{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:03:51Z","timestamp":1789693431449,"version":"4.0.1"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100007452","name":"Wu Jieping Medical Foundation","doi-asserted-by":"publisher","award":["320.6750.2024-21-14"],"award-info":[{"award-number":["320.6750.2024-21-14"]}],"id":[{"id":"10.13039\/100007452","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007452","name":"Wu Jieping Medical Foundation","doi-asserted-by":"publisher","award":["320.6750.2025-213"],"award-info":[{"award-number":["320.6750.2025-213"]}],"id":[{"id":"10.13039\/100007452","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.cellsig.2026.112822","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T23:38:02Z","timestamp":1787269082000},"page":"112822","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["NID2 drives paclitaxel resistance in triple-negative breast cancer via an LDHA\u2013lactate\u2013histone lactylation axis"],"prefix":"10.1016","volume":"148","author":[{"given":"Siliang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yitong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaicheng","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqing","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cellsig.2026.112822_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2019.102855","article-title":"Triple negative breast cancer: a thorough review of biomarkers","volume":"145","author":"da Silva","year":"2020","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.cellsig.2026.112822_bb0010","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/s41523-017-0038-2","article-title":"Androgen receptor as a mediator and biomarker of radioresistance in triple-negative breast cancer","volume":"3","author":"Speers","year":"2017","journal-title":"NPJ Breast Cancer."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112822_bb0015","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11010105","article-title":"Varlitinib downregulates HER\/ERK signaling and induces apoptosis in triple negative breast cancer cells","volume":"11","author":"Liu","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.cellsig.2026.112822_bb0020","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.749753","article-title":"Competitive endogenous role of the LINC00511\/miR-185-3p Axis and miR-301a-3p from liquid biopsy as molecular markers for breast cancer diagnosis","volume":"11","author":"Mahmoud","year":"2021","journal-title":"Front. Oncol."},{"issue":"9","key":"10.1016\/j.cellsig.2026.112822_bb0025","doi-asserted-by":"crossref","DOI":"10.3390\/cells8090957","article-title":"Mechanisms of chemotherapy resistance in triple-negative breast cancer-how we can rise to the challenge","volume":"8","author":"Nedeljkovi\u0107","year":"2019","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112822_bb0030","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s13045-022-01341-0","article-title":"Recent advances in therapeutic strategies for triple-negative breast cancer","volume":"15","author":"Li","year":"2022","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.cellsig.2026.112822_bb0035","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.770663","article-title":"Platinum and Taxane based adjuvant and neoadjuvant chemotherapy in early triple-negative breast cancer: a narrative review","volume":"12","author":"Tian","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112822_bb0040","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.ccell.2025.02.016","article-title":"Exploring the \u201cchemo\u201d in chemoimmunotherapy for triple-negative breast cancer","volume":"43","author":"Liu","year":"2025","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112822_bb0045","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13045-021-01223-x","article-title":"HLF regulates ferroptosis, development and chemoresistance of triple-negative breast cancer by activating tumor cell-macrophage crosstalk","volume":"15","author":"Li","year":"2022","journal-title":"J. Hematol. Oncol."},{"issue":"9","key":"10.1016\/j.cellsig.2026.112822_bb0050","doi-asserted-by":"crossref","DOI":"10.1002\/cam4.70803","article-title":"Targeting triple-negative breast cancer: resistance mechanisms and therapeutic advancements","volume":"14","author":"Raman","year":"2025","journal-title":"Cancer Med."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112822_bb0055","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.cell.2018.03.041","article-title":"Chemoresistance evolution in triple-negative breast cancer delineated by single-cell sequencing","volume":"173","author":"Kim","year":"2018","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.cellsig.2026.112822_bb0060","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/s41419-020-02952-6","article-title":"A miR-210-3p regulon that controls the Warburg effect by modulating HIF-1\u03b1 and p53 activity in triple-negative breast cancer","volume":"11","author":"Du","year":"2020","journal-title":"Cell Death Dis."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112822_bb0065","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/s41587-020-0707-9","article-title":"Mitochondrial copper depletion suppresses triple-negative breast cancer in mice","volume":"39","author":"Cui","year":"2021","journal-title":"Nat. Biotechnol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112822_bb0070","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.cmet.2018.04.022","article-title":"Aerobic glycolysis controls myeloid-derived suppressor cells and tumor immunity via a specific CEBPB isoform in triple-negative breast cancer","volume":"28","author":"Li","year":"2018","journal-title":"Cell Metab."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112822_bb0075","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.cmet.2024.11.004","article-title":"Early downmodulation of tumor glycolysis predicts response to fasting-mimicking diet in triple-negative breast cancer patients","volume":"37","author":"Ligorio","year":"2025","journal-title":"Cell Metab."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112822_bb0080","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.tibs.2018.10.011","article-title":"Lactate: a metabolic driver in the tumour landscape","volume":"44","author":"Ippolito","year":"2019","journal-title":"Trends Biochem. Sci."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112822_bb0085","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.cell.2017.09.019","article-title":"Lactate metabolism in human lung tumors","volume":"171","author":"Faubert","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.cellsig.2026.112822_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2021.103627","article-title":"Lactate in the tumour microenvironment: from immune modulation to therapy","volume":"73","author":"Wang","year":"2021","journal-title":"EBioMedicine"},{"key":"10.1016\/j.cellsig.2026.112822_bb0095","article-title":"Lactylation, an emerging hallmark of metabolic reprogramming: current progress and open challenges","volume":"10","author":"Liu","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"issue":"7779","key":"10.1016\/j.cellsig.2026.112822_bb0100","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/s41586-019-1678-1","article-title":"Metabolic regulation of gene expression by histone lactylation","volume":"574","author":"Zhang","year":"2019","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112822_bb0105","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/s41467-023-44121-1","article-title":"Histone lactylation couples cellular metabolism with developmental gene regulatory networks","volume":"15","author":"Merkuri","year":"2024","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112822_bb0110","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1038\/s41467-024-47900-6","article-title":"HBO1 catalyzes lysine lactylation and mediates histone H3K9la to regulate gene transcription","volume":"15","author":"Niu","year":"2024","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112822_bb0115","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abi6696","article-title":"Class I histone deacetylases (HDAC1-3) are histone lysine delactylases","volume":"8","author":"Moreno-Yruela","year":"2022","journal-title":"Sci. Adv."},{"issue":"45","key":"10.1016\/j.cellsig.2026.112822_bb0120","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.1038\/s41388-023-02841-0","article-title":"GPR37 promotes colorectal cancer liver metastases by enhancing the glycolysis and histone lactylation via Hippo pathway","volume":"42","author":"Zhou","year":"2023","journal-title":"Oncogene"},{"key":"10.1016\/j.cellsig.2026.112822_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2023.101758","article-title":"Oncometabolite lactate enhances breast cancer progression by orchestrating histone lactylation-dependent c-Myc expression","volume":"37","author":"Pandkar","year":"2023","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.cellsig.2026.112822_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2025.101222","article-title":"The combination of flaxseed lignans and PD-1\/ PD-L1 inhibitor inhibits breast cancer growth via modulating gut microbiome and host immunity","volume":"80","author":"Wu","year":"2025","journal-title":"Drug Resist. Updat."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112822_bb0135","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s12943-024-02008-9","article-title":"Positive feedback regulation between glycolysis and histone lactylation drives oncogenesis in pancreatic ductal adenocarcinoma","volume":"23","author":"Li","year":"2024","journal-title":"Mol. Cancer"},{"issue":"3","key":"10.1016\/j.cellsig.2026.112822_bb0140","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/s12276-025-01410-7","article-title":"Protein lactylation in cancer: mechanisms and potential therapeutic implications","volume":"57","author":"Rho","year":"2025","journal-title":"Exp. Mol. Med."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112822_bb0145","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/s10020-025-01205-6","article-title":"Warburg effect and lactylation in cancer: mechanisms for chemoresistance","volume":"31","author":"Zhang","year":"2025","journal-title":"Mol. Med."},{"issue":"7","key":"10.1016\/j.cellsig.2026.112822_bb0150","first-page":"789","article-title":"Lactate and lactylation in breast cancer: current understanding and therapeutic opportunities","volume":"22","author":"Huang","year":"2025","journal-title":"Cancer Biol. Med."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112822_bb0155","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41392-024-02082-x","article-title":"Lactate and lactylation in cancer","volume":"10","author":"Chen","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"issue":"8","key":"10.1016\/j.cellsig.2026.112822_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114633","article-title":"A CLIC1 network coordinates matrix stiffness and the Warburg effect to promote tumor growth in pancreatic cancer","volume":"43","author":"Zheng","year":"2024","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112822_bb0165","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1186\/s12935-022-02736-2","article-title":"Notch-associated lncRNAs profiling circuiting epigenetic modification in colorectal cancer","volume":"22","author":"Emam","year":"2022","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.cellsig.2026.112822_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2022.154183","article-title":"Insights on the potential oncogenic impact of long non-coding RNA nicotinamide nucleotide transhydrogenase antisense RNA 1 in different cancer types; integrating pathway(s) and clinical outcome(s) association","volume":"240","author":"El-Sheikh","year":"2022","journal-title":"Pathol. Res. Pract."},{"issue":"10","key":"10.1016\/j.cellsig.2026.112822_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113175","article-title":"Microenvironmental stiffness induces metabolic reprogramming in glioblastoma","volume":"42","author":"Sohrabi","year":"2023","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112822_bb0180","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s40170-025-00413-2","article-title":"Matrix composition and glucose availability cooperatively determine cancer spheroid bioenergetics in 3D hydrogels","volume":"13","author":"Guerrero-L\u00f3pez","year":"2025","journal-title":"Cancer Metab."},{"issue":"9","key":"10.1016\/j.cellsig.2026.112822_bb0185","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1016\/j.cmet.2023.07.005","article-title":"The diapause-like colorectal cancer cells induced by SMC4 attenuation are characterized by low proliferation and chemotherapy insensitivity","volume":"35","author":"Sun","year":"2023","journal-title":"Cell Metab."},{"issue":"27","key":"10.1016\/j.cellsig.2026.112822_bb0190","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adl1197","article-title":"Temporally resolved proteomics identifies nidogen-2 as a cotarget in pancreatic cancer that modulates fibrosis and therapy response","volume":"10","author":"Pereira","year":"2024","journal-title":"Sci. Adv."},{"issue":"Suppl C","key":"10.1016\/j.cellsig.2026.112822_bb0195","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0305-7372(93)90049-W","article-title":"An overview of experience with TAXOL (paclitaxel) in the U.S.A.","volume":"19","author":"Donehower","year":"1993","journal-title":"Cancer Treat. Rev."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112822_bb0200","article-title":"Apoptosis-amplified intracellular paclitaxel nanoparticle formation enhances microtubule aggregation and PANoptosis","volume":"65","author":"Liu","year":"2026","journal-title":"Angew. Chem. Int. Ed. Eng."},{"key":"10.1016\/j.cellsig.2026.112822_bb0205","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.canlet.2017.02.024","article-title":"Suppression of spindly delays mitotic exit and exacerbates cell death response of cancer cells treated with low doses of paclitaxel","volume":"394","author":"Silva","year":"2017","journal-title":"Cancer Lett."},{"key":"10.1016\/j.cellsig.2026.112822_bb0210","article-title":"Paclitaxel resistance in breast cancer: current challenges and recent advanced therapeutic strategies","volume":"43","author":"Abouzeid","year":"2025","journal-title":"Cancer Treat. Res. Commun."},{"key":"10.1016\/j.cellsig.2026.112822_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2023.100951","article-title":"Replacing the tropolonic methoxyl group of colchicine with methylamino increases tubulin binding affinity with improved therapeutic index and overcomes paclitaxel cross-resistance","volume":"68","author":"Yang","year":"2023","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.cellsig.2026.112822_bb0220","article-title":"EDNRA forms a positive feedback loop with the Hippo\/YAP axis to drive triple-negative breast cancer progression","author":"Hong","year":"2026","journal-title":"Adv. Sci. (Weinh)."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112822_bb0225","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s40364-025-00824-9","article-title":"Crosstalk between lactylation and RNA modifications in tumorigenesis: mechanisms and therapeutic implications","volume":"13","author":"Liu","year":"2025","journal-title":"Biomark. Res."},{"issue":"46","key":"10.1016\/j.cellsig.2026.112822_bb0230","article-title":"Lactylation-driven IGF2BP3-mediated serine metabolism reprogramming and RNA m6A-modification promotes Lenvatinib resistance in HCC","volume":"11","author":"Lu","year":"2024","journal-title":"Adv. Sci. (Weinh)."},{"issue":"27","key":"10.1016\/j.cellsig.2026.112822_bb0235","article-title":"PP1A modulates the efficacy of Lenvatinib plus ICIs therapy by inhibiting ferroptosis in hepatocellular carcinoma","volume":"12","author":"Zhou","year":"2025","journal-title":"Adv. Sci. (Weinh)."},{"issue":"8021","key":"10.1016\/j.cellsig.2026.112822_bb0240","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/s41586-024-07620-9","article-title":"NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance","volume":"631","author":"Chen","year":"2024","journal-title":"Nature"},{"issue":"35","key":"10.1016\/j.cellsig.2026.112822_bb0245","article-title":"Adipocytes promote cisplatin resistance through secreting A1BG and regulating NAMPT\/PARP1 Axis-mediated DNA repair in osteosarcoma","volume":"12","author":"Liang","year":"2025","journal-title":"Adv. Sci. (Weinh)."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112822_bb0250","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2025.13702","article-title":"Impact of lactylation on the pathogenesis of cancer and its clinical application potential (review)","volume":"32","author":"Wang","year":"2025","journal-title":"Mol. Med. Rep."},{"issue":"9","key":"10.1016\/j.cellsig.2026.112822_bb0255","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0162633","article-title":"Cell division cycle 6 promotes mitotic slippage and contributes to drug resistance in paclitaxel-treated Cancer cells","volume":"11","author":"He","year":"2016","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.cellsig.2026.112822_bb0260","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.ccell.2016.08.005","article-title":"Lactate dehydrogenase B controls lysosome activity and autophagy in cancer","volume":"30","author":"Brisson","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cellsig.2026.112822_bb0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2023.154570","article-title":"LncRNA NNT-AS1\/hsa-miR-485-5p\/HSP90 axis in-silico and clinical prospect correlated-to histologic grades-based CRC stratification: a step toward ncRNA precision","volume":"247","author":"El-Sheikh","year":"2023","journal-title":"Pathol. Res. Pract."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112822_bb0270","doi-asserted-by":"crossref","first-page":"29388","DOI":"10.1038\/s41598-025-10938-7","article-title":"Long intergenic non-coding RNA 00511 (LINC00511) genetic variations and haplotype implication for colorectal cancer susceptibility and prognosis","volume":"15","author":"Sanad","year":"2025","journal-title":"Sci. Rep."},{"issue":"48","key":"10.1016\/j.cellsig.2026.112822_bb0275","doi-asserted-by":"crossref","first-page":"78859","DOI":"10.18632\/oncotarget.12889","article-title":"Metastasis-suppressing NID2, an epigenetically-silenced gene, in the pathogenesis of nasopharyngeal carcinoma and esophageal squamous cell carcinoma","volume":"7","author":"Chai","year":"2016","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112822_bb0280","doi-asserted-by":"crossref","first-page":"10633","DOI":"10.1038\/s41598-024-84880-5","article-title":"Nidogen-1 suppresses cell proliferation, migration, and glycolysis via integrin \u03b21-mediated HIF-1\u03b1 downregulation in triple-negative breast cancer","volume":"15","author":"Lee","year":"2025","journal-title":"Sci. Rep."},{"issue":"15","key":"10.1016\/j.cellsig.2026.112822_bb0285","doi-asserted-by":"crossref","first-page":"6846","DOI":"10.1128\/MCB.25.15.6846-6856.2005","article-title":"Compound genetic ablation of nidogen 1 and 2 causes basement membrane defects and perinatal lethality in mice","volume":"25","author":"Bader","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.cellsig.2026.112822_bb0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.116049","article-title":"Camptothecin structure simplification elaborated new imidazo[2,1-b]quinazoline derivative as a human topoisomerase I inhibitor with efficacy against bone cancer cells and colon adenocarcinoma","volume":"265","author":"Khodair","year":"2024","journal-title":"Eur. J. Med. Chem."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112822_bb0295","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0193810","article-title":"Biomolecular study of human thymidylate synthase conformer-selective inhibitors: new chemotherapeutic approach","volume":"13","author":"El-Mesallamy","year":"2018","journal-title":"PLoS One"},{"issue":"16","key":"10.1016\/j.cellsig.2026.112822_bb0300","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.2174\/1568026614666140929124445","article-title":"Structure-based virtual screening for drug discovery: principles, applications and recent advances","volume":"14","author":"Lionta","year":"2014","journal-title":"Curr. Top. Med. Chem."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826004808?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826004808?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:20:15Z","timestamp":1789690815000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656826004808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":60,"alternative-id":["S0898656826004808"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112822","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NID2 drives paclitaxel resistance in triple-negative breast cancer via an LDHA\u2013lactate\u2013histone lactylation axis","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112822","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112822"}}