{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:05:19Z","timestamp":1789693519284,"version":"4.0.1"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100012547","name":"Natural Science Foundation of Guangxi Zhuang Autonomous Region","doi-asserted-by":"publisher","award":["2025GXNSFAA069052"],"award-info":[{"award-number":["2025GXNSFAA069052"]}],"id":[{"id":"10.13039\/100012547","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012434","name":"Middle-aged and Young Teachers' Basic Ability Promotion Project of Guangxi","doi-asserted-by":"publisher","award":["2024KY0112"],"award-info":[{"award-number":["2024KY0112"]}],"id":[{"id":"10.13039\/501100012434","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82560035"],"award-info":[{"award-number":["82560035"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160039"],"award-info":[{"award-number":["82160039"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.cellsig.2026.112801","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T15:21:27Z","timestamp":1786029687000},"page":"112801","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["METTL14-mediated m6A modification of CCNE1 accelerates progression of myelodysplastic syndromes via MAPK-ERK and PI3K-AKT signaling pathways"],"prefix":"10.1016","volume":"148","author":[{"given":"Xiaolin","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiamin","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoke","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanhu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiquan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibin","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyuan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunrui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenfang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.cellsig.2026.112801_bb0005","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1001\/jama.2022.14578","article-title":"Diagnosis and treatment of myelodysplastic syndromes: a review","volume":"328","author":"Sekeres","year":"2022","journal-title":"Jama"},{"issue":"10","key":"10.1016\/j.cellsig.2026.112801_bb0010","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1158\/1078-0432.CCR-22-3804","article-title":"A pre-leukemic DNA methylation signature in healthy individuals at higher risk for developing myeloid malignancy","volume":"30","author":"Lao","year":"2024","journal-title":"Clin. Cancer Res."},{"issue":"5","key":"10.1016\/j.cellsig.2026.112801_bb0015","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1111\/ijlh.14297","article-title":"DNA methyltransferases-associated long non-coding RNA PRKCQ-AS1 regulate DNA methylation in myelodysplastic syndrome","volume":"46","author":"Wen","year":"2024","journal-title":"Int. J. Lab. Hematol."},{"key":"10.1016\/j.cellsig.2026.112801_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.dnarep.2024.103803","article-title":"The Ataxia-telangiectasia mutated (ATM) is the most important gene for repairing the DNA in Myelodysplastic Neoplasm","volume":"146","author":"Pinheiro","year":"2025","journal-title":"DNA Repair"},{"key":"10.1016\/j.cellsig.2026.112801_bb0025","doi-asserted-by":"crossref","DOI":"10.12659\/MSM.928454","article-title":"Evaluation of reduced-dose decitabine and azacitidine for treating myelodysplastic syndromes: a retrospective study","volume":"27","author":"Hu","year":"2021","journal-title":"Med. Sci. Monit."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112801_bb0030","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3390\/curroncol32030159","article-title":"Targeting m(6)A RNA modification in tumor therapeutics","volume":"32","author":"Mao","year":"2025","journal-title":"Curr. Oncol. (Toronto, Ont)."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112801_bb0035","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.molmed.2023.03.005","article-title":"N6-methyladenosine-mediated gene regulation and therapeutic implications","volume":"29","author":"Liu","year":"2023","journal-title":"Trends Mol. Med."},{"issue":"8","key":"10.1016\/j.cellsig.2026.112801_bb0040","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.3390\/biom14081042","article-title":"The role of m6A methylation in tumor immunity and immune-associated disorder","volume":"14","author":"Mu","year":"2024","journal-title":"Biomolecules"},{"issue":"13","key":"10.1016\/j.cellsig.2026.112801_bb0045","doi-asserted-by":"crossref","first-page":"7239","DOI":"10.1093\/nar\/gkab378","article-title":"A comprehensive review of m6A\/m6Am RNA methyltransferase structures","volume":"49","author":"Oerum","year":"2021","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112801_bb0050","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s13045-022-01231-5","article-title":"Functions, mechanisms, and therapeutic implications of METTL14 in human cancer","volume":"15","author":"Guan","year":"2022","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.cellsig.2026.112801_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104142","article-title":"METTL14-mediated epitranscriptome modification of MN1 mRNA promote tumorigenicity and all-trans-retinoic acid resistance in osteosarcoma","volume":"82","author":"Li","year":"2022","journal-title":"EBioMedicine"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112801_bb0060","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1186\/s12967-024-05293-6","article-title":"The biological function of the N6-Methyladenosine reader YTHDC2 and its role in diseases","volume":"22","author":"Wu","year":"2024","journal-title":"J. Transl. Med."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112801_bb0065","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020105977","article-title":"M(6) a RNA methylation: from mechanisms to therapeutic potential","volume":"40","author":"He","year":"2021","journal-title":"EMBO J."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112801_bb0070","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.7150\/jca.60381","article-title":"The m(6)A RNA methyltransferase METTL3\/METTL14 promotes leukemogenesis through the mdm2\/p53 pathway in acute myeloid leukemia","volume":"13","author":"Sang","year":"2022","journal-title":"J. Cancer"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112801_bb0075","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s12943-022-01521-z","article-title":"METTL14-mediated m(6)A modification of circORC5 suppresses gastric cancer progression by regulating miR-30c-2-3p\/AKT1S1 axis","volume":"21","author":"Fan","year":"2022","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112801_bb0080","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s12943-020-01220-7","article-title":"METTL14-mediated N6-methyladenosine modification of SOX4 mRNA inhibits tumor metastasis in colorectal cancer","volume":"19","author":"Chen","year":"2020","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.cellsig.2026.112801_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2026.109892","article-title":"Pyrimethamine regulates m6A modification of CCND1 via METTL14\/YTHDF2 to inhibit hepatocellular carcinoma","volume":"176","author":"Han","year":"2026","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.cellsig.2026.112801_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2024.111304","article-title":"METTL14-mediated N6-methyladenosine modification of TCP1 mRNA promotes acute myeloid leukemia progression","volume":"122","author":"Zhang","year":"2024","journal-title":"Cell. Signal."},{"key":"10.1016\/j.cellsig.2026.112801_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107509","article-title":"METTL14-mediated m(6)A modification enhances USP22-ER\u03b1 axis to drive breast cancer malignancy","volume":"210","author":"Zhuang","year":"2024","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112801_bb0100","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s12943-020-01249-8","article-title":"Upregulation of METTL14 mediates the elevation of PERP mRNA N(6) adenosine methylation promoting the growth and metastasis of pancreatic cancer","volume":"19","author":"Wang","year":"2020","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112801_bb0105","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41420-022-00939-0","article-title":"METTL14 promotes prostate tumorigenesis by inhibiting THBS1 via an m6A-YTHDF2-dependent mechanism","volume":"8","author":"Wang","year":"2022","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112801_bb0110","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s12015-022-10444-7","article-title":"METTLing in stem cell and cancer biology","volume":"19","author":"Tooley","year":"2023","journal-title":"Stem Cell Rev. Rep."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112801_bb0115","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.stem.2017.11.016","article-title":"METTL14 inhibits hematopoietic stem\/progenitor differentiation and promotes leukemogenesis via mRNA m(6)A modification","volume":"22","author":"Weng","year":"2018","journal-title":"Cell Stem Cell"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112801_bb0120","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s13058-022-01510-6","article-title":"Cellular mechanisms underlying response and resistance to CDK4\/6 inhibitors in the treatment of hormone receptor-positive breast cancer","volume":"24","author":"Watt","year":"2022","journal-title":"Breast Cancer Res."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112801_bb0125","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1186\/s12935-022-02747-z","article-title":"A review on the role of cyclin dependent kinases in cancers","volume":"22","author":"Ghafouri-Fard","year":"2022","journal-title":"Cancer Cell Int."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112801_bb0130","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1007\/s11033-020-06100-3","article-title":"Mechanisms of resistance to cyclin-dependent kinase 4\/6 inhibitors","volume":"48","author":"Gomatou","year":"2021","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.cellsig.2026.112801_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2024.104324","article-title":"Cyclin-dependent kinase 2 (CDK2) inhibitors and others novel CDK inhibitors (CDKi) in breast cancer: clinical trials, current impact, and future directions","volume":"196","author":"Gerosa","year":"2024","journal-title":"Crit. Rev. Oncol. Hematol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112801_bb0140","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s12885-019-5290-4","article-title":"CCNE1 amplification is associated with poor prognosis in patients with triple negative breast cancer","volume":"19","author":"Zhao","year":"2019","journal-title":"BMC Cancer"},{"key":"10.1016\/j.cellsig.2026.112801_bb0145","article-title":"Methyltransferase-like 3\/14-mediated m(6)A silencing of GPx3 drives lipophagy dysfunction and ferroptosis resistance in colorectal cancer","volume":"9","author":"Wang","year":"2026","journal-title":"Research (Washington, DC)."},{"issue":"20","key":"10.1016\/j.cellsig.2026.112801_bb0150","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1038\/s41388-023-02675-w","article-title":"N6-methyladenosine reader YTHDF2 promotes multiple myeloma cell proliferation through EGR1\/p21(cip1\/waf1)\/CDK2-Cyclin E1 axis-mediated cell cycle transition","volume":"42","author":"Liu","year":"2023","journal-title":"Oncogene"},{"issue":"3","key":"10.1016\/j.cellsig.2026.112801_bb0155","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1177\/1087057115623264","article-title":"A radioactivity-based assay for screening human m6A-RNA methyltransferase, METTL3-METTL14 complex, and demethylase ALKBH5","volume":"21","author":"Li","year":"2016","journal-title":"J. Biomol. Screen."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112801_bb0160","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s12943-019-1038-7","article-title":"METTL3\/ALKBH5-mediated N6-methyladenosine modification drives macrophage M1 polarization via the SLC15A3-TASL-IRF5 signaling Axis in psoriasis","volume":"18","author":"Li","year":"2019","journal-title":"Mol. Cancer"},{"issue":"5","key":"10.1016\/j.cellsig.2026.112801_bb0165","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.7150\/ijbs.77133","article-title":"M6A-modified circRBM33 promotes prostate cancer progression via PDHA1-mediated mitochondrial respiration regulation and presents a potential target for ARSI therapy","volume":"19","author":"Zhong","year":"2023","journal-title":"Int. J. Biol. Sci."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112801_bb0170","doi-asserted-by":"crossref","first-page":"3521","DOI":"10.1111\/jcmm.15042","article-title":"Methyltransferase like 3 promotes colorectal cancer proliferation by stabilizing CCNE1 mRNA in an m6A-dependent manner","volume":"24","author":"Zhu","year":"2020","journal-title":"J. Cell. Mol. Med."},{"issue":"10","key":"10.1016\/j.cellsig.2026.112801_bb0175","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1038\/s41417-024-00789-1","article-title":"Regulatory roles of N6-methyladenosine (m(6)A) methylation in RNA processing and non-communicable diseases","volume":"31","author":"Khan","year":"2024","journal-title":"Cancer Gene Ther."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112801_bb0180","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s10020-025-01123-7","article-title":"Integrating advanced analytical methods to assess epigenetic marks affecting response to hypomethylating agents in higher risk myelodysplastic syndrome","volume":"31","author":"Nikolopoulos","year":"2025","journal-title":"Mol. Med. (Cambridge, Mass)."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112801_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2021.188609","article-title":"The RNA m6A writer METTL14 in cancers: roles, structures, and applications","volume":"1876","author":"Zhou","year":"2021","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"10.1016\/j.cellsig.2026.112801_bb0190","article-title":"m(6)A methyltransferase METTL14-mediated upregulation of cytidine deaminase promoting gemcitabine resistance in pancreatic cancer","volume":"11","author":"Zhang","year":"2021","journal-title":"Front. Oncol."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112801_bb0195","doi-asserted-by":"crossref","first-page":"399","DOI":"10.4143\/crt.2020.870","article-title":"Upregulated N6-Methyladenosine RNA in peripheral blood: potential diagnostic biomarker for breast cancer","volume":"53","author":"Xiao","year":"2021","journal-title":"Cancer Res. Treat."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112801_bb0200","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s12935-024-03302-8","article-title":"LncRNA RASAL2-AS1 promotes METTL14-mediated m6A methylation in the proliferation and progression of head and neck squamous cell carcinoma","volume":"24","author":"Rong","year":"2024","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.cellsig.2026.112801_bb0205","article-title":"M6A RNA modification: focusing on non-small cell lung cancer progression, therapeutic strategies and challenges","volume":"15","author":"Yan","year":"2025","journal-title":"Front. Oncol."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112801_bb0210","doi-asserted-by":"crossref","first-page":"415","DOI":"10.24272\/j.issn.2095-8137.2023.236","article-title":"RNA m6A dynamic modification mediated by nucleus-localized FTO is involved in follicular reserve","volume":"45","author":"Zhang","year":"2024","journal-title":"Zool. Res."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112801_bb0215","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/s41419-024-06664-z","article-title":"The relationship between the network of non-coding RNAs-molecular targets and N6-methyladenosine modification in tumors of urinary system","volume":"15","author":"Li","year":"2024","journal-title":"Cell Death Dis."},{"issue":"10","key":"10.1016\/j.cellsig.2026.112801_bb0220","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines12102211","article-title":"Interplay of RNA m(6)A modification-related geneset in pan-cancer","volume":"12","author":"Zhang","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.cellsig.2026.112801_bb0225","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-981-99-7471-9_7","article-title":"N(6)-methyladenosine RNA modification in normal and malignant hematopoiesis","volume":"1442","author":"Weng","year":"2023","journal-title":"Adv. Exp. Med. Biol."},{"issue":"1\u20132","key":"10.1016\/j.cellsig.2026.112801_bb0230","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.cell.2017.11.031","article-title":"R-2HG exhibits anti-tumor activity by targeting FTO\/m(6)A\/MYC\/CEBPA signaling","volume":"172","author":"Su","year":"2018","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112801_bb0235","doi-asserted-by":"crossref","DOI":"10.1080\/21505594.2023.2232910","article-title":"METTL14 and FTO mediated m(6)A modification regulate PCV2 replication by affecting miR-30a-5p maturity","volume":"14","author":"Li","year":"2023","journal-title":"Virulence"},{"issue":"5","key":"10.1016\/j.cellsig.2026.112801_bb0240","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1007\/s12011-022-03345-w","article-title":"Study on the correlation between regulatory proteins of N(6)-methyladenosine and oxidative damage in cadmium-induced renal injury","volume":"201","author":"Sun","year":"2023","journal-title":"Biol. Trace Elem. Res."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112801_bb0245","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s10020-023-00726-2","article-title":"Interaction between N(6)-methyladenosine modification and the tumor microenvironment in colorectal cancer","volume":"29","author":"Yao","year":"2023","journal-title":"Mol. Med. (Cambridge, Mass)."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112801_bb0250","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s40364-022-00410-3","article-title":"Physio-pathological effects of N6-methyladenosine and its therapeutic implications in leukemia","volume":"10","author":"Liu","year":"2022","journal-title":"Biomark. Res."},{"issue":"14","key":"10.1016\/j.cellsig.2026.112801_bb0255","doi-asserted-by":"crossref","first-page":"6252","DOI":"10.7150\/ijbs.120058","article-title":"Unveiling the dynamics and therapeutic potential of m(6)a methyltransferases and demethylases in liver diseases","volume":"21","author":"Chen","year":"2025","journal-title":"Int. J. Biol. Sci."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112801_bb0260","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1186\/s12885-024-12275-w","article-title":"CHOP regulated by METTL14-m6A affects cell cycle arrest and regorafenib sensitivity in HCC cells","volume":"24","author":"Pan","year":"2024","journal-title":"BMC Cancer"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112801_bb0265","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s12967-022-03257-2","article-title":"piRNA-14633 promotes cervical cancer cell malignancy in a METTL14-dependent m6A RNA methylation manner","volume":"20","author":"Xie","year":"2022","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.cellsig.2026.112801_bb0270","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.16308","article-title":"Sulforaphene suppressed cell proliferation and promoted apoptosis of COV362 cells in endometrioid ovarian cancer","volume":"11","author":"Yu","year":"2023","journal-title":"PeerJ"},{"issue":"7","key":"10.1016\/j.cellsig.2026.112801_bb0275","doi-asserted-by":"crossref","first-page":"3565","DOI":"10.62347\/QHFA9669","article-title":"M(6)a modification of CDC5L promotes lung adenocarcinoma progression through transcriptionally regulating WNT7B expression","volume":"14","author":"Yu","year":"2024","journal-title":"Am. J. Cancer Res."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112801_bb0280","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/1759-7714.14741","article-title":"RNA m6A methyltransferase METTL14 promotes the procession of non-small cell lung cancer by targeted CSF1R","volume":"14","author":"Ren","year":"2023","journal-title":"Thoracic Cancer"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112801_bb0285","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/s41420-024-02133-w","article-title":"METTL14-mediated m6A mRNA modification of G6PD promotes lung adenocarcinoma","volume":"10","author":"Wu","year":"2024","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112801_bb0290","doi-asserted-by":"crossref","DOI":"10.1186\/s12943-022-01549-1","article-title":"N(6)-methyladenosine-modified TRAF1 promotes sunitinib resistance by regulating apoptosis and angiogenesis in a METTL14-dependent manner in renal cell carcinoma","volume":"21","author":"Chen","year":"2022","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.cellsig.2026.112801_bb0295","article-title":"LncRNA UCA1 promotes the progression of AML by upregulating the expression of CXCR4 and CYP1B1 by affecting the stability of METTL14","volume":"2022","author":"Li","year":"2022","journal-title":"J. Oncol."},{"issue":"10","key":"10.1016\/j.cellsig.2026.112801_bb0300","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1038\/s41375-024-02350-3","article-title":"The m(6)A methyltransferase METTL14 promotes cell proliferation via SETBP1-mediated activation of PI3K-AKT signaling pathway in myelodysplastic neoplasms","volume":"38","author":"Jiang","year":"2024","journal-title":"Leukemia"},{"issue":"6","key":"10.1016\/j.cellsig.2026.112801_bb0305","doi-asserted-by":"crossref","first-page":"140","DOI":"10.3892\/ijo.2023.5588","article-title":"MEK\/ERK and PI3K\/AKT pathway inhibitors affect the transformation of myelodysplastic syndrome into acute myeloid leukemia via H3K27me3 methylases and de-methylases","volume":"63","author":"Zheng","year":"2023","journal-title":"Int. J. Oncol."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112801_bb0310","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/s41419-021-03891-6","article-title":"METTL14 promotes tumorigenesis by regulating lncRNA OIP5-AS1\/miR-98\/ADAMTS8 signaling in papillary thyroid cancer","volume":"12","author":"Zhang","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cellsig.2026.112801_bb0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2022.101794","article-title":"Analysis of the function and mechanism of DIRAS1 in osteosarcoma","volume":"76","author":"Liu","year":"2022","journal-title":"Tissue Cell"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112801_bb0320","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12964-022-00831-5","article-title":"METTL14-mediated N(6)-methyladenosine modification of ITGB4 mRNA inhibits metastasis of clear cell renal cell carcinoma","volume":"20","author":"Liu","year":"2022","journal-title":"Cell Commun. Signal"},{"issue":"31","key":"10.1016\/j.cellsig.2026.112801_bb0325","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1038\/s41388-024-03092-3","article-title":"N6-methyladenosine modified TGFB2 triggers lipid metabolism reprogramming to confer pancreatic ductal adenocarcinoma gemcitabine resistance","volume":"43","author":"Ma","year":"2024","journal-title":"Oncogene"},{"issue":"2","key":"10.1016\/j.cellsig.2026.112801_bb0330","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/s41418-023-01247-5","article-title":"LncRNA LY6E-DT and its encoded metastatic-related protein play oncogenic roles via different pathways and promote breast cancer progression","volume":"31","author":"Liu","year":"2024","journal-title":"Cell Death Differ."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826004596?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826004596?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:19:10Z","timestamp":1789690750000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656826004596"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":66,"alternative-id":["S0898656826004596"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112801","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"METTL14-mediated m6A modification of CCNE1 accelerates progression of myelodysplastic syndromes via MAPK-ERK and PI3K-AKT signaling pathways","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112801","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112801"}}