{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:20:49Z","timestamp":1787239249795,"version":"build-2736575974"},"reference-count":171,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012135","name":"Jiangxi Normal University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012135","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC 21365013"],"award-info":[{"award-number":["NSFC 21365013"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.cellsig.2026.112688","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T06:18:06Z","timestamp":1782109086000},"page":"112688","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Nicotinamide N-methyltransferase as a stress-responsive metabolic-epigenetic regulator of tubular senescence in chronic kidney disease"],"prefix":"10.1016","volume":"146","author":[{"given":"An","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Juan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Dong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang-Zhou","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang-Hua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellsig.2026.112688_bb0005","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1089\/ars.2020.8184","article-title":"Inflammation and oxidative stress in chronic kidney disease and dialysis patients","volume":"35","author":"Ebert","year":"2021","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.cellsig.2026.112688_bb0010","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/S0140-6736(16)32064-5","article-title":"Chronic kidney disease","volume":"389","author":"Webster","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.cellsig.2026.112688_bb0015","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.3390\/jcm13071881","article-title":"Fibrosis in chronic kidney disease: pathophysiology and therapeutic targets","volume":"13","author":"Reiss","year":"2024","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.cellsig.2026.112688_bb0020","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1053\/j.ajkd.2016.01.022","article-title":"Educational interventions for patients with CKD: a systematic review","volume":"68","author":"Lopez-Vargas","year":"2016","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.cellsig.2026.112688_bb0025","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1681\/ASN.2012040390","article-title":"Mechanisms and treatment of CKD","volume":"23","author":"Ruggenenti","year":"2012","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2026.112688_bb0030","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.mpmed.2011.04.007","article-title":"Epidemiology and causes of chronic kidney disease","volume":"39","author":"Evans","year":"2011","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.cellsig.2026.112688_bb0035","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1053\/j.ajkd.2018.12.044","article-title":"Hypertension in CKD: Core curriculum 2019","volume":"74","author":"Ku","year":"2019","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.cellsig.2026.112688_bb0040","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1159\/000355760","article-title":"Aging and chronic kidney disease","volume":"38","author":"Nitta","year":"2014","journal-title":"Kidney Blood Press. Res."},{"key":"10.1016\/j.cellsig.2026.112688_bb0045","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/nrneph.2011.16","article-title":"Pathophysiology of ischemic acute kidney injury","volume":"7","author":"Sharfuddin","year":"2011","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.cellsig.2026.112688_bb0050","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1681\/ASN.2014121181","article-title":"Deletion of Lkb1 in renal tubular epithelial cells leads to CKD by altering metabolism","volume":"27","author":"Han","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2026.112688_bb0055","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.166001","article-title":"REST contributes to AKI-to-CKD transition through inducing ferroptosis in renal tubular epithelial cells","volume":"8","author":"Gong","year":"2023","journal-title":"JCI Insight"},{"key":"10.1016\/j.cellsig.2026.112688_bb0060","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1093\/ndt\/gfu046","article-title":"Interaction between systemic inflammation and renal tubular epithelial cells","volume":"29","author":"Cantaluppi","year":"2014","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.cellsig.2026.112688_bb0065","article-title":"Cellular senescence of renal tubular epithelial cells in renal fibrosis","volume":"14","author":"Zhang","year":"2023","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.cellsig.2026.112688_bb0070","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1038\/s41419-018-1157-x","article-title":"Renal tubular epithelial cells: the neglected mediator of tubulointerstitial fibrosis after injury","volume":"9","author":"Qi","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cellsig.2026.112688_bb0075","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s13577-024-01156-w","article-title":"High glucose induces renal tubular epithelial cell senescence by inhibiting autophagic flux","volume":"38","author":"Zhang","year":"2025","journal-title":"Hum. Cell"},{"key":"10.1016\/j.cellsig.2026.112688_bb0080","article-title":"Klotho retards renal fibrosis through targeting mitochondrial dysfunction and cellular senescence in renal tubular cells","volume":"9","author":"Miao","year":"2021","journal-title":"Phys. Rep."},{"key":"10.1016\/j.cellsig.2026.112688_bb0085","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.3390\/ijms19072038","article-title":"Epithelial cell cycle behaviour in the injured kidney","volume":"19","author":"Moonen","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cellsig.2026.112688_bb0090","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14236","article-title":"Identification of nicotinamide N-methyltransferase as a promising therapeutic target for sarcopenia","volume":"23","author":"Liang","year":"2024","journal-title":"Aging Cell"},{"key":"10.1016\/j.cellsig.2026.112688_bb0095","doi-asserted-by":"crossref","first-page":"3660","DOI":"10.1038\/s41598-018-22081-7","article-title":"A small molecule inhibitor of nicotinamide N-methyltransferase for the treatment of metabolic disorders","volume":"8","author":"Kannt","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cellsig.2026.112688_bb0100","doi-asserted-by":"crossref","first-page":"8637","DOI":"10.1038\/s41598-018-26882-8","article-title":"NNMT activation can contribute to the development of fatty liver disease by modulating the NAD + metabolism","volume":"8","author":"Komatsu","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cellsig.2026.112688_bb0105","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.2147\/IJGM.S420706","article-title":"Nicotinamide N-methyl transferase as a predictive marker of tubular fibrosis in CKD","volume":"16","author":"Ye","year":"2023","journal-title":"Int. J. Gen. Med."},{"key":"10.1016\/j.cellsig.2026.112688_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.116823","article-title":"NNMT inhibition counteracts tubular senescence and fibrosis in early stages of chronic kidney disease","volume":"45","author":"Chanvillard","year":"2026","journal-title":"Cell Rep."},{"key":"10.1016\/j.cellsig.2026.112688_bb0115","doi-asserted-by":"crossref","first-page":"6398","DOI":"10.1038\/s41598-022-10476-6","article-title":"The significance of NAD + metabolites and nicotinamide N-methyltransferase in chronic kidney disease","volume":"12","author":"Takahashi","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cellsig.2026.112688_bb0120","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1743-7075-9-36","article-title":"Exploring metabolic dysfunction in chronic kidney disease","volume":"9","author":"Slee","year":"2012","journal-title":"Nutr. Metab."},{"key":"10.1016\/j.cellsig.2026.112688_bb0125","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1007\/s00467-018-4005-4","article-title":"Oxidative stress in chronic kidney disease","volume":"34","author":"Daenen","year":"2019","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.cellsig.2026.112688_bb0130","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2017.00099","article-title":"Renal hypoxia in CKD; pathophysiology and detecting methods","volume":"8","author":"Hirakawa","year":"2017","journal-title":"Front. Physiol."},{"key":"10.1016\/j.cellsig.2026.112688_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2021.101165","article-title":"Nicotinamide N-methyltransferase: at the crossroads between cellular metabolism and epigenetic regulation","volume":"45","author":"Roberti","year":"2021","journal-title":"Mol. Metab."},{"key":"10.1016\/j.cellsig.2026.112688_bb0140","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1007\/s00125-014-3490-7","article-title":"Association of nicotinamide-N-methyltransferase mRNA expression in human adipose tissue and the plasma concentration of its product, 1-methylnicotinamide, with insulin resistance","volume":"58","author":"Kannt","year":"2015","journal-title":"Diabetologia"},{"key":"10.1016\/j.cellsig.2026.112688_bb0145","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/nm.3882","article-title":"Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization","volume":"21","author":"Hong","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.cellsig.2026.112688_bb0150","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.jhep.2020.04.038","article-title":"ER stress-induced upregulation of NNMT contributes to alcohol-related fatty liver development","volume":"73","author":"Song","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cellsig.2026.112688_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2021.119082","article-title":"Nicotinamide N-methyltransferase in endothelium protects against oxidant stress-induced endothelial injury","volume":"1868","author":"Campagna","year":"2021","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Cell Res."},{"key":"10.1016\/j.cellsig.2026.112688_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.115882","article-title":"Nicotinamide N-methyltransferase mediates redox regulation and colonic epithelial barrier impairment by SIRT1\/PPAR-\u03b3\/NLRP6\/NRF2 axis in inflammatory bowel disease","volume":"168","author":"Chen","year":"2026","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.cellsig.2026.112688_bb0165","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.placenta.2025.09.017","article-title":"NNMT expression in preeclampsia: analyses on placental tissues and cell lines","volume":"171","author":"Tossetta","year":"2025","journal-title":"Placenta"},{"key":"10.1016\/j.cellsig.2026.112688_bb0170","series-title":"Regulation of Nicotinamide N-Methyltransferase by Oxidative Stress in Hepatocytes [Master\u2019s Thesis] [in Korean]","author":"Shin","year":"2024"},{"key":"10.1016\/j.cellsig.2026.112688_bb0175","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1164\/rccm.200906-0936OC","article-title":"Expression and functional significance of nicotinamide N-methyl transferase in skeletal muscles of patients with chronic obstructive pulmonary disease","volume":"181","author":"Kim","year":"2010","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.cellsig.2026.112688_bb0180","doi-asserted-by":"crossref","DOI":"10.1177\/1010428320977124","article-title":"Hepatoblastomas exhibit marked NNMT downregulation driven by promoter DNA hypermethylation","volume":"42","author":"Rivas","year":"2020","journal-title":"Tumour Biol."},{"key":"10.1016\/j.cellsig.2026.112688_bb0185","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202522837","article-title":"Detachment-induced FAK-STAT3-NNMT inhibits CTCs anoikis to promote breast cancer metastasis by enhancing fatty acid oxidation","volume":"13","author":"Tong","year":"2026","journal-title":"Adv. Sci."},{"key":"10.1016\/j.cellsig.2026.112688_bb0190","doi-asserted-by":"crossref","first-page":"343","DOI":"10.3390\/metabo14060343","article-title":"Nicotinamide N-methyltransferase (NNMT): a new hope for treating aging and age-related conditions","volume":"14","author":"Li","year":"2024","journal-title":"Metabolites"},{"key":"10.1016\/j.cellsig.2026.112688_bb0195","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s44324-025-00067-0","article-title":"The role of NAD+ metabolism and its modulation of mitochondria in aging and disease","volume":"3","author":"Yusri","year":"2025","journal-title":"Npj Metab. Health Dis."},{"key":"10.1016\/j.cellsig.2026.112688_bb0200","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.molmed.2017.08.001","article-title":"NAD + in aging: molecular mechanisms and translational implications","volume":"23","author":"Fang","year":"2017","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.cellsig.2026.112688_bb0205","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.3390\/antiox10081198","article-title":"Sirtuins and renal oxidative stress","volume":"10","author":"Ogura","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.cellsig.2026.112688_bb0210","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1159\/000447067","article-title":"Up-regulation of SIRT1 reduces endoplasmic reticulum stress and renal fibrosis","volume":"133","author":"Chang","year":"2016","journal-title":"Nephron"},{"key":"10.1016\/j.cellsig.2026.112688_bb0215","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/s00210-017-1360-9","article-title":"PARP inhibition ameliorates nephropathy in an animal model of type 2 diabetes: focus on oxidative stress, inflammation, and fibrosis","volume":"390","author":"Zakaria","year":"2017","journal-title":"Naunyn Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"10.1016\/j.cellsig.2026.112688_bb0220","doi-asserted-by":"crossref","DOI":"10.1515\/CCLM.2007.356","article-title":"The role of hyperhomocysteinemia and B-vitamin deficiency in neurological and psychiatric diseases","volume":"45","author":"Obeid","year":"2007","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.cellsig.2026.112688_bb0225","article-title":"Nicotinamide N-methyltransferase (NNMT): a novel therapeutic target for metabolic syndrome","volume":"15","author":"Sun","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.cellsig.2026.112688_bb0230","doi-asserted-by":"crossref","DOI":"10.3390\/nu17040626","article-title":"Association of homocysteine, S-adenosylhomocysteine and S-adenosylmethionine with cardiovascular events in chronic kidney disease","volume":"17","author":"Emrich","year":"2025","journal-title":"Nutrients"},{"key":"10.1016\/j.cellsig.2026.112688_bb0235","doi-asserted-by":"crossref","first-page":"S243","DOI":"10.1046\/j.1523-1755.2001.59780243.x","article-title":"Homocyst(e)ine, oxidative stress, and endothelium function in uremic patients","volume":"59","author":"Massy","year":"2001","journal-title":"Kidney Int."},{"key":"10.1016\/j.cellsig.2026.112688_bb0240","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1161\/CIRCRESAHA.116.308750","article-title":"Chronic kidney disease induces inflammatory CD40+ monocyte differentiation via homocysteine elevation and DNA hypomethylation","volume":"119","author":"Yang","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.cellsig.2026.112688_bb0245","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1159\/000444900","article-title":"Homocysteine in renal injury","volume":"2","author":"Long","year":"2016","journal-title":"Kidney Dis."},{"key":"10.1016\/j.cellsig.2026.112688_bb0250","doi-asserted-by":"crossref","first-page":"15554","DOI":"10.1038\/s41598-024-66034-9","article-title":"Nicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged mice","volume":"14","author":"Dimet-Wiley","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cellsig.2026.112688_bb0255","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.bcp.2019.02.008","article-title":"Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle","volume":"163","author":"Neelakantan","year":"2019","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cellsig.2026.112688_bb0260","doi-asserted-by":"crossref","DOI":"10.3390\/biom15091281","article-title":"Nicotinamide N-methyltransferase in cardiovascular diseases: metabolic regulator and emerging therapeutic target","volume":"15","author":"Jawaria","year":"2025","journal-title":"Biomolecules"},{"key":"10.1016\/j.cellsig.2026.112688_bb0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2025.117790","article-title":"Nicotinamide N-methyltransferase in cardiovascular diseases: mechanistic insights and therapeutic potential","volume":"295","author":"Bi","year":"2025","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.cellsig.2026.112688_bb0270","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1007\/s12035-020-02259-9","article-title":"High expression of nicotinamide N-methyltransferase in patients with sporadic alzheimer\u2019s disease","volume":"58","author":"Kocinaj","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.cellsig.2026.112688_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2025.115253","article-title":"Nicotinamide N-methyltransferase as a potential therapeutic target for neurodegenerative disorders: mechanisms, challenges, and future directions","volume":"389","author":"Liu","year":"2025","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.cellsig.2026.112688_bb0280","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/s41419-022-04713-z","article-title":"Complex roles of nicotinamide N-methyltransferase in cancer progression","volume":"13","author":"Wang","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cellsig.2026.112688_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113208","article-title":"Nicotinamide N-methyltransferase (NNMT): a key enzyme in cancer metabolism and therapeutic target","volume":"142","author":"Sun","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.cellsig.2026.112688_bb0290","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/s41420-024-01831-9","article-title":"Cellular senescence of renal tubular epithelial cells in acute kidney injury","volume":"10","author":"Chen","year":"2024","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.cellsig.2026.112688_bb0295","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1681\/ASN.2020091373","article-title":"Progressive cellular senescence mediates renal dysfunction in ischemic nephropathy","volume":"32","author":"Kim","year":"2021","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2026.112688_bb0300","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1631\/jzus.B0900249","article-title":"Nicotinamide N-methyltransferase protein expression in renal cell cancer","volume":"11","author":"Zhang","year":"2010","journal-title":"J. Zhejiang Univ. Sci. B"},{"key":"10.1016\/j.cellsig.2026.112688_bb0305","doi-asserted-by":"crossref","first-page":"F1138","DOI":"10.1152\/ajprenal.00315.2002","article-title":"Diabetic kidney disease in the db \/ db mouse","volume":"284","author":"Sharma","year":"2003","journal-title":"Am. J. Physiol.-Ren. Physiol."},{"key":"10.1016\/j.cellsig.2026.112688_bb0310","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/171383","article-title":"Age-associated molecular changes in the kidney in aged mice","volume":"2012","author":"Lim","year":"2012","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.cellsig.2026.112688_bb0315","article-title":"Nicotinamide N-methyltransferase ameliorates renal fibrosis by its metabolite 1-methylnicotinamide inhibiting the TGF-\u03b21\/Smad3 pathway","volume":"36","author":"Zhang","year":"2022","journal-title":"FASEB J."},{"key":"10.1016\/j.cellsig.2026.112688_bb0320","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.16301","article-title":"Elucidating the role of nicotinamide N-methyltransferase-p53 axis in the progression of chronic kidney disease","volume":"11","author":"Zhen","year":"2023","journal-title":"PeerJ"},{"key":"10.1016\/j.cellsig.2026.112688_bb0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdiacomp.2025.108952","article-title":"Nicotinamide n-methyltransferase inhibitor synergizes with sodium-glucose cotransporter 2 inhibitor to protect renal tubular epithelium in experimental models of type 2 diabetes mellitus","volume":"39","author":"Yang","year":"2025","journal-title":"J. Diabetes Complicat."},{"key":"10.1016\/j.cellsig.2026.112688_bb0330","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/s41581-019-0216-6","article-title":"NAD+ homeostasis in renal health and disease","volume":"16","author":"Ralto","year":"2020","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.cellsig.2026.112688_bb0335","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/nature17184","article-title":"PGC1\u03b1 drives NAD biosynthesis linking oxidative metabolism to renal protection","volume":"531","author":"Tran","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.cellsig.2026.112688_bb0340","doi-asserted-by":"crossref","first-page":"3995","DOI":"10.1111\/jcmm.14285","article-title":"Nicotinamide reduces renal interstitial fibrosis by suppressing tubular injury and inflammation","volume":"23","author":"Zheng","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.cellsig.2026.112688_bb0345","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.649547","article-title":"Nicotinamide mononucleotide attenuates renal interstitial fibrosis after AKI by suppressing tubular DNA damage and senescence","volume":"12","author":"Jia","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.cellsig.2026.112688_bb0350","article-title":"NNMT-DNMT1 axis is essential for maintaining cancer cell sensitivity to oxidative phosphorylation inhibition","volume":"10","author":"Wu","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.cellsig.2026.112688_bb0355","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s00109-021-02044-8","article-title":"Epigenetic modifications of klotho expression in kidney diseases","volume":"99","author":"Xia","year":"2021","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.cellsig.2026.112688_bb0360","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1161\/HYPERTENSIONAHA.120.14642","article-title":"Epigenetic regulation of KL (klotho) via H3K27me3 (histone 3 lysine [K] 27 trimethylation) in renal tubule cells","volume":"75","author":"Han","year":"2020","journal-title":"Hypertension"},{"key":"10.1016\/j.cellsig.2026.112688_bb0365","article-title":"Downregulation of EZH2 promotes renal epithelial cellular senescence and kidney aging","volume":"39","author":"Zhang","year":"2025","journal-title":"FASEB J."},{"key":"10.1016\/j.cellsig.2026.112688_bb0370","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1186\/s12882-023-03295-y","article-title":"Association of hyperhomocysteinemia and chronic kidney disease in the general population: a systematic review and meta-analysis","volume":"24","author":"Chen","year":"2023","journal-title":"BMC Nephrol."},{"key":"10.1016\/j.cellsig.2026.112688_bb0375","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1161\/ATVBAHA.114.303899","article-title":"Homocysteine accelerates senescence of endothelial cells via DNA hypomethylation of human telomerase reverse transcriptase","volume":"35","author":"Zhang","year":"2015","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.cellsig.2026.112688_bb0380","doi-asserted-by":"crossref","first-page":"219","DOI":"10.7150\/ijbs.16725","article-title":"Hyperhomocysteinemia exacerbates cisplatin-induced acute kidney injury","volume":"13","author":"Long","year":"2017","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.cellsig.2026.112688_bb0385","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1681\/ASN.2017050574","article-title":"Wnt9a promotes renal fibrosis by accelerating cellular senescence in tubular epithelial cells","volume":"29","author":"Luo","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2026.112688_bb0390","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nm.2144","article-title":"Epithelial cell cycle arrest in G2\/M mediates kidney fibrosis after injury","volume":"16","author":"Yang","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.cellsig.2026.112688_bb0395","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.166643","article-title":"Tubular cell senescence promotes maladaptive kidney repair and chronic kidney disease after cisplatin nephrotoxicity","volume":"8","author":"Li","year":"2023","journal-title":"JCI Insight"},{"key":"10.1016\/j.cellsig.2026.112688_bb0400","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.tibs.2006.11.006","article-title":"NAD+ metabolism in health and disease","volume":"32","author":"Belenky","year":"2007","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.cellsig.2026.112688_bb0405","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41580-020-00313-x","article-title":"NAD+ metabolism and its roles in cellular processes during ageing","volume":"22","author":"Covarrubias","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cellsig.2026.112688_bb0410","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.cmet.2016.07.005","article-title":"Loss of NAD homeostasis leads to progressive and reversible degeneration of skeletal muscle","volume":"24","author":"Frederick","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.cellsig.2026.112688_bb0415","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3390\/ijms24010137","article-title":"Roles of NAD+ in acute and chronic kidney diseases","volume":"24","author":"Morevati","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cellsig.2026.112688_bb0420","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1046\/j.1523-1755.63.s84.36.x","article-title":"N-methyl-2-pyridone-5-carboxamide: a novel uremic toxin?","volume":"63","author":"Rutkowski","year":"2003","journal-title":"Kidney Int."},{"key":"10.1016\/j.cellsig.2026.112688_bb0425","doi-asserted-by":"crossref","first-page":"339","DOI":"10.3390\/toxins8110339","article-title":"N-methyl-2-pyridone-5-carboxamide (2PY)\u2014major metabolite of nicotinamide: An update on an old uremic toxin","volume":"8","author":"Lenglet","year":"2016","journal-title":"Toxins"},{"key":"10.1016\/j.cellsig.2026.112688_bb0430","article-title":"Impaired nicotinamide adenine dinucleotide biosynthesis in the kidney of chronic kidney disease","volume":"12","author":"Liu","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.cellsig.2026.112688_bb0435","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1038\/s41591-018-0138-z","article-title":"De novo NAD+ biosynthetic impairment in acute kidney injury in humans","volume":"24","author":"Poyan Mehr","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.cellsig.2026.112688_bb0440","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3390\/toxins13010050","article-title":"Nicotinamide attenuates the progression of renal failure in a mouse model of adenine-induced chronic kidney disease","volume":"13","author":"Kumakura","year":"2021","journal-title":"Toxins"},{"key":"10.1016\/j.cellsig.2026.112688_bb0445","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1159\/000510943","article-title":"Nicotinamide supplementation attenuates renal interstitial fibrosis via boosting the activity of sirtuins","volume":"7","author":"Zhen","year":"2021","journal-title":"Kidney Dis."},{"key":"10.1016\/j.cellsig.2026.112688_bb0450","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1126\/science.aad8242","article-title":"A conserved NAD+ binding pocket that regulates protein-protein interactions during aging","volume":"355","author":"Li","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.cellsig.2026.112688_bb0455","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.126749","article-title":"TFEB-driven lysosomal biogenesis is pivotal for PGC1\u03b1-dependent renal stress resistance","volume":"4","author":"Lynch","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.cellsig.2026.112688_bb0460","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2020.111215","article-title":"SIRT1 and aging related signaling pathways","volume":"187","author":"Chen","year":"2020","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.cellsig.2026.112688_bb0465","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1164\/rccm.201810-1975TR","article-title":"Cellular senescence as a mechanism and target in chronic lung diseases","volume":"200","author":"Barnes","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.cellsig.2026.112688_bb0470","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.arr.2011.12.005","article-title":"AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network","volume":"11","author":"Salminen","year":"2012","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.cellsig.2026.112688_bb0475","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.yjmcc.2007.08.008","article-title":"Sirt1 modulates premature senescence-like phenotype in human endothelial cells","volume":"43","author":"Ota","year":"2007","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.cellsig.2026.112688_bb0480","first-page":"1030","article-title":"Oxidative stress and senescence in aging kidneys: the protective role of SIRT1","volume":"23","author":"Almalki","year":"2024","journal-title":"EXCLI J."},{"key":"10.1016\/j.cellsig.2026.112688_bb0485","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.943321","article-title":"Therapeutic application of quercetin in aging-related diseases: SIRT1 as a potential mechanism","volume":"13","author":"Cui","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cellsig.2026.112688_bb0490","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.3390\/jcm9082623","article-title":"Virus-induced asthma exacerbations: SIRT1 targeted approach","volume":"9","author":"Fukuda","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.cellsig.2026.112688_bb0495","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.tcb.2025.07.006","article-title":"The wnt\u2013NAD+ axis in cancer, aging, and tissue regeneration","volume":"36","author":"Lamprecht","year":"2026","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.cellsig.2026.112688_bb0500","doi-asserted-by":"crossref","first-page":"77707","DOI":"10.18632\/oncotarget.12774","article-title":"SIRT1 suppresses adipogenesis by activating wnt\/\u03b2-catenin signaling in vivo and in vitro","volume":"7","author":"Zhou","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.cellsig.2026.112688_bb0505","doi-asserted-by":"crossref","first-page":"9216","DOI":"10.1073\/pnas.0911325107","article-title":"SIRT1 regulates dishevelled proteins and promotes transient and constitutive wnt signaling","volume":"107","author":"Holloway","year":"2010","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.cellsig.2026.112688_bb0510","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1158\/1541-7786.MCR-14-0223-T","article-title":"SIRT2 interacts with \u03b2-catenin to inhibit wnt signaling output in response to radiation-induced stress","volume":"12","author":"Nguyen","year":"2014","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.cellsig.2026.112688_bb0515","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13004","article-title":"Wnt\/\u03b2-catenin\/RAS signaling mediates age-related renal fibrosis and is associated with mitochondrial dysfunction","volume":"18","author":"Miao","year":"2019","journal-title":"Aging Cell"},{"key":"10.1016\/j.cellsig.2026.112688_bb0520","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1006\/abbi.1997.0249","article-title":"Pancreatic exocrine secretion is blocked by inhibitors of methylation","volume":"345","author":"Capdevila","year":"1997","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.cellsig.2026.112688_bb0525","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1016\/j.drudis.2021.05.011","article-title":"Nicotinamide N-methyl transferase (NNMT): An emerging therapeutic target","volume":"26","author":"Gao","year":"2021","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.cellsig.2026.112688_bb0530","doi-asserted-by":"crossref","first-page":"5524","DOI":"10.1021\/acs.biochem.8b00775","article-title":"Kinetic mechanism of nicotinamide N-methyltransferase","volume":"57","author":"Loring","year":"2018","journal-title":"Biochemistry"},{"key":"10.1016\/j.cellsig.2026.112688_bb0535","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1186\/s12882-024-03916-0","article-title":"DNA methylation in chronic kidney disease","volume":"26","author":"Cheng","year":"2025","journal-title":"BMC Nephrol."},{"key":"10.1016\/j.cellsig.2026.112688_bb0540","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s10157-022-02181-5","article-title":"Altered DNA methylation in kidney disease: useful markers and therapeutic targets","volume":"26","author":"Hayashi","year":"2022","journal-title":"Clin. Exp. Nephrol."},{"key":"10.1016\/j.cellsig.2026.112688_bb0545","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/nchembio.1204","article-title":"NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink","volume":"9","author":"Ulanovskaya","year":"2013","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.cellsig.2026.112688_bb0550","doi-asserted-by":"crossref","first-page":"21070","DOI":"10.1038\/s41598-025-06713-3","article-title":"DNMT3B aggravated renal fibrosis in diabetic kidney disease via activating wnt\/\u03b2-catenin signaling pathway","volume":"15","author":"Qu","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cellsig.2026.112688_bb0555","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1681\/ASN.2015040449","article-title":"Sustained activation of wnt\/\u03b2-catenin signaling drives AKI to CKD progression","volume":"27","author":"Xiao","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2026.112688_bb0560","series-title":"Histone Mutations and cancer","year":"2021"},{"key":"10.1016\/j.cellsig.2026.112688_bb0565","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"L\u00f3pez-Ot\u00edn","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.cellsig.2026.112688_bb0570","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13212","article-title":"Histone methyltransferase Smyd3 is a new regulator for vascular senescence","volume":"19","author":"Yang","year":"2020","journal-title":"Aging Cell"},{"key":"10.1016\/j.cellsig.2026.112688_bb0575","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1681\/ASN.2015040457","article-title":"Enhancer of zeste homolog 2 inhibition attenuates renal fibrosis by maintaining Smad7 and phosphatase and tensin homolog expression","volume":"27","author":"Zhou","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2026.112688_bb0580","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.7150\/thno.83353","article-title":"Histone H3K27 methyltransferase EZH2 regulates apoptotic and inflammatory responses in sepsis-induced AKI","volume":"13","author":"Li","year":"2023","journal-title":"Theranostics"},{"key":"10.1016\/j.cellsig.2026.112688_bb0585","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/s41419-023-05782-4","article-title":"Enhancer of zeste homolog 2 promotes renal fibrosis after acute kidney injury by inducing epithelial-mesenchymal transition and activation of M2 macrophage polarization","volume":"14","author":"Zhou","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cellsig.2026.112688_bb0590","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1186\/s12967-025-07350-0","article-title":"Histone modification\u2013mediated epigenetic regulation in AKI-to-CKD transition: a cell-type-specific perspective","volume":"23","author":"Chai","year":"2025","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.cellsig.2026.112688_bb0595","doi-asserted-by":"crossref","first-page":"114","DOI":"10.4103\/jrpp.jrpp_75_21","article-title":"Homocysteine-lowering interventions in chronic kidney disease","volume":"10","author":"Badri","year":"2021","journal-title":"J. Res. Pharm. Pract."},{"key":"10.1016\/j.cellsig.2026.112688_bb0600","series-title":"Adv. Clin. Chem.","first-page":"77","article-title":"Homocysteine in chronic kidney disease","year":"2015"},{"key":"10.1016\/j.cellsig.2026.112688_bb0605","doi-asserted-by":"crossref","first-page":"183","DOI":"10.23876\/j.krcp.20.163","article-title":"Implications of oxidative stress in chronic kidney disease: a review on current concepts and therapies","volume":"40","author":"Verma","year":"2021","journal-title":"Kidney Res. Clin. Pract."},{"key":"10.1016\/j.cellsig.2026.112688_bb0610","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s00005-017-0496-0","article-title":"Oxidative stress in kidney diseases: the cause or the consequence?","volume":"66","author":"Krata","year":"2018","journal-title":"Arch. Immunol. Ther. Exp."},{"key":"10.1016\/j.cellsig.2026.112688_bb0615","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jep.2015.06.049","article-title":"Evaluation of anti-asthmatic and antioxidant potential of boerhavia procumbens in toluene diisocyanate (TDI) treated rats","volume":"172","author":"Bokhari","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.cellsig.2026.112688_bb0620","first-page":"1","article-title":"Hypoxia-induced ROS contribute to myoblast pyroptosis during obstructive sleep apnea via the NF-\u03baB\/HIF-1\u03b1 signaling pathway","volume":"2019","author":"Yu","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.cellsig.2026.112688_bb0625","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102022","article-title":"Protease-activated receptor 2 induces ROS-mediated inflammation through akt-mediated NF-\u03baB and FoxO6 modulation during skin photoaging","volume":"44","author":"Bang","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.cellsig.2026.112688_bb0630","doi-asserted-by":"crossref","first-page":"C621","DOI":"10.1152\/ajpcell.00096.2014","article-title":"Impact of ER stress-regulated ATF4\/p16 signaling on the premature senescence of renal tubular epithelial cells in diabetic nephropathy","volume":"308","author":"Liu","year":"2015","journal-title":"Am. J. Physiol.-Cell Physiol."},{"key":"10.1016\/j.cellsig.2026.112688_bb0635","doi-asserted-by":"crossref","first-page":"C415","DOI":"10.1152\/ajpcell.00334.2014","article-title":"The unfolded protein response and cellular senescence. A review in the theme: cellular mechanisms of endoplasmic reticulum stress signaling in health and disease","volume":"308","author":"Pluquet","year":"2015","journal-title":"Am. J. Physiol.-Cell Physiol."},{"key":"10.1016\/j.cellsig.2026.112688_bb0640","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1158\/1541-7786.MCR-18-0055","article-title":"Ferroptosis-induced endoplasmic reticulum stress: cross-talk between ferroptosis and apoptosis","volume":"16","author":"Lee","year":"2018","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.cellsig.2026.112688_bb0645","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.cellsig.2013.10.002","article-title":"Receptor for advanced glycation end-products promotes premature senescence of proximal tubular epithelial cells via activation of endoplasmic reticulum stress-dependent p21 signaling","volume":"26","author":"Liu","year":"2014","journal-title":"Cell. Signal."},{"key":"10.1016\/j.cellsig.2026.112688_bb0650","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1159\/000363717","article-title":"Apoptosis, fibrosis and senescence","volume":"127","author":"Portilla","year":"2014","journal-title":"Nephron Clin. Pract."},{"key":"10.1016\/j.cellsig.2026.112688_bb0655","doi-asserted-by":"crossref","first-page":"454","DOI":"10.33545\/26174693.2025.v9.i12f.6532","article-title":"Cellular senescence and fibrosis as key drivers in the aftermath of acute kidney injury","volume":"9","author":"Salem","year":"2025","journal-title":"Int. J. Adv. Biochem. Res."},{"key":"10.1016\/j.cellsig.2026.112688_bb0660","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.823935","article-title":"Sympathetic denervation ameliorates renal fibrosis via inhibition of cellular senescence","volume":"12","author":"Li","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cellsig.2026.112688_bb0665","doi-asserted-by":"crossref","first-page":"64520","DOI":"10.18632\/oncotarget.17327","article-title":"Cellular senescence, senescence-associated secretory phenotype, and chronic kidney disease","volume":"8","author":"Wang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.cellsig.2026.112688_bb0670","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1038\/nm.3218","article-title":"Origin and function of myofibroblasts in kidney fibrosis","volume":"19","author":"LeBleu","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.cellsig.2026.112688_bb0675","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/nm.3902","article-title":"Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis","volume":"21","author":"Lovisa","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.cellsig.2026.112688_bb0680","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.numecd.2011.01.005","article-title":"Plasma cytokines, glomerular filtration rate and adipose tissue cytokines gene expression in chronic kidney disease (CKD) patients","volume":"22","author":"Spoto","year":"2012","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"10.1016\/j.cellsig.2026.112688_bb0685","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.immuni.2013.10.022","article-title":"Interleukin-6 signaling drives fibrosis in unresolved inflammation","volume":"40","author":"Fielding","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.cellsig.2026.112688_bb0690","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s12931-020-1319-0","article-title":"TGF-\u03b2 pathway activation by idiopathic pulmonary fibrosis (IPF) fibroblast derived soluble factors is mediated by IL-6 trans-signaling","volume":"21","author":"Epstein Shochet","year":"2020","journal-title":"Respir. Res."},{"key":"10.1016\/j.cellsig.2026.112688_bb0695","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.3390\/biomedicines11092408","article-title":"Protein-bound uremic toxins in senescence and kidney fibrosis","volume":"11","author":"Yang","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.cellsig.2026.112688_bb0700","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a022145","article-title":"TGF-\u03b2 family signaling in the control of cell proliferation and survival","volume":"9","author":"Zhang","year":"2017","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.cellsig.2026.112688_bb0705","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a022293","article-title":"TGF-\u03b21 signaling and tissue fibrosis","volume":"10","author":"Kim","year":"2018","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.cellsig.2026.112688_bb0710","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.cell.2017.08.028","article-title":"Putting p53 in context","volume":"170","author":"Kastenhuber","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.cellsig.2026.112688_bb0715","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.3390\/biomedicines12091942","article-title":"Renal fibrosis: SIRT1 still of value","volume":"12","author":"Wu","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.cellsig.2026.112688_bb0720","doi-asserted-by":"crossref","first-page":"6686","DOI":"10.3390\/ijms21186686","article-title":"The role of sirtuins in kidney diseases","volume":"21","author":"Hong","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cellsig.2026.112688_bb0725","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1172\/JCI41563","article-title":"Sirt1 activation protects the mouse renal medulla from oxidative injury","volume":"120","author":"He","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cellsig.2026.112688_bb0730","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.3390\/cells11091477","article-title":"Loss of proximal tubular sirtuin 6 aggravates unilateral ureteral obstruction-induced tubulointerstitial inflammation and fibrosis by regulation of \u03b2-catenin acetylation","volume":"11","author":"Jin","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.cellsig.2026.112688_bb0735","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s10495-016-1341-3","article-title":"SIRT2-mediated FOXO3a deacetylation drives its nuclear translocation triggering FasL-induced cell apoptosis during renal ischemia reperfusion","volume":"22","author":"Wang","year":"2017","journal-title":"Apoptosis"},{"key":"10.1016\/j.cellsig.2026.112688_bb0740","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1007\/s10157-024-02545-z","article-title":"Knockdown of nicotinamide N-methyltransferase ameliorates renal fibrosis caused by ischemia\u2013reperfusion injury and remodels sphingosine metabolism","volume":"28","author":"Xu","year":"2024","journal-title":"Clin. Exp. Nephrol."},{"key":"10.1016\/j.cellsig.2026.112688_bb0745","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2025.110558","article-title":"Nicotinamide N-methyltransferase in non-alcoholic fatty liver disease: mechanistic insights and emerging therapeutic strategies","volume":"772","author":"Zhang","year":"2025","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.cellsig.2026.112688_bb0750","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0071272","article-title":"RNA-mediated gene silencing of nicotinamide N-methyltransferase is associated with decreased tumorigenicity in human oral carcinoma cells","volume":"8","author":"Pozzi","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.cellsig.2026.112688_bb0755","doi-asserted-by":"crossref","first-page":"6057","DOI":"10.1080\/21655979.2021.1967711","article-title":"Long non-coding RNA XIST promotes osteoporosis by inhibiting the differentiation of bone marrow mesenchymal stem cell by sponging miR-29b-3p that suppresses nicotinamide N-methyltransferase","volume":"12","author":"Yu","year":"2021","journal-title":"Bioengineered"},{"key":"10.1016\/j.cellsig.2026.112688_bb0760","doi-asserted-by":"crossref","first-page":"12482","DOI":"10.1080\/21655979.2021.2006863","article-title":"Knockdown of long non-coding RNA HOTAIR promotes bone marrow mesenchymal stem cell differentiation by sponging microRNA miR-378g that inhibits nicotinamide N-methyltransferase","volume":"12","author":"Wang","year":"2021","journal-title":"Bioengineered"},{"key":"10.1016\/j.cellsig.2026.112688_bb0765","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1177\/039463201102400109","article-title":"Inhibiting proliferation in KB cancer cells by RNA interference-mediated knockdown of nicotinamide N-methyltransferase expression","volume":"24","author":"Pozzi","year":"2011","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"10.1016\/j.cellsig.2026.112688_bb0770","doi-asserted-by":"crossref","DOI":"10.1681\/ASN.20257za33bc1","article-title":"Inhibition of nicotinamide N-methyltransferase (NNMT), linked to progression of human CKD, blocks kidney injury in a mouse model of diabetic kidney disease: SA-PO0336","volume":"36","author":"Stromstedt","year":"2025","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2026.112688_bb0775","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1021\/acsmedchemlett.5c00762","article-title":"Structure-based drug discovery of non-SAM-mimetic bisubstrate inhibitors against nicotinamide N -methyltransferase","volume":"17","author":"Yoshida","year":"2026","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.cellsig.2026.112688_bb0780","article-title":"Wcn26-2200 inhibition of NNMT, a kidney failure-associated gene indentified by transcriptomic analysis, blocks progression of DKD in mice","volume":"11","author":"Ju","year":"2026","journal-title":"Kidney Int. Rep."},{"key":"10.1016\/j.cellsig.2026.112688_bb0785","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.7150\/ijbs.93598","article-title":"Chk2 modulates Bmi1-deficiency-induced renal aging and fibrosis via oxidative stress, DNA damage, and p53\/TGF\u03b21-induced epithelial-mesenchymal transition","volume":"20","author":"Lu","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.cellsig.2026.112688_bb0790","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1039\/D1MD00016K","article-title":"Mechanisms and inhibitors of nicotinamide N -methyltransferase","volume":"12","author":"Iyamu","year":"2021","journal-title":"RSC Med. Chem."},{"key":"10.1016\/j.cellsig.2026.112688_bb0795","doi-asserted-by":"crossref","DOI":"10.1016\/j.tips.2026.04.002","article-title":"Emerging opportunities for nicotinamide N-methyltransferase (NNMT) inhibitor clinical translation","author":"Puleo","year":"2026","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.cellsig.2026.112688_bb0800","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2025.108492","article-title":"Mechanism and kinetics of turnover inhibitors of nicotinamide N-methyl transferase in vitro and in vivo","volume":"301","author":"Akerud","year":"2025","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2026.112688_bb0805","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.smhs.2019.08.006","article-title":"Physical activity, exercise, and chronic diseases: a brief review","volume":"1","author":"Anderson","year":"2019","journal-title":"Sports Med. Health Sci."},{"key":"10.1016\/j.cellsig.2026.112688_bb0810","doi-asserted-by":"crossref","first-page":"485","DOI":"10.2165\/00007256-200535060-00003","article-title":"Exercise and chronic kidney disease: current recommendations","volume":"35","author":"Johansen","year":"2005","journal-title":"Sports Med."},{"key":"10.1016\/j.cellsig.2026.112688_bb0815","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1681\/ASN.2013070702","article-title":"Evidence for anti-inflammatory effects of exercise in CKD","volume":"25","author":"Viana","year":"2014","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cellsig.2026.112688_bb0820","article-title":"Aerobic exercise up-regulates klotho to improve renal fibrosis associated with aging and its mechanism","volume":"19","author":"Zhao","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.cellsig.2026.112688_bb0825","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.scispo.2016.06.004","article-title":"Influence of exercises using different energy metabolism systems on NNMT expression in different types of skeletal muscle fibers","volume":"32","author":"Li","year":"2017","journal-title":"Sci. Sports"},{"key":"10.1016\/j.cellsig.2026.112688_bb0830","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S1734-1140(12)70777-6","article-title":"Single bout of endurance exercise increases NNMT activity in the liver and MNA concentration in plasma; the role of IL-6","volume":"64","author":"Ch\u0142opicki","year":"2012","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.cellsig.2026.112688_bb0835","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.neurobiolaging.2022.08.014","article-title":"Evidence of sex differences in cellular senescence","volume":"120","author":"Ng","year":"2022","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.cellsig.2026.112688_bb0840","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.kint.2025.10.019","article-title":"Targeting cellular senescence in diabetic kidney disease: potential of regenerative, cell-based therapies and other senotherapeutic approaches","volume":"109","author":"Patel","year":"2026","journal-title":"Kidney Int."},{"key":"10.1016\/j.cellsig.2026.112688_bb0845","doi-asserted-by":"crossref","first-page":"6585","DOI":"10.3390\/ijms25126585","article-title":"Kidney aging and chronic kidney disease","volume":"25","author":"Zhang","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cellsig.2026.112688_bb0850","doi-asserted-by":"crossref","first-page":"322","DOI":"10.3390\/jcm13020322","article-title":"SA-\u03b2-gal in kidney tubules as a predictor of renal outcome in patients with chronic kidney disease","volume":"13","author":"Esposito","year":"2024","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.cellsig.2026.112688_bb0855","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-19634-2","article-title":"Novel tricyclic small molecule inhibitors of nicotinamide N-methyltransferase for the treatment of metabolic disorders","volume":"12","author":"Ruf","year":"2022","journal-title":"Sci. Rep."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826003438?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826003438?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T04:18:51Z","timestamp":1785903531000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656826003438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":171,"alternative-id":["S0898656826003438"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112688","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nicotinamide N-methyltransferase as a stress-responsive metabolic-epigenetic regulator of tubular senescence in chronic kidney disease","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112688","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112688"}}