{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T12:28:28Z","timestamp":1787056108728,"version":"build-2736575974"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.cellsig.2026.112753","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T15:08:06Z","timestamp":1784732886000},"page":"112753","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Multi-omics and artificial intelligence nominate PCLAF as a prognostic and druggable target for hepatitis B virus-associated hepatocellular carcinoma"],"prefix":"10.1016","volume":"147","author":[{"given":"Feihong","family":"Shu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yidan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaorong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoyou","family":"Gou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guonian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youjia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellsig.2026.112753_bb0005","doi-asserted-by":"crossref","first-page":"S228","DOI":"10.3350\/cmh.2024.0824","article-title":"Hepatocellular carcinoma: updates on epidemiology, surveillance, diagnosis and treatment","volume":"31","author":"Hwang","year":"2025","journal-title":"Clin. Mol. Hepatol."},{"key":"10.1016\/j.cellsig.2026.112753_bb0010","doi-asserted-by":"crossref","first-page":"e609","DOI":"10.1016\/S2214-109X(16)30143-7","article-title":"Global burden of cancers attributable to infections in 2012: a synthetic analysis","volume":"4","author":"Plummer","year":"2016","journal-title":"Lancet Glob. Health"},{"key":"10.1016\/j.cellsig.2026.112753_bb0015","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1002\/hep.29321","article-title":"Increasing burden of liver cancer despite extensive use of antiviral agents in a hepatitis B virus-endemic population","volume":"66","author":"Choi","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.cellsig.2026.112753_bb0020","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1002\/hep.26385","article-title":"Prediction models of long-term cirrhosis and hepatocellular carcinoma risk in chronic hepatitis B patients: risk scores integrating host and virus profiles","volume":"58","author":"Lee","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.cellsig.2026.112753_bb0025","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.jcmgh.2023.01.001","article-title":"Hepatitis B virus DNA integration drives carcinogenesis and provides a new biomarker for HBV-related HCC","volume":"15","author":"Yeh","year":"2023","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cellsig.2026.112753_bb0030","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1002\/hep.31230","article-title":"Cell-free virus-host chimera DNA from hepatitis B virus integration sites as a circulating biomarker of hepatocellular cancer","volume":"72","author":"Li","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.cellsig.2026.112753_bb0035","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1093\/biomet\/asz071","article-title":"Adaptive nonparametric regression with the K-nearest neighbour fused lasso","volume":"107","author":"Madrid","year":"2020","journal-title":"Biometrika"},{"key":"10.1016\/j.cellsig.2026.112753_bb0040","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbad002","article-title":"A review on longitudinal data analysis with random forest","volume":"24","author":"Hu","year":"2023","journal-title":"Brief. Bioinform."},{"key":"10.1016\/j.cellsig.2026.112753_bb0045","doi-asserted-by":"crossref","first-page":"6439","DOI":"10.1038\/ncomms7439","article-title":"Structure of p15(PAF)-PCNA complex and implications for clamp sliding during DNA replication and repair","volume":"6","author":"De Biasio","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cellsig.2026.112753_bb0050","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms13935","article-title":"Structural basis of human PCNA sliding on DNA","volume":"8","author":"De March","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cellsig.2026.112753_bb0055","doi-asserted-by":"crossref","first-page":"9816","DOI":"10.1093\/nar\/gky723","article-title":"p15PAF binding to PCNA modulates the DNA sliding surface","volume":"46","author":"De March","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cellsig.2026.112753_bb0060","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.molcel.2016.12.020","article-title":"Forging ahead through darkness: PCNA, still the principal conductor at the replication fork","volume":"65","author":"Choe","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cellsig.2026.112753_bb0065","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nrm3562","article-title":"Regulation of PCNA-protein interactions for genome stability","volume":"14","author":"Mailand","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cellsig.2026.112753_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.109905","article-title":"Dysregulated NF-\u03baB signal promotes the hub gene PCLAF expression to facilitate nasopharyngeal carcinoma proliferation and metastasis","volume":"125","author":"Ma","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.cellsig.2026.112753_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2025.102280","article-title":"MAZ-mediated tumor progression and immune evasion in hormone receptor-positive breast cancer: targeting tumor microenvironment and PCLAF+ subtype-specific therapy","volume":"52","author":"Ni","year":"2025","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.cellsig.2026.112753_bb0080","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1080\/21691401.2018.1553783","article-title":"MiR-30a-5p frequently downregulated in prostate cancer inhibits cell proliferation via targeting PCLAF","volume":"47","author":"Zhao","year":"2019","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"10.1016\/j.cellsig.2026.112753_bb0085","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.4251\/wjgo.v13.i10.1425","article-title":"Proliferating cell nuclear antigen clamp associated factor, a potential proto-oncogene with increased expression in malignant gastrointestinal tumors","volume":"13","author":"Liu","year":"2021","journal-title":"World J. Gastrointest. Oncol."},{"key":"10.1016\/j.cellsig.2026.112753_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2025.152092","article-title":"Therapeutic potential of targeting PCLAF in endometrial cancer: insights from Wnt\/\u03b2-catenin and P53 regulatory mechanisms","volume":"774","author":"Wang","year":"2025","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cellsig.2026.112753_bb0095","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/s41419-022-04635-w","article-title":"PCLAF promotes neuroblastoma G1\/S cell cycle progression via the E2F1\/PTTG1 axis","volume":"13","author":"Liu","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cellsig.2026.112753_bb0100","article-title":"Single-cell and spatial atlas of glioblastoma heterogeneity: characterizing the PCLAF+ subtype and YEATS4\u2019s oncogenic role","volume":"16","author":"Ma","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cellsig.2026.112753_bb0105","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.cell.2020.11.041","article-title":"Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma","volume":"184","author":"Sun","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.cellsig.2026.112753_bb0110","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.ccell.2019.08.007","article-title":"Tumor cell biodiversity drives microenvironmental reprogramming in liver cancer","volume":"36","author":"Ma","year":"2019","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cellsig.2026.112753_bb0115","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/s41586-020-2157-4","article-title":"Construction of a human cell landscape at single-cell level","volume":"581","author":"Han","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.cellsig.2026.112753_bb0120","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1016\/j.cell.2017.05.035","article-title":"Landscape of infiltrating T cells in liver cancer revealed by single-cell sequencing","volume":"169","author":"Zheng","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.cellsig.2026.112753_bb0125","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.133","article-title":"Analysis of single-cell RNAseq identifies transitional states of T cells associated with hepatocellular carcinoma","volume":"10","author":"Yang","year":"2020","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.cellsig.2026.112753_bb0130","doi-asserted-by":"crossref","DOI":"10.1126\/science.abe6474","article-title":"Pan-cancer single-cell landscape of tumor-infiltrating T cells","volume":"374","author":"Zheng","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.cellsig.2026.112753_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2018.11.043","article-title":"Dysfunctional CD8 T cells form a proliferative, dynamically regulated compartment within human melanoma","volume":"176","author":"Li","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.cellsig.2026.112753_bb0140","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/s41467-022-35238-w","article-title":"A comprehensive single-cell map of T cell exhaustion-associated immune environments in human breast cancer","volume":"14","author":"Tietscher","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cellsig.2026.112753_bb0145","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2016.1200778","article-title":"Tumor-infiltrating Tim-3(+) T cells proliferate avidly except when PD-1 is co-expressed: evidence for intracellular cross talk","volume":"5","author":"Li","year":"2016","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.cellsig.2026.112753_bb0150","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1636839","article-title":"Macrophage migration inhibitory factor (MIF) and the tumor ecosystem: a tale of inflammation, immune escape, and tumor growth","volume":"16","author":"Youness","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cellsig.2026.112753_bb0155","doi-asserted-by":"crossref","first-page":"4452","DOI":"10.1111\/bph.15622","article-title":"Macrophage migration inhibitory factor exerts pro-proliferative and anti-apoptotic effects via CD74 in murine hepatocellular carcinoma","volume":"178","author":"Wirtz","year":"2021","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.cellsig.2026.112753_bb0160","doi-asserted-by":"crossref","first-page":"3749","DOI":"10.1038\/s41467-024-47981-3","article-title":"CD74 supports accumulation and function of regulatory T cells in tumors","volume":"15","author":"Bonnin","year":"2024","journal-title":"Nat. Commun."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826004109?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826004109?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T11:41:41Z","timestamp":1787053301000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656826004109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":32,"alternative-id":["S0898656826004109"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112753","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multi-omics and artificial intelligence nominate PCLAF as a prognostic and druggable target for hepatitis B virus-associated hepatocellular carcinoma","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112753","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112753"}}