{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:53:37Z","timestamp":1791500017894,"version":"4.3.4"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100010722","name":"Harbin Medical University","doi-asserted-by":"publisher","award":["2024B06"],"award-info":[{"award-number":["2024B06"]}],"id":[{"id":"10.13039\/100010722","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.cellsig.2026.112904","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:18:09Z","timestamp":1790291889000},"page":"112904","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The molecular interplay between USP32 and ERP44 in driving multiple myeloma progression and tumor growth"],"prefix":"10.1016","volume":"149","author":[{"given":"Yujuan","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayue","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8345-7855","authenticated-orcid":false,"given":"Guibo","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.cellsig.2026.112904_bb0005","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nrc2189","article-title":"Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets","volume":"7","author":"Hideshima","year":"2007","journal-title":"Nat. Rev. Cancer"},{"issue":"5","key":"10.1016\/j.cellsig.2026.112904_bb0010","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1182\/bloodadvances.2024014717","article-title":"Elotuzumab in combination with pomalidomide, bortezomib, and dexamethasone in relapsed and refractory multiple myeloma","volume":"9","author":"Yee","year":"2025","journal-title":"Blood Adv."},{"issue":"13","key":"10.1016\/j.cellsig.2026.112904_bb0015","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1056\/NEJMoa1506348","article-title":"Targeting CD38 with daratumumab monotherapy in multiple myeloma","volume":"373","author":"Lokhorst","year":"2015","journal-title":"N. Engl. J. Med."},{"issue":"13","key":"10.1016\/j.cellsig.2026.112904_bb0020","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.1158\/1078-0432.CCR-12-1881","article-title":"New strategies in the treatment of multiple myeloma","volume":"19","author":"Munshi","year":"2013","journal-title":"Clin. Cancer Res."},{"issue":"8","key":"10.1016\/j.cellsig.2026.112904_bb0025","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1080\/15548627.2023.2184958","article-title":"LAMTOR1 ubiquitination restricts its interaction with the vacuolar-type H(+)-ATPase, promotes autophagy and is controlled by USP32","volume":"19","author":"Hertel","year":"2023","journal-title":"Autophagy"},{"issue":"10","key":"10.1016\/j.cellsig.2026.112904_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111653","article-title":"USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation and autophagy induction","volume":"41","author":"Hertel","year":"2022","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112904_bb0035","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1038\/s41467-019-09437-x","article-title":"USP32 regulates late endosomal transport and recycling through deubiquitylation of Rab7","volume":"10","author":"Sapmaz","year":"2019","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.cellsig.2026.112904_bb0040","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/s41388-023-02600-1","article-title":"Deubiquitylation of Rab35 by USP32 promotes the transmission of imatinib resistance by enhancing exosome secretion in gastrointestinal stromal tumours","volume":"42","author":"Li","year":"2023","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112904_bb0045","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/s41420-023-01629-1","article-title":"USP32 deubiquitinase: cellular functions, regulatory mechanisms, and potential as a cancer therapy target","volume":"9","author":"Li","year":"2023","journal-title":"Cell Death Discov."},{"issue":"7\u20138","key":"10.1016\/j.cellsig.2026.112904_bb0050","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1007\/s00335-010-9268-4","article-title":"USP32 is an active, membrane-bound ubiquitin protease overexpressed in breast cancers","volume":"21","author":"Akhavantabasi","year":"2010","journal-title":"Mamm. Genome"},{"issue":"20","key":"10.1016\/j.cellsig.2026.112904_bb0055","doi-asserted-by":"crossref","first-page":"9752","DOI":"10.7150\/thno.63806","article-title":"USP32 confers cancer cell resistance to YM155 via promoting ER-associated degradation of solute carrier protein SLC35F2","volume":"11","author":"Chandrasekaran","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.cellsig.2026.112904_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2022.215604","article-title":"Inhibitors of ERp44, PDIA1, and AGR2 induce disulfide-mediated oligomerization of death receptors 4 and 5 and cancer cell death","volume":"534","author":"Law","year":"2022","journal-title":"Cancer Lett."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112904_bb0065","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s10549-016-3820-1","article-title":"Protein disulfide isomerases in the endoplasmic reticulum promote anchorage-independent growth of breast cancer cells","volume":"157","author":"Wise","year":"2016","journal-title":"Breast Cancer Res. Treat."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112904_bb0070","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s12967-020-02694-1","article-title":"ER resident protein 44 promotes malignant phenotype in nasopharyngeal carcinoma through the interaction with ATP citrate lyase","volume":"19","author":"Tian","year":"2021","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.cellsig.2026.112904_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.jprot.2020.103635","article-title":"Identification of tumor-associated antigens with diagnostic ability of colorectal cancer by in-depth immunomic and seroproteomic analysis","volume":"214","author":"Garranzo-Asensio","year":"2020","journal-title":"J. Proteome"},{"issue":"10","key":"10.1016\/j.cellsig.2026.112904_bb0080","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1182\/bloodadvances.2019001275","article-title":"Metaphase cytogenetics and plasma cell proliferation index for risk stratification in newly diagnosed multiple myeloma","volume":"4","author":"Mellors","year":"2020","journal-title":"Blood Adv."},{"key":"10.1016\/j.cellsig.2026.112904_bb0085","doi-asserted-by":"crossref","DOI":"10.1111\/febs.70093","article-title":"Extracellular vesicles in multiple myeloma: pathogenesis and therapeutic application","author":"Wylie","year":"2025","journal-title":"FEBS J."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112904_bb0090","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.70457","article-title":"USP32 promotes colorectal carcinoma progression through activating NF-kappaB signalling pathway","volume":"29","author":"Duan","year":"2025","journal-title":"J. Cell. Mol. Med."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112904_bb0095","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41389-024-00528-z","article-title":"USP32 facilitates non-small cell lung cancer progression via deubiquitinating BAG3 and activating RAF-MEK-ERK signaling pathway","volume":"13","author":"Li","year":"2024","journal-title":"Oncogenesis"},{"issue":"9","key":"10.1016\/j.cellsig.2026.112904_bb0100","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.7150\/ijbs.43117","article-title":"USP32 promotes tumorigenesis and chemoresistance in gastric carcinoma via upregulation of SMAD2","volume":"16","author":"Dou","year":"2020","journal-title":"Int. J. Biol. Sci."},{"issue":"35","key":"10.1016\/j.cellsig.2026.112904_bb0105","article-title":"Furin egress from the TGN is regulated by membrane-associated RING-CH finger (MARCHF) proteins and ubiquitin-specific protease 32 (USP32) via nondegradable K33-polyubiquitination","volume":"11","author":"Su","year":"2024","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112904_bb0110","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1002\/ijc.28333","article-title":"Antimyeloma activity of NK012, a micelle-forming macromolecular prodrug of SN-38, in an orthotopic model","volume":"134","author":"Miyazaki","year":"2014","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.cellsig.2026.112904_bb0115","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1186\/1471-2407-11-394","article-title":"Tracking human multiple myeloma xenografts in NOD-Rag-1\/IL-2 receptor gamma chain-null mice with the novel biomarker AKAP-4","volume":"11","author":"Mirandola","year":"2011","journal-title":"BMC Cancer"},{"issue":"7","key":"10.1016\/j.cellsig.2026.112904_bb0120","doi-asserted-by":"crossref","first-page":"4171","DOI":"10.1111\/jcmm.15078","article-title":"FAM46C controls antibody production by the polyadenylation of immunoglobulin mRNAs and inhibits cell migration in multiple myeloma","volume":"24","author":"Herrero","year":"2020","journal-title":"J. Cell. Mol. Med."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112904_bb0125","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1186\/s12885-021-08712-9","article-title":"Exosomal ERp44 derived from ER-stressed cells strengthens cisplatin resistance of nasopharyngeal carcinoma","volume":"21","author":"Xia","year":"2021","journal-title":"BMC Cancer"},{"key":"10.1016\/j.cellsig.2026.112904_bb0130","article-title":"The dual effect of endoplasmic reticulum stress in digestive system tumors and intervention of Chinese botanical drug extracts: a review","volume":"15","author":"Zhang","year":"2024","journal-title":"Front. Pharmacol."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826005632?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826005632?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:29:59Z","timestamp":1791498599000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656826005632"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":26,"alternative-id":["S0898656826005632"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112904","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The molecular interplay between USP32 and ERP44 in driving multiple myeloma progression and tumor growth","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112904","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112904"}}