{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:03:54Z","timestamp":1789693434453,"version":"4.0.1"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.cellsig.2026.112784","type":"journal-article","created":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T20:03:56Z","timestamp":1785701036000},"page":"112784","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Mogroside V inhibits high glucose-induced inflammatory responses and promotes osteogenic differentiation in diabetic osteoporosis via the PI3K\/Akt\/mTOR pathway"],"prefix":"10.1016","volume":"148","author":[{"given":"Zhao","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huwei","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingqing","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellsig.2026.112784_bb0005","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1186\/s12967-024-05191-x","article-title":"Type 2 diabetic mellitus related osteoporosis: focusing on ferroptosis","volume":"22","author":"Chen","year":"2024","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.cellsig.2026.112784_bb0010","doi-asserted-by":"crossref","first-page":"1595228","DOI":"10.3389\/fendo.2025.1595228","article-title":"Research progress of diabetic osteoporosis: a comprehensive review","volume":"16","author":"Ma","year":"2025","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.cellsig.2026.112784_bb0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12902-022-01260-8","article-title":"Prevalence of osteoporosis in patients with diabetes mellitus: a systematic review and meta-analysis of observational studies","volume":"23","author":"Liu","year":"2023","journal-title":"BMC Endocr. Disord."},{"key":"10.1016\/j.cellsig.2026.112784_bb0020","doi-asserted-by":"crossref","first-page":"1052592","DOI":"10.3389\/fendo.2022.1052592","article-title":"A narrative review of diabetic bone disease: characteristics, pathogenesis, and treatment","volume":"13","author":"Wu","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.cellsig.2026.112784_bb0025","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1302\/2046-3758.114.BJR-2020-0308.R2","article-title":"N,N-Dimethylformamide inhibits high glucose-induced osteoporosis via attenuating MAPK and NF-\u03baB signalling","volume":"11","author":"Liu","year":"2022","journal-title":"Bone Jt. Res."},{"key":"10.1016\/j.cellsig.2026.112784_bb0030","doi-asserted-by":"crossref","first-page":"23","DOI":"10.64229\/6epkqc16","article-title":"Evaluation of the relationship between vitamin D and inflammation in type 2 diabetes and diabetic complications","volume":"1","author":"Tuba Taslamacioglu","year":"2025","journal-title":"Adv. Mod. Biomed."},{"key":"10.1016\/j.cellsig.2026.112784_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157671","article-title":"Corylin ameliorates diabetic osteoporosis by inhibiting inflammation via targeting RAG1","volume":"150","author":"Lin","year":"2026","journal-title":"Phytomedicine"},{"key":"10.1016\/j.cellsig.2026.112784_bb0040","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/s41574-021-00555-5","article-title":"Update on the pathogenesis and treatment of skeletal fragility in type 2 diabetes mellitus","volume":"17","author":"Khosla","year":"2021","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.cellsig.2026.112784_bb0045","doi-asserted-by":"crossref","first-page":"43","DOI":"10.64229\/d5fqg290","article-title":"Edible and medicinal plants as nutraceuticals: a comprehensive pharmacognostic review","volume":"3","author":"Dhiman","year":"2026","journal-title":"Adv. Clin. Pharmacol. Ther."},{"key":"10.1016\/j.cellsig.2026.112784_bb0050","doi-asserted-by":"crossref","DOI":"10.3390\/biom14070836","article-title":"Antioxidant, anti-inflammatory, anti-diabetic, and pro-osteogenic activities of polyphenols for the treatment of two different chronic diseases: type 2 diabetes mellitus and osteoporosis","volume":"14","author":"Scarpa","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.cellsig.2026.112784_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157250","article-title":"Mogroside V: molecular mechanisms and therapeutic applications","volume":"148","author":"He","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.cellsig.2026.112784_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2022.105326","article-title":"Mogroside V exerts anti-inflammatory effects on fine particulate matter-induced inflammation in porcine alveolar macrophages","volume":"80","author":"Shen","year":"2022","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.cellsig.2026.112784_bb0065","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1080\/08820139.2024.2321353","article-title":"Mogroside V inhibits M1 polarization and inflammation of diabetic mouse macrophages via p38 MAPK\/NF-\u039ab signaling pathway","volume":"53","author":"Dong","year":"2024","journal-title":"Immunol. Investig."},{"key":"10.1016\/j.cellsig.2026.112784_bb0070","article-title":"Mogroside V improves follicular development and ovulation in young-adult PCOS rats induced by letrozole and high-fat diet through promoting glycolysis","volume":"13","author":"Huang","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.cellsig.2026.112784_bb0075","doi-asserted-by":"crossref","first-page":"998","DOI":"10.2174\/0113862073299904240416114653","article-title":"Mogroside V promotes osteogenic differentiation of bone marrow mesenchymal stem cells from diabetic mice by altering MicroRNA profiles","volume":"28","author":"Luo","year":"2025","journal-title":"Comb. Chem. High Throughput Screen."},{"key":"10.1016\/j.cellsig.2026.112784_bb0080","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.cpt.2022.09.001","article-title":"PI3K\/AKT\/mTOR pathway, hypoxia, and glucose metabolism: potential targets to overcome radioresistance in small cell lung cancer","volume":"1","author":"Deng","year":"2023","journal-title":"Cancer Pathog. Ther."},{"key":"10.1016\/j.cellsig.2026.112784_bb0085","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.semcancer.2021.06.019","article-title":"Attacking the PI3K\/Akt\/mTOR signaling pathway for targeted therapeutic treatment in human cancer","volume":"85","author":"Yu","year":"2022","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.cellsig.2026.112784_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.107025","article-title":"Resistin targets TAZ to promote osteogenic differentiation through PI3K\/AKT\/mTOR pathway","volume":"26","author":"Shang","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.cellsig.2026.112784_bb0095","doi-asserted-by":"crossref","first-page":"42251","DOI":"10.1038\/s41598-025-26289-2","article-title":"Knockdown of GCNT2 promoted osteoblast differentiation by activating PI3K\/AKT\/mTOR pathway in osteoblasts","volume":"15","author":"Huang","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cellsig.2026.112784_bb0100","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1093\/bbb\/zbaa010","article-title":"Morroniside promotes the osteogenesis by activating PI3K\/Akt\/mTOR signaling","volume":"85","author":"Liu","year":"2021","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.cellsig.2026.112784_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157295","article-title":"Mangiferin reverses high glucose-induced osteoblast damage and ameliorates osteoporosis by targeting SOX9","volume":"148","author":"Chen","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.cellsig.2026.112784_bb0110","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1186\/s13018-025-05684-5","article-title":"Mogroside V enhances bone marrow mesenchymal stem cells osteogenesis under hyperglycemic conditions through upregulating miR-10b-5p and PI3K\/Akt signaling","volume":"20","author":"Lan","year":"2025","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.cellsig.2026.112784_bb0115","article-title":"Maresin1 suppresses high-glucose-induced ferroptosis in osteoblasts via NRF2 activation in type 2 diabetic osteoporosis","volume":"11","author":"Zhang","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.cellsig.2026.112784_bb0120","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s12035-025-05331-4","article-title":"Mogroside V ameliorates spinal cord injury by inhibiting M1 microglia polarization","volume":"63","author":"Xie","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.cellsig.2026.112784_bb0125","article-title":"Vitamin D ameliorates insulin resistance-induced osteopenia by inactivating the nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome","volume":"9","author":"Wu","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.cellsig.2026.112784_bb0130","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41413-024-00399-5","article-title":"Enhanced SIRT3 expression restores mitochondrial quality control mechanism to reverse osteogenic impairment in type 2 diabetes mellitus","volume":"13","author":"Xian","year":"2025","journal-title":"Bone Res."},{"key":"10.1016\/j.cellsig.2026.112784_bb0135","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s12902-022-01103-6","article-title":"Metformin activates Wnt\/\u03b2-catenin for the treatment of diabetic osteoporosis","volume":"22","author":"Huang","year":"2022","journal-title":"BMC Endocr. Disord."},{"key":"10.1016\/j.cellsig.2026.112784_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118044","article-title":"Melatonin rescues glucocorticoid-induced inhibition of osteoblast differentiation in MC3T3-E1 cells via the PI3K\/AKT and BMP\/Smad signalling pathways","volume":"257","author":"Zhao","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.cellsig.2026.112784_bb0145","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1080\/13880209.2020.1738502","article-title":"Inhibition of tanshinone IIA on renin activity protected against osteoporosis in diabetic mice","volume":"58","author":"Zhang","year":"2020","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.cellsig.2026.112784_bb0150","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.2147\/DDDT.S503930","article-title":"MK-4 ameliorates diabetic osteoporosis in angiogenesis-dependent bone formation by promoting mitophagy in endothelial cells","volume":"19","author":"Ding","year":"2025","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.cellsig.2026.112784_bb0155","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.jare.2024.11.036","article-title":"Asperosaponin VI inhibition of DNMT alleviates GPX4 suppression-mediated osteoblast ferroptosis and diabetic osteoporosis","volume":"75","author":"Wei","year":"2025","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.cellsig.2026.112784_bb0160","doi-asserted-by":"crossref","first-page":"1178573","DOI":"10.3389\/fnut.2023.1178573","article-title":"Iron metabolism and ferroptosis in diabetic bone loss: from mechanism to therapy","volume":"10","author":"Bao","year":"2023","journal-title":"Front. Nutr."},{"key":"10.1016\/j.cellsig.2026.112784_bb0165","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/s42003-025-08263-w","article-title":"Short-term high-fat diet impacts bone material properties and metabolism for adult and aged C57BL\/6JN mice","volume":"8","author":"Brown","year":"2025","journal-title":"Commun. Biol."},{"key":"10.1016\/j.cellsig.2026.112784_bb0170","doi-asserted-by":"crossref","DOI":"10.1186\/s40001-025-03749-z","article-title":"High glucose induces osteoblasts ferroptosis via the TXNIP\/Trx-1\/GPX4 pathway in type 2 diabetic osteoporosis","volume":"31","author":"Zhao","year":"2025","journal-title":"Eur. J. Med. Res."},{"key":"10.1016\/j.cellsig.2026.112784_bb0175","first-page":"138","article-title":"High glucose promotes apoptosis and autophagy of MC3T3-E1 osteoblasts","volume":"19","author":"Zhang","year":"2023","journal-title":"Arch. Med. Sci."},{"key":"10.1016\/j.cellsig.2026.112784_bb0180","article-title":"Inflammation in focus: the beginning and the end","volume":"27","author":"A","year":"2021","journal-title":"Pathol. Oncol. Res."},{"key":"10.1016\/j.cellsig.2026.112784_bb0185","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.759843","article-title":"Chondroitin sulfate alleviates diabetic osteoporosis and repairs bone microstructure via anti-oxidation, anti-inflammation, and regulating bone metabolism","volume":"12","author":"Qi","year":"2021","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.cellsig.2026.112784_bb0190","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1186\/s13018-025-05685-4","article-title":"Epimedin B protects against bone loss and inflammation in diabetic osteoporosis rats by regulating OPG\/RANKL pathway","volume":"20","author":"Zhang","year":"2025","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.cellsig.2026.112784_bb0195","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.753194","article-title":"PPAR\u03b2\/\u03b4 agonist alleviates diabetic osteoporosis via regulating M1\/M2 macrophage polarization","volume":"9","author":"Chen","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.cellsig.2026.112784_bb0200","article-title":"Fueling bone loss: the immunometabolic reprogramming of the bone microenvironment in diabetic osteoporosis","volume":"17","author":"Wang","year":"2026","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cellsig.2026.112784_bb0205","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1186\/s13287-025-04677-9","article-title":"BMDMs in metabolic memory impair fracture healing in diabetes","volume":"16","author":"Zhang","year":"2025","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.cellsig.2026.112784_bb0210","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22136651","article-title":"Osteoblast differentiation and signaling: established concepts and emerging topics","volume":"22","author":"Ponzetti","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cellsig.2026.112784_bb0215","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41413-024-00394-w","article-title":"Nuclear farnesoid X receptor protects against bone loss by driving osteoblast differentiation through stabilizing RUNX2","volume":"13","author":"Dong","year":"2025","journal-title":"Bone Res."},{"key":"10.1016\/j.cellsig.2026.112784_bb0220","article-title":"Cyclophilin a promotes osteoblast differentiation by regulating Runx2","volume":"23","author":"Piao","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cellsig.2026.112784_bb0225","doi-asserted-by":"crossref","first-page":"3929","DOI":"10.2147\/DDDT.S377001","article-title":"ED-71 prevents glucocorticoid-induced osteoporosis by regulating osteoblast differentiation via notch and Wnt\/\u03b2-catenin pathways","volume":"16","author":"Rong","year":"2022","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.cellsig.2026.112784_bb0230","article-title":"Identification of a novel osteogenetic oligodeoxynucleotide (osteoDN) that promotes osteoblast differentiation in a TLR9-independent manner","volume":"12","author":"Nihashi","year":"2022","journal-title":"Nanomaterials (Basel, Switzerland)."},{"key":"10.1016\/j.cellsig.2026.112784_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115864","article-title":"Advances in the roles of ATF4 in osteoporosis","volume":"169","author":"Xiao","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.cellsig.2026.112784_bb0240","first-page":"7576","article-title":"Zoledronic acid epigenetically alleviates high-glucose-suppressed osteogenic differentiation of MC3T3-E1 cells","volume":"27","author":"Chen","year":"2023","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.cellsig.2026.112784_bb0245","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3724\/abbs.2023043","article-title":"Metformin promotes osteogenic differentiation and prevents hyperglycaemia-induced osteoporosis by suppressing PPAR\u03b3 expression","volume":"55","author":"Zheng","year":"2023","journal-title":"Acta Biochim. Biophys. Sin. Shanghai"},{"key":"10.1016\/j.cellsig.2026.112784_bb0250","doi-asserted-by":"crossref","first-page":"11963","DOI":"10.1007\/s00210-025-04009-x","article-title":"Calycosin alleviates ovariectomy-induced osteoporosis by promoting BMSCs autophagy via the PI3K\/Akt\/mTOR pathway","volume":"398","author":"Xiang","year":"2025","journal-title":"Naunyn Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"10.1016\/j.cellsig.2026.112784_bb0255","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.1111\/bph.70016","article-title":"Activation of autophagy mediated by PI3K\/Akt\/mTOR signalling cascade alleviates impaired adipose-derived stem cell osteogenesis in a diabetic microenvironment","volume":"182","author":"Lou","year":"2025","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.cellsig.2026.112784_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156755","article-title":"Gouqi-derived nanovesicles (GqDNVs) promoted MC3T3-E1 cells proliferation and improve fracture healing","volume":"142","author":"Xu","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.cellsig.2026.112784_bb0265","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1186\/s12951-024-02888-5","article-title":"Hypoxic glioma-derived exosomal miR-25-3p promotes macrophage M2 polarization by activating the PI3K-AKT-mTOR signaling pathway","volume":"22","author":"Xue","year":"2024","journal-title":"J. Nanbiotechnol."},{"key":"10.1016\/j.cellsig.2026.112784_bb0270","first-page":"205","article-title":"Hydrogel microspheres for bone regeneration through regulation of the regenerative microenvironment","volume":"5","author":"Zhang","year":"2024","journal-title":"Biomater. Transl."},{"key":"10.1016\/j.cellsig.2026.112784_bb0275","series-title":"Nerve\u2013Bone Crosstalk Manipulates Bone Organoid Development and Bone Regeneration: A Review and Perspectives","volume":"vol. 1","author":"Song","year":"2025"}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826004420?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826004420?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:15:43Z","timestamp":1789690543000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656826004420"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":55,"alternative-id":["S0898656826004420"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112784","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mogroside V inhibits high glucose-induced inflammatory responses and promotes osteogenic differentiation in diabetic osteoporosis via the PI3K\/Akt\/mTOR pathway","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112784","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"112784"}}