{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:40:38Z","timestamp":1789753238204,"version":"4.0.1"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007128","name":"Shaanxi Province Natural Science Foundation","doi-asserted-by":"publisher","award":["2024JC-YBQN-0934"],"award-info":[{"award-number":["2024JC-YBQN-0934"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.cellsig.2026.112772","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T23:22:29Z","timestamp":1785453749000},"page":"112772","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["TBX1 suppresses colorectal cancer cells via PPP2R2B-mediated inhibition of MAPK\/ERK and PI3K\/AKT pathways"],"prefix":"10.1016","volume":"148","author":[{"given":"Man","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing Yi","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze Kun","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen Fang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Du","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10207","key":"10.1016\/j.cellsig.2026.112772_bb0005","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/S0140-6736(19)32319-0","article-title":"Colorectal cancer","volume":"394","author":"Dekker","year":"2019","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.cellsig.2026.112772_bb0010","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S1535-6108(04)00026-1","article-title":"Identification of specific PP2A complexes involved in human cell transformation","volume":"5","author":"Chen","year":"2004","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112772_bb0015","doi-asserted-by":"crossref","first-page":"5878","DOI":"10.1038\/s41467-020-19704-x","article-title":"EZH2-mediated PP2A inactivation confers resistance to HER2-targeted breast cancer therapy","volume":"11","author":"Bao","year":"2020","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.cellsig.2026.112772_bb0020","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.ccr.2010.10.021","article-title":"B55 beta-associated PP2A complex controls PDK1-directed Myc signaling and modulates rapamycin sensitivity in colorectal cancer","volume":"18","author":"Tan","year":"2010","journal-title":"Cancer Cell"},{"issue":"4","key":"10.1016\/j.cellsig.2026.112772_bb0025","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.molcel.2011.02.007","article-title":"Clk2 and B56 beta mediate insulin-regulated assembly of the PP2A phosphatase holoenzyme complex on Akt","volume":"41","author":"Rodgers","year":"2011","journal-title":"Mol. Cell"},{"issue":"6","key":"10.1016\/j.cellsig.2026.112772_bb0030","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.molcel.2014.04.023","article-title":"PP2A-mediated regulation of Ras signaling in G2 is essential for stable quiescence and normal G1 length","volume":"54","author":"Naetar","year":"2014","journal-title":"Mol. Cell"},{"issue":"12","key":"10.1016\/j.cellsig.2026.112772_bb0035","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000803","article-title":"Loss of hepatic aldolase B activates Akt and promotes hepatocellular carcinogenesis by destabilizing the Aldob\/Akt\/PP2A protein complex","volume":"18","author":"He","year":"2020","journal-title":"PLoS Biol."},{"key":"10.1016\/j.cellsig.2026.112772_bb0040","article-title":"Modified 5-aminolevulinic acid photodynamic therapy (M-PDT) inhibits cutaneous squamous cell carcinoma cell proliferation via targeting PP2A\/PP5-mediated MAPK signaling pathway","volume":"137","author":"Zhang","year":"2021","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"5","key":"10.1016\/j.cellsig.2026.112772_bb0045","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1083\/jcb.201606033","article-title":"A PP2A-B55 recognition signal controls substrate dephosphorylation kinetics during mitotic exit","volume":"214","author":"Cundell","year":"2016","journal-title":"J. Cell Biol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112772_bb0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41388-021-02068-x","article-title":"PP2A-B55: substrates and regulators in the control of cellular functions","volume":"41","author":"Amin","year":"2022","journal-title":"Oncogene"},{"issue":"3","key":"10.1016\/j.cellsig.2026.112772_bb0055","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s12311-019-1009-y","article-title":"Differential expression of genes for ubiquitin ligases in medulloblastoma subtypes","volume":"18","author":"Vriend","year":"2019","journal-title":"Cerebellum"},{"issue":"3","key":"10.1016\/j.cellsig.2026.112772_bb0060","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1089\/thy.2018.0312","article-title":"TBX1 functions as a tumor suppressor in thyroid cancer through inhibiting the activities of the PI3K\/AKT and MAPK\/ERK pathways","volume":"29","author":"Wang","year":"2019","journal-title":"Thyroid"},{"key":"10.1016\/j.cellsig.2026.112772_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.ctdb.2016.06.004","article-title":"Evolution and classification of the T-box transcription factor family","volume":"122","author":"Seb\u00e9-Pedr\u00f3s","year":"2017","journal-title":"Curr. Top. Dev. Biol."},{"issue":"20","key":"10.1016\/j.cellsig.2026.112772_bb0070","doi-asserted-by":"crossref","first-page":"3819","DOI":"10.1242\/dev.104471","article-title":"The T-box gene family: emerging roles in development, stem cells and cancer","volume":"141","author":"Papaioannou","year":"2014","journal-title":"Development"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112772_bb0075","doi-asserted-by":"crossref","first-page":"306","DOI":"10.3892\/or.2016.4792","article-title":"T-box transcription factor brachyury promotes tumor cell invasion and metastasis in non-small cell lung cancer via upregulation of matrix metalloproteinase 12","volume":"36","author":"Wan","year":"2016","journal-title":"Oncol. Rep."},{"issue":"11","key":"10.1016\/j.cellsig.2026.112772_bb0080","doi-asserted-by":"crossref","first-page":"3620","DOI":"10.3390\/ijms19113620","article-title":"Transfection of T-box transcription factor BRACHYURY and SOX2 synergistically promote self-renewal and invasive phenotype in oral cancer cells","volume":"19","author":"Akimoto","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cellsig.2026.112772_bb0085","doi-asserted-by":"crossref","first-page":"5971","DOI":"10.1038\/s41388-019-0853-z","article-title":"TBX2 interacts with heterochromatin protein 1 to recruit a novel repression complex to EGR1-targeted promoters to drive the proliferation of breast cancer cells","volume":"38","author":"Crawford","year":"2019","journal-title":"Oncogene"},{"key":"10.1016\/j.cellsig.2026.112772_bb0090","doi-asserted-by":"crossref","unstructured":"Krstic M, Kolendowski B, Cecchini MJ, Postenka CO, Hassan HM, Andrews J, MacMillan CD, Williams KC, Leong HS, Brackstone M, et al: TBX3 promotes progression of pre-invasive breast cancer cells by inducing EMT and directly up-regulating SLUG. J. Pathol. 2019, 248:191\u2013203.","DOI":"10.1002\/path.5245"},{"key":"10.1016\/j.cellsig.2026.112772_bb0095","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1038\/labinvest.2017.88","article-title":"Expression, function, and regulation of the embryonic transcription factor TBX1 in parathyroid tumors","volume":"97","author":"Verdelli","year":"2017","journal-title":"Lab. Investig."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112772_bb0100","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21020607","article-title":"TBX1 and basal cell carcinoma: expression and interactions with Gli2 and Dvl2 signaling","volume":"21","author":"Caprio","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112772_bb0105","doi-asserted-by":"crossref","DOI":"10.1186\/s13046-021-02195-z","article-title":"ZIP10 is a negative determinant for anti-tumor effect of mannose in thyroid cancer by activating phosphate mannose isomerase","volume":"40","author":"Ma","year":"2021","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112772_bb0110","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41698-020-00140-5","article-title":"Synergistic activation of mutant TERT promoter by Sp1 and GABPA in BRAF(V600E)-driven human cancers","volume":"5","author":"Wu","year":"2021","journal-title":"npj Precis. Oncol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112772_bb0115","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/s41392-021-00793-z","article-title":"HACE1-mediated NRF2 activation causes enhanced malignant phenotypes and decreased radiosensitivity of glioma cells","volume":"6","author":"Da","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.cellsig.2026.112772_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.176517","article-title":"Inhibition of melanoma cell migration and invasion by natural coumarin auraptene through regulating EMT markers and reducing MMP-2 and MMP-9 activity","volume":"971","author":"Hosseini","year":"2024","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.cellsig.2026.112772_bb0125","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1002\/1878-0261.13163","article-title":"KRAS mutation-independent downregulation of MAPK\/PI3K signaling in colorectal cancer","volume":"16","author":"Lam","year":"2022","journal-title":"Mol. Oncol."},{"issue":"7586","key":"10.1016\/j.cellsig.2026.112772_bb0130","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/nature16508","article-title":"Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer","volume":"529","author":"Shu","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.cellsig.2026.112772_bb0135","doi-asserted-by":"crossref","first-page":"162","DOI":"10.3109\/10409238.2016.1143913","article-title":"PP2A as a master regulator of the cell cycle","volume":"51","author":"Wlodarchak","year":"2016","journal-title":"Crit. Rev. Biochem. Mol."},{"key":"10.1016\/j.cellsig.2026.112772_bb0140","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1155\/2021\/6290261","article-title":"Identification of a tumor microenvironment-related gene signature indicative of disease prognosis and treatment response in colon cancer","volume":"2021","author":"Chen","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112772_bb0145","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s12929-019-0557-2","article-title":"Penfluridol triggers cytoprotective autophagy and cellular apoptosis through ROS induction and activation of the PP2A-modulated MAPK pathway in acute myeloid leukemia with different FLT3 statuses","volume":"26","author":"Wu","year":"2019","journal-title":"J. Biomed. Sci."},{"issue":"11","key":"10.1016\/j.cellsig.2026.112772_bb0150","first-page":"1586","article-title":"PP2A-B55 holoenzyme regulation and cancer molecules","volume":"10","author":"Goguet-Rubio","year":"2020","journal-title":"Cancer Med."},{"key":"10.1016\/j.cellsig.2026.112772_bb0155","doi-asserted-by":"crossref","first-page":"3929","DOI":"10.1007\/s00018-013-1305-5","article-title":"Regulation of organogenesis and stem cell properties by T-box transcription factors","volume":"70","author":"Takashima","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.cellsig.2026.112772_bb0160","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/bs.ctdb.2016.08.002","article-title":"Tbx1: transcriptional and developmental functions","volume":"122","author":"Baldini","year":"2017","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.cellsig.2026.112772_bb0165","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1146\/annurev.genet.39.073003.105925","article-title":"T-box genes in vertebrate development","volume":"39","author":"Naiche","year":"2005","journal-title":"Annu. Rev. Genet."},{"issue":"10","key":"10.1016\/j.cellsig.2026.112772_bb0170","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0047054","article-title":"The prognostic value of BRAF mutation in colorectal cancer and melanoma: a systematic review and meta-analysis","volume":"7","author":"Safaee Ardekani","year":"2012","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.cellsig.2026.112772_bb0175","first-page":"164","article-title":"Progression-free survival remains poor over sequential lines of systemic therapy in patients with BRAF-mutated colorectal cancer","volume":"13","author":"Morris","year":"2014","journal-title":"Clin. Colorectal Cancer"},{"issue":"11","key":"10.1016\/j.cellsig.2026.112772_bb0180","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1056\/NEJMoa1305275","article-title":"Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer","volume":"369","author":"Douillard","year":"2013","journal-title":"New. Engl. J. Med."},{"issue":"9","key":"10.1016\/j.cellsig.2026.112772_bb0185","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1136\/gut.2008.159137","article-title":"Concomitant mutations and splice variants in KRAS and BRAF demonstrate complex perturbation of the Ras\/Raf signalling pathway in advanced colorectal cancer","volume":"58","author":"Seth","year":"2009","journal-title":"Gut"},{"issue":"14","key":"10.1016\/j.cellsig.2026.112772_bb0190","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1038\/onc.2013.122","article-title":"ERK and AKT signaling cooperate to translationally regulate survivin expression for metastatic progression of colorectal cancer","volume":"33","author":"Ye","year":"2014","journal-title":"Oncogene"},{"issue":"11","key":"10.1016\/j.cellsig.2026.112772_bb0195","doi-asserted-by":"crossref","first-page":"4311","DOI":"10.1172\/JCI57909","article-title":"Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers","volume":"121","author":"Ebi","year":"2011","journal-title":"J. Clin. Invest."},{"issue":"17","key":"10.1016\/j.cellsig.2026.112772_bb0200","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.1002\/1878-0261.13257","article-title":"High prevalence of unusual KRAS, NRAS and BRAF mutations in POLE hypermutated colorectal cancers","volume":"16","author":"Favre","year":"2022","journal-title":"Mol. Oncol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112772_bb0205","first-page":"162","article-title":"Accurate detection of KRAS, NRAS and BRAF mutations in metastatic colorectal cancers by bridged nucleic acid-clamp real-time PCR","volume":"12","author":"Nagakubo","year":"2019","journal-title":"BMC Med. Genet."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112772_bb0210","first-page":"677","article-title":"MicroRNA expression in KRAS- and BRAF-mutated colorectal cancers","volume":"38","author":"Lundberg","year":"2018","journal-title":"Anticancer"},{"issue":"5","key":"10.1016\/j.cellsig.2026.112772_bb0215","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1139\/bcb-2019-0351","article-title":"Down-regulation of NTSR3 inhibits cell growth and metastasis, as well as the PI3K-AKT and MAPK signaling pathways in colorectal cancer","volume":"98","author":"Liu","year":"2020","journal-title":"Biochem. Cell Biol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112772_bb0220","doi-asserted-by":"crossref","DOI":"10.1186\/s12943-017-0629-4","article-title":"Tumor-derived CXCL5 promotes human colorectal cancer metastasis through activation of the ERK\/Elk-1\/snail and AKT\/GSK3 beta\/beta-catenin pathways","volume":"16","author":"Zhao","year":"2017","journal-title":"Mol. Cancer"},{"issue":"11","key":"10.1016\/j.cellsig.2026.112772_bb0225","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1093\/hmg\/dds071","article-title":"Tbx1 regulates oral epithelial adhesion and palatal development","volume":"21","author":"Funato","year":"2012","journal-title":"Hum. Mol. Genet."},{"issue":"17","key":"10.1016\/j.cellsig.2026.112772_bb0230","doi-asserted-by":"crossref","first-page":"11103","DOI":"10.1021\/acsnano.3c11651","article-title":"Multiwalled carbon nanotubes-reprogrammed macrophages facilitate breast cancer metastasis via NBR2\/TBX1 Axis","volume":"18","author":"Ding","year":"2024","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112772_bb0235","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1080\/21655979.2021.1880732","article-title":"T-box transcription factor TBX1, targeted by microRNA-6727-5p, inhibits cell growth and enhances cisplatin chemosensitivity of cervical cancer cells through AKT and MAPK pathways","volume":"12","author":"Liu","year":"2021","journal-title":"Bioengineered"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112772_bb0240","doi-asserted-by":"crossref","first-page":"20188","DOI":"10.1038\/s41598-022-24604-9","article-title":"TBX1 targets the miR-200-ZEB2 axis to induce epithelial differentiation and inhibit stem cell properties","volume":"12","author":"Funato","year":"2022","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112772_bb0245","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.3892\/ijo.2015.2814","article-title":"Combination treatment with triptolide and hydroxycamptothecin synergistically enhances apoptosis in A549 lung adenocarcinoma cells through PP2A-regulated ERK, p38 MAPKs and Akt signaling pathways","volume":"46","author":"Meng","year":"2015","journal-title":"Int. J. Oncol."},{"issue":"11","key":"10.1016\/j.cellsig.2026.112772_bb0250","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1038\/leu.2011.146","article-title":"Low expression of PP2A regulatory subunit B55alpha is associated with T308 phosphorylation of AKT and shorter complete remission duration in acute myeloid leukemia patients","volume":"25","author":"Ruvolo","year":"2011","journal-title":"Leukemia"},{"issue":"9","key":"10.1016\/j.cellsig.2026.112772_bb0255","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1016\/j.bbamcr.2014.05.006","article-title":"The protein phosphatase 2A regulatory subunit B55alpha is a modulator of signaling and microRNA expression in acute myeloid leukemia cells","volume":"1843","author":"Ruvolo","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"issue":"7","key":"10.1016\/j.cellsig.2026.112772_bb0260","doi-asserted-by":"crossref","first-page":"4221","DOI":"10.1073\/pnas.072071699","article-title":"Actions of PP2A on the MAP kinase pathway and apoptosis are mediated by distinct regulatory subunits","volume":"99","author":"Silverstein","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112772_bb0265","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.canlet.2013.02.036","article-title":"Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer","volume":"335","author":"Seshacharyulu","year":"2013","journal-title":"Cancer Lett."},{"key":"10.1016\/j.cellsig.2026.112772_bb0270","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.biocel.2018.01.005","article-title":"Non-genomic mechanisms of protein phosphatase 2A (PP2A) regulation in cancer","volume":"96","author":"Kauko","year":"2018","journal-title":"Int. J. Biochem. Cell. B."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112772_bb0275","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1038\/s12276-025-01486-1","article-title":"C1QL1 inhibits breast cancer through the HSP90alpha\/VCP-ERS\/UPR axis","volume":"57","author":"Zhang","year":"2025","journal-title":"Exp. Mol. Med."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112772_bb0280","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/s41419-024-06501-3","article-title":"CUL4B mutations impair human cortical neurogenesis through PP2A-dependent inhibition of AKT and ERK","volume":"15","author":"Ma","year":"2024","journal-title":"Cell Death Dis."},{"issue":"11","key":"10.1016\/j.cellsig.2026.112772_bb0285","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1093\/annonc\/mdu439","article-title":"MiR-29c mediates epithelial-to-mesenchymal transition in human colorectal carcinoma metastasis via PTP4A and GNA13 regulation of beta-catenin signaling","volume":"25","author":"Zhang","year":"2014","journal-title":"Ann. Oncol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112772_bb0290","doi-asserted-by":"crossref","DOI":"10.1186\/s12943-024-02180-y","article-title":"THBS2 + cancer-associated fibroblasts promote EMT leading to oxaliplatin resistance via COL8A1-mediated PI3K\/AKT activation in colorectal cancer","volume":"23","author":"Zhou","year":"2024","journal-title":"Mol. Cancer"},{"issue":"24","key":"10.1016\/j.cellsig.2026.112772_bb0295","doi-asserted-by":"crossref","first-page":"11063","DOI":"10.7150\/thno.45674","article-title":"CSRP2 suppresses colorectal cancer progression via p130Cas\/Rac1 axis-meditated ERK, PAK, and HIPPO signaling pathways","volume":"10","author":"Chen","year":"2020","journal-title":"Theranostics"}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826004298?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826004298?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:12:03Z","timestamp":1789690323000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656826004298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":59,"alternative-id":["S0898656826004298"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112772","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TBX1 suppresses colorectal cancer cells via PPP2R2B-mediated inhibition of MAPK\/ERK and PI3K\/AKT pathways","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112772","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"112772"}}