{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T12:28:24Z","timestamp":1787056104344,"version":"build-2736575974"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:00:00Z","timestamp":1784332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013254","name":"National College Students Innovation and Entrepreneurship Training Program","doi-asserted-by":"publisher","award":["202504302108"],"award-info":[{"award-number":["202504302108"]}],"id":[{"id":"10.13039\/501100013254","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013254","name":"National College Students Innovation and Entrepreneurship Training Program","doi-asserted-by":"publisher","award":["202610573009S"],"award-info":[{"award-number":["202610573009S"]}],"id":[{"id":"10.13039\/501100013254","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013254","name":"National College Students Innovation and Entrepreneurship Training Program","doi-asserted-by":"publisher","award":["S202610573047"],"award-info":[{"award-number":["S202610573047"]}],"id":[{"id":"10.13039\/501100013254","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.cellsig.2026.112748","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T07:00:36Z","timestamp":1784530836000},"page":"112748","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Crosstalk between TFF2+ HCC cells and regulatory T cells drives hepatocellular carcinoma prometastatic niche formation and portal vein tumor thrombosis"],"prefix":"10.1016","volume":"147","author":[{"given":"Senlin","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuohao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junxi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhang","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wuyan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongming","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangjie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongxin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulun","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.cellsig.2026.112748_bb0005","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112748_bb0010","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1016\/j.jhep.2022.08.021","article-title":"Global burden of primary liver cancer in 2020 and predictions to 2040","volume":"77","author":"Rumgay","year":"2022","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112748_bb0015","doi-asserted-by":"crossref","DOI":"10.1038\/s41572-020-00240-3","article-title":"Hepatocellular carcinoma","volume":"7","author":"Llovet","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.cellsig.2026.112748_bb0020","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ijsu.2015.05.009","article-title":"The strategies for treating primary hepatocellular carcinoma with portal vein tumor thrombus","volume":"20","author":"Zhang","year":"2015","journal-title":"Int. J. Surg."},{"issue":"9","key":"10.1016\/j.cellsig.2026.112748_bb0025","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S2468-1253(19)30178-5","article-title":"Management of patients with hepatocellular carcinoma and portal vein tumour thrombosis: comparing east and west","volume":"4","author":"Lu","year":"2019","journal-title":"Lancet Gastroenterol. Hepatol."},{"issue":"20","key":"10.1016\/j.cellsig.2026.112748_bb0030","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1056\/NEJMoa1915745","article-title":"Atezolizumab plus bevacizumab in unresectable hepatocellular carcinoma","volume":"382","author":"Finn","year":"2020","journal-title":"N. Engl. J. Med."},{"issue":"10360","key":"10.1016\/j.cellsig.2026.112748_bb0035","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/S0140-6736(22)01200-4","article-title":"Hepatocellular carcinoma","volume":"400","author":"Vogel","year":"2022","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112748_bb0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000487148","article-title":"Lenvatinib may drastically change the treatment landscape of hepatocellular carcinoma","volume":"7","author":"Kudo","year":"2018","journal-title":"Liver Can."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112748_bb0045","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.cell.2020.11.041","article-title":"Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma","volume":"184","author":"Sun","year":"2021","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.cellsig.2026.112748_bb0050","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12092495","article-title":"Translational considerations to improve response and overcome therapy resistance in immunotherapy for hepatocellular carcinoma","volume":"12","author":"Heinrich","year":"2020","journal-title":"Cancers (Basel)"},{"issue":"4","key":"10.1016\/j.cellsig.2026.112748_bb0055","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1158\/2159-8290.CD-20-1808","article-title":"Therapeutic targeting of the tumor microenvironment","volume":"11","author":"Bejarano","year":"2021","journal-title":"Cancer Discov."},{"key":"10.1016\/j.cellsig.2026.112748_bb0060","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.01280","article-title":"Cancer stem cells-origins and biomarkers: perspectives for targeted personalized therapies","volume":"11","author":"Walcher","year":"2020","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112748_bb0065","article-title":"Targeting cancer stem cell pathways for cancer therapy","volume":"5","author":"Yang","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112748_bb0070","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/s41580-020-0237-9","article-title":"Guidelines and definitions for research on epithelial-mesenchymal transition","volume":"21","author":"Yang","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112748_bb0075","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.tcb.2018.12.001","article-title":"EMT transition states during tumor progression and metastasis","volume":"29","author":"Pastushenko","year":"2019","journal-title":"Trends Cell Biol."},{"issue":"5","key":"10.1016\/j.cellsig.2026.112748_bb0080","article-title":"Identification of a cancer stem cell-like subcluster that promotes HCC metastasis","volume":"7","author":"Yang","year":"2024","journal-title":"JHEP Rep."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112748_bb0085","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s13045-021-01105-2","article-title":"Applications of single-cell sequencing in cancer research: progress and perspectives","volume":"14","author":"Lei","year":"2021","journal-title":"J. Hematol. Oncol."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112748_bb0090","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.cell.2019.10.003","article-title":"Landscape and dynamics of single immune cells in hepatocellular carcinoma","volume":"179","author":"Zhang","year":"2019","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.cellsig.2026.112748_bb0095","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/s41592-022-01409-2","article-title":"Museum of spatial transcriptomics","volume":"19","author":"Moses","year":"2022","journal-title":"Nat. Methods"},{"issue":"7871","key":"10.1016\/j.cellsig.2026.112748_bb0100","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41586-021-03634-9","article-title":"Exploring tissue architecture using spatial transcriptomics","volume":"596","author":"Rao","year":"2021","journal-title":"Nature"},{"issue":"51","key":"10.1016\/j.cellsig.2026.112748_bb0105","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abg3750","article-title":"Comprehensive analysis of spatial architecture in primary liver cancer","volume":"7","author":"Wu","year":"2021","journal-title":"Sci. Adv."},{"issue":"13","key":"10.1016\/j.cellsig.2026.112748_bb0110","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"issue":"7735","key":"10.1016\/j.cellsig.2026.112748_bb0115","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/s41586-018-0694-x","article-title":"Lineage tracking reveals dynamic relationships of T cells in colorectal cancer","volume":"564","author":"Zhang","year":"2018","journal-title":"Nature"},{"issue":"6190","key":"10.1016\/j.cellsig.2026.112748_bb0120","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1126\/science.1254257","article-title":"Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma","volume":"344","author":"Patel","year":"2014","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.cellsig.2026.112748_bb0125","article-title":"clusterProfiler 4.0: a universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation"},{"key":"10.1016\/j.cellsig.2026.112748_bb0130","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2105-14-7","article-title":"GSVA: gene set variation analysis for microarray and RNA-seq data","volume":"14","author":"H\u00e4nzelmann","year":"2013","journal-title":"BMC Bioinformat."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112748_bb0135","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The molecular signatures database (MSigDB) hallmark gene set collection","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell Syst."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112748_bb0140","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/nbt.2859","article-title":"The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells","volume":"32","author":"Trapnell","year":"2014","journal-title":"Nat. Biotechnol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112748_bb0145","doi-asserted-by":"crossref","DOI":"10.1186\/s12864-018-4772-0","article-title":"Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics","volume":"19","author":"Street","year":"2018","journal-title":"BMC Genomics"},{"issue":"6476","key":"10.1016\/j.cellsig.2026.112748_bb0150","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1126\/science.aax0249","article-title":"Single-cell transcriptional diversity is a hallmark of developmental potential","volume":"367","author":"Gulati","year":"2020","journal-title":"Science"},{"issue":"42","key":"10.1016\/j.cellsig.2026.112748_bb0155","doi-asserted-by":"crossref","first-page":"3098","DOI":"10.1038\/s41388-023-02805-4","article-title":"Deciphering pathogenic cellular module at single-cell resolution in checkpoint inhibitor-related pneumonitis","volume":"42","author":"Cui","year":"2023","journal-title":"Oncogene"},{"issue":"4","key":"10.1016\/j.cellsig.2026.112748_bb0160","first-page":"505","article-title":"Cell type and gene expression deconvolution with BayesPrism enables Bayesian integrative analysis across bulk and single-cell RNA sequencing in oncology","volume":"3","author":"Chu","year":"2022","journal-title":"Nat. Can."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112748_bb0165","doi-asserted-by":"crossref","DOI":"10.1186\/s13073-021-01001-x","article-title":"Beyondcell: targeting cancer therapeutic heterogeneity in single-cell RNA-seq data","volume":"13","author":"Fustero-Torre","year":"2021","journal-title":"Genome Med."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112748_bb0170","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbab260","article-title":"Oncopredict: an R package for predicting in vivo or cancer patient drug response and biomarkers from cell line screening data","volume":"22","author":"Maeser","year":"2021","journal-title":"Brief. Bioinform."},{"issue":"7","key":"10.1016\/j.cellsig.2026.112748_bb0175","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1038\/s41596-020-0336-2","article-title":"A scalable SCENIC workflow for single-cell gene regulatory network analysis","volume":"15","author":"Van de Sande","year":"2020","journal-title":"Nat. Protoc."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112748_bb0180","doi-asserted-by":"crossref","DOI":"10.1093\/bioadv\/vbac016","article-title":"DecoupleR: ensemble of computational methods to infer biological activities from omics data","volume":"2","author":"Badia-I-Mompel","year":"2022","journal-title":"Bioinformatics Adv."},{"key":"10.1016\/j.cellsig.2026.112748_bb0185","doi-asserted-by":"crossref","unstructured":"Jin S, Guerrero-Juarez CF, Zhang L, et al. Inference and analysis of cell-cell communication using CellChat. Nat. Commun. 2021;12(1):1088. Published 2021 Feb 17. doi:https:\/\/doi.org\/10.1038\/s41467-021-21246-9.","DOI":"10.1038\/s41467-021-21246-9"},{"issue":"2","key":"10.1016\/j.cellsig.2026.112748_bb0190","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/s41592-019-0667-5","article-title":"NicheNet: modeling intercellular communication by linking ligands to target genes","volume":"17","author":"Browaeys","year":"2020","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cellsig.2026.112748_bb0195","article-title":"In vitro differentiation of human CD4+FOXP3+ induced regulatory T cells (iTregs) from na\u00efve CD4+ T cells using a TGF-\u03b2-containing protocol","volume":"118","author":"Schmidt","year":"2016","journal-title":"J. Vis. Exp."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112748_bb0200","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ccell.2023.11.010","article-title":"Integrated multi-omics profiling to dissect the spatiotemporal evolution of metastatic hepatocellular carcinoma","volume":"42","author":"Sun","year":"2024","journal-title":"Cancer Cell"},{"issue":"6859","key":"10.1016\/j.cellsig.2026.112748_bb0205","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/35102167","article-title":"Stem cells, cancer, and cancer stem cells","volume":"414","author":"Reya","year":"2001","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.cellsig.2026.112748_bb0210","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.tcb.2020.07.003","article-title":"EMT, MET, plasticity, and tumor metastasis","volume":"30","author":"Bakir","year":"2020","journal-title":"Trends Cell Biol."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112748_bb0215","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.jhep.2021.11.018","article-title":"BCLC strategy for prognosis prediction and treatment recommendation: the 2022 update","volume":"76","author":"Reig","year":"2022","journal-title":"J. Hepatol."},{"issue":"8","key":"10.1016\/j.cellsig.2026.112748_bb0220","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-024-06936-8","article-title":"Triggering of endoplasmic reticulum stress via ATF4-SPHK1 signaling promotes glioblastoma invasion and chemoresistance","volume":"15","author":"Lan","year":"2024","journal-title":"Cell Death Dis."},{"issue":"22","key":"10.1016\/j.cellsig.2026.112748_bb0225","doi-asserted-by":"crossref","first-page":"5697","DOI":"10.1158\/1078-0432.CCR-17-3125","article-title":"Activating transcription factor 4 modulates TGF\u03b2-induced aggressiveness in triple-negative breast cancer via SMAD2\/3\/4 and mTORC2 signaling","volume":"24","author":"Gonz\u00e1lez-Gonz\u00e1lez","year":"2018","journal-title":"Clin. Cancer Res."},{"issue":"D1","key":"10.1016\/j.cellsig.2026.112748_bb0230","doi-asserted-by":"crossref","first-page":"D184","DOI":"10.1093\/nar\/gkaf1209","article-title":"JASPAR 2026: expansion of transcription factor binding profiles and integration of deep learning models","volume":"54","author":"Ovek Baydar","year":"2026","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112748_bb0235","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/s41388-022-02540-2","article-title":"CCL18 signaling from tumor-associated macrophages activates fibroblasts to adopt a chemoresistance-inducing phenotype","volume":"42","author":"Zeng","year":"2023","journal-title":"Oncogene"},{"issue":"9","key":"10.1016\/j.cellsig.2026.112748_bb0240","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/s41568-025-00832-9","article-title":"Regulatory T cells in the tumour microenvironment","volume":"25","author":"Imianowski","year":"2025","journal-title":"Nat. Rev. Cancer"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112748_bb0245","doi-asserted-by":"crossref","DOI":"10.1186\/s13073-025-01515-8","article-title":"Blocking CXCR4+ CD4+ T cells reprograms Treg-mediated immunosuppression via modulating the rho-GTPase\/NF-\u03baB signaling axis","volume":"17","author":"Cao","year":"2025","journal-title":"Genome Med."},{"issue":"5","key":"10.1016\/j.cellsig.2026.112748_bb0250","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1097\/HEP.0000000000001445","article-title":"The OGT-TFF2 axis mediates intrahepatic crosstalk and MASH pathogenesis","volume":"83","author":"Zhang","year":"2026","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112748_bb0255","article-title":"Alleviation of liver fibrosis by inhibiting a non-canonical ATF4-regulated enhancer program in hepatic stellate cells","volume":"16","author":"Yang","year":"2025","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112748_bb0260","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-021-03574-2","article-title":"Cancer-associated fibroblasts-mediated ATF4 expression promotes malignancy and gemcitabine resistance in pancreatic cancer via the TGF-\u03b21\/SMAD2\/3 pathway and ABCC1 transactivation","volume":"12","author":"Wei","year":"2021","journal-title":"Cell Death Dis."},{"issue":"5","key":"10.1016\/j.cellsig.2026.112748_bb0265","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.jhep.2016.05.044","article-title":"Survival benefit of liver resection for hepatocellular carcinoma associated with portal vein invasion","volume":"65","author":"Kokudo","year":"2016","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112748_bb0270","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ejso.2021.08.014","article-title":"Long-term outcomes of deceased donor liver transplantation in hepatocellular carcinoma patients with portal vein tumor thrombus: a multicenter study","volume":"48","author":"Yu","year":"2022","journal-title":"Eur. J. Surg. Oncol."},{"issue":"11","key":"10.1016\/j.cellsig.2026.112748_bb0275","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.neo.2020.09.007","article-title":"Epigenome-wide DNA methylation profiling of portal vein tumor thrombosis (PVTT) tissues in hepatocellular carcinoma patients","volume":"22","author":"Fan","year":"2020","journal-title":"Neoplasia"},{"issue":"2","key":"10.1016\/j.cellsig.2026.112748_bb0280","doi-asserted-by":"crossref","first-page":"795","DOI":"10.21037\/jgo-21-162","article-title":"Transcriptome sequencing-based personalized analysis of hepatocellular carcinoma patients with portal vein tumor thrombus","volume":"12","author":"Qiu","year":"2021","journal-title":"J. Gastrointest Oncol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112748_bb0285","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/hep.29778","article-title":"Single-cell analysis reveals cancer stem cell heterogeneity in hepatocellular carcinoma","volume":"68","author":"Zheng","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.cellsig.2026.112748_bb0290","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.canlet.2019.06.002","article-title":"Single-cell transcriptomics reveals the landscape of intra-tumoral heterogeneity and stemness-related subpopulations in liver cancer","volume":"459","author":"Ho","year":"2019","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112748_bb0295","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41575-021-00508-3","article-title":"Cancer stem cells in hepatocellular carcinoma - from origin to clinical implications","volume":"19","author":"Lee","year":"2022","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cellsig.2026.112748_bb0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.neo.2025.101134","article-title":"Cancer stem-like cells stay in a plastic state ready for tumor evolution","volume":"61","author":"Xu","year":"2025","journal-title":"Neoplasia"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112748_bb0305","doi-asserted-by":"crossref","DOI":"10.1186\/s12943-024-02062-3","article-title":"Single-cell tumor heterogeneity landscape of hepatocellular carcinoma: unraveling the pro-metastatic subtype and its interaction loop with fibroblasts","volume":"23","author":"Guo","year":"2024","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.cellsig.2026.112748_bb0310","article-title":"PERK signaling through C\/EBP\u03b4 contributes to ER stress-induced expression of immunomodulatory and tumor promoting chemokines by cancer cells","volume":"12","author":"Hart","year":"2021","journal-title":"Cell Death Dis."},{"issue":"11","key":"10.1016\/j.cellsig.2026.112748_bb0315","article-title":"PERK\/ATF4-dependent ZFAS1 upregulation is associated with Sorafenib resistance in hepatocellular carcinoma cells","volume":"22","author":"Yang","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cellsig.2026.112748_bb0320","doi-asserted-by":"crossref","DOI":"10.1038\/s41586-026-10216-0","article-title":"Ageing promotes metastasis via activation of the integrated stress response","author":"Patel","year":"2026","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.cellsig.2026.112748_bb0325","doi-asserted-by":"crossref","DOI":"10.1007\/s00432-024-05892-2","article-title":"Regulatory T cells inhibit FoxP3 to increase the population of tumor initiating cells in hepatocellular carcinoma","volume":"150","author":"Liu","year":"2024","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.cellsig.2026.112748_bb0330","doi-asserted-by":"crossref","DOI":"10.1038\/srep35056","article-title":"Regulatory T cells, especially ICOS+ FOXP3+ regulatory T cells, are increased in the hepatocellular carcinoma microenvironment and predict reduced survival","volume":"6","author":"Tu","year":"2016","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112748_bb0335","doi-asserted-by":"crossref","DOI":"10.1186\/s40425-019-0701-2","article-title":"Colorectal cancer cell-derived CCL20 recruits regulatory T cells to promote chemoresistance via FOXO1\/CEBPB\/NF-\u03baB signaling","volume":"7","author":"Wang","year":"2019","journal-title":"J. Immunother. Cancer"},{"issue":"7","key":"10.1016\/j.cellsig.2026.112748_bb0340","article-title":"Mechanisms of regulatory T cell infiltration in tumors: implications for innovative immune precision therapies","volume":"9","author":"Nishikawa","year":"2021","journal-title":"J. Immunother. Cancer"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112748_bb0345","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1158\/0008-5472.CAN-24-4916","article-title":"SPP1 drives colorectal cancer liver metastasis and immunotherapy resistance by stimulating CXCL12 production in cancer-associated fibroblasts","volume":"86","author":"Liu","year":"2026","journal-title":"Cancer Res."},{"key":"10.1016\/j.cellsig.2026.112748_bb0350","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.217452","article-title":"Single-cell transcriptomics reveals intratumor heterogeneity and the potential roles of cancer stem cells and myCAFs in colorectal cancer liver metastasis and recurrence","volume":"612","author":"Zhan","year":"2025","journal-title":"Cancer Lett."},{"issue":"5","key":"10.1016\/j.cellsig.2026.112748_bb0355","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1002\/hep.32707","article-title":"Profiling of syngeneic mouse HCC tumor models as a framework to understand anti-PD-1 sensitive tumor microenvironments","volume":"77","author":"Zabransky","year":"2023","journal-title":"Hepatology"}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826004055?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826004055?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T11:40:42Z","timestamp":1787053242000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656826004055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":71,"alternative-id":["S0898656826004055"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112748","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Crosstalk between TFF2+ HCC cells and regulatory T cells drives hepatocellular carcinoma prometastatic niche formation and portal vein tumor thrombosis","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112748","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"112748"}}