{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:03:51Z","timestamp":1789693431566,"version":"4.0.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.cellsig.2026.112742","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:48:30Z","timestamp":1785858510000},"page":"112742","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["FGF21-modified adipose stem cell-derived exosomes promote wound healing by activating fibroblast glycolysis through AMPK\/mTOR signaling"],"prefix":"10.1016","volume":"148","author":[{"given":"Kewei","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyi","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijin","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.cellsig.2026.112742_bb0005","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1038\/s41596-022-00681-y","article-title":"Generation and characterization of hair-bearing skin organoids from human pluripotent stem cells","volume":"17","author":"Lee","year":"2022","journal-title":"Nat. Protoc."},{"issue":"8","key":"10.1016\/j.cellsig.2026.112742_bb0010","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.stem.2022.07.006","article-title":"Wound healing, fibroblast heterogeneity, and fibrosis","volume":"29","author":"Talbott","year":"2022","journal-title":"Cell Stem Cell"},{"issue":"10","key":"10.1016\/j.cellsig.2026.112742_bb0015","article-title":"Diabetic wound-healing science","volume":"57","author":"Burgess","year":"2021","journal-title":"Medicina (Kaunas, Lithuania)"},{"issue":"8","key":"10.1016\/j.cellsig.2026.112742_bb0020","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/s41579-024-01035-z","article-title":"The wound microbiota: microbial mechanisms of impaired wound healing and infection","volume":"22","author":"Uberoi","year":"2024","journal-title":"Nat. Rev. Microbiol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112742_bb0025","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s13287-023-03345-0","article-title":"Stem cell-derived exosomes: emerging therapeutic opportunities for wound healing","volume":"14","author":"Zhou","year":"2023","journal-title":"Stem Cell Res Ther"},{"issue":"3","key":"10.1016\/j.cellsig.2026.112742_bb0030","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12993","article-title":"Exosomes from adipose-derived stem cells and application to skin wound healing","volume":"54","author":"An","year":"2021","journal-title":"Cell Prolif."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112742_bb0035","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1186\/s12951-021-00942-0","article-title":"Hypoxia adipose stem cell-derived exosomes promote high-quality healing of diabetic wound involves activation of PI3K\/Akt pathways","volume":"19","author":"Wang","year":"2021","journal-title":"J. Nanobiotechnol."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112742_bb0040","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24021337","article-title":"The machinery of exosomes: biogenesis, release, and uptake","volume":"24","author":"Krylova","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.cellsig.2026.112742_bb0045","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.7150\/thno.52570","article-title":"Engineering exosomes for targeted drug delivery","volume":"11","author":"Liang","year":"2021","journal-title":"Theranostics"},{"issue":"8","key":"10.1016\/j.cellsig.2026.112742_bb0050","doi-asserted-by":"crossref","DOI":"10.3390\/cells10081959","article-title":"Mesenchymal stem cell-derived exosomes: applications in regenerative medicine","volume":"10","author":"Hade","year":"2021","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112742_bb0055","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1186\/s12951-024-02684-1","article-title":"Exosomes: compositions, biogenesis, and mechanisms in diabetic wound healing","volume":"22","author":"Li","year":"2024","journal-title":"J. Nanobiotechnol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112742_bb0060","doi-asserted-by":"crossref","DOI":"10.1186\/s12951-021-00894-5","article-title":"Exosomes derived from pioglitazone-pretreated MSCs accelerate diabetic wound healing through enhancing angiogenesis","volume":"19","author":"Hu","year":"2021","journal-title":"J. Nanobiotechnol."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112742_bb0065","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/s42255-021-00354-2","article-title":"Metabolic messengers: FGF21","volume":"3","author":"Flippo","year":"2021","journal-title":"Nat. Metab."},{"key":"10.1016\/j.cellsig.2026.112742_bb0070","doi-asserted-by":"crossref","first-page":"1510691","DOI":"10.3389\/fmed.2025.1510691","article-title":"Research progress and strategy of FGF21 for skin wound healing","volume":"12","author":"Lin","year":"2025","journal-title":"Front. Med."},{"key":"10.1016\/j.cellsig.2026.112742_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103390","article-title":"Methionine restriction alleviates diabetes-associated cognitive impairment via activation of FGF21","volume":"77","author":"Zhang","year":"2024","journal-title":"Redox Biol."},{"issue":"8","key":"10.1016\/j.cellsig.2026.112742_bb0080","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/s41580-024-00715-1","article-title":"Cellular and molecular mechanisms of skin wound healing","volume":"25","author":"Pe\u00f1a","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cellsig.2026.112742_bb0085","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1233800","article-title":"Fibroblasts - the cellular choreographers of wound healing","volume":"14","author":"Knoedler","year":"2023","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112742_bb0090","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41420-023-01725-2","article-title":"PDK4 rescues high-glucose-induced senescent fibroblasts and promotes diabetic wound healing through enhancing glycolysis and regulating YAP and JNK pathway","volume":"9","author":"Ma","year":"2023","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112742_bb0095","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1080\/07853890.2023.2191217","article-title":"Role of PFKFB3-driven glycolysis in sepsis","volume":"55","author":"Xiao","year":"2023","journal-title":"Ann. Med."},{"issue":"18","key":"10.1016\/j.cellsig.2026.112742_bb0100","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22189765","article-title":"AMPK-mTOR signaling and cellular adaptations in hypoxia","volume":"22","author":"Chun","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cellsig.2026.112742_bb0105","doi-asserted-by":"crossref","first-page":"671","DOI":"10.3389\/fcell.2020.00671","article-title":"Insight on transcriptional regulation of the energy sensing AMPK and biosynthetic mTOR pathway genes","volume":"8","author":"Sukumaran","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112742_bb0110","doi-asserted-by":"crossref","first-page":"581","DOI":"10.3892\/etm.2021.10013","article-title":"Metformin prevents PFKFB3-related aerobic glycolysis from enhancing collagen synthesis in lung fibroblasts by regulating AMPK\/mTOR pathway","volume":"21","author":"Tang","year":"2021","journal-title":"Exp. Ther. Med."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112742_bb0115","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1080\/21691401.2020.1825092","article-title":"The effects and mechanisms of isoliquiritigenin loaded nanoliposomes regulated AMPK\/mTOR mediated glycolysis in colorectal cancer","volume":"48","author":"Wang","year":"2020","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112742_bb0120","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s10787-022-01115-7","article-title":"Exosome engineering in cell therapy and drug delivery","volume":"31","author":"Sadeghi","year":"2023","journal-title":"Inflammopharmacology"},{"issue":"4","key":"10.1016\/j.cellsig.2026.112742_bb0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-018-0058-5","article-title":"Exosomes from adipose-derived stem cells overexpressing Nrf2 accelerate cutaneous wound healing by promoting vascularization in a diabetic foot ulcer rat model","volume":"50","author":"Li","year":"2018","journal-title":"Exp. Mol. Med."},{"issue":"7","key":"10.1016\/j.cellsig.2026.112742_bb0130","doi-asserted-by":"crossref","DOI":"10.1007\/s11433-019-1528-y","article-title":"Excellent thermoelectric performance in weak-coupling molecular junctions with electrode doping and electrochemical gating","volume":"63","author":"Wu","year":"2020","journal-title":"Sci. China Phys. Mech. Astron."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112742_bb0135","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1186\/s13287-020-01824-2","article-title":"Exosomes derived from atorvastatin-pretreated MSC accelerate diabetic wound repair by enhancing angiogenesis via AKT\/eNOS pathway","volume":"11","author":"Yu","year":"2020","journal-title":"Stem Cell Res. Ther."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112742_bb0140","doi-asserted-by":"crossref","first-page":"164","DOI":"10.15283\/ijsc21067","article-title":"Pharmaceutical activation of Nrf2 accelerates diabetic wound healing by exosomes from bone marrow mesenchymal stem cells","volume":"15","author":"Wang","year":"2022","journal-title":"International Journal of Stem Cells"},{"key":"10.1016\/j.cellsig.2026.112742_bb0145","article-title":"Anlotinib inhibits PFKFB3-driven glycolysis in Myofibroblasts to reverse pulmonary fibrosis","volume":"12","author":"Chen","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"6545","key":"10.1016\/j.cellsig.2026.112742_bb0150","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1126\/science.abd5491","article-title":"Mitochondrial NADP(H) generation is essential for proline biosynthesis","volume":"372","author":"Zhu","year":"2021","journal-title":"Science (New York, N.Y.)"},{"issue":"Pt 3","key":"10.1016\/j.cellsig.2026.112742_bb0155","article-title":"Lactate triggers KAT8-mediated LTBP1 lactylation at lysine 752 to promote skin rejuvenation by inducing collagen synthesis in fibroblasts","volume":"277","author":"Zou","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"8","key":"10.1016\/j.cellsig.2026.112742_bb0160","doi-asserted-by":"crossref","first-page":"3506","DOI":"10.1038\/s44319-024-00180-z","article-title":"Lactate supports cell-autonomous ECM production to sustain metastatic behavior in prostate cancer","volume":"25","author":"Ippolito","year":"2024","journal-title":"EMBO Rep."},{"key":"10.1016\/j.cellsig.2026.112742_bb0165","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2023.1129538","article-title":"Engineered exosomes derived from miR-132-overexpresssing adipose stem cells promoted diabetic wound healing and skin reconstruction","volume":"11","author":"Ge","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112742_bb0170","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s13287-025-04203-x","article-title":"Exosomes from adipose-derived stem cells accelerate wound healing by increasing the release of IL-33 from macrophages","volume":"16","author":"Wang","year":"2025","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112742_bb0175","first-page":"103","article-title":"Traditional Chinese medicine properties and microcalorimetry: BioScience evaluation","volume":"1","author":"Li","year":"2025","journal-title":"Med Res."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112742_bb0180","doi-asserted-by":"crossref","first-page":"165","DOI":"10.20517\/evcna.2025.161","article-title":"80 years of extracellular vesicles: from discovery to clinical translation","volume":"7","author":"Li","year":"2026","journal-title":"Extracell. Vesicl. Circul. Nucl. Acids"}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826003992?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826003992?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:20:51Z","timestamp":1789690851000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656826003992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":36,"alternative-id":["S0898656826003992"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112742","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"FGF21-modified adipose stem cell-derived exosomes promote wound healing by activating fibroblast glycolysis through AMPK\/mTOR signaling","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112742","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"112742"}}