{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:03:27Z","timestamp":1789693407565,"version":"4.0.1"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100014125","name":"Fujian Provincial Health Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017686","name":"Fujian Provincial Health Technology Project","doi-asserted-by":"publisher","award":["2025CXA059"],"award-info":[{"award-number":["2025CXA059"]}],"id":[{"id":"10.13039\/501100017686","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017686","name":"Fujian Provincial Health Technology Project","doi-asserted-by":"publisher","award":["2024GGB19"],"award-info":[{"award-number":["2024GGB19"]}],"id":[{"id":"10.13039\/501100017686","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.cellsig.2026.112773","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:56:31Z","timestamp":1785772591000},"page":"112773","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Citrulline alleviates oxidative stress-induced pyroptosis of nucleus pulposus cells via inhibiting the assembly of NLRP3 inflammasome"],"prefix":"10.1016","volume":"148","author":[{"given":"Naikun","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binxiang","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhidong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Rui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjun","family":"Mi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoshan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenge","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.cellsig.2026.112773_bb0005","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41572-025-00681-8","article-title":"Intervertebral disc degeneration","volume":"12","author":"Hammoor","year":"2026","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"10159","key":"10.1016\/j.cellsig.2026.112773_bb0010","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(18)32279-7","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the global burden of Disease study 2017","volume":"392","author":"Disease","year":"2018","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112773_bb0015","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/s41413-025-00416-1","article-title":"Reprogramming to restore youthful epigenetics of senescent nucleus pulposus cells for mitigating intervertebral disc degeneration and alleviating low back pain","volume":"13","author":"Ma","year":"2025","journal-title":"Bone Res."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112773_bb0020","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/s41584-020-00568-w","article-title":"Cell-based strategies for IVD repair: clinical progress and translational obstacles","volume":"17","author":"Binch","year":"2021","journal-title":"Nat. Rev. Rheumatol."},{"issue":"36","key":"10.1016\/j.cellsig.2026.112773_bb0025","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202507178","article-title":"Modulating macrophage-nucleus pulposus cell crosstalk via sequential drug delivery attenuates disc degeneration","volume":"12","author":"Kong","year":"2025","journal-title":"Adv. Sci."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112773_bb0030","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24010208","article-title":"Discogenic low back pain: anatomy, pathophysiology and treatments of intervertebral disc degeneration","volume":"24","author":"Mohd Isa","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112773_bb0035","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s41413-025-00472-7","article-title":"What a pain in the back: etiology, diagnosis and future treatment directions for discogenic low back pain","volume":"13","author":"Kaneda","year":"2025","journal-title":"Bone Res."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112773_bb0040","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/s12276-024-01168-4","article-title":"Nucleus pulposus cells regulate macrophages in degenerated intervertebral discs via the integrated stress response-mediated CCL2\/7-CCR2 signaling pathway","volume":"56","author":"Tian","year":"2024","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.cellsig.2026.112773_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.jare.2026.01.045","article-title":"Decoding intervertebral disc degeneration pathomechanics: from mechanisms to therapeutic horizons","author":"Qiao","year":"2026","journal-title":"J. Adv. Res."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112773_bb0050","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202411290","article-title":"A one-stone-two-birds strategy for intervertebral disc repair: constructing a reductive chelation hydrogel to mitigate oxidative stress and promote disc matrix reconstruction","volume":"37","author":"Bu","year":"2025","journal-title":"Adv. Mater."},{"issue":"16","key":"10.1016\/j.cellsig.2026.112773_bb0055","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202516477","article-title":"CRISPLD2 attenuates intervertebral disc degeneration by suppressing oxidative stress-induced ferroptosis through the miR-548I-IL17A Axis","volume":"13","author":"Shi","year":"2026","journal-title":"Adv. Sci."},{"key":"10.1016\/j.cellsig.2026.112773_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123326","article-title":"Seeds-and-soil inspired hydrogel microspheres: a dual-action antioxidant and cellular therapy for reversing intervertebral disc degeneration","volume":"321","author":"Yang","year":"2025","journal-title":"Biomaterials"},{"key":"10.1016\/j.cellsig.2026.112773_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102323","article-title":"The role of oxidative stress in intervertebral disc degeneration: mechanisms and therapeutic implications","volume":"98","author":"Chen","year":"2024","journal-title":"Ageing Res. Rev."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112773_bb0070","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/s12276-022-00729-9","article-title":"Cytosolic escape of mitochondrial DNA triggers cGAS-STING-NLRP3 axis-dependent nucleus pulposus cell pyroptosis","volume":"54","author":"Zhang","year":"2022","journal-title":"Exp. Mol. Med."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112773_bb0075","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.tips.2025.04.007","article-title":"Targeting the NLRP3 inflammasome for inflammatory disease therapy","volume":"46","author":"Cabral","year":"2025","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.cellsig.2026.112773_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2025.110086","article-title":"Dietary omega-3 alleviates copper-induced nephrotoxicity via suppression of NLRP3-mediated pyroptosis and lipid metabolism disorder in chickens","volume":"147","author":"Zhang","year":"2026","journal-title":"J. Nutr. Biochem."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112773_bb0085","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s11658-023-00462-9","article-title":"The NLRP3 inflammasome: contributions to inflammation-related diseases","volume":"28","author":"Chen","year":"2023","journal-title":"Cell. Mol. Biol. Lett."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112773_bb0090","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41413-024-00355-3","article-title":"Osteopontin deficiency promotes cartilaginous endplate degeneration by enhancing the NF-kappaB signaling to recruit macrophages and activate the NLRP3 inflammasome","volume":"12","author":"Wang","year":"2024","journal-title":"Bone Res."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112773_bb0095","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1631\/jzus.B2300409","article-title":"Endoplasmic reticulum stress-induced NLRP3 inflammasome activation as a novel mechanism of polystyrene microplastics (PS-MPs)-induced pulmonary inflammation in chickens","volume":"25","author":"Lu","year":"2024","journal-title":"J. Zhejiang Univ. Sci. B"},{"issue":"5","key":"10.1016\/j.cellsig.2026.112773_bb0100","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1038\/s41423-021-00670-3","article-title":"An update on the regulatory mechanisms of NLRP3 inflammasome activation","volume":"18","author":"Paik","year":"2021","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.cellsig.2026.112773_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102938","article-title":"Dimethyl fumarate ameliorates erectile dysfunction in bilateral cavernous nerve injury rats by inhibiting oxidative stress and NLRP3 inflammasome-mediated pyroptosis of nerve via activation of Nrf2\/HO-1 signaling pathway","volume":"68","author":"Song","year":"2023","journal-title":"Redox Biol."},{"issue":"9","key":"10.1016\/j.cellsig.2026.112773_bb0110","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1038\/s12276-022-00848-3","article-title":"Activating SIRT3 in peritoneal mesothelial cells alleviates postsurgical peritoneal adhesion formation by decreasing oxidative stress and inhibiting the NLRP3 inflammasome","volume":"54","author":"Shen","year":"2022","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.cellsig.2026.112773_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2022.110180","article-title":"Secondary brain injury after polystyrene microplastic-induced intracerebral hemorrhage is associated with inflammation and pyroptosis","volume":"367","author":"Yin","year":"2022","journal-title":"Chem. Biol. Interact."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112773_bb0120","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/s41590-022-01365-1","article-title":"Ammonia detoxification promotes CD8(+) T cell memory development by urea and citrulline cycles","volume":"24","author":"Tang","year":"2023","journal-title":"Nat. Immunol."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112773_bb0125","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.molcel.2021.12.006","article-title":"Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses","volume":"82","author":"Mao","year":"2022","journal-title":"Mol. Cell"},{"issue":"8","key":"10.1016\/j.cellsig.2026.112773_bb0130","doi-asserted-by":"crossref","DOI":"10.3390\/nu15081995","article-title":"Absence of effects of L-arginine and L-citrulline on inflammatory biomarkers and oxidative stress in response to physical exercise: a systematic review with meta-analysis","volume":"15","author":"Porto","year":"2023","journal-title":"Nutrients"},{"issue":"9","key":"10.1016\/j.cellsig.2026.112773_bb0135","doi-asserted-by":"crossref","DOI":"10.3390\/nu13093133","article-title":"L-citrulline supplementation and exercise in the management of sarcopenia","volume":"13","author":"Caballero-Garcia","year":"2021","journal-title":"Nutrients"},{"issue":"12","key":"10.1016\/j.cellsig.2026.112773_bb0140","article-title":"L-citrulline supplementation reduces blood pressure and myocardial infarct size under chronic intermittent hypoxia, a major feature of sleep apnea syndrome","volume":"11","author":"Ozcan","year":"2022","journal-title":"Antioxidants (Basel)"},{"issue":"6","key":"10.1016\/j.cellsig.2026.112773_bb0145","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/s41419-021-03853-y","article-title":"SLC7A2 deficiency promotes hepatocellular carcinoma progression by enhancing recruitment of myeloid-derived suppressors cells","volume":"12","author":"Xia","year":"2021","journal-title":"Cell Death Dis."},{"issue":"25","key":"10.1016\/j.cellsig.2026.112773_bb0150","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1161\/CIRCULATIONAHA.125.074889","article-title":"Nuclear eNOS interacts with and S-Nitrosates ADAR1 to modulate type I interferon signaling and endothelial function","volume":"152","author":"Zhou","year":"2025","journal-title":"Circulation"},{"issue":"17","key":"10.1016\/j.cellsig.2026.112773_bb0155","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1097\/00007632-200109010-00011","article-title":"Magnetic resonance classification of lumbar intervertebral disc degeneration","volume":"26","author":"Pfirrmann","year":"2001","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.cellsig.2026.112773_bb0160","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41413-020-0087-2","article-title":"Melatonin alleviates intervertebral disc degeneration by disrupting the IL-1beta\/NF-kappaB-NLRP3 inflammasome positive feedback loop","volume":"8","author":"Chen","year":"2020","journal-title":"Bone Res."},{"key":"10.1016\/j.cellsig.2026.112773_bb0165","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.redox.2018.09.006","article-title":"Sirtuin 3-dependent mitochondrial redox homeostasis protects against AGEs-induced intervertebral disc degeneration","volume":"19","author":"Song","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.cellsig.2026.112773_bb0170","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.2147\/DDDT.S251623","article-title":"Epigallocatechin-3-gallate protects H(2)O(2)-induced nucleus pulposus cell apoptosis and inflammation by inhibiting cGAS\/Sting\/NLRP3 activation","volume":"14","author":"Tian","year":"2020","journal-title":"Drug Des. Devel. Ther."},{"issue":"5","key":"10.1016\/j.cellsig.2026.112773_bb0175","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/s12276-020-0441-x","article-title":"The RCAN1.4-calcineurin\/NFAT signaling pathway is essential for hypoxic adaption of intervertebral discs","volume":"52","author":"Huang","year":"2020","journal-title":"Exp. Mol. Med."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112773_bb0180","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/stem.3322","article-title":"Cartilage endplate stem cells inhibit intervertebral disc degeneration by releasing exosomes to nucleus pulposus cells to activate Akt\/autophagy","volume":"39","author":"Luo","year":"2021","journal-title":"Stem Cells"},{"issue":"11","key":"10.1016\/j.cellsig.2026.112773_bb0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-018-0173-3","article-title":"Small molecule natural compound agonist of SIRT3 as a therapeutic target for the treatment of intervertebral disc degeneration","volume":"50","author":"Wang","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.cellsig.2026.112773_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102707","article-title":"The deubiquitinase USP11 ameliorates intervertebral disc degeneration by regulating oxidative stress-induced ferroptosis via deubiquitinating and stabilizing Sirt3","volume":"62","author":"Zhu","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.cellsig.2026.112773_bb0195","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1146\/annurev-immunol-081022-021207","article-title":"Structural mechanisms of NLRP3 inflammasome assembly and activation","volume":"41","author":"Fu","year":"2023","journal-title":"Annu. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112773_bb0200","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1186\/s12967-024-05913-1","article-title":"SOX4 accelerates intervertebral disc degeneration via EZH2\/NRF2 pathway in response to mitochondrial ROS-dependent NLRP3 inflammasome activation in nucleus pulposus cells","volume":"23","author":"Zhao","year":"2025","journal-title":"J. Transl. Med."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112773_bb0205","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.joca.2017.10.007","article-title":"TIGAR mediates the inhibitory role of hypoxia on ROS production and apoptosis in rat nucleus pulposus cells","volume":"26","author":"Jiang","year":"2018","journal-title":"Osteoarthr. Cartil."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112773_bb0210","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41413-021-00179-5","article-title":"Kindlin-2 inhibits Nlrp3 inflammasome activation in nucleus pulposus to maintain homeostasis of the intervertebral disc","volume":"10","author":"Chen","year":"2022","journal-title":"Bone Res."},{"key":"10.1016\/j.cellsig.2026.112773_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157736","article-title":"Salvianolic acid B alleviates rheumatoid arthritis by inhibiting oxidative stress and pyroptosis through the Keap1-Nrf2\/ROS\/NLRP3 axis","volume":"150","author":"Zhou","year":"2026","journal-title":"Phytomedicine"},{"key":"10.1016\/j.cellsig.2026.112773_bb0220","first-page":"19","article-title":"The anti-oxidation related bioactive materials for intervertebral disc degeneration regeneration and repair","volume":"45","author":"Mai","year":"2025","journal-title":"Bioact. Mater."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112773_bb0225","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1186\/s13046-024-03168-8","article-title":"Synthetic lethality of combined ULK1 defection and p53 restoration induce pyroptosis by directly upregulating GSDME transcription and cleavage activation through ROS\/NLRP3 signaling","volume":"43","author":"Chen","year":"2024","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112773_bb0230","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/s41419-017-0257-3","article-title":"Yang B: nicotine promotes atherosclerosis via ROS-NLRP3-mediated endothelial cell pyroptosis","volume":"9","author":"Wu","year":"2018","journal-title":"Cell Death Dis."},{"issue":"8","key":"10.1016\/j.cellsig.2026.112773_bb0235","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41577-019-0165-0","article-title":"The NLRP3 inflammasome: molecular activation and regulation to therapeutics","volume":"19","author":"Swanson","year":"2019","journal-title":"Nat. Rev. Immunol."},{"issue":"7775","key":"10.1016\/j.cellsig.2026.112773_bb0240","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/s41586-019-1551-2","article-title":"DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome","volume":"573","author":"Samir","year":"2019","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.cellsig.2026.112773_bb0245","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/s41423-025-01284-9","article-title":"Updated insights into the molecular networks for NLRP3 inflammasome activation","volume":"22","author":"Paik","year":"2025","journal-title":"Cell. Mol. Immunol."},{"issue":"10","key":"10.1016\/j.cellsig.2026.112773_bb0250","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.tibs.2018.05.003","article-title":"Amino acid transporters revisited: new views in health and disease","volume":"43","author":"Kandasamy","year":"2018","journal-title":"Trends Biochem. Sci."},{"issue":"2\u20133","key":"10.1016\/j.cellsig.2026.112773_bb0255","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.mam.2012.10.007","article-title":"The SLC3 and SLC7 families of amino acid transporters","volume":"34","author":"Fotiadis","year":"2013","journal-title":"Mol. Asp. Med."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112773_bb0260","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s12974-024-03038-2","article-title":"Elevated SLC7A2 expression is associated with an abnormal neuroinflammatory response and nitrosative stress in Huntington\u2019s disease","volume":"21","author":"Gaudet","year":"2024","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.cellsig.2026.112773_bb0265","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s40104-020-00507-5","article-title":"Dietary L-citrulline supplementation modulates nitric oxide synthesis and anti-oxidant status of laying hens during summer season","volume":"11","author":"Uyanga","year":"2020","journal-title":"J. Anim. Sci. Biotechnol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112773_bb0270","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s11658-023-00423-2","article-title":"Endothelial dysfunction due to eNOS uncoupling: molecular mechanisms as potential therapeutic targets","volume":"28","author":"Janaszak-Jasiecka","year":"2023","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.cellsig.2026.112773_bb0275","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.freeradbiomed.2026.05.300","article-title":"Vanadium exposure promotes pulmonary fibrosis via crosstalk between cGAS-STING\/NF-kappaB and Wnt signaling in ducks","volume":"253","author":"Chu","year":"2026","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112773_bb0280","doi-asserted-by":"crossref","first-page":"43","DOI":"10.7150\/ijbs.123482","article-title":"Dual-pathway mechanism of vanadium-induced hepatotoxicity in ducks: synergistic crosstalk between glucose homeostasis disruption and NADH\/FSP1\/COQ10 axis-driven ferroptosis","volume":"22","author":"Chen","year":"2026","journal-title":"Int. J. Biol. Sci."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826004304?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826004304?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:13:09Z","timestamp":1789690389000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656826004304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":56,"alternative-id":["S0898656826004304"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112773","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Citrulline alleviates oxidative stress-induced pyroptosis of nucleus pulposus cells via inhibiting the assembly of NLRP3 inflammasome","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112773","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112773"}}