{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:04:07Z","timestamp":1789693447841,"version":"4.0.1"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007194","name":"Wenzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["Y20220152"],"award-info":[{"award-number":["Y20220152"]}],"id":[{"id":"10.13039\/501100007194","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071007"],"award-info":[{"award-number":["82071007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","award":["LY24C060001"],"award-info":[{"award-number":["LY24C060001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.cellsig.2026.112778","type":"journal-article","created":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T20:04:53Z","timestamp":1785701093000},"page":"112778","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Progressive mitochondrial and autophagic dysfunction during RGC development driven by a LHON-associated mitochondrial tRNAThr mutation"],"prefix":"10.1016","volume":"148","author":[{"given":"Wei","family":"Guan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shidan","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanjuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellsig.2026.112778_bb0005","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/B978-0-12-821751-1.00010-5","article-title":"Mitochondrial optic neuropathies","volume":"194","author":"Carelli","year":"2023","journal-title":"Handb. Clin. Neurol."},{"key":"10.1016\/j.cellsig.2026.112778_bb0010","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.mito.2021.08.013","article-title":"Leber's hereditary optic neuropathy: current approaches and future perspectives on mesenchymal stem cell-mediated rescue","volume":"60","author":"Subramaniam","year":"2021","journal-title":"Mitochondrion"},{"issue":"2","key":"10.1016\/j.cellsig.2026.112778_bb0015","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/S1474-4422(22)00174-0","article-title":"Understanding the molecular basis and pathogenesis of hereditary optic neuropathies: towards improved diagnosis and management","volume":"22","author":"Newman","year":"2023","journal-title":"Lancet Neurol."},{"issue":"9","key":"10.1016\/j.cellsig.2026.112778_bb0020","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1007\/s00417-020-04993-1","article-title":"Leber hereditary optic neuropathy-new insights and old challenges","volume":"259","author":"Sundaramurthy","year":"2021","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.cellsig.2026.112778_bb0025","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.mito.2017.12.003","article-title":"Leber's hereditary optic neuropathy caused by a mutation in mitochondrial tRNAThr gene in eight Chinese pedigrees","volume":"42","author":"Zhang","year":"2018","journal-title":"Mitochondrion"},{"issue":"9","key":"10.1016\/j.cellsig.2026.112778_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2024.107728","article-title":"Defective post-transcriptional modification of tRNA disrupts mitochondrial homeostasis in Leber's hereditary optic neuropathy","volume":"300","author":"Zhang","year":"2024","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112778_bb0035","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors","volume":"126","author":"Takahashi","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.cellsig.2026.112778_bb0040","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2021.648916","article-title":"Exploiting hiPSCs in Leber's hereditary optic neuropathy (LHON): present achievements and future perspectives","volume":"12","author":"Peron","year":"2021","journal-title":"Front. Neurol."},{"key":"10.1016\/j.cellsig.2026.112778_bb0045","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/7651_2015_204","article-title":"Generation of integration-free patient specific iPS cells using Episomal plasmids under feeder free conditions","volume":"1353","author":"Caxaria","year":"2016","journal-title":"Methods Mol. Biol."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112778_bb0050","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1002\/stem.2356","article-title":"Stepwise differentiation of retinal ganglion cells from human pluripotent stem cells enables analysis of glaucomatous neurodegeneration","volume":"34","author":"Ohlemacher","year":"2016","journal-title":"Stem Cells"},{"issue":"8","key":"10.1016\/j.cellsig.2026.112778_bb0055","doi-asserted-by":"crossref","first-page":"3531","DOI":"10.1167\/iovs.17-23439","article-title":"Defined conditions for differentiation of functional retinal ganglion cells from human pluripotent stem cells","volume":"59","author":"Lee","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.cellsig.2026.112778_bb0060","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.scr.2017.12.014","article-title":"Human induced pluripotent stem cell line with cytochrome P450 enzyme polymorphism (CYP2C19*2\/CYP3A5*3C) generated from lymphoblastoid cells","volume":"27","author":"Lee","year":"2018","journal-title":"Stem Cell Res."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112778_bb0065","first-page":"152","article-title":"Differentiation of retinal ganglion cells from induced pluripotent stem cells: a review","volume":"12","author":"Ji","year":"2019","journal-title":"Int. J. Ophthalmol."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112778_bb0070","doi-asserted-by":"crossref","first-page":"424","DOI":"10.5966\/sctm.2013-0147","article-title":"Chemically induced specification of retinal ganglion cells from human embryonic and induced pluripotent stem cells","volume":"3","author":"Riazifar","year":"2014","journal-title":"Stem Cells Transl. Med."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112778_bb0075","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.yexcr.2018.01.020","article-title":"Bioactivity and gene expression profiles of hiPSC-generated retinal ganglion cells in MT-ND4 mutated Leber's hereditary optic neuropathy","volume":"363","author":"Wu","year":"2018","journal-title":"Exp. Cell Res."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112778_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111124","article-title":"Pathological mitophagy disrupts mitochondrial homeostasis in Leber's hereditary optic neuropathy","volume":"40","author":"Danese","year":"2022","journal-title":"Cell Rep."},{"issue":"9","key":"10.1016\/j.cellsig.2026.112778_bb0085","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1167\/iovs.62.9.38","article-title":"Assocation between Leber's hereditary optic neuropathy and MT-ND1 3460G>A mutation-induced alterations in mitochondrial function, apoptosis, and mitophagy","volume":"62","author":"Zhang","year":"2021","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"19","key":"10.1016\/j.cellsig.2026.112778_bb0090","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.1093\/hmg\/ddac109","article-title":"Leber's hereditary optic neuropathy (LHON)-associated ND6 14484 T>C mutation caused pleiotropic effects on the complex I, RNA homeostasis, apoptosis and mitophagy","volume":"31","author":"Liang","year":"2022","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.cellsig.2026.112778_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2024.148853","article-title":"Dysregulation of mitochondria, apoptosis and mitophagy in Leber's hereditary optic neuropathy with MT-ND1 3635G>A mutation","volume":"930","author":"Chen","year":"2024","journal-title":"Gene"},{"key":"10.1016\/j.cellsig.2026.112778_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101817","article-title":"PINK1\/Parkin-mediated mitophagy in neurodegenerative diseases","volume":"84","author":"Li","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.cellsig.2026.112778_bb0105","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.neures.2020.04.007","article-title":"PINK1 and parkin: the odd couple","volume":"159","author":"Yoboue","year":"2020","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.cellsig.2026.112778_bb0110","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.neures.2020.01.006","article-title":"The PINK1-parkin axis: an overview","volume":"159","author":"Tanaka","year":"2020","journal-title":"Neurosci. Res."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112778_bb0115","doi-asserted-by":"crossref","DOI":"10.14440\/jbm.2020.296","article-title":"Highly efficient induced pluripotent stem cell reprogramming of cryopreserved lymphoblastoid cell lines","volume":"7","author":"Kumar","year":"2020","journal-title":"J. Biol. Methods"},{"issue":"12","key":"10.1016\/j.cellsig.2026.112778_bb0120","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.5966\/sctm.2014-0121","article-title":"Reliable generation of induced pluripotent stem cells from human lymphoblastoid cell lines","volume":"3","author":"Barrett","year":"2014","journal-title":"Stem Cells Transl. Med."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112778_bb0125","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nbt.1529","article-title":"Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling","volume":"27","author":"Chambers","year":"2009","journal-title":"Nat. Biotechnol."},{"issue":"Web Server issue","key":"10.1016\/j.cellsig.2026.112778_bb0130","doi-asserted-by":"crossref","first-page":"W170","DOI":"10.1093\/nar\/gkn294","article-title":"QUMA: quantification tool for methylation analysis","volume":"36","author":"Kumaki","year":"2008","journal-title":"Nucleic Acids Res."},{"issue":"11","key":"10.1016\/j.cellsig.2026.112778_bb0135","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1093\/hmg\/ddy107","article-title":"Leber's hereditary optic neuropathy (LHON)-associated ND5 12338T > C mutation altered the assembly and function of complex I, apoptosis and mitophagy","volume":"27","author":"Zhang","year":"2018","journal-title":"Hum. Mol. Genet."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112778_bb0140","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.cell.2005.08.020","article-title":"Core transcriptional regulatory circuitry in human embryonic stem cells","volume":"122","author":"Boyer","year":"2005","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112778_bb0145","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/cr.2012.175","article-title":"Embryonic stem cell and induced pluripotent stem cell: an epigenetic perspective","volume":"23","author":"Liang","year":"2013","journal-title":"Cell Res."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112778_bb0150","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12409","article-title":"Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles","volume":"13","author":"Chen","year":"2024","journal-title":"J. Extracell. Vesicles"},{"issue":"4","key":"10.1016\/j.cellsig.2026.112778_bb0155","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1093\/nar\/gky1241","article-title":"A coronary artery disease-associated tRNAThr mutation altered mitochondrial function, apoptosis and angiogenesis","volume":"47","author":"Jia","year":"2019","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112778_bb0160","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/s41580-024-00785-1","article-title":"Molecular mechanisms of mitochondrial dynamics","volume":"26","author":"T\u00e1bara","year":"2025","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"9","key":"10.1016\/j.cellsig.2026.112778_bb0165","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.263640","article-title":"Mitochondrial fission - changing perspectives for future progress","volume":"138","author":"Kamerkar","year":"2025","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.cellsig.2026.112778_bb0170","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1146\/annurev-cellbio-120219-035530","article-title":"Mechanisms of selective autophagy","volume":"37","author":"Lamark","year":"2021","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.cellsig.2026.112778_bb0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ceb.2019.12.001","article-title":"The ATG conjugation systems in autophagy","volume":"63","author":"Mizushima","year":"2020","journal-title":"Curr. Opin. Cell Biol."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112778_bb0180","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.bulcan.2020.11.004","article-title":"An overview of autophagy: mechanism, regulation and research progress","volume":"108","author":"Cao","year":"2021","journal-title":"Bull. Cancer"},{"issue":"12","key":"10.1016\/j.cellsig.2026.112778_bb0185","doi-asserted-by":"crossref","first-page":"4182","DOI":"10.1080\/15548627.2021.1907167","article-title":"The role of mitophagy in the regulation of mitochondrial energetic status in neurons","volume":"17","author":"Han","year":"2021","journal-title":"Autophagy"},{"issue":"3","key":"10.1016\/j.cellsig.2026.112778_bb0190","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020104705","article-title":"Molecular mechanisms and physiological functions of mitophagy","volume":"40","author":"Onishi","year":"2021","journal-title":"EMBO J."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112778_bb0195","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3390\/cells11010038","article-title":"Molecular mechanisms and regulation of mammalian mitophagy","volume":"11","author":"Choubey","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.cellsig.2026.112778_bb0200","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.585675","article-title":"Generation of a transplantable population of human iPSC-derived retinal ganglion cells","volume":"8","author":"Rabesandratana","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"issue":"11","key":"10.1016\/j.cellsig.2026.112778_bb0205","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1007\/s11427-024-2647-8","article-title":"MSC-mediated mitochondrial transfer restores mitochondrial DNA and function in neural progenitor cells of Leber's hereditary optic neuropathy","volume":"67","author":"Wang","year":"2024","journal-title":"Sci. China Life Sci."},{"issue":"11","key":"10.1016\/j.cellsig.2026.112778_bb0210","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1016\/j.cell.2024.04.037","article-title":"Mitochondria at the crossroads of health and disease","volume":"187","author":"Suomalainen","year":"2024","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112778_bb0215","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.cell.2020.02.051","article-title":"Mitochondrial diseases: Hope for the future","volume":"181","author":"Russell","year":"2020","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.cellsig.2026.112778_bb0220","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1042\/EBC20170104","article-title":"Mitochondrial dynamics: overview of molecular mechanisms","volume":"62","author":"Tilokani","year":"2018","journal-title":"Essays Biochem."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112778_bb0225","first-page":"242","article-title":"Leber hereditary optic neuropathy-light at the end of the tunnel?","volume":"7","author":"Kim","year":"2018","journal-title":"Asia Pac. J. Ophthalmol (Phila)"},{"issue":"2","key":"10.1016\/j.cellsig.2026.112778_bb0230","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1093\/hmg\/ddac190","article-title":"Abnormal morphology and function in retinal ganglion cells derived from patients-specific iPSCs generated from individuals with Leber's hereditary optic neuropathy","volume":"32","author":"Nie","year":"2022","journal-title":"Hum. Mol. Genet."},{"issue":"9","key":"10.1016\/j.cellsig.2026.112778_bb0235","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1093\/hmg\/ddad001","article-title":"Nuclear modifier YARS2 allele correction restored retinal ganglion cells-specific deficiencies in Leber's hereditary optic neuropathy","volume":"32","author":"Chen","year":"2023","journal-title":"Hum. Mol. Genet."},{"issue":"20","key":"10.1016\/j.cellsig.2026.112778_bb0240","doi-asserted-by":"crossref","first-page":"4064","DOI":"10.1093\/hmg\/ddt256","article-title":"Coronary heart disease is associated with a mutation in mitochondrial tRNA","volume":"22","author":"Jia","year":"2013","journal-title":"Hum. Mol. Genet."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112778_bb0245","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/s41420-025-02458-0","article-title":"DRP1, fission and apoptosis","volume":"11","author":"Wang","year":"2025","journal-title":"Cell Death Discov."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112778_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.108883","article-title":"Deficient tRNA posttranscription modification dysregulated the mitochondrial quality controls and apoptosis","volume":"27","author":"He","year":"2024","journal-title":"iScience"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112778_bb0255","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15548627.2020.1797280","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)","volume":"17","author":"Klionsky","year":"2021","journal-title":"Autophagy"},{"issue":"10","key":"10.1016\/j.cellsig.2026.112778_bb0260","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1038\/s41556-024-01513-9","article-title":"The role of PINK1-Parkin in mitochondrial quality control","volume":"26","author":"Narendra","year":"2024","journal-title":"Nat. Cell Biol."},{"issue":"9","key":"10.1016\/j.cellsig.2026.112778_bb0265","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1093\/hmg\/ddaa063","article-title":"Mitochondrial transport mediates survival of retinal ganglion cells in affected LHON patients","volume":"29","author":"Yang","year":"2020","journal-title":"Hum. Mol. Genet."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112778_bb0270","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s40478-025-01942-z","article-title":"Disruption of mitochondrial homeostasis and permeability transition pore opening in OPA1 iPSC-derived retinal ganglion cells","volume":"13","author":"Whitehead","year":"2025","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.cellsig.2026.112778_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2025.112121","article-title":"Estradiol alleviates disease phenotypes caused by m.3635G > A mutation by activating mitochondrial biogenesis and PINK1-parkin mediated mitophagy in iPSC-derived retinal pigment epithelium cells","volume":"136","author":"Hu","year":"2025","journal-title":"Cell. Signal."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826004365?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826004365?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:21:06Z","timestamp":1789690866000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656826004365"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":55,"alternative-id":["S0898656826004365"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112778","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Progressive mitochondrial and autophagic dysfunction during RGC development driven by a LHON-associated mitochondrial tRNAThr mutation","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112778","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112778"}}