{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:04:34Z","timestamp":1789693474192,"version":"4.0.1"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","award":["LZ26H160005"],"award-info":[{"award-number":["LZ26H160005"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272814"],"award-info":[{"award-number":["82272814"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972879"],"award-info":[{"award-number":["81972879"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.cellsig.2026.112785","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T23:33:53Z","timestamp":1786145633000},"page":"112785","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["APOC1 in tumor-associated macrophages enhances protumorigenic M2 polarization and promotes PAAD progression"],"prefix":"10.1016","volume":"148","author":[{"given":"Yue","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoyao","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaina","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenchen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiyi","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibiao","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xihan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.cellsig.2026.112785_bb0005","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3322\/caac.21763","article-title":"Cancer statistics, 2023","volume":"73","author":"Siegel","year":"2023","journal-title":"CA-Cancer J. Clin."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112785_bb0010","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1136\/gutjnl-2018-316451","article-title":"Stromal biology and therapy in pancreatic cancer: ready for clinical translation?","volume":"68","author":"Neesse","year":"2019","journal-title":"Gut"},{"issue":"3","key":"10.1016\/j.cellsig.2026.112785_bb0015","doi-asserted-by":"crossref","DOI":"10.2174\/0109298665359781250114055525","article-title":"MARVELD1 promotes the invasiveness in pancreatic adenocarcinoma through the activation of epithelial-to-mesenchymal transition","volume":"32","author":"Luo","year":"2025","journal-title":"Protein Pept. Lett."},{"key":"10.1016\/j.cellsig.2026.112785_bb0020","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/ncomms15095","article-title":"Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer","volume":"8","author":"Carstens","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cellsig.2026.112785_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.109783","article-title":"MARCO is a potential prognostic and immunotherapy biomarker","volume":"116","author":"Dong","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"11","key":"10.1016\/j.cellsig.2026.112785_bb0030","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/s41573-022-00520-5","article-title":"Macrophages as tools and targets in cancer therapy","volume":"21","author":"Mantovani","year":"2022","journal-title":"Nat. Rev. Drug Discov."},{"issue":"8","key":"10.1016\/j.cellsig.2026.112785_bb0035","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1016\/j.cell.2023.02.014","article-title":"Pancreatic cancer: advances and challenges","volume":"186","author":"Halbrook","year":"2023","journal-title":"Cell"},{"issue":"23","key":"10.1016\/j.cellsig.2026.112785_bb0040","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3390\/ijms20235939","article-title":"Apolipoprotein C1: its pleiotropic effects in lipid metabolism and beyond","volume":"20","author":"Fuior","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112785_bb0045","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1080\/01616412.2022.2132458","article-title":"ApoC1 promotes glioma metastasis by enhancing epithelial-mesenchymal transition and activating the STAT3 pathway","volume":"45","author":"Liang","year":"2023","journal-title":"Neurol. Res."},{"key":"10.1016\/j.cellsig.2026.112785_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114611","article-title":"APOC1 expressed in macrophages promotes the pulmonary metastasis of colorectal cancer via CCL2\/CCL5","volume":"154","author":"Qin","year":"2025","journal-title":"Int. Immunopharmacol."},{"issue":"5","key":"10.1016\/j.cellsig.2026.112785_bb0055","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.17305\/bb.2024.11550","article-title":"APOC1 knockdown induces apoptosis and decreases angiogenesis in diffuse large B-cell lymphoma cells through blocking the PI3K\/AKT\/mTOR pathway","volume":"25","author":"Gao","year":"2025","journal-title":"Biomol. Biomed."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112785_bb0060","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1471-2407-10-16","article-title":"APOC1 is a prognostic biomarker associated with M2 macrophages in ovarian cancer","volume":"24","author":"Yang","year":"2024","journal-title":"BMC Cancer"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112785_bb0065","article-title":"ZKSCAN5 transcriptional regulation of APOC1 modulates ferroptosis via PI3K\/AKT\/SREBP2\/SLC1A5 axis","volume":"23","author":"Liu","year":"2025","journal-title":"J. Transl. Med."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112785_bb0070","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.cellsig.2026.112785_bb0075","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.redox.2019.101107","article-title":"NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis","volume":"23","author":"Dodson","year":"2019","journal-title":"Redox Biol."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112785_bb0080","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/s41422-019-0263-3","article-title":"The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression","volume":"30","author":"Lei","year":"2020","journal-title":"Cell Res."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112785_bb0085","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1097\/CAD.0000000000001430","article-title":"Exosomal circ-ADRM1 promotes lung adenocarcinoma progression and induces macrophage M2 polarization through regulating MMP14 mRNA and protein","volume":"34","author":"Qian","year":"2023","journal-title":"Anticancer Drugs"},{"issue":"9","key":"10.1016\/j.cellsig.2026.112785_bb0090","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics13091493","article-title":"M1 macrophage-derived exosomes loaded with gemcitabine and deferasirox against chemoresistant pancreatic cancer","volume":"13","author":"Zhao","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.cellsig.2026.112785_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2023.100960","article-title":"Cancer-associated fibroblasts suppress ferroptosis and induce gemcitabine resistance in pancreatic cancer cells by secreting exosome-derived ACSL4-targeting miRNAs","volume":"68","author":"Qi","year":"2023","journal-title":"Drug Resist. Updat."},{"issue":"9","key":"10.1016\/j.cellsig.2026.112785_bb0100","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1136\/gutjnl-2015-309304","article-title":"Stromal biology and therapy in pancreatic cancer: a changing paradigm","volume":"64","author":"Neesse","year":"2015","journal-title":"Gut"},{"issue":"18","key":"10.1016\/j.cellsig.2026.112785_bb0105","doi-asserted-by":"crossref","first-page":"5057","DOI":"10.1158\/0008-5472.CAN-13-3723","article-title":"CSF1\/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic Cancer models","volume":"74","author":"Zhu","year":"2014","journal-title":"Cancer Res."},{"issue":"5","key":"10.1016\/j.cellsig.2026.112785_bb0110","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S1470-2045(16)00078-4","article-title":"Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-Centre, open-label, dose-finding, non-randomised, phase 1b trial","volume":"17","author":"Nywening","year":"2016","journal-title":"Lancet Oncol."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112785_bb0115","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1021\/acs.molpharmaceut.4c01277","article-title":"Antitumor research based on drug delivery carriers: reversing the polarization of tumor-associated macrophages","volume":"22","author":"Cao","year":"2025","journal-title":"Mol. Pharm."},{"issue":"7148","key":"10.1016\/j.cellsig.2026.112785_bb0120","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1038\/nature05894","article-title":"Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance","volume":"447","author":"Odegaard","year":"2007","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112785_bb0125","doi-asserted-by":"crossref","DOI":"10.1186\/s12951-022-01382-0","article-title":"Extracellular vesicle-mediated crosstalk between pancreatic cancer and stromal cells in the tumor microenvironment","volume":"20","author":"Li","year":"2022","journal-title":"J. Nanobiotechnol."},{"issue":"9","key":"10.1016\/j.cellsig.2026.112785_bb0130","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3390\/antiox12091739","article-title":"NRF2, a superstar of ferroptosis","volume":"12","author":"Yan","year":"2023","journal-title":"Antioxidants"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112785_bb0135","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/s41419-017-0020-9","article-title":"ELANE enhances KEAP1 protein stability and reduces NRF2-mediated ferroptosis inhibition in metabolic dysfunction-associated fatty liver disease","volume":"16","author":"Yang","year":"2025","journal-title":"Cell Death Dis."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112785_bb0140","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1200\/JCO.1997.15.6.2403","article-title":"Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial","volume":"15","author":"Burris","year":"1997","journal-title":"J. Clin. Oncol."},{"issue":"18","key":"10.1016\/j.cellsig.2026.112785_bb0145","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1056\/NEJMoa1304369","article-title":"Increased survival in pancreatic Cancer with nab-paclitaxel plus gemcitabine","volume":"369","author":"Von Hoff","year":"2013","journal-title":"N. Engl. J. Med."},{"issue":"5","key":"10.1016\/j.cellsig.2026.112785_bb0150","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1053\/j.gastro.2013.07.025","article-title":"Activated pancreatic stellate cells sequester CD8<SUP>+<\/SUP> T cells to reduce their infiltration of the Juxtatumoral compartment of pancreatic ductal adenocarcinoma","volume":"145","author":"Ene-Obong","year":"2013","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112785_bb0155","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12933-022-01703-5","article-title":"Role of apolipoprotein C1 in lipoprotein metabolism, atherosclerosis and diabetes: a systematic review","volume":"21","author":"Rouland","year":"2022","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.cellsig.2026.112785_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106376","article-title":"Systematic pan-cancer analysis identifies APOC1 as an immunological biomarker which regulates macrophage polarization and promotes tumor metastasis","volume":"183","author":"Ren","year":"2022","journal-title":"Pharmacol. Res."},{"issue":"11","key":"10.1016\/j.cellsig.2026.112785_bb0165","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S1471-4906(02)02302-5","article-title":"Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes","volume":"23","author":"Mantovani","year":"2002","journal-title":"Trends Immunol."},{"issue":"7","key":"10.1016\/j.cellsig.2026.112785_bb0170","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nrclinonc.2016.217","article-title":"Tumour-associated macrophages as treatment targets in oncology","volume":"14","author":"Mantovani","year":"2017","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"7","key":"10.1016\/j.cellsig.2026.112785_bb0175","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.tem.2012.05.001","article-title":"PPARs at the crossroads of lipid signaling and inflammation","volume":"23","author":"Wahli","year":"2012","journal-title":"Trends Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112785_bb0180","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.cmet.2007.06.010","article-title":"PPARgamma activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties","volume":"6","author":"Bouhlel","year":"2007","journal-title":"Cell Metab."},{"issue":"10","key":"10.1016\/j.cellsig.2026.112785_bb0185","doi-asserted-by":"crossref","first-page":"4098","DOI":"10.7150\/ijbs.97076","article-title":"Exosomes: emerging insights into the progression of pancreatic cancer","volume":"20","author":"Zhou","year":"2024","journal-title":"Int. J. Biol. Sci."},{"issue":"5","key":"10.1016\/j.cellsig.2026.112785_bb0190","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1074\/mcp.M800449-MCP200","article-title":"MMP-9 sheds the \u03b22 integrin subunit (CD18) from macrophages","volume":"8","author":"Vaisar","year":"2009","journal-title":"Mol. Cell. Proteomics"},{"issue":"12","key":"10.1016\/j.cellsig.2026.112785_bb0195","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1038\/ng.3421","article-title":"NRF2 regulates serine biosynthesis in non-small cell lung cancer","volume":"47","author":"DeNicola","year":"2015","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112785_bb0200","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1101\/gad.13.1.76","article-title":"Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain","volume":"13","author":"Itoh","year":"1999","journal-title":"Genes Dev."},{"issue":"20","key":"10.1016\/j.cellsig.2026.112785_bb0205","doi-asserted-by":"crossref","first-page":"13291","DOI":"10.1074\/jbc.R900010200","article-title":"The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress","volume":"284","author":"Nguyen","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"25","key":"10.1016\/j.cellsig.2026.112785_bb0210","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1056\/NEJMoa1809775","article-title":"FOLFIRINOX or gemcitabine as adjuvant therapy for pancreatic Cancer","volume":"379","author":"Conroy","year":"2018","journal-title":"N. Engl. J. Med."},{"issue":"10409","key":"10.1016\/j.cellsig.2026.112785_bb0215","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/S0140-6736(23)01366-1","article-title":"NALIRIFOX versus nab-paclitaxel and gemcitabine in treatment-naive patients with metastatic pancreatic ductal adenocarcinoma (NAPOLI 3): a randomised, open-label, phase 3trial","volume":"402","author":"Wainberg","year":"2023","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112785_bb0220","doi-asserted-by":"crossref","DOI":"10.1186\/s13148-020-00961-y","article-title":"LncRNA STXBP5-AS1 suppresses stem cell-like properties of pancreatic cancer by epigenetically inhibiting neighboring androglobin gene expression","volume":"12","author":"Chen","year":"2020","journal-title":"Clin. Epigenetics"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112785_bb0225","doi-asserted-by":"crossref","DOI":"10.1186\/s12943-024-02128-2","article-title":"Sulindac (K-80003) with nab-paclitaxel and gemcitabine overcomes drug-resistant pancreatic cancer","volume":"23","author":"Xie","year":"2024","journal-title":"Mol. Cancer"},{"issue":"30","key":"10.1016\/j.cellsig.2026.112785_bb0230","doi-asserted-by":"crossref","first-page":"12425","DOI":"10.1073\/pnas.1106645108","article-title":"Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem\/initiating cells","volume":"108","author":"Jinushi","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826004432?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826004432?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:18:35Z","timestamp":1789690715000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656826004432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":46,"alternative-id":["S0898656826004432"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112785","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"APOC1 in tumor-associated macrophages enhances protumorigenic M2 polarization and promotes PAAD progression","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112785","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112785"}}