{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:03:02Z","timestamp":1789693382148,"version":"4.0.1"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2025MH245"],"award-info":[{"award-number":["ZR2025MH245"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011324","name":"Qingdao University","doi-asserted-by":"publisher","award":["YHDYY-2022-12"],"award-info":[{"award-number":["YHDYY-2022-12"]}],"id":[{"id":"10.13039\/501100011324","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.cellsig.2026.112795","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T23:17:07Z","timestamp":1785885427000},"page":"112795","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["RUVBL1 supports TIP60-associated proteasome adaptation and temozolomide resistance in glioblastoma"],"prefix":"10.1016","volume":"148","author":[{"given":"Yang","family":"Kong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caifeng","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangqiang","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinghan","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.cellsig.2026.112795_bb0005","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1093\/neuonc\/nou087","article-title":"The epidemiology of glioma in adults: a \u201cstate of the science\u201d review","volume":"16","author":"Ostrom","year":"2014","journal-title":"Neuro-Oncology."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112795_bb0010","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s12885-020-07778-1","article-title":"Recent incidence trend of elderly patients with glioblastoma in the United States, 2000-2017","volume":"21","author":"Chen","year":"2021","journal-title":"BMC Cancer"},{"key":"10.1016\/j.cellsig.2026.112795_bb0015","doi-asserted-by":"crossref","unstructured":".Price M, Ballard C, Benedetti J, Neff C, Cioffi G, Waite KA, et al. CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2017\u20132021. Neuro-Oncology 2024;26(Suppl 6):vi1\u2013vi85. doi:https:\/\/doi.org\/10.1093\/neuonc\/noae145.","DOI":"10.1093\/neuonc\/noae145"},{"issue":"10","key":"10.1016\/j.cellsig.2026.112795_bb0020","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJMoa043330","article-title":"Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma","volume":"352","author":"Stupp","year":"2005","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112795_bb0025","doi-asserted-by":"crossref","first-page":"102","DOI":"10.2174\/1874467211205010102","article-title":"Temozolomide: mechanisms of action, repair and resistance","volume":"5","author":"Zhang","year":"2012","journal-title":"Curr. Mol. Pharmacol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112795_bb0030","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0305-7372(97)90019-0","article-title":"Temozolomide: a review of its discovery, chemical properties, pre-clinical development and clinical trials","volume":"23","author":"Newlands","year":"1997","journal-title":"Cancer Treat. Rev."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112795_bb0035","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.gendis.2016.04.007","article-title":"Temozolomide resistance in glioblastoma multiforme","volume":"3","author":"Lee","year":"2016","journal-title":"Genes Dis."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112795_bb0040","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.cell.2013.09.034","article-title":"The somatic genomic landscape of glioblastoma","volume":"155","author":"Brennan","year":"2013","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.cellsig.2026.112795_bb0045","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1056\/NEJMoa043331","article-title":"MGMT gene silencing and benefit from temozolomide in glioblastoma","volume":"352","author":"Hegi","year":"2005","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112795_bb0050","doi-asserted-by":"crossref","first-page":"417","DOI":"10.3892\/ijo.2015.3026","article-title":"Regulation of expression of O6-methylguanine-DNA methyltransferase and the treatment of glioblastoma","volume":"47","author":"Cabrini","year":"2015","journal-title":"Int. J. Oncol."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112795_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2021.188616","article-title":"Elucidating the mechanisms of Temozolomide resistance in gliomas and the strategies to overcome the resistance","volume":"1876","author":"Tomar","year":"2021","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"issue":"470","key":"10.1016\/j.cellsig.2026.112795_bb0060","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aal2323","article-title":"Endoplasmic reticulum proteostasis in glioblastoma-from molecular mechanisms to therapeutic perspectives","volume":"10","author":"Obacz","year":"2017","journal-title":"Sci. Signal."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112795_bb0065","doi-asserted-by":"crossref","first-page":"7222","DOI":"10.1038\/s41598-018-25588-1","article-title":"Alterations in cell motility, proliferation, and metabolism in novel models of acquired temozolomide resistant glioblastoma","volume":"8","author":"Tiek","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cellsig.2026.112795_bb0070","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.pharmthera.2017.10.017","article-title":"Glioblastoma and chemoresistance to alkylating agents: involvement of apoptosis, autophagy, and unfolded protein response","volume":"184","author":"Hombach-Klonisch","year":"2018","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.cellsig.2026.112795_bb0075","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.semcancer.2015.04.003","article-title":"ER proteostasis addiction in cancer biology: novel concepts","volume":"33","author":"Dufey","year":"2015","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.cellsig.2026.112795_bb0080","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.canlet.2019.01.034","article-title":"Endoplasmic reticulum proteostasis control and gastric cancer","volume":"449","author":"Wang","year":"2019","journal-title":"Cancer Lett."},{"issue":"5","key":"10.1016\/j.cellsig.2026.112795_bb0085","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.molcel.2009.05.016","article-title":"RVB1\/RVB2: running rings around molecular biology","volume":"34","author":"Jha","year":"2009","journal-title":"Mol. Cell"},{"issue":"50","key":"10.1016\/j.cellsig.2026.112795_bb0090","doi-asserted-by":"crossref","first-page":"38918","DOI":"10.1074\/jbc.M605625200","article-title":"Crystal structure of the human AAA+ protein RuvBL1","volume":"281","author":"Matias","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.cellsig.2026.112795_bb0095","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1128\/MCB.01983-07","article-title":"Human Rvb1\/Tip49 is required for the histone acetyltransferase activity of Tip60\/NuA4 and for the downregulation of phosphorylation on H2AX after DNA damage","volume":"28","author":"Jha","year":"2008","journal-title":"Mol. Cell. Biol."},{"issue":"9","key":"10.1016\/j.cellsig.2026.112795_bb0100","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202154128","article-title":"LINC00839 promotes colorectal cancer progression by recruiting RUVBL1\/Tip60 complexes to activate NRF1","volume":"23","author":"Liu","year":"2022","journal-title":"EMBO Rep."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112795_bb0105","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1074\/jbc.RA118.006290","article-title":"Nrf1-mediated transcriptional regulation of the proteasome requires a functional TIP60 complex","volume":"294","author":"Vangala","year":"2019","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.cellsig.2026.112795_bb0110","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.3892\/or.2012.1968","article-title":"Increased Pontin expression is a potential predictor for outcome in sporadic colorectal carcinoma","volume":"28","author":"Lauscher","year":"2012","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.cellsig.2026.112795_bb0115","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3389\/fmolb.2017.00058","article-title":"The role of Pontin and Reptin in cellular physiology and Cancer etiology","volume":"4","author":"Mao","year":"2017","journal-title":"Front. Mol. Biosci."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112795_bb0120","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.cell.2017.06.010","article-title":"Defining a cancer dependency map","volume":"170","author":"Tsherniak","year":"2017","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.cellsig.2026.112795_bb0125","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-022-05265-y","article-title":"Recruitment of LEF1 by Pontin chromatin modifier amplifies TGFBR2 transcription and activates TGF\u03b2\/SMAD signalling during gliomagenesis","volume":"13","author":"Zhou","year":"2022","journal-title":"Cell Death Dis."},{"issue":"7216","key":"10.1016\/j.cellsig.2026.112795_bb0130","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/nature07385","article-title":"Comprehensive genomic characterization defines human glioblastoma genes and core pathways","volume":"455","author":"Cancer Genome Atlas Research Network","year":"2008","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.cellsig.2026.112795_bb0135","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/ng.2653","article-title":"The genotype-tissue expression (GTEx) project","volume":"45","author":"GTEx Consortium","year":"2013","journal-title":"Nat. Genet."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112795_bb0140","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1158\/1541-7786.MCR-08-0435","article-title":"Rembrandt: helping personalized medicine become a reality through integrative translational research","volume":"7","author":"Madhavan","year":"2009","journal-title":"Mol. Cancer Res."},{"issue":"6220","key":"10.1016\/j.cellsig.2026.112795_bb0145","doi-asserted-by":"crossref","DOI":"10.1126\/science.1260419","article-title":"Tissue-based map of the human proteome","volume":"347","author":"Uhl\u00e9n","year":"2015","journal-title":"Science"},{"issue":"7793","key":"10.1016\/j.cellsig.2026.112795_bb0150","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/s41586-020-1969-6","article-title":"Pan-cancer analysis of whole genomes","volume":"578","author":"ICGC\/TCGA Pan-Cancer Analysis of Whole Genomes Consortium","year":"2020","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.cellsig.2026.112795_bb0155","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nmeth.3337","article-title":"Robust enumeration of cell subsets from tissue expression profiles","volume":"12","author":"Newman","year":"2015","journal-title":"Nat. Methods"},{"issue":"43","key":"10.1016\/j.cellsig.2026.112795_bb0160","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"2","key":"10.1016\/j.cellsig.2026.112795_bb0165","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1021\/acschembio.8b00904","article-title":"CB-6644 is a selective inhibitor of the RUVBL1\/2 complex with anticancer activity","volume":"14","author":"Assimon","year":"2019","journal-title":"ACS Chem. Biol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112795_bb0170","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.molcel.2010.02.029","article-title":"Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells","volume":"38","author":"Radhakrishnan","year":"2010","journal-title":"Mol. Cell"},{"issue":"14","key":"10.1016\/j.cellsig.2026.112795_bb0175","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1016\/j.cub.2014.06.004","article-title":"Proteasome-mediated processing of Nrf1 is essential for coordinate induction of all proteasome subunits and p97","volume":"24","author":"Sha","year":"2014","journal-title":"Curr. Biol."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112795_bb0180","first-page":"513","article-title":"Temozolomide: an updated overview of resistance mechanisms, nanotechnology advances and clinical applications","volume":"19","author":"Ortiz","year":"2021","journal-title":"Curr. Neuropharmacol."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112795_bb0185","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1042\/BJ20111779","article-title":"First identification of small-molecule inhibitors of Pontin by combining virtual screening and enzymatic assay","volume":"443","author":"Elkaim","year":"2012","journal-title":"Biochem. J."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112795_bb0190","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.ccell.2017.02.009","article-title":"The microenvironmental landscape of brain tumors","volume":"31","author":"Quail","year":"2017","journal-title":"Cancer Cell"},{"issue":"2","key":"10.1016\/j.cellsig.2026.112795_bb0195","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.85841","article-title":"Glioblastoma-infiltrated innate immune cells resemble M0 macrophage phenotype","volume":"1","author":"Gabrusiewicz","year":"2016","journal-title":"JCI Insight"},{"issue":"7","key":"10.1016\/j.cellsig.2026.112795_bb0200","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1016\/j.cell.2020.04.055","article-title":"Single-cell mapping of human brain cancer reveals tumor-specific instruction of tissue-invading leukocytes","volume":"181","author":"Friebel","year":"2020","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.cellsig.2026.112795_bb0205","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.molcel.2017.06.017","article-title":"The unfolded protein response and cell fate control","volume":"69","author":"Hetz","year":"2018","journal-title":"Mol. Cell"},{"issue":"9","key":"10.1016\/j.cellsig.2026.112795_bb0210","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1158\/1078-0432.CCR-10-1950","article-title":"Nonproteasomal targets of the proteasome inhibitors bortezomib and carfilzomib: a link to clinical adverse events","volume":"17","author":"Arastu-Kapur","year":"2011","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.cellsig.2026.112795_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2021.105136","article-title":"Antioxidant responses related to temozolomide resistance in glioblastoma","volume":"149","author":"Campos-Sandoval","year":"2021","journal-title":"Neurochem. Int."},{"issue":"45","key":"10.1016\/j.cellsig.2026.112795_bb0220","doi-asserted-by":"crossref","first-page":"18378","DOI":"10.1073\/pnas.1115031108","article-title":"High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer","volume":"108","author":"Santagata","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"11","key":"10.1016\/j.cellsig.2026.112795_bb0225","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1007\/s12272-020-01281-8","article-title":"Ubiquitin-proteasome system (UPS) as a target for anticancer treatment","volume":"43","author":"Park","year":"2020","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.cellsig.2026.112795_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2025.117411","article-title":"Discovery of a novel Wnt inhibitor DK419: reversing temozolomide resistance in glioblastoma by switching off Wnt\/\u03b2-catenin signaling pathway to inhibit MGMT expression","volume":"288","author":"Bai","year":"2025","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.cellsig.2026.112795_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2025.116886","article-title":"Natural small molecule thymoquinone increases the chemosensitivity of glioblastoma to temozolomide through inhibiting Wnt\/\u03b2-catenin signaling pathway to downregulate MGMT expression: in vitro and in vivo validation","volume":"236","author":"Bai","year":"2025","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cellsig.2026.112795_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115726","article-title":"Modulating MGMT expression through interfering with cell signaling pathways","volume":"215","author":"Bai","year":"2023","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cellsig.2026.112795_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2024.116588","article-title":"Novel strategies to overcome chemoresistance in human glioblastoma","volume":"230","author":"Tang","year":"2024","journal-title":"Biochem. Pharmacol."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112795_bb0250","doi-asserted-by":"crossref","first-page":"323","DOI":"10.2174\/0109298665308572240513113105","article-title":"Depletion of SLC7A11 sensitizes nasopharyngeal carcinoma cells to ionizing radiation","volume":"31","author":"Yang","year":"2024","journal-title":"Protein Pept. Lett."},{"key":"10.1016\/j.cellsig.2026.112795_bb0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115029","article-title":"2-deoxy-D-glucose increases the sensitivity of glioblastoma cells to BCNU through the regulation of glycolysis, ROS and ERS pathways: in vitro and in vivo validation","volume":"199","author":"Sun","year":"2022","journal-title":"Biochem. Pharmacol."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826004535?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826004535?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:09:48Z","timestamp":1789690188000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656826004535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":51,"alternative-id":["S0898656826004535"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112795","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RUVBL1 supports TIP60-associated proteasome adaptation and temozolomide resistance in glioblastoma","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112795","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112795"}}