{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T00:47:05Z","timestamp":1793839625214,"version":"4.6.1"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013795","name":"Fujian Medical University","doi-asserted-by":"publisher","award":["2025PYXKC01"],"award-info":[{"award-number":["2025PYXKC01"]}],"id":[{"id":"10.13039\/501100013795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017686","name":"Fujian Provincial Health Technology Project","doi-asserted-by":"publisher","award":["2024CXA015"],"award-info":[{"award-number":["2024CXA015"]}],"id":[{"id":"10.13039\/501100017686","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2024J01647"],"award-info":[{"award-number":["2024J01647"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.cellsig.2026.112824","type":"journal-article","created":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T06:07:09Z","timestamp":1786774029000},"page":"112824","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["ALK regulates macrophage polarization via the USP7\/SOX9\/MFAP2-mediated glycolytic pathway to promote neuroblastoma progression"],"prefix":"10.1016","volume":"148","author":[{"given":"Caimin","family":"Lai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunting","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renfu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.cellsig.2026.112824_bb0005","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1053\/j.semnuclmed.2022.12.004","article-title":"Current status and future perspective on molecular imaging and treatment of neuroblastoma","volume":"53","author":"Feng","year":"2023","journal-title":"Semin. Nucl. Med."},{"key":"10.1016\/j.cellsig.2026.112824_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2024.102964","article-title":"Global, regional, and national epidemiology of childhood neuroblastoma (1990-2021): a statistical analysis of incidence, mortality, and DALYs","volume":"79","author":"Nong","year":"2025","journal-title":"EClinicalMedicine"},{"issue":"5","key":"10.1016\/j.cellsig.2026.112824_bb0015","doi-asserted-by":"crossref","DOI":"10.3390\/biom11050750","article-title":"Acceleration or brakes: which is rational for cell cycle-targeting neuroblastoma therapy?","volume":"11","author":"Ando","year":"2021","journal-title":"Biomolecules"},{"issue":"8","key":"10.1016\/j.cellsig.2026.112824_bb0020","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1038\/s41416-023-02208-y","article-title":"Genomic ALK alterations in primary and relapsed neuroblastoma","volume":"128","author":"Rosswog","year":"2023","journal-title":"Br. J. Cancer"},{"issue":"3","key":"10.1016\/j.cellsig.2026.112824_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.113927","article-title":"ALK upregulates POSTN and WNT signaling to drive neuroblastoma","volume":"43","author":"Huang","year":"2024","journal-title":"Cell Rep."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112824_bb0030","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.ccr.2012.02.010","article-title":"Activated ALK collaborates with MYCN in neuroblastoma pathogenesis","volume":"21","author":"Zhu","year":"2012","journal-title":"Cancer Cell"},{"issue":"5","key":"10.1016\/j.cellsig.2026.112824_bb0035","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1038\/s41588-025-02158-6","article-title":"Longitudinal single-cell multiomic atlas of high-risk neuroblastoma reveals chemotherapy-induced tumor microenvironment rewiring","volume":"57","author":"Yu","year":"2025","journal-title":"Nat. Genet."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112824_bb0040","doi-asserted-by":"crossref","DOI":"10.3390\/cells12060885","article-title":"Monocyte and macrophage in neuroblastoma: blocking their pro-tumoral functions and strengthening their crosstalk with natural killer cells","volume":"12","author":"Vitale","year":"2023","journal-title":"Cells"},{"issue":"6","key":"10.1016\/j.cellsig.2026.112824_bb0045","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1007\/s00262-023-03382-x","article-title":"Luo D Lactate from glycolysis regulates inflammatory macrophage polarization in breast cancer","volume":"72","author":"Wang","year":"2023","journal-title":"Cancer Immunol. Immunother."},{"issue":"40","key":"10.1016\/j.cellsig.2026.112824_bb0050","doi-asserted-by":"crossref","first-page":"4547","DOI":"10.1038\/s41388-022-02453-0","article-title":"ALK fusion promotes metabolic reprogramming of cancer cells by transcriptionally upregulating PFKFB3","volume":"41","author":"Hu","year":"2022","journal-title":"Oncogene"},{"issue":"6","key":"10.1016\/j.cellsig.2026.112824_bb0055","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1182\/blood-2013-01-482026","article-title":"Integrated phosphoproteomic and metabolomic profiling reveals NPM-ALK-mediated phosphorylation of PKM2 and metabolic reprogramming in anaplastic large cell lymphoma","volume":"122","author":"McDonnell","year":"2013","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112824_bb0060","doi-asserted-by":"crossref","DOI":"10.1007\/s11033-024-09694-0","article-title":"Canonical WNT\/\u03b2-catenin signaling upregulates aerobic glycolysis in diverse cancer types","volume":"51","author":"Rathee","year":"2024","journal-title":"Mol. Biol. Rep."},{"issue":"9","key":"10.1016\/j.cellsig.2026.112824_bb0065","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.3724\/abbs.2023079","article-title":"MFAP2 promotes the progression of oral squamous cell carcinoma by activating the Wnt\/\u03b2-catenin signaling pathway through autophagy","volume":"55","author":"Zhang","year":"2023","journal-title":"Acta Biochim. Biophys. Sin."},{"issue":"8","key":"10.1016\/j.cellsig.2026.112824_bb0070","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1002\/kjm2.12546","article-title":"MFAP2 aggravates tumor progression through activating FOXM1\/\u03b2-catenin-mediated glycolysis in ovarian cancer","volume":"38","author":"Zhao","year":"2022","journal-title":"Kaohsiung J. Med. Sci."},{"issue":"24","key":"10.1016\/j.cellsig.2026.112824_bb0075","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.18632\/oncotarget.27636","article-title":"Lineage-restricted sympathoadrenal progenitors confer neuroblastoma origin and its tumorigenicity","volume":"11","author":"Yang","year":"2020","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112824_bb0080","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s12943-024-02046-3","article-title":"Ubiquitination and deubiquitination in cancer: from mechanisms to novel therapeutic approaches","volume":"23","author":"Liu","year":"2024","journal-title":"Mol. Cancer"},{"issue":"3","key":"10.1016\/j.cellsig.2026.112824_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2023.188903","article-title":"USP7 - a crucial regulator of cancer hallmarks","volume":"1878","author":"Saha","year":"2023","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"10.1016\/j.cellsig.2026.112824_bb0090","article-title":"Proteome analysis of USP7 substrates revealed its role in melanoma through PI3K\/Akt\/FOXO and AMPK pathways","volume":"11","author":"Gao","year":"2021","journal-title":"Front. Oncol."},{"issue":"12","key":"10.1016\/j.cellsig.2026.112824_bb0095","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1509","article-title":"USP7 promotes non-small-cell lung cancer cell glycolysis and survival by stabilizing and activating c-Abl","volume":"13","author":"He","year":"2023","journal-title":"Clin. Transl. Med."},{"issue":"18","key":"10.1016\/j.cellsig.2026.112824_bb0100","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241813780","article-title":"USP7 inhibition suppresses neuroblastoma growth via induction of p53-mediated apoptosis and EZH2 and N-Myc downregulation","volume":"24","author":"Le Clorennec","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.cellsig.2026.112824_bb0105","doi-asserted-by":"crossref","first-page":"13768","DOI":"10.1021\/acsomega.5c11995","article-title":"Virtual screening and MD simulation-driven discovery of USP7 inhibitors BML-284","volume":"11","author":"Liu","year":"2026","journal-title":"ACS Omega"},{"issue":"7","key":"10.1016\/j.cellsig.2026.112824_bb0110","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1158\/1541-7786.MCR-25-1153","article-title":"Inhibition of USP7 destabilizes the noncanonical PRC1.1 complex and induces neuroblastoma differentiation","volume":"24","author":"Cmarik","year":"2026","journal-title":"Mol. Cancer Res."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112824_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114366","article-title":"The phosphorylation-deubiquitination positive feedback loop of the CHK2-USP7 axis stabilizes p53 under oxidative stress","volume":"43","author":"Liu","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.cellsig.2026.112824_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.108994","article-title":"The role of glycolysis and lactate in the induction of tumor-associated macrophages immunosuppressive phenotype","volume":"110","author":"Zhang","year":"2022","journal-title":"Int. Immunopharmacol."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112824_bb0125","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s11523-025-01155-3","article-title":"Efficacy and safety of anti-GD2 immunotherapy with dinutuximab beta in the treatment of relapsed\/refractory high-risk neuroblastoma","volume":"20","author":"Wieczorek","year":"2025","journal-title":"Target. Oncol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112824_bb0130","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-62979-1","article-title":"A humanized anaplastic lymphoma kinase (ALK)-directed antibody-drug conjugate with pyrrolobenzodiazepine payload demonstrates efficacy in ALK-expressing cancers","volume":"16","author":"Guerra","year":"2025","journal-title":"Nat. Commun."},{"issue":"13","key":"10.1016\/j.cellsig.2026.112824_bb0135","doi-asserted-by":"crossref","first-page":"3543","DOI":"10.1158\/1078-0432.CCR-20-4224","article-title":"Activity of Crizotinib in patients with ALK-aberrant relapsed\/refractory neuroblastoma: a children\u2019s oncology group study (ADVL0912)","volume":"27","author":"Foster","year":"2021","journal-title":"Clin. Cancer Res."},{"issue":"12","key":"10.1016\/j.cellsig.2026.112824_bb0140","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1016\/j.ccell.2023.11.004","article-title":"ALK inhibitors increase ALK expression and sensitize neuroblastoma cells to ALK.CAR-T cells","volume":"41","author":"Bergaggio","year":"2023","journal-title":"Cancer Cell"},{"issue":"14","key":"10.1016\/j.cellsig.2026.112824_bb0145","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1200\/JCO-24-02407","article-title":"Frequency and clinical significance of clonal and subclonal driver mutations in high-risk neuroblastoma at diagnosis: a children\u2019s oncology group study","volume":"43","author":"Berko","year":"2025","journal-title":"J. Clin. Oncol."},{"issue":"10","key":"10.1016\/j.cellsig.2026.112824_bb0150","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1093\/neuonc\/noae109","article-title":"Super-enhancer-driven IRF2BP2 enhances ALK activity and promotes neuroblastoma cell proliferation","volume":"26","author":"Chen","year":"2024","journal-title":"Neuro-Oncology"},{"issue":"5","key":"10.1016\/j.cellsig.2026.112824_bb0155","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1038\/s41591-023-02297-5","article-title":"Lorlatinib with or without chemotherapy in ALK-driven refractory\/relapsed neuroblastoma: phase 1 trial results","volume":"29","author":"Goldsmith","year":"2023","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112824_bb0160","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1186\/s12967-024-05962-6","article-title":"Ubiquitin-specific protease 7 maintains c-Myc stability to support pancreatic cancer glycolysis and tumor growth","volume":"22","author":"Gu","year":"2024","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.cellsig.2026.112824_bb0165","doi-asserted-by":"crossref","first-page":"1530924","DOI":"10.3389\/fonc.2025.1530924","article-title":"Yu RL Ubiquitin specific protease 7 is a potential therapeutic target for gastric cancer","volume":"15","author":"Wang","year":"2025","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112824_bb0170","doi-asserted-by":"crossref","first-page":"97","DOI":"10.4103\/jcrt.jcrt_517_22","article-title":"USP7 mediates TRAF4 deubiquitination to facilitate the malignant phenotype of ovarian cancer via the RSK4\/PI3K\/AKT axis","volume":"19","author":"Wang","year":"2023","journal-title":"J. Cancer Res. Ther."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112824_bb0175","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.7150\/ijbs.67476","article-title":"ENKUR expression induced by chemically synthesized cinobufotalin suppresses malignant activities of hepatocellular carcinoma by modulating \u03b2-catenin\/c-Jun\/MYH9\/USP7\/c-Myc axis","volume":"18","author":"Hou","year":"2022","journal-title":"Int. J. Biol. Sci."},{"issue":"7214","key":"10.1016\/j.cellsig.2026.112824_bb0180","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/nature07290","article-title":"The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network","volume":"455","author":"Song","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.cellsig.2026.112824_bb0185","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms6059","article-title":"ABRO1 suppresses tumourigenesis and regulates the DNA damage response by stabilizing p53","volume":"5","author":"Zhang","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cellsig.2026.112824_bb0190","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2025.1700812","article-title":"SOX9: a novel janus-faced regulator in immunity and its promise as a therapeutic target","volume":"12","author":"Shi","year":"2025","journal-title":"Front. Mol. Biosci."},{"issue":"9","key":"10.1016\/j.cellsig.2026.112824_bb0195","doi-asserted-by":"crossref","first-page":"4033","DOI":"10.7150\/thno.109771","article-title":"Hepatic stellate cell-derived microfibrillar-associated protein 2 prevents liver fibrosis by regulating extracellular matrix and inflammation","volume":"15","author":"Zhang","year":"2025","journal-title":"Theranostics"},{"key":"10.1016\/j.cellsig.2026.112824_bb0200","doi-asserted-by":"crossref","DOI":"10.12659\/MSM.923808","article-title":"Microfibril-associated protein 2 (MFAP2) potentiates invasion and migration of melanoma by EMT and Wnt\/\u03b2-catenin pathway","volume":"26","author":"Chen","year":"2020","journal-title":"Med. Sci. Monit."},{"issue":"8","key":"10.1016\/j.cellsig.2026.112824_bb0205","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202502538RR","article-title":"Mi Z lactate activates TGF-\u03b2\/SNAIL signaling to drive M2 macrophage polarization and CD8(+) T cell exhaustion in breast cancer","volume":"40","author":"Zhu","year":"2026","journal-title":"FASEB J."},{"key":"10.1016\/j.cellsig.2026.112824_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2025.103202","article-title":"Lactic acid inhibits ferroptosis and promotes M2 macrophage polarization in colon cancer via GPX4 regulation","volume":"98","author":"Wang","year":"2026","journal-title":"Tissue Cell"}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826004821?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826004821?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:13:16Z","timestamp":1789690396000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656826004821"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":42,"alternative-id":["S0898656826004821"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112824","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ALK regulates macrophage polarization via the USP7\/SOX9\/MFAP2-mediated glycolytic pathway to promote neuroblastoma progression","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112824","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112824"}}