{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:05:38Z","timestamp":1789995938488,"version":"4.0.1"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100017964","name":"Tianjin Municipal Health Commission","doi-asserted-by":"publisher","award":["2025169"],"award-info":[{"award-number":["2025169"]}],"id":[{"id":"10.13039\/100017964","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin Municipality","doi-asserted-by":"publisher","award":["23JCYBJC01350"],"award-info":[{"award-number":["23JCYBJC01350"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470063"],"award-info":[{"award-number":["82470063"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270069"],"award-info":[{"award-number":["82270069"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.cellsig.2026.112883","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T22:53:38Z","timestamp":1789253618000},"page":"112883","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["PITX1 facilitates the proliferation and tumorigenesis of NSCLC cells via potentiating PHB2-mediated AKT activity"],"prefix":"10.1016","volume":"149","author":[{"given":"Lei","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoxian","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.cellsig.2026.112883_bb0005","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/s41571-025-01021-1","article-title":"Tumour and microenvironment crosstalk in NSCLC progression and response to therapy","volume":"22","author":"Rahal","year":"2025","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112883_bb0010","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1200\/JCO.21.01626","article-title":"Targeted therapies for lung cancer patients with oncogenic driver molecular alterations","volume":"40","author":"Tan","year":"2022","journal-title":"J. Clin. Oncol."},{"issue":"10","key":"10.1016\/j.cellsig.2026.112883_bb0015","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/j.jtho.2025.05.024","article-title":"Advances in lung cancer basic and translational research in 2025 - overview and perspectives focusing on NSCLC","volume":"20","author":"Mascaux","year":"2025","journal-title":"J. Thorac. Oncol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112883_bb0020","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s41571-025-01085-z","article-title":"Navigating the landscape of EGFR TKI resistance in EGFR-mutant NSCLC - mechanisms and evolving treatment approaches","volume":"23","author":"Zhao","year":"2026","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"49","key":"10.1016\/j.cellsig.2026.112883_bb0025","doi-asserted-by":"crossref","first-page":"18621","DOI":"10.1073\/pnas.0609055103","article-title":"Prediction of active nodes in the transcriptional network of neural tube patterning","volume":"103","author":"Kioussi","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"11","key":"10.1016\/j.cellsig.2026.112883_bb0030","doi-asserted-by":"crossref","first-page":"4921","DOI":"10.1007\/s00018-021-03833-7","article-title":"Pitx genes in development and disease","volume":"78","author":"Tran","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.cellsig.2026.112883_bb0035","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1253238","article-title":"PITX1 plays essential functions in cancer","volume":"13","author":"Zhao","year":"2023","journal-title":"Front. Oncol."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112883_bb0040","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.cell.2005.04.017","article-title":"A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity","volume":"121","author":"Kolfschoten","year":"2005","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112883_bb0045","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-97791-6","article-title":"PITX1 inhibits the growth and proliferation of melanoma cells through regulation of SOX family genes","volume":"11","author":"Ohira","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cellsig.2026.112883_bb0050","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/7694239","article-title":"Upregulated transcription factor PITX1 predicts poor prognosis in kidney renal clear cell carcinoma-based bioinformatic analysis and experimental verification","volume":"2021","author":"Zhang","year":"2021","journal-title":"Dis. Markers"},{"issue":"5","key":"10.1016\/j.cellsig.2026.112883_bb0055","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14051267","article-title":"PITX1 is a regulator of TERT expression in prostate cancer with prognostic power","volume":"14","author":"Poos","year":"2022","journal-title":"Cancers"},{"issue":"4","key":"10.1016\/j.cellsig.2026.112883_bb0060","article-title":"Inhibition of PHB1\/PHB2 suppresses atherosclerotic plaque formation by interrupting PI3K\/AKT\/mTOR signaling","volume":"20","author":"Li","year":"2025","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112883_bb0065","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s13046-023-02937-1","article-title":"PHB2 promotes SHIP2 ubiquitination via the E3 ligase NEDD4 to regulate AKT signaling in gastric cancer","volume":"43","author":"Xu","year":"2024","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"11","key":"10.1016\/j.cellsig.2026.112883_bb0070","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1038\/sj.cdd.4402209","article-title":"Transcriptional activation of p53 by Pitx1","volume":"14","author":"Liu","year":"2007","journal-title":"Cell Death Differ."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112883_bb0075","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1159\/000489590","article-title":"Downregulated PITX1 modulated by MiR-19a-3p promotes cell malignancy and predicts a poor prognosis of gastric cancer by affecting transcriptionally activated PDCD5","volume":"46","author":"Qiao","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112883_bb0080","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1684\/ejd.2013.2021","article-title":"Decreased PITX1 gene expression in human cutaneous malignant melanoma and its clinicopathological significance","volume":"23","author":"Osaki","year":"2013","journal-title":"Eur. J. Dermatol."},{"issue":"11","key":"10.1016\/j.cellsig.2026.112883_bb0085","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1007\/s00384-012-1460-4","article-title":"Loss of desmocollin 1-3 and homeobox genes PITX1 and CDX2 are associated with tumor progression and survival in colorectal carcinoma","volume":"27","author":"Kn\u00f6sel","year":"2012","journal-title":"Int. J. Color. Dis."},{"issue":"24","key":"10.1016\/j.cellsig.2026.112883_bb0090","doi-asserted-by":"crossref","first-page":"3878","DOI":"10.4161\/15384101.2014.972889","article-title":"PITX1, a specificity determinant in the HIF-1\u03b1-mediated transcriptional response to hypoxia","volume":"13","author":"Mudie","year":"2014","journal-title":"Cell Cycle"},{"issue":"12","key":"10.1016\/j.cellsig.2026.112883_bb0095","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1016\/j.prp.2018.09.025","article-title":"High PITX1 expression in lung adenocarcinoma patients is associated with DNA methylation and poor prognosis","volume":"214","author":"Song","year":"2018","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.cellsig.2026.112883_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.122371","article-title":"Prohibitin 2: a key regulator of cell function","volume":"338","author":"Zhang","year":"2024","journal-title":"Life Sci."},{"issue":"8","key":"10.1016\/j.cellsig.2026.112883_bb0105","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1111\/j.1349-7006.2009.01209.x","article-title":"Activation of an estrogen\/estrogen receptor signaling by BIG3 through its inhibitory effect on nuclear transport of PHB2\/REA in breast cancer","volume":"100","author":"Kim","year":"2009","journal-title":"Cancer Sci."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112883_bb0110","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/s41419-023-05575-9","article-title":"PHB2 promotes colorectal cancer cell proliferation and tumorigenesis through NDUFS1-mediated oxidative phosphorylation","volume":"14","author":"Ren","year":"2023","journal-title":"Cell Death Dis."},{"issue":"7","key":"10.1016\/j.cellsig.2026.112883_bb0115","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.7150\/thno.52848","article-title":"PHB2 promotes tumorigenesis via RACK1 in non-small cell lung cancer","volume":"11","author":"Wu","year":"2021","journal-title":"Theranostics"},{"issue":"5","key":"10.1016\/j.cellsig.2026.112883_bb0120","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1111\/cas.12654","article-title":"Therapeutic advances in BIG3-PHB2 inhibition targeting the crosstalk between estrogen and growth factors in breast cancer","volume":"106","author":"Yoshimaru","year":"2015","journal-title":"Cancer Sci."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112883_bb0125","doi-asserted-by":"crossref","DOI":"10.3390\/cancers18040578","article-title":"Advances in the understanding of Akt signaling in cancers and the potential of inhibiting Akt-driven tumors using small molecule inhibitors: an overview","volume":"18","author":"Aswathanarayan","year":"2026","journal-title":"Cancers"},{"issue":"8","key":"10.1016\/j.cellsig.2026.112883_bb0130","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.7150\/ijbs.89942","article-title":"The PI3K\/Akt pathway and glucose metabolism: a dangerous liaison in cancer","volume":"20","author":"Fontana","year":"2024","journal-title":"Int. J. Biol. Sci."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112883_bb0135","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/s41392-021-00828-5","article-title":"Targeting PI3K\/Akt signal transduction for cancer therapy","volume":"6","author":"He","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"issue":"24","key":"10.1016\/j.cellsig.2026.112883_bb0140","doi-asserted-by":"crossref","first-page":"4126","DOI":"10.1158\/0008-5472.CAN-24-1846","article-title":"AKT and the hallmarks of cancer","volume":"84","author":"Sementino","year":"2024","journal-title":"Cancer Res."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826005425?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826005425?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:22:42Z","timestamp":1789993362000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656826005425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":28,"alternative-id":["S0898656826005425"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112883","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PITX1 facilitates the proliferation and tumorigenesis of NSCLC cells via potentiating PHB2-mediated AKT activity","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112883","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112883"}}