cellsig.2026.112634_bb0205","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3909\/ricm0834","article-title":"Balancing low-density lipoprotein cholesterol reduction and hepatotoxicity with Lomitapide Mesylate and Mipomersen in patients with homozygous familial hypercholesterolemia","volume":"18","author":"Won","year":"2017","journal-title":"Rev. Cardiovasc. Med."},{"key":"10.1016\/j.cellsig.2026.112634_bb0210","doi-asserted-by":"crossref","DOI":"10.1186\/s13046-022-02528-6","article-title":"UBR7 inhibits HCC tumorigenesis by targeting Keap1\/Nrf2\/Bach1\/HK2 and glycolysis","volume":"41","author":"Zhao","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.cellsig.2026.112634_bb0215","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s13046-015-0221-y","article-title":"Metabolic reprogramming: the emerging concept and associated therapeutic strategies","volume":"34","author":"Yoshida","year":"2015","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.cellsig.2026.112634_bb0220","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/s41419-024-07048-z","article-title":"Identification of STAM-binding protein as a target for the treatment of gemcitabine resistance pancreatic cancer in a nutrient-poor microenvironment","volume":"15","author":"Zhang","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cellsig.2026.112634_bb0225","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.neo.2020.12.009","article-title":"Glycolysis-induced drug resistance in tumors-a response to danger signals?","volume":"23","author":"Marcucci","year":"2021","journal-title":"Neoplasia"},{"key":"10.1016\/j.cellsig.2026.112634_bb0230","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1016\/j.cmet.2024.07.011","article-title":"Glycometabolic reprogramming-induced XRCC1 lactylation confers therapeutic resistance in ALDH1A3-overexpressing glioblastoma","volume":"36","author":"Li","year":"2024","journal-title":"Cell Metab."},{"key":"10.1016\/j.cellsig.2026.112634_bb0235","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1037341","article-title":"Targeting glycolysis in non-small cell lung cancer: promises and challenges","volume":"13","author":"Xu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.cellsig.2026.112634_bb0240","doi-asserted-by":"crossref","first-page":"5359","DOI":"10.2147\/OTT.S212465","article-title":"The combination of the glycolysis inhibitor 2-DG and sorafenib can be effective against sorafenib-tolerant persister cancer cells","volume":"12","author":"Wang","year":"2019","journal-title":"Onco. Targets Ther."},{"key":"10.1016\/j.cellsig.2026.112634_bb0245","doi-asserted-by":"crossref","DOI":"10.1002\/cam4.70972","article-title":"SPARC promotes aerobic glycolysis and 5-fluorouracil resistance in colorectal cancer through the STAT3\/HK2 axis","volume":"14","author":"Xiang","year":"2025","journal-title":"Cancer Med."},{"key":"10.1016\/j.cellsig.2026.112634_bb0250","article-title":"Deregulation of hexokinase II is associated with glycolysis, autophagy, and the epithelial-mesenchymal transition in tongue squamous cell carcinoma under hypoxia","volume":"2018","author":"Chen","year":"2018","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.cellsig.2026.112634_bb0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2026.101355","article-title":"The hallmarks of oncogenic signaling: from pathways to resistance in cancer therapy","volume":"85","author":"Tufail","year":"2026","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.cellsig.2026.112634_bb0260","doi-asserted-by":"crossref","first-page":"8836","DOI":"10.1111\/jcmm.16842","article-title":"Targeting hexokinase 2 increases the sensitivity of oxaliplatin by Twist1 in colorectal cancer","volume":"25","author":"Zhang","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.cellsig.2026.112634_bb0265","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/s41586-023-06388-8","article-title":"From target discovery to clinical drug development with human genetics","volume":"620","author":"Trajanoska","year":"2023","journal-title":"Nature"}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826002871?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826002871?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:27:12Z","timestamp":1785151632000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656826002871"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":53,"alternative-id":["S0898656826002871"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112634","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Drug repurposing for pancreatic cancer: Lomitapide Mesylate as a potent HK2 inhibitor discovered via virtual screening","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112634","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112634"}}