{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T12:29:00Z","timestamp":1787056140761,"version":"build-2736575974"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["e-26\/210.516\/2025\\u2014SEI\\u201460003\/004592\/2025"],"award-info":[{"award-number":["e-26\/210.516\/2025\\u2014SEI\\u201460003\/004592\/2025"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.cellsig.2026.112736","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T15:40:28Z","timestamp":1783698028000},"page":"112736","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Inorganic phosphate beyond a mineral: Signal transduction in multi-organ pathology"],"prefix":"10.1016","volume":"147","author":[{"given":"Amanda Lima","family":"Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz Bereda","family":"da Silva Freitas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Henrique Silva","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filipe","family":"de Oliveira-Nascimento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederico Freire","family":"Bastos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Antonio","family":"Lacerda-Abreu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.cellsig.2026.112736_bb0005","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.bbcan.2018.05.001","article-title":"Inorganic phosphate transporters in cancer: functions, molecular mechanisms and possible clinical applications","volume":"1870","author":"Lacerda-Abreu","year":"2018","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"issue":"3","key":"10.1016\/j.cellsig.2026.112736_bb0010","doi-asserted-by":"crossref","first-page":"187","DOI":"10.2174\/1568009622666220928140702","article-title":"Inorganic phosphate (pi) in the breast cancer microenvironment: production, transport and signal transduction as potential targets for anticancer strategies","volume":"23","author":"Lacerda-Abreu","year":"2023","journal-title":"Curr. Cancer Drug Targets"},{"issue":"15","key":"10.1016\/j.cellsig.2026.112736_bb0015","doi-asserted-by":"crossref","first-page":"7768","DOI":"10.3390\/ijms22157768","article-title":"Extracellular inorganic phosphate-induced release of reactive oxygen species: roles in physiological processes and disease development","volume":"22","author":"Lacerda-Abreu","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"18","key":"10.1016\/j.cellsig.2026.112736_bb0020","doi-asserted-by":"crossref","DOI":"10.3390\/ijms221810096","article-title":"Hydrogen peroxide generation as an underlying response to high extracellular inorganic phosphate (pi) in breast cancer cells","volume":"22","author":"Lacerda-Abreu","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112736_bb0025","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1161\/ATVBAHA.123.319198","article-title":"Phosphate in cardiovascular disease: from new insights into molecular mechanisms to clinical implications","volume":"44","author":"Turner","year":"2024","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.cellsig.2026.112736_bb0030","series-title":"Nephrology Secrets","first-page":"551","article-title":"Disorders of phosphorus metabolism","author":"Rudolph","year":"2012"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112736_bb0035","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/s41392-022-01036-5","article-title":"Signalling pathways of chronic kidney diseases, implications for therapeutics","volume":"7","author":"Yuan","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"issue":"11","key":"10.1016\/j.cellsig.2026.112736_bb0040","first-page":"2077","article-title":"Signalling pathways involved in vascular smooth muscle cell calcification during hyperphosphataemia","volume":"76","author":"Voelkl","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.cellsig.2026.112736_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.122309","article-title":"Vascular calcification and cellular signalling pathways as potential therapeutic targets","volume":"336","author":"Kang","year":"2024","journal-title":"Life Sci."},{"key":"10.1016\/j.cellsig.2026.112736_bb0050","article-title":"SGLT2 inhibitors and diabetic kidney disease: targeting multiple and interrelated signaling pathways for renal protection","volume":"17","author":"Papaetis","year":"2024","journal-title":"Curr. Mol. Pharmacol."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112736_bb0055","doi-asserted-by":"crossref","first-page":"153","DOI":"10.2174\/0113892029300247240325080421","article-title":"Genomics in diabetic kidney disease: a 2024 update","volume":"25","author":"Roumeliotis","year":"2024","journal-title":"Curr. Genomics"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112736_bb0060","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3390\/membranes13010042","article-title":"The role of inorganic phosphate transporters in highly proliferative cells: from protozoan parasites to cancer cells","volume":"13","author":"Lacerda-Abreu","year":"2022","journal-title":"Membranes"},{"key":"10.1016\/j.cellsig.2026.112736_bb0145","doi-asserted-by":"crossref","first-page":"13648","DOI":"10.1111\/jcmm.15813","article-title":"Aldosterone enhances high phosphate\u2013induced vascular calcification through inhibition of AMPK-mediated autophagy","volume":"24","author":"Gao","year":"2020","journal-title":"J. Cell. Mol. Med."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112736_bb0150","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.bbrc.2020.07.136","article-title":"Metformin, resveratrol, and exendin-4 inhibit high phosphate-induced vascular calcification via AMPK-RANKL signalling","volume":"530","author":"Lee","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112736_bb0155","doi-asserted-by":"crossref","first-page":"4303","DOI":"10.1002\/jcp.30887","article-title":"Metformin protects against vascular calcification through the selective degradation of Runx2 by the p62 autophagy receptor","volume":"237","author":"Phadwal","year":"2022","journal-title":"J. Cell. Physiol."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112736_bb0160","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1159\/000366336","article-title":"Inactivation of AMPK mediates high phosphate-induced extracellular matrix accumulation via NOX4\/TGF\u00df-1 signalling in human mesangial cells","volume":"34","author":"Papadimitriou","year":"2014","journal-title":"Cell. Physiol. Biochem."},{"issue":"21","key":"10.1016\/j.cellsig.2026.112736_bb0185","doi-asserted-by":"crossref","first-page":"21446","DOI":"10.18632\/aging.103896","article-title":"High phosphate induces skeletal muscle atrophy and suppresses myogenic differentiation by increasing oxidative stress and activating Nrf2 signalling","volume":"12","author":"Chung","year":"2020","journal-title":"Aging"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112736_bb0190","article-title":"Targeting NF-\u03baB pathway for the therapy of diseases: mechanism and clinical study","volume":"5","author":"Yu","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112736_bb0215","first-page":"e65","article-title":"Insulin attenuates vascular smooth muscle calcification but increases vascular smooth muscle cell phosphate transport","volume":"195","author":"Low","year":"2007","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.cellsig.2026.112736_bb0220","doi-asserted-by":"crossref","first-page":"3743","DOI":"10.1016\/j.lfs.2015.03.017","article-title":"Extracellular regulated protein kinases play a key role via bone morphogenetic protein 4 in high phosphate-induced endothelial cell apoptosis","volume":"131","author":"Qin","year":"2015","journal-title":"Life Sci."},{"key":"10.1016\/j.cellsig.2026.112736_bb0225","article-title":"DAXX mediates high phosphate-induced endothelial cell apoptosis in vitro through activating ERK signalling","volume":"8","author":"Wang","year":"2020","journal-title":"PeerJ"},{"issue":"6","key":"10.1016\/j.cellsig.2026.112736_bb0065","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1165\/rcmb.2024-0008OC","article-title":"Chronic kidney disease\u2013associated lung injury is mediated by phosphate-induced MAPK\/AKT signalling","volume":"71","author":"Bollenbecker","year":"2024","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112736_bb0230","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1159\/000339054","article-title":"Inorganic phosphate stimulates fibronectin expression in renal fibroblasts","volume":"30","author":"Chen","year":"2012","journal-title":"Cell. Physiol. Biochem."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112736_bb0235","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1158\/1940-6207.CAPR-09-0068","article-title":"Elevated phosphate activates N-ras and promotes cell transformation and skin tumorigenesis","volume":"3","author":"Camalier","year":"2010","journal-title":"Cancer Prev. Res. (Phila.)"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112736_bb0240","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1093\/toxsci\/kfj066","article-title":"A high inorganic phosphate diet perturbs brain growth, alters Akt-ERK signalling, and results in changes in cap-dependent translation","volume":"90","author":"Jin","year":"2006","journal-title":"Toxicol. Sci. Off. J. Soc. Toxicol."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112736_bb0255","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1159\/000371454","article-title":"Hyperphosphate-induced myocardial hypertrophy through the GATA-4\/NFAT-3 signalling pathway is attenuated by ERK inhibitor treatment","volume":"5","author":"Liu","year":"2015","journal-title":"Cardiorenal Med."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112736_bb0200","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jjcc.2022.09.002","article-title":"The roles of HIF-1\u03b1 signalling in cardiovascular diseases","volume":"81","author":"Sato","year":"2023","journal-title":"J. Cardiol."},{"key":"10.1016\/j.cellsig.2026.112736_bb0260","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.kint.2016.05.020","article-title":"Hypoxia-inducible factor-1 plays a role in phosphate-induced vascular smooth muscle cell calcification","volume":"90","author":"Mokas","year":"2016","journal-title":"Kidney Int."},{"key":"10.1016\/j.cellsig.2026.112736_bb0265","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1161\/ATVBAHA.119.312509","article-title":"Hypoxia triggers osteochondrogenic differentiation of vascular smooth muscle cells in an HIF-1 (hypoxia-inducible factor 1)-dependent and reactive oxygen species-dependent manner","volume":"39","author":"Balogh","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.cellsig.2026.112736_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.100483","article-title":"MicroRNA-223-3p inhibits vascular calcification and the osteogenic switch of vascular smooth muscle cells","volume":"296","author":"Han","year":"2021","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cellsig.2026.112736_bb0285","article-title":"Research progress on the intrinsic link between the occurrence and progression of malignant tumors, chronic kidney disease and drug safety","volume":"17","author":"Zhang","year":"2026","journal-title":"Front. Pharmacol."},{"issue":"8","key":"10.1016\/j.cellsig.2026.112736_bb0300","doi-asserted-by":"crossref","DOI":"10.1111\/eci.13561","article-title":"Magnesium supplementation reduces inflammation in rats with induced chronic kidney disease","volume":"51","author":"L\u00f3pez-Baltan\u00e1s","year":"2021","journal-title":"Eur. J. Clin. Investig."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112736_bb0305","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1007\/s40620-018-0530-2","article-title":"NF-\u03baB activation contributes to parathyroid cell proliferation in chronic kidney disease","volume":"31","author":"Kan","year":"2018","journal-title":"J. Nephrol."},{"key":"10.1016\/j.cellsig.2026.112736_bb0310","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.74782","article-title":"Hyperphosphataemia increases inflammation to exacerbate anemia and skeletal muscle wasting independently of FGF23-FGFR4 signalling","volume":"11","author":"Czaya","year":"2022","journal-title":"eLife"},{"issue":"2","key":"10.1016\/j.cellsig.2026.112736_bb0125","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/cbin.12095","article-title":"Elevated extracellular inorganic phosphate inhibits ecto-phosphatase activity in breast cancer cells: regulation by hydrogen peroxide","volume":"48","author":"Lacerda-Abreu","year":"2024","journal-title":"Cell Biol. Int."},{"issue":"5","key":"10.1016\/j.cellsig.2026.112736_bb0330","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1002\/jcb.20999","article-title":"Fibronectin enhances in vitro vascular calcification by promoting osteoblastic differentiation of vascular smooth muscle cells via ERK pathway","volume":"99","author":"Ding","year":"2006","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.cellsig.2026.112736_bb0340","first-page":"C1012","article-title":"PALMD haploinsufficiency aggravates extracellular matrix remodelling in vascular smooth muscle cells and promotes calcification","volume":"327","author":"Zhang","year":"2024","journal-title":"Am. J. Phys. Cell Phys."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112736_bb0350","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1038\/s41467-018-03260-6","article-title":"A transcriptome-wide association study identifies PALMD as a susceptibility gene for calcific aortic valve stenosis","volume":"9","author":"Th\u00e9riault","year":"2018","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112736_bb0355","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1159\/000366400","article-title":"Vascular calcification in chronic kidney disease is induced by bone morphogenetic protein-2 via a mechanism involving the Wnt\/\u03b2-catenin pathway","volume":"34","author":"Rong","year":"2014","journal-title":"Cell. Physiol. Biochem."},{"issue":"8","key":"10.1016\/j.cellsig.2026.112736_bb0370","doi-asserted-by":"crossref","first-page":"F1136","DOI":"10.1152\/ajprenal.00684.2011","article-title":"In vascular smooth muscle cells paricalcitol prevents phosphate-induced Wnt\/\u03b2-catenin activation","volume":"303","author":"Mart\u00ednez-Moreno","year":"2012","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112736_bb0375","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0089525","article-title":"Magnesium inhibits Wnt\/\u03b2-catenin activity and reverses the osteogenic transformation of vascular smooth muscle cells","volume":"9","author":"Montes de Oca","year":"2014","journal-title":"PloS One"},{"issue":"3","key":"10.1016\/j.cellsig.2026.112736_bb0360","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1002\/jcb.26460","article-title":"BMP9\/COX-2 axial mediates high phosphate-induced calcification in vascular smooth muscle cells via Wnt\/\u03b2-catenin pathway","volume":"119","author":"He","year":"2018","journal-title":"J. Cell. Biochem."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112736_bb0380","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1111\/nep.13677","article-title":"Vascular calcification is associated with Wnt-signalling pathway and blood pressure variability in chronic kidney disease rats","volume":"25","author":"Liao","year":"2020","journal-title":"Nephrology (Carlton, Vic.)"},{"issue":"10","key":"10.1016\/j.cellsig.2026.112736_bb0385","doi-asserted-by":"crossref","first-page":"3539","DOI":"10.3390\/ijms21103539","article-title":"Reduction of secreted frizzled-related protein 5 drives vascular calcification through Wnt3a-mediated rho\/ROCK\/JNK signalling in chronic kidney disease","volume":"21","author":"Oh","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.cellsig.2026.112736_bb0390","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1002\/kjm2.12542","article-title":"MiR-708-5p\/Pit-1 axis mediates high phosphate-induced calcification in vascular smooth muscle cells via Wnt8b\/\u03b2-catenin pathway","volume":"38","author":"Wu","year":"2022","journal-title":"Kaohsiung J. Med. Sci."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112736_bb0395","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1097\/SHK.0000000000002488","article-title":"ZBTB16 drives vascular calcification through accelerationg VSMCS osteoblastic transition in chonic kidney disease via Wnt\/B-catenin pathway","volume":"63","author":"Shen","year":"2025","journal-title":"Shock"},{"issue":"6","key":"10.1016\/j.cellsig.2026.112736_bb0400","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1159\/000517095","article-title":"Secreted frizzled-related protein 5 ameliorates vascular calcification in a rat model of chronic kidney disease through the Wnt\/\u03b2-catenin pathway","volume":"46","author":"Deng","year":"2021","journal-title":"Kidney Blood Press. Res."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112736_bb0070","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.bbrc.2009.02.034","article-title":"Inorganic phosphate regulates Glvr-1 and -2 expression: role of calcium and ERK1\/2","volume":"381","author":"Wittrant","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cellsig.2026.112736_bb0080","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0191270","article-title":"Characterization of inorganic phosphate transport in the triplenegative breast cancer cell line, MDA-MB-231","volume":"13","author":"Russo-Abrah\u00e3o","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.cellsig.2026.112736_bb0085","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1016\/j.bbadis.2019.04.015","article-title":"H+-dependent inorganic phosphate transporter in breast cancer cells: possible functions in the tumor microenvironment","volume":"1865","author":"Lacerda-Abreu","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112736_bb0090","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1159\/000485874","article-title":"High phosphate-induced calcification of vascular smooth muscle cells is associated with the TLR4\/NF-\u03baB signalling pathway","volume":"42","author":"Zhang","year":"2017","journal-title":"Kidney Blood Press. Res."},{"key":"10.1016\/j.cellsig.2026.112736_bb0095","first-page":"C1113","article-title":"Na+\u2212independent phosphate transport in Caco2BBE cells","volume":"307","author":"Candeal","year":"2014","journal-title":"Am. J. Phys. Cell Phys."},{"key":"10.1016\/j.cellsig.2026.112736_bb0100","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s00424-018-2231-z","article-title":"Physiological regulation of phosphate by vitamin D, parathyroid hormone (PTH) and phosphate (Pi)","volume":"471","author":"Jacquillet","year":"2019","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.cellsig.2026.112736_bb0105","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1590\/1806-9282.63.01.85","article-title":"The role of oxidative stress on the pathophysiology of metabolic syndrome","volume":"63","author":"Francisqueti","year":"2017","journal-title":"Rev. Assoc. Med. Bras."},{"key":"10.1016\/j.cellsig.2026.112736_bb0110","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41580-020-0230-3","article-title":"Reactive oxygen species (ROS) as pleiotropic physiological signalling agents","volume":"21","author":"Sies","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cellsig.2026.112736_bb0115","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1152\/physrev.00018.2001","article-title":"Free radicals in the physiological control of cell function","volume":"82","author":"Dr\u00f6ge","year":"2002","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.cellsig.2026.112736_bb0120","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1080\/10715760400009258","article-title":"Phosphate increases mitochondrial reactive oxygen species release","volume":"38","author":"Oliveira","year":"2004","journal-title":"Free Radic. Res."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112736_bb0130","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.mehy.2013.10.028","article-title":"Measurement of blood phosphorus: a quick and inexpensive method for detection of the existence of cancer in the body. Too good to be true, or forgotten knowledge of the past?","volume":"82","author":"Papaloucas","year":"2014","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.cellsig.2026.112736_bb0135","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.670222","article-title":"AMPK: potential therapeutic target for vascular calcification","volume":"8","author":"Lu","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.cellsig.2026.112736_bb0140","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/ndt\/gfv111","article-title":"Vascular calcification in chronic kidney disease: an update","volume":"31","author":"Schlieper","year":"2016","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.cellsig.2026.112736_bb0170","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/ncb2021","article-title":"The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1","volume":"12","author":"Komatsu","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cellsig.2026.112736_bb0175","doi-asserted-by":"crossref","first-page":"279","DOI":"10.4161\/auto.7.3.14487","article-title":"Selective autophagy mediated by autophagic adapter proteins","volume":"7","author":"Johansen","year":"2014","journal-title":"Autophagy"},{"key":"10.1016\/j.cellsig.2026.112736_bb0180","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-46824-2","article-title":"Activation of KEAP1\/NRF2\/P62 signalling alleviates high phosphate-induced calcification of vascular smooth muscle cells by suppressing reactive oxygen species production","volume":"9","author":"Wei","year":"2019","journal-title":"Sci. Rep."},{"issue":"10","key":"10.1016\/j.cellsig.2026.112736_bb0195","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/s41580-020-0255-7","article-title":"ERK signalling: a master regulator of cell behaviour, life and fate","volume":"21","author":"Lavoie","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cellsig.2026.112736_bb0205","doi-asserted-by":"crossref","first-page":"4389","DOI":"10.1093\/eurheartj\/ehab447","article-title":"The JAK-STAT pathway: an emerging target for cardiovascular disease in rheumatoid arthritis and myeloproliferative neoplasms","volume":"42","author":"Baldini","year":"2021","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.cellsig.2026.112736_bb0210","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/ki.2012.40","article-title":"Activation of nuclear factor-kappa B accelerates vascular calcification by inhibiting ankylosis protein homolog expression","volume":"82","author":"Zhao","year":"2012","journal-title":"Kidney Int."},{"issue":"9","key":"10.1016\/j.cellsig.2026.112736_bb0245","doi-asserted-by":"crossref","first-page":"15910","DOI":"10.3390\/molecules200915910","article-title":"Inorganic phosphate prevents Erk1\/2 and Stat3 activation and improves sensitivity to doxorubicin of MDA-MB-231 breast cancer cells","volume":"20","author":"Sapio","year":"2015","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112736_bb0250","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1089\/biores.2012.0266","article-title":"Inorganic phosphate as a novel signaling molecule with antiproliferative action in MDA-MB-231 breast cancer cells","volume":"2","author":"Spina","year":"2013","journal-title":"Bioresour. Open Access"},{"key":"10.1016\/j.cellsig.2026.112736_bb0270","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.798053","article-title":"Daprodustat accelerates high phosphate-induced calcification through the activation of HIF-1 signalling","volume":"13","author":"T\u00f3th","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112736_bb0275","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/s41392-023-01468-7","article-title":"Evolving cognition of the JAK-STAT signalling pathway: autoimmune disorders and cancer","volume":"8","author":"Xue","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.cellsig.2026.112736_bb0280","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3390\/biom14010029","article-title":"High phosphate-induced JAK-STAT signalling sustains vascular smooth muscle cell inflammation and limits calcification","volume":"14","author":"Macr\u00ec","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.cellsig.2026.112736_bb0290","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.007248","article-title":"Smooth muscle\u2013selective nuclear factor-\u03baB inhibition reduces phosphate-induced arterial medial calcification in mice with chronic kidney disease","volume":"6","author":"Yoshida","year":"2017","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.cellsig.2026.112736_bb0295","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.intimp.2016.08.026","article-title":"Potential therapeutic targets for inflammation in toll-like receptor 4 (TLR4)-mediated signalling pathways","volume":"40","author":"Roy","year":"2016","journal-title":"Int. Immunopharmacol."},{"issue":"12","key":"10.1016\/j.cellsig.2026.112736_bb0315","article-title":"TGF-\u03b2 signalling induces the expression of OPN in blood vessel endothelial cells","volume":"65","author":"Jiang","year":"2019","journal-title":"Clin. Lab."},{"key":"10.1016\/j.cellsig.2026.112736_bb0320","doi-asserted-by":"crossref","first-page":"e60","DOI":"10.1159\/000313831","article-title":"Role of TGF-\u03b21 in bone matrix production in vascular smooth muscle cells induced by a high-phosphate environment","volume":"115","author":"Wang","year":"2010","journal-title":"Nephron Exp. Nephrol."},{"key":"10.1016\/j.cellsig.2026.112736_bb0325","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.708470","article-title":"Wnt signalling in vascular calcification","volume":"8","author":"Bundy","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.cellsig.2026.112736_bb0335","article-title":"Role of TGF-\u03b21 in production of fibronectin in vascular smooth muscle cells cultured under high-phosphate conditions","author":"Wang","year":"2012","journal-title":"J. Nephrol."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112736_bb0345","first-page":"215","article-title":"From diagnostic marker-to-therapeutic modality: emerging paradigms in tumor biomineralization","volume":"45","author":"Liu","year":"2026","journal-title":"Cancer Metastasis Rev."},{"issue":"5","key":"10.1016\/j.cellsig.2026.112736_bb0365","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1007\/s00223-007-9073-6","article-title":"Regulation of in vitro vascular calcification by BMP4, VEGF and Wnt3a","volume":"81","author":"Mikhaylova","year":"2007","journal-title":"Calcif. Tissue Int."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826003931?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826003931?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T11:41:28Z","timestamp":1787053288000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656826003931"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":79,"alternative-id":["S0898656826003931"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112736","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inorganic phosphate beyond a mineral: Signal transduction in multi-organ pathology","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112736","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"112736"}}