{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T12:28:58Z","timestamp":1787056138329,"version":"build-2736575974"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M754280"],"award-info":[{"award-number":["2024M754280"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007289","name":"Nanjing Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.cellsig.2026.112724","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T15:35:53Z","timestamp":1783524953000},"page":"112724","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["IP3R1-mediated Ca2+ overload promotes SAH-induced neuron apoptosis through MAMs"],"prefix":"10.1016","volume":"147","author":[{"given":"Zhonghua","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peipei","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellsig.2026.112724_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102960","article-title":"CXCR4-BTK axis mediate pyroptosis and lipid peroxidation in early brain injury after subarachnoid hemorrhage via NLRP3 inflammasome and NF-kappaB pathway","volume":"68","author":"Liu","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.cellsig.2026.112724_bb0010","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6966394","article-title":"Rh-CXCL-12 attenuates neuronal pyroptosis after subarachnoid hemorrhage in rats via regulating the CXCR4\/NLRP1 pathway","volume":"2021","author":"Gu","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112724_bb0015","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/s41419-020-2248-z","article-title":"Inhibition of AIM2 inflammasome activation alleviates GSDMD-induced pyroptosis in early brain injury after subarachnoid haemorrhage","volume":"11","author":"Yuan","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cellsig.2026.112724_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainresbull.2023.110743","article-title":"MCC950 ameliorates cognitive function by reducing white matter microstructure damage in rats after SAH","volume":"202","author":"Cao","year":"2023","journal-title":"Brain Res. Bull."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112724_bb0025","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/cns.13548","article-title":"Acyl-CoA synthetase long chain family member 4 plays detrimental role in early brain injury after subarachnoid hemorrhage in rats by inducing ferroptosis","volume":"27","author":"Qu","year":"2021","journal-title":"CNS Neurosci. Ther."},{"issue":"16","key":"10.1016\/j.cellsig.2026.112724_bb0030","doi-asserted-by":"crossref","DOI":"10.3390\/jcm11164679","article-title":"Montreal cognitive assessment for evaluating cognitive impairment in subarachnoid hemorrhage: a systematic review","volume":"11","author":"Cornea","year":"2022","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.cellsig.2026.112724_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2021.101169","article-title":"A guide to understanding endoplasmic reticulum stress in metabolic disorders","volume":"47","author":"Lemmer","year":"2021","journal-title":"Mol. Metab."},{"key":"10.1016\/j.cellsig.2026.112724_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2026.103096","article-title":"Endoplasmic reticulum stress in Parkinson\u2019s disease: a pivotal role in cell fate and a therapeutic target","volume":"118","author":"Chen","year":"2026","journal-title":"Ageing Res. Rev."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112724_bb0045","first-page":"4043","article-title":"Calcium-mediated calreticulin-IRE1alpha interaction drives dynamic fluctuation of IRE1alpha activity under chronic endoplasmic reticulum stress","volume":"17","author":"Cao","year":"2026","journal-title":"Nat"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112724_bb0050","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/cns.14011","article-title":"Disruption of mitochondrial-associated ER membranes by HIV-1 tat protein contributes to premature brain aging","volume":"29","author":"Arjona","year":"2023","journal-title":"CNS Neurosci. Ther."},{"issue":"5","key":"10.1016\/j.cellsig.2026.112724_bb0055","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2022.12681","article-title":"Preserving mitochondrial function by inhibiting GRP75 ameliorates neuron injury under ischemic stroke","volume":"25","author":"Wen","year":"2022","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.cellsig.2026.112724_bb0060","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.685201","article-title":"Sigma-1 receptor: a potential therapeutic target for traumatic brain injury","volume":"15","author":"Shi","year":"2021","journal-title":"Front. Cell. Neurosci."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112724_bb0065","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.31190","article-title":"By regulating the IP3R\/GRP75\/VDAC1 complex to restore mitochondrial dynamic balance, selenomethionine reduces lipopolysaccharide-induced neuronal apoptosis","volume":"239","author":"Xu","year":"2024","journal-title":"J. Cell. Physiol."},{"issue":"5","key":"10.1016\/j.cellsig.2026.112724_bb0070","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci13050816","article-title":"Role of protein tyrosine phosphatase 1B inhibitor in early brain injury of subarachnoid hemorrhage in mice","volume":"13","author":"Zhang","year":"2023","journal-title":"Brain Sci."},{"key":"10.1016\/j.cellsig.2026.112724_bb0075","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.freeradbiomed.2018.06.035","article-title":"Cerebroprotection by salvianolic acid B after experimental subarachnoid hemorrhage occurs via Nrf2- and SIRT1-dependent pathways","volume":"124","author":"Zhang","year":"2018","journal-title":"Free Radic. Biol. Med."},{"issue":"10","key":"10.1016\/j.cellsig.2026.112724_bb0080","doi-asserted-by":"crossref","first-page":"6920","DOI":"10.1002\/jcp.30351","article-title":"Atorvastatin ameliorates early brain injury after subarachnoid hemorrhage via inhibition of pyroptosis and neuroinflammation","volume":"236","author":"Chen","year":"2021","journal-title":"J. Cell. Physiol."},{"issue":"5\u20136","key":"10.1016\/j.cellsig.2026.112724_bb0085","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1089\/neu.2021.0382","article-title":"Restoration of brain angiotensin-converting enzyme 2 alleviates neurological deficits after severe traumatic brain injury via mitigation of pyroptosis and apoptosis","volume":"39","author":"Li","year":"2022","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.cellsig.2026.112724_bb0090","series-title":"Temporal Immune Profiling in the CSF and Blood of Patients with Aneurysmal Subarachnoid Hemorrhage","author":"Ujas","year":"2024"},{"key":"10.1016\/j.cellsig.2026.112724_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102289","article-title":"IP3R1\/GRP75\/VDAC1 complex mediates endoplasmic reticulum stress-mitochondrial oxidative stress in diabetic atrial remodeling","volume":"52","author":"Yuan","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.cellsig.2026.112724_bb0100","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2020.592129","article-title":"The molecular mechanisms underlying mitochondria-associated endoplasmic reticulum membrane-induced insulin resistance","volume":"11","author":"Cheng","year":"2020","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.cellsig.2026.112724_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceca.2023.102743","article-title":"The ER-mitochondria interface, where Ca(2+) and cell death meet","volume":"112","author":"de Ridder","year":"2023","journal-title":"Cell Calcium"},{"issue":"7","key":"10.1016\/j.cellsig.2026.112724_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.102061","article-title":"Regulation of calcium homeostasis and flux between the endoplasmic reticulum and the cytosol","volume":"298","author":"Daverkausen-Fischer","year":"2022","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2026.112724_bb0115","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2025.1665272","article-title":"ER stress sensors at the ER-mitochondrial interface, controlling mitochondrial health in neurodegenerative diseases","volume":"19","author":"Kunja","year":"2025","journal-title":"Front. Neurosci."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112724_bb0120","doi-asserted-by":"crossref","DOI":"10.3390\/cells15040352","article-title":"The interplay between Ca(2+) homeostasis, endoplasmic reticulum stress, and the unfolded protein response in human diseases","volume":"15","author":"Ranzato","year":"2026","journal-title":"Cells"},{"issue":"19","key":"10.1016\/j.cellsig.2026.112724_bb0125","doi-asserted-by":"crossref","first-page":"3843","DOI":"10.1007\/s00018-019-03091-8","article-title":"Bcl-2 and IP(3) compete for the ligand-binding domain of IP(3)Rs modulating Ca(2+) signaling output","volume":"76","author":"Ivanova","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112724_bb0130","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1038\/s41467-022-28930-4","article-title":"iRhom pseudoproteases regulate ER stress-induced cell death through IP(3) receptors and BCL-2","volume":"13","author":"Dulloo","year":"2022","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112724_bb0135","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/s41418-021-00894-w","article-title":"Bcl-xL acts as an inhibitor of IP(3)R channels, thereby antagonizing Ca(2+)-driven apoptosis","volume":"29","author":"Rosa","year":"2022","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.cellsig.2026.112724_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceca.2021.102453","article-title":"Ca(2+) handling at the mitochondria-ER contact sites in neurodegeneration","volume":"98","author":"Lim","year":"2021","journal-title":"Cell Calcium"},{"issue":"5","key":"10.1016\/j.cellsig.2026.112724_bb0145","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1002\/jcb.30414","article-title":"The mitochondrial calcium signaling, regulation, and cellular functions: a novel target for therapeutic medicine in neurological disorders","volume":"124","author":"Bagheri-Mohammadi","year":"2023","journal-title":"J. Cell. Biochem."},{"issue":"12","key":"10.1016\/j.cellsig.2026.112724_bb0150","doi-asserted-by":"crossref","first-page":"3349","DOI":"10.4103\/NRR.NRR-D-24-00630","article-title":"Calcium bridges built by mitochondria-associated endoplasmic reticulum membranes: potential targets for neural repair in neurological diseases","volume":"20","author":"Peng","year":"2024","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.cellsig.2026.112724_bb0155","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.920228","article-title":"The potential of small molecules to modulate the mitochondria-endoplasmic reticulum interplay in Alzheimer\u2019s disease","volume":"10","author":"Dentoni","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112724_bb0160","article-title":"Increased Ca2 + transport across the mitochondria-associated membranes by Mfn2 inhibiting endoplasmic reticulum stress in ischemia\/reperfusion kidney injury","volume":"13","author":"Wang","year":"2023","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112724_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.cstres.2025.100112","article-title":"The role of Atp2a2-mediated calcium imbalance and endoplasmic reticulum stress in hydrocortisone-induced neurotoxicity","volume":"30","author":"Kong","year":"2025","journal-title":"Cell Stress Chaperones"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112724_bb0170","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1007\/s12035-025-05558-1","article-title":"Metformin ameliorates early brain injury after subarachnoid hemorrhage via improving endoplasmic reticulum stress and mitochondrial stress-mediated Ca(2+) imbalance","volume":"63","author":"Zhang","year":"2025","journal-title":"Mol. Neurobiol."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112724_bb0175","article-title":"Noncanonical feedback loop between \u201cRIP3-MLKL\u201d and \u201c4EBP1-eIF4E\u201d promotes neuronal necroptosis","volume":"6","author":"Wang","year":"2025","journal-title":"MedComm (2020)"},{"issue":"4","key":"10.1016\/j.cellsig.2026.112724_bb0180","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.4103\/NRR.NRR-D-24-00674","article-title":"Voltage-dependent anion channel 1 oligomerization regulates PANoptosis in retinal ischemia-reperfusion injury","volume":"21","author":"Wan","year":"2026","journal-title":"Neural Regen. Res."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826003803?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826003803?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T11:40:06Z","timestamp":1787053206000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656826003803"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":36,"alternative-id":["S0898656826003803"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112724","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IP3R1-mediated Ca2+ overload promotes SAH-induced neuron apoptosis through MAMs","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112724","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"112724"}}