{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:04:21Z","timestamp":1789693461561,"version":"4.0.1"},"reference-count":100,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["lzujbky-2023-ct06"],"award-info":[{"award-number":["lzujbky-2023-ct06"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012899","name":"Lanzhou University","doi-asserted-by":"publisher","award":["2025-21-zdfy-009"],"award-info":[{"award-number":["2025-21-zdfy-009"]}],"id":[{"id":"10.13039\/100012899","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.cellsig.2026.112853","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T13:16:30Z","timestamp":1787922990000},"page":"112853","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Type I collagen matrix signaling in cancer: receptor sensing and mechanotransduction"],"prefix":"10.1016","volume":"148","author":[{"given":"Xi","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongze","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zewen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longtu","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhilong","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.cellsig.2026.112853_bb0005","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.ccell.2023.02.016","article-title":"The evolving tumor microenvironment: from cancer initiation to metastatic outgrowth","volume":"41","author":"de Visser","year":"2023","journal-title":"Cancer Cell"},{"issue":"16","key":"10.1016\/j.cellsig.2026.112853_bb0010","doi-asserted-by":"crossref","first-page":"R921","DOI":"10.1016\/j.cub.2020.06.081","article-title":"The tumor microenvironment","volume":"30","author":"Anderson","year":"2020","journal-title":"Curr. Biol."},{"issue":"5","key":"10.1016\/j.cellsig.2026.112853_bb0015","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1002\/ijc.33985","article-title":"Targeting type I collagen for cancer treatment","volume":"151","author":"Shi","year":"2022","journal-title":"Int. J. Cancer"},{"issue":"5","key":"10.1016\/j.cellsig.2026.112853_bb0020","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.cell.2009.10.027","article-title":"Matrix crosslinking forces tumor progression by enhancing integrin signaling","volume":"139","author":"Levental","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.cellsig.2026.112853_bb0025","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ceb.2021.05.004","article-title":"Aligned forces: origins and mechanisms of cancer dissemination guided by extracellular matrix architecture","volume":"72","author":"Ray","year":"2021","journal-title":"Curr. Opin. Cell Biol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112853_bb0030","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s40425-019-0556-6","article-title":"Collagen density regulates the activity of tumor-infiltrating T cells","volume":"7","author":"Kuczek","year":"2019","journal-title":"J. Immunother. Cancer"},{"issue":"9","key":"10.1016\/j.cellsig.2026.112853_bb0035","first-page":"2497","article-title":"Role of extracellular matrix assembly in interstitial transport in solid tumors","volume":"60","author":"Netti","year":"2000","journal-title":"Cancer Res."},{"issue":"7886","key":"10.1016\/j.cellsig.2026.112853_bb0040","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/s41586-021-04057-2","article-title":"Tumour DDR1 promotes collagen fibre alignment to instigate immune exclusion","volume":"599","author":"Sun","year":"2021","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.cellsig.2026.112853_bb0045","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/s41568-018-0038-z","article-title":"Every step of the way: integrins in cancer progression and metastasis","volume":"18","author":"Hamidi","year":"2018","journal-title":"Nat. Rev. Cancer"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112853_bb0050","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S1097-2765(00)80003-9","article-title":"The discoidin domain receptor tyrosine kinases are activated by collagen","volume":"1","author":"Vogel","year":"1997","journal-title":"Mol. Cell"},{"issue":"5","key":"10.1016\/j.cellsig.2026.112853_bb0055","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.tcb.2023.08.003","article-title":"Multifaceted collagen-DDR1 signaling in cancer","volume":"34","author":"Su","year":"2024","journal-title":"Trends Cell Biol."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112853_bb0060","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1083\/jcb.200708137","article-title":"Collagen I-mediated up-regulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor 1","volume":"180","author":"Shintani","year":"2008","journal-title":"J. Cell Biol."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112853_bb0065","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1084\/jem.20052554","article-title":"Collagens are functional, high affinity ligands for the inhibitory immune receptor LAIR-1","volume":"203","author":"Lebbink","year":"2006","journal-title":"J. Exp. Med."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112853_bb0070","doi-asserted-by":"crossref","first-page":"4520","DOI":"10.1038\/s41467-020-18298-8","article-title":"Collagen promotes anti-PD-1\/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion","volume":"11","author":"Peng","year":"2020","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112853_bb0075","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.ccell.2021.02.007","article-title":"Type I collagen deletion in \u03b1SMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer","volume":"39","author":"Chen","year":"2021","journal-title":"Cancer Cell"},{"issue":"11","key":"10.1016\/j.cellsig.2026.112853_bb0080","doi-asserted-by":"crossref","DOI":"10.1172\/JCI146987","article-title":"Tumor restriction by type I collagen opposes tumor-promoting effects of cancer-associated fibroblasts","volume":"131","author":"Bhattacharjee","year":"2021","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112853_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.106275","article-title":"Matrix stiffness induces epithelial-to-mesenchymal transition via Piezo1-regulated calcium flux in prostate cancer cells","volume":"26","author":"Lopez-Cavestany","year":"2023","journal-title":"iScience"},{"issue":"6","key":"10.1016\/j.cellsig.2026.112853_bb0090","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1083\/jcb.200704042","article-title":"Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix","volume":"179","author":"Wipff","year":"2007","journal-title":"J. Cell Biol."},{"issue":"7350","key":"10.1016\/j.cellsig.2026.112853_bb0095","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature10137","article-title":"Role of YAP\/TAZ in mechanotransduction","volume":"474","author":"Dupont","year":"2011","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112853_bb0100","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a004978","article-title":"The collagen family","volume":"3","author":"Ricard-Blum","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"29","key":"10.1016\/j.cellsig.2026.112853_bb0105","doi-asserted-by":"crossref","first-page":"22276","DOI":"10.1074\/jbc.M110.102079","article-title":"Molecular mechanism of type I collagen homotrimer resistance to mammalian collagenases","volume":"285","author":"Han","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"Pt 7","key":"10.1016\/j.cellsig.2026.112853_bb0110","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1242\/jcs.01731","article-title":"Procollagen trafficking, processing and fibrillogenesis","volume":"118","author":"Canty","year":"2005","journal-title":"J. Cell Sci."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112853_bb0115","doi-asserted-by":"crossref","DOI":"10.1088\/1748-605X\/ac2b79","article-title":"Collagen crosslinking: effect on structure, mechanics and fibrosis progression","volume":"16","author":"Kong","year":"2021","journal-title":"Biomed. Mater."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112853_bb0120","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1186\/s12967-024-05199-3","article-title":"Understanding the matrix: collagen modifications in tumors and their implications for immunotherapy","volume":"22","author":"Borst","year":"2024","journal-title":"J. Transl. Med."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112853_bb0125","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/s41568-019-0238-1","article-title":"A framework for advancing our understanding of cancer-associated fibroblasts","volume":"20","author":"Sahai","year":"2020","journal-title":"Nat. Rev. Cancer"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112853_bb0130","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/path.6207","article-title":"The collagen landscape in cancer: profiling collagens in tumors and in circulation reveals novel markers of cancer-associated fibroblast subtypes","volume":"262","author":"Thorlacius-Ussing","year":"2024","journal-title":"J. Pathol."},{"issue":"12","key":"10.1016\/j.cellsig.2026.112853_bb0135","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1038\/s41571-021-00546-5","article-title":"Clinical and therapeutic relevance of cancer-associated fibroblasts","volume":"18","author":"Chen","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"8","key":"10.1016\/j.cellsig.2026.112853_bb0140","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.ccell.2022.06.011","article-title":"Oncogenic collagen I homotrimers from cancer cells bind to \u03b13\u03b21 integrin and impact tumor microbiome and immunity to promote pancreatic cancer","volume":"40","author":"Chen","year":"2022","journal-title":"Cancer Cell"},{"issue":"6","key":"10.1016\/j.cellsig.2026.112853_bb0145","doi-asserted-by":"crossref","DOI":"10.1111\/bpa.13265","article-title":"Fibrillar extracellular matrix produced by pericyte-like cells facilitates glioma cell dissemination","volume":"34","author":"Vymola","year":"2024","journal-title":"Brain Pathol."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112853_bb0150","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1002\/ijc.31775","article-title":"Adipose tissue-derived stromal cells are sources of cancer-associated fibroblasts and enhance tumor progression by dense collagen matrix","volume":"144","author":"Okumura","year":"2019","journal-title":"Int. J. Cancer"},{"issue":"31","key":"10.1016\/j.cellsig.2026.112853_bb0155","doi-asserted-by":"crossref","first-page":"7928","DOI":"10.1016\/j.biomaterials.2010.06.055","article-title":"Mineralized human primary osteoblast matrices as a model system to analyse interactions of prostate cancer cells with the bone microenvironment","volume":"31","author":"Reichert","year":"2010","journal-title":"Biomaterials"},{"issue":"4","key":"10.1016\/j.cellsig.2026.112853_bb0160","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.slast.2022.05.001","article-title":"A biomimetic high throughput model of cancer cell spheroid dissemination onto aligned Fibrillar collagen","volume":"27","author":"Ibrahim","year":"2022","journal-title":"SLAS Technol."},{"key":"10.1016\/j.cellsig.2026.112853_bb0165","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.matbio.2025.09.004","article-title":"Extracellular matrix architecture promotes immunosuppressive microenvironments in pancreatic cancer","volume":"141","author":"Callaway","year":"2025","journal-title":"Matrix Biol."},{"issue":"7931","key":"10.1016\/j.cellsig.2026.112853_bb0170","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/s41586-022-05169-z","article-title":"Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome","volume":"610","author":"Su","year":"2022","journal-title":"Nature"},{"issue":"42","key":"10.1016\/j.cellsig.2026.112853_bb0175","doi-asserted-by":"crossref","first-page":"68954","DOI":"10.18632\/oncotarget.12135","article-title":"Association between tumor-stroma ratio and prognosis in solid tumor patients: a systematic review and meta-analysis","volume":"7","author":"Wu","year":"2016","journal-title":"Oncotarget"},{"issue":"6516","key":"10.1016\/j.cellsig.2026.112853_bb0180","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaz0868","article-title":"Physical traits of cancer","volume":"370","author":"Nia","year":"2020","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.cellsig.2026.112853_bb0185","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/nprot.2012.009","article-title":"Second harmonic generation microscopy for quantitative analysis of collagen fibrillar structure","volume":"7","author":"Chen","year":"2012","journal-title":"Nat. Protoc."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112853_bb0190","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1186\/s13046-021-02133-z","article-title":"Serological assessment of collagen fragments and tumor fibrosis may guide immune checkpoint inhibitor therapy","volume":"40","author":"Jensen","year":"2021","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"8","key":"10.1016\/j.cellsig.2026.112853_bb0195","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1369\/0022155417718541","article-title":"Fluorescence of Picrosirius red multiplexed with immunohistochemistry for the quantitative assessment of collagen in tissue sections","volume":"65","author":"Wegner","year":"2017","journal-title":"J. Histochem. Cytochem."},{"issue":"D1","key":"10.1016\/j.cellsig.2026.112853_bb0200","doi-asserted-by":"crossref","first-page":"D1670","DOI":"10.1093\/nar\/gkae973","article-title":"Generic diagramming platform (GDP): a comprehensive database of high-quality biomedical graphics","volume":"53","author":"Jiang","year":"2025","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112853_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2025.108330","article-title":"Collagen remodeling-mediated signaling pathways and their impact on tumor therapy","volume":"301","author":"Yuan","year":"2025","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.cellsig.2026.112853_bb0210","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1158\/0008-5472.CAN-22-2034","article-title":"Collagens in cancer: structural regulators and guardians of cancer progression","volume":"83","author":"De Martino","year":"2023","journal-title":"Cancer Res."},{"key":"10.1016\/j.cellsig.2026.112853_bb0215","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1146\/annurev-cellbio-092910-154013","article-title":"Transmembrane collagen receptors","volume":"27","author":"Leitinger","year":"2011","journal-title":"Annu. Rev. Cell Dev. Biol."},{"issue":"5","key":"10.1016\/j.cellsig.2026.112853_bb0220","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s00018-022-04249-7","article-title":"uPARAP\/Endo180: a multifaceted protein of mesenchymal cells","volume":"79","author":"Gucciardo","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.cellsig.2026.112853_bb0225","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.45508","article-title":"DDR2 controls breast tumor stiffness and metastasis by regulating integrin mediated mechanotransduction in CAFs","volume":"8","author":"Bayer","year":"2019","journal-title":"Elife"},{"issue":"12","key":"10.1016\/j.cellsig.2026.112853_bb0230","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0052209","article-title":"Discoidin domain receptors promote \u03b11\u03b21- and \u03b12\u03b21-integrin mediated cell adhesion to collagen by enhancing integrin activation","volume":"7","author":"Xu","year":"2012","journal-title":"PLoS ONE"},{"issue":"3","key":"10.1016\/j.cellsig.2026.112853_bb0235","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/0006-291X(92)91834-D","article-title":"Affinity of integrins for damaged extracellular matrix: alpha v beta 3 binds to denatured collagen type I through RGD sites","volume":"182","author":"Davis","year":"1992","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cellsig.2026.112853_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106694","article-title":"The challenges and opportunities of \u03b1v\u03b23-based therapeutics in cancer: from bench to clinical trials","volume":"189","author":"Gu","year":"2023","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.cellsig.2026.112853_bb0245","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.matbio.2015.05.005","article-title":"Latent TGF-\u03b2-binding proteins","volume":"47","author":"Robertson","year":"2015","journal-title":"Matrix Biol."},{"issue":"11","key":"10.1016\/j.cellsig.2026.112853_bb0250","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a005017","article-title":"Cross talk among TGF-\u03b2 signaling pathways, integrins, and the extracellular matrix","volume":"3","author":"Munger","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"7","key":"10.1016\/j.cellsig.2026.112853_bb0255","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/s41580-018-0007-0","article-title":"Contextual determinants of TGF\u03b2 action in development, immunity and cancer","volume":"19","author":"David","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112853_bb0260","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/ncb2756","article-title":"Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts","volume":"15","author":"Calvo","year":"2013","journal-title":"Nat. Cell Biol."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112853_bb0265","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.ccell.2016.05.005","article-title":"YAP\/TAZ at the roots of cancer","volume":"29","author":"Zanconato","year":"2016","journal-title":"Cancer Cell"},{"issue":"19","key":"10.1016\/j.cellsig.2026.112853_bb0270","doi-asserted-by":"crossref","first-page":"13461","DOI":"10.1074\/jbc.M113.529115","article-title":"The transcriptional regulators TAZ and YAP direct transforming growth factor \u03b2-induced tumorigenic phenotypes in breast cancer cells","volume":"289","author":"Hiemer","year":"2014","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.cellsig.2026.112853_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2020.101416","article-title":"Modeling the control of TGF-\u03b2\/Smad nuclear accumulation by the Hippo pathway effectors, Taz\/Yap","volume":"23","author":"Labibi","year":"2020","journal-title":"iScience"},{"issue":"21","key":"10.1016\/j.cellsig.2026.112853_bb0280","doi-asserted-by":"crossref","first-page":"3407","DOI":"10.1016\/j.jmb.2015.04.015","article-title":"Crosstalk between hippo and TGF\u03b2: subcellular localization of YAP\/TAZ\/Smad complexes","volume":"427","author":"Grannas","year":"2015","journal-title":"J. Mol. Biol."},{"issue":"6000","key":"10.1016\/j.cellsig.2026.112853_bb0285","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1126\/science.1193270","article-title":"Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels","volume":"330","author":"Coste","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.cellsig.2026.112853_bb0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceb.2023.102208","article-title":"Cellular mechanosignaling for sensing and transducing matrix rigidity","volume":"83","author":"Young","year":"2023","journal-title":"Curr. Opin. Cell Biol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112853_bb0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2024.119871","article-title":"PIEZO1 mediates matrix stiffness-induced tumor progression in kidney renal clear cell carcinoma by activating the Ca2+\/Calpain\/YAP pathway","volume":"1872","author":"Zhu","year":"2025","journal-title":"Biochim. Biophys. Acta, Mol. Cell Res."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112853_bb0300","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3390\/molecules28010213","article-title":"Immunoregulatory role of the mechanosensitive ion channel piezo1 in inflammation and cancer","volume":"28","author":"Wang","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.cellsig.2026.112853_bb0305","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.791453","article-title":"Immune modulatory properties of collagen in cancer","volume":"12","author":"R\u00f8mer","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cellsig.2026.112853_bb0310","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.733561","article-title":"Collagen fragments produced in cancer mediate T cell suppression through leukocyte-associated immunoglobulin-like receptor 1","volume":"12","author":"Vijver","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cellsig.2026.112853_bb0315","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.62927","article-title":"Cancer immunotherapy by NC410, a LAIR-2 fc protein blocking human LAIR-collagen interaction","volume":"10","author":"Ramos","year":"2021","journal-title":"Elife"},{"issue":"9","key":"10.1016\/j.cellsig.2026.112853_bb0320","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1093\/jimmun\/vkaf121","article-title":"NC410, a bivalent LAIR-2 construct, remodels collagen in the tumor microenvironment and abrogates neutrophil-driven T cell suppression","volume":"214","author":"Giridharan","year":"2025","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112853_bb0325","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1083\/jcb.200602125","article-title":"Endosomes generate localized rho-ROCK-MLC2-based contractile signals via Endo180 to promote adhesion disassembly","volume":"175","author":"Sturge","year":"2006","journal-title":"J. Cell Biol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112853_bb0330","doi-asserted-by":"crossref","first-page":"3516","DOI":"10.1038\/s41467-021-23583-1","article-title":"Impairment of a distinct cancer-associated fibroblast population limits tumour growth and metastasis","volume":"12","author":"Jungwirth","year":"2021","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112853_bb0335","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1182\/blood-2002-12-3882","article-title":"Platelet-collagen interaction: is GPVI the central receptor?","volume":"102","author":"Nieswandt","year":"2003","journal-title":"Blood"},{"issue":"14","key":"10.1016\/j.cellsig.2026.112853_bb0340","first-page":"1146","article-title":"Platelet glycoprotein VI promotes metastasis through interaction with cancer cell-derived galectin-3","volume":"135","author":"Mammadova-Bach","year":"2020","journal-title":"Blood"},{"issue":"Suppl. 1","key":"10.1016\/j.cellsig.2026.112853_bb0345","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/j.1538-7836.2007.02521.x","article-title":"Platelet receptor recognition and cross-talk in collagen-induced activation of platelets","volume":"5","author":"Farndale","year":"2007","journal-title":"J. Thromb. Haemost."},{"issue":"8","key":"10.1016\/j.cellsig.2026.112853_bb0350","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1039\/C6IB00030D","article-title":"Local extracellular matrix alignment directs cellular protrusion dynamics and migration through Rac1 and FAK","volume":"8","author":"Carey","year":"2016","journal-title":"Integr. Biol."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112853_bb0355","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/nrm.2017.11","article-title":"Planar cell polarity in development and disease","volume":"18","author":"Butler","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112853_bb0360","doi-asserted-by":"crossref","DOI":"10.1186\/s13058-023-01651-2","article-title":"Vangl-dependent Wnt\/planar cell polarity signaling mediates collective breast carcinoma motility and distant metastasis","volume":"25","author":"VanderVorst","year":"2023","journal-title":"Breast Cancer Res."},{"issue":"11","key":"10.1016\/j.cellsig.2026.112853_bb0365","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1158\/2159-8290.CD-21-1714","article-title":"Spatial positioning and matrix programs of cancer-associated fibroblasts promote T-cell exclusion in human lung tumors","volume":"12","author":"Grout","year":"2022","journal-title":"Cancer Discov."},{"issue":"9","key":"10.1016\/j.cellsig.2026.112853_bb0370","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/s41592-021-01203-6","article-title":"Spatial omics and multiplexed imaging to explore cancer biology","volume":"18","author":"Lewis","year":"2021","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cellsig.2026.112853_bb0375","doi-asserted-by":"crossref","first-page":"500","DOI":"10.3389\/fimmu.2015.00500","article-title":"Real-time imaging of resident T cells in human lung and ovarian carcinomas reveals how different tumor microenvironments control T lymphocyte migration","volume":"6","author":"Bougherara","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cellsig.2026.112853_bb0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2023.216166","article-title":"Barrier permeation and improved nanomedicine delivery in tumor microenvironments","volume":"562","author":"Liu","year":"2023","journal-title":"Cancer Lett."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112853_bb0385","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.trecan.2018.02.010","article-title":"Reengineering the tumor vasculature: improving drug delivery and efficacy","volume":"4","author":"Stylianopoulos","year":"2018","journal-title":"Trends Cancer"},{"key":"10.1016\/j.cellsig.2026.112853_bb0390","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1038\/ncomms3516","article-title":"Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels","volume":"4","author":"Chauhan","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cellsig.2026.112853_bb0395","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.113786","article-title":"Targeting tumor extracellular matrix with nanoparticles to circumvent therapeutic resistance","volume":"383","author":"Ding","year":"2025","journal-title":"J. Control. Release"},{"issue":"12","key":"10.1016\/j.cellsig.2026.112853_bb0400","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1002\/jbmr.3618","article-title":"Understanding the bone in cancer metastasis","volume":"33","author":"Fornetti","year":"2018","journal-title":"J. Bone Miner. Res."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112853_bb0405","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.bone.2013.07.006","article-title":"Prostate cancer metastases alter bone mineral and matrix composition independent of effects on bone architecture in mice--a quantitative study using microCT and Raman spectroscopy","volume":"56","author":"Bi","year":"2013","journal-title":"Bone"},{"issue":"5","key":"10.1016\/j.cellsig.2026.112853_bb0410","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1002\/1878-0261.12937","article-title":"Cancer-associated fibroblast migration in non-small cell lung cancers is modulated by increased integrin \u03b111 expression","volume":"15","author":"Iwai","year":"2021","journal-title":"Mol. Oncol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112853_bb0415","doi-asserted-by":"crossref","first-page":"2742","DOI":"10.1038\/s41467-021-22953-z","article-title":"Ultraviolet light-induced collagen degradation inhibits melanoma invasion","volume":"12","author":"Budden","year":"2021","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112853_bb0420","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/exd.14713","article-title":"Quantitative collagen analysis using second harmonic generation images for the detection of basal cell carcinoma with ex vivo multiphoton microscopy","volume":"32","author":"Send\u00edn-Mart\u00edn","year":"2023","journal-title":"Exp. Dermatol."},{"issue":"7","key":"10.1016\/j.cellsig.2026.112853_bb0425","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1097\/CAD.0000000000001612","article-title":"Targeting HSP47 for cancer treatment","volume":"35","author":"Shi","year":"2024","journal-title":"Anti-Cancer Drugs"},{"issue":"9","key":"10.1016\/j.cellsig.2026.112853_bb0430","first-page":"1326","article-title":"A first-in-class pan-lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer","volume":"4","author":"Chitty","year":"2023","journal-title":"Nat. Can."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112853_bb0435","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1021\/acsmedchemlett.1c00006","article-title":"Discovery of a lead compound for specific inhibition of type I collagen production in fibrosis","volume":"12","author":"Stefanovic","year":"2021","journal-title":"ACS Med. Chem. Lett."},{"issue":"12","key":"10.1016\/j.cellsig.2026.112853_bb0440","doi-asserted-by":"crossref","first-page":"9005","DOI":"10.1002\/jcp.29752","article-title":"Cryptic collagen elements as signaling hubs in the regulation of tumor growth and metastasis","volume":"235","author":"Han","year":"2020","journal-title":"J. Cell. Physiol."},{"issue":"12","key":"10.1016\/j.cellsig.2026.112853_bb0445","doi-asserted-by":"crossref","first-page":"2774","DOI":"10.1158\/2159-8290.CD-22-0192","article-title":"Stromal reprogramming by FAK inhibition overcomes radiation resistance to allow for immune priming and response to checkpoint blockade","volume":"12","author":"Lander","year":"2022","journal-title":"Cancer Discov."},{"issue":"8","key":"10.1016\/j.cellsig.2026.112853_bb0450","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1158\/1535-7163.MCT-23-0866","article-title":"Antitumor activity of a novel LAIR1 antagonist in combination with anti-PD1 to treat collagen-rich solid tumors","volume":"23","author":"Rodriguez","year":"2024","journal-title":"Mol. Cancer Ther."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112853_bb0455","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1158\/1535-7163.MCT-22-0312","article-title":"Endo180 (MRC2) antibody-drug conjugate for the treatment of sarcoma","volume":"22","author":"Evans","year":"2023","journal-title":"Mol. Cancer Ther."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112853_bb0460","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1158\/1535-7163.MCT-25-0051","article-title":"The recycling collagen receptor uPARAP is a unique mediator of stromal drug delivery to carcinoma cells","volume":"25","author":"N\u00f8rregaard","year":"2026","journal-title":"Mol. Cancer Ther."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112853_bb0465","article-title":"Antitumor efficacy and potential mechanism of FAP-targeted radioligand therapy combined with immune checkpoint blockade","volume":"9","author":"Zhao","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"issue":"24","key":"10.1016\/j.cellsig.2026.112853_bb0470","doi-asserted-by":"crossref","first-page":"5330","DOI":"10.1158\/1078-0432.CCR-22-1379","article-title":"Monitoring therapeutic response to anti-FAP CAR T cells using [18F]AlF-FAPI-74","volume":"28","author":"Lee","year":"2022","journal-title":"Clin. Cancer Res."},{"issue":"7","key":"10.1016\/j.cellsig.2026.112853_bb0475","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1007\/s13346-023-01308-9","article-title":"Targeting fibroblast activation protein (FAP): advances in CAR-T cell, antibody, and vaccine in cancer immunotherapy","volume":"13","author":"Shahvali","year":"2023","journal-title":"Drug Deliv. Transl. Res."},{"issue":"8","key":"10.1016\/j.cellsig.2026.112853_bb0480","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1158\/0008-5472.CAN-18-2757","article-title":"Wnt\/PCP signaling contribution to carcinoma collective cell migration and metastasis","volume":"79","author":"VanderVorst","year":"2019","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112853_bb0485","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13045-022-01252-0","article-title":"Targeting extracellular matrix stiffness and mechanotransducers to improve cancer therapy","volume":"15","author":"Jiang","year":"2022","journal-title":"J. Hematol. Oncol."},{"issue":"10","key":"10.1016\/j.cellsig.2026.112853_bb0490","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202103939","article-title":"Quantifying cell-derived changes in collagen synthesis, alignment, and mechanics in a 3D connective tissue model","volume":"9","author":"Wilks","year":"2022","journal-title":"Adv. Sci."},{"issue":"5","key":"10.1016\/j.cellsig.2026.112853_bb0495","article-title":"Combining spatial transcriptomics and ECM imaging in 3D for mapping cellular interactions in the tumor microenvironment","volume":"16","author":"Pentimalli","year":"2025","journal-title":"Cell Syst."},{"key":"10.1016\/j.cellsig.2026.112853_bb0500","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.matbio.2020.04.004","article-title":"Spatial-omics: novel approaches to probe cell heterogeneity and extracellular matrix biology","volume":"91-92","author":"Bingham","year":"2020","journal-title":"Matrix Biol."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826005115?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826005115?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:15:25Z","timestamp":1789690525000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656826005115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":100,"alternative-id":["S0898656826005115"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112853","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Type I collagen matrix signaling in cancer: receptor sensing and mechanotransduction","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112853","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112853"}}