{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:45:30Z","timestamp":1791974730757,"version":"4.4.0"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100008871","name":"Yunnan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["202501AY070001-132"],"award-info":[{"award-number":["202501AY070001-132"]}],"id":[{"id":"10.13039\/501100008871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Signalling"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.cellsig.2026.112941","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:21:21Z","timestamp":1791588081000},"page":"112941","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["SIRT1 alleviates hypoxia-induced mitochondrial dysfunction and scleral remodeling in scleral fibroblasts by regulating AMPK via FOXO1"],"prefix":"10.1016","author":[{"given":"Zhijuan","family":"Hua","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanglong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingfei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.cellsig.2026.112941_bb0005","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.ophtha.2016.01.006","article-title":"Global prevalence of myopia and high myopia and temporal trends from 2000 through 2050","volume":"123","author":"Holden","year":"2016","journal-title":"Ophthalmology"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112941_bb0010","doi-asserted-by":"crossref","first-page":"21704","DOI":"10.1038\/s41598-022-26323-7","article-title":"Myopia: why the retina stops inhibiting eye growth","volume":"12","author":"Swiatczak","year":"2022","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.cellsig.2026.112941_bb0015","doi-asserted-by":"crossref","first-page":"2800","DOI":"10.4103\/ijo.IJO_2098_21","article-title":"Current concepts in the management of childhood myopia","volume":"70","author":"Dhiman","year":"2022","journal-title":"Indian J. Ophthalmol."},{"issue":"5","key":"10.1016\/j.cellsig.2026.112941_bb0020","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1167\/iovs.62.5.6","article-title":"IMI prevention of myopia and its progression","volume":"62","author":"Jonas","year":"2021","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.cellsig.2026.112941_bb0025","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.2147\/OPTH.S523283","article-title":"The role of scleral changes in the progression of myopia: a review and future directions","volume":"19","author":"Yin","year":"2025","journal-title":"Clin. Ophthalmol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112941_bb0030","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1167\/iovs.65.1.19","article-title":"FOXM1 participates in scleral remodeling in myopia by upregulating APOA1 expression through METTL3\/YTHDF2","volume":"65","author":"Xue","year":"2024","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.cellsig.2026.112941_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2022.109071","article-title":"Candidate pathways for retina to scleral signaling in refractive eye growth","volume":"219","author":"Brown","year":"2022","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.cellsig.2026.112941_bb0040","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.jconrel.2024.07.031","article-title":"Palladium nanocrystals regulates scleral extracellular matrix remodeling in myopic progression by modulating the hypoxia signaling pathway Nrf-2\/Ho-1","volume":"373","author":"Zhang","year":"2024","journal-title":"J. Control. Release"},{"key":"10.1016\/j.cellsig.2026.112941_bb0045","first-page":"0969","article-title":"N-acetyltransferase 2 inhibits myopia by maintaining mitochondrial metabolism in scleral fibroblasts","volume":"8","author":"Gong","year":"2025","journal-title":"Research (Wash D C)"},{"issue":"6","key":"10.1016\/j.cellsig.2026.112941_bb0050","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27061962","article-title":"Nobiletin alleviates astrocyte activation and oxidative stress induced by hypoxia in vitro","volume":"27","author":"Wang","year":"2022","journal-title":"Molecules"},{"issue":"9","key":"10.1016\/j.cellsig.2026.112941_bb0055","doi-asserted-by":"crossref","first-page":"4921","DOI":"10.1007\/s11010-025-05299-8","article-title":"Therapeutic applications of exercise in neurodegenerative diseases: focusing on the mechanism of SIRT1","volume":"480","author":"Li","year":"2025","journal-title":"Mol. Cell. Biochem."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112941_bb0060","doi-asserted-by":"crossref","first-page":"87","DOI":"10.14348\/molcells.2016.2318","article-title":"Sirt1 and the mitochondria","volume":"39","author":"Luen Tang","year":"2016","journal-title":"Mol. Cell"},{"issue":"1","key":"10.1016\/j.cellsig.2026.112941_bb0065","doi-asserted-by":"crossref","first-page":"41354","DOI":"10.1038\/s41598-025-25240-9","article-title":"Resveratrol delays senescence of human dental pulp stem cells via activating the SIRT1-mitochondrial autophagy","volume":"15","author":"Li","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cellsig.2026.112941_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2026.117698","article-title":"Quercetin ameliorates SIRT1-mediated oxidative stress and inflammation to attenuate ciliary muscle remodeling in experimental myopia","volume":"245","author":"Yang","year":"2026","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112941_bb0075","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s10020-025-01155-z","article-title":"Sirtuin1 mitigates hypoxia-induced cardiomyocyte apoptosis in myocardial infarction via PHD3\/HIF-1\u03b1","volume":"31","author":"Chen","year":"2025","journal-title":"Mol. Med."},{"key":"10.1016\/j.cellsig.2026.112941_bb0080","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.redox.2015.06.019","article-title":"Redox regulation of FoxO transcription factors","volume":"6","author":"Klotz","year":"2015","journal-title":"Redox Biol."},{"key":"10.1016\/j.cellsig.2026.112941_bb0085","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.freeradbiomed.2025.07.032","article-title":"SIRT1 alleviates hyperglycemia-induced oxidative stress and dysfunction of limbal niche cells by deacetylating FOXO1","volume":"239","author":"Shen","year":"2025","journal-title":"Free Radic. Biol. Med."},{"issue":"11","key":"10.1016\/j.cellsig.2026.112941_bb0090","doi-asserted-by":"crossref","first-page":"4888","DOI":"10.1172\/JCI66218","article-title":"AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function","volume":"123","author":"Dugan","year":"2013","journal-title":"J. Clin. Invest."},{"issue":"8","key":"10.1016\/j.cellsig.2026.112941_bb0095","first-page":"4549","article-title":"The effect of an AMPK kinase agonist on myopia development in chicks","volume":"66","author":"Mishra","year":"2025","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.cellsig.2026.112941_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.174858","article-title":"Acacetin ameliorates cardiac hypertrophy by activating Sirt1\/AMPK\/PGC-1\u03b1 pathway","volume":"920","author":"Cui","year":"2022","journal-title":"Eur. J. Pharmacol."},{"issue":"30","key":"10.1016\/j.cellsig.2026.112941_bb0105","doi-asserted-by":"crossref","first-page":"E7091","DOI":"10.1073\/pnas.1721443115","article-title":"Scleral hypoxia is a target for myopia control","volume":"115","author":"Wu","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"8","key":"10.1016\/j.cellsig.2026.112941_bb0110","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1167\/iovs.63.8.2","article-title":"Hypoxia-induced scleral HIF-2\u03b1 upregulation contributes to rises in MMP-2 expression and myopia development in mice","volume":"63","author":"Wu","year":"2022","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"3","key":"10.1016\/j.cellsig.2026.112941_bb0115","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.cmet.2023.12.023","article-title":"Augmentation of scleral glycolysis promotes myopia through histone lactylation","volume":"36","author":"Lin","year":"2024","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112941_bb0120","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/s12974-021-02250-8","article-title":"NAD(+) improves cognitive function and reduces neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1\/PGC-1\u03b1 pathway","volume":"18","author":"Zhao","year":"2021","journal-title":"J. Neuroinflammation"},{"issue":"2","key":"10.1016\/j.cellsig.2026.112941_bb0125","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nrm.2017.95","article-title":"AMPK: guardian of metabolism and mitochondrial homeostasis","volume":"19","author":"Herzig","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112941_bb0130","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1097\/ICL.0000000000000499","article-title":"A review of current concepts of the etiology and treatment of myopia","volume":"44","author":"Cooper","year":"2018","journal-title":"Eye Contact Lens"},{"key":"10.1016\/j.cellsig.2026.112941_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.jprot.2023.104949","article-title":"Complement-mediated inflammation and mitochondrial energy metabolism in the proteomic profile of myopic human corneas","volume":"285","author":"Huang","year":"2023","journal-title":"J. Proteome"},{"issue":"12","key":"10.1016\/j.cellsig.2026.112941_bb0140","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.3390\/genes14122163","article-title":"RNA-sequencing analysis reveals the role of mitochondrial energy metabolism alterations and immune cell activation in form-deprivation and Lens-induced myopia in mice","volume":"14","author":"Kim","year":"2023","journal-title":"Genes"},{"issue":"12","key":"10.1016\/j.cellsig.2026.112941_bb0145","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.18240\/ijo.2023.12.05","article-title":"Electroacupuncture alleviates ciliary muscle cell apoptosis in lens-induced myopic guinea pigs through inhibiting the mitochondrial signaling pathway","volume":"16","author":"Yang","year":"2023","journal-title":"Int. J. Ophthalmol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112941_bb0150","doi-asserted-by":"crossref","first-page":"29392","DOI":"10.1038\/s41598-025-12800-2","article-title":"0.01% atropine combined with carteolol hydrochloride can inhibit the scleral remodeling in guinea pigs with form-deprivation myopia","volume":"15","author":"Xiang","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cellsig.2026.112941_bb0155","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1422686","article-title":"Advances in pathogenesis and treatment of vascular endothelial injury-related diseases mediated by mitochondrial abnormality","volume":"15","author":"Pang","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112941_bb0160","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s10456-024-09938-4","article-title":"Emerging insights into the pathogenesis and therapeutic strategies for vascular endothelial injury-associated diseases: focus on mitochondrial dysfunction","volume":"27","author":"Pang","year":"2024","journal-title":"Angiogenesis"},{"key":"10.1016\/j.cellsig.2026.112941_bb0165","article-title":"The role of atropine in myopia control: insights into choroidal and scleral mechanisms","volume":"16","author":"Huang","year":"2025","journal-title":"Front. Pharmacol."},{"issue":"10","key":"10.1016\/j.cellsig.2026.112941_bb0170","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.18240\/ijo.2024.10.03","article-title":"Molecular mechanism of hypoxia and alpha-ketoglutaric acid on collagen expression in scleral fibroblasts","volume":"17","author":"Sun","year":"2024","journal-title":"Int. J. Ophthalmol."},{"issue":"14","key":"10.1016\/j.cellsig.2026.112941_bb0175","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1167\/iovs.66.14.40","article-title":"Mfn2 regulates scleral remodeling in myopia by maintaining endoplasmic reticulum homeostasis in scleral fibroblasts","volume":"66","author":"Wang","year":"2025","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112941_bb0180","doi-asserted-by":"crossref","first-page":"6172","DOI":"10.3390\/s100606172","article-title":"SirT1--a sensor for monitoring self-renewal and aging process in retinal stem cells","volume":"10","author":"Peng","year":"2010","journal-title":"Sensors (Basel)"},{"issue":"3","key":"10.1016\/j.cellsig.2026.112941_bb0185","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22031295","article-title":"New highlights of resveratrol: a review of properties against ocular diseases","volume":"22","author":"Delmas","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112941_bb0190","first-page":"13","article-title":"Role of Sirtuin 1 in the pathogenesis of ocular disease (review)","volume":"42","author":"Zhou","year":"2018","journal-title":"Int. J. Mol. Med."},{"issue":"8","key":"10.1016\/j.cellsig.2026.112941_bb0195","doi-asserted-by":"crossref","first-page":"3602","DOI":"10.1167\/iovs.07-0131","article-title":"SIRT1 activation confers neuroprotection in experimental optic neuritis","volume":"48","author":"Shindler","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"4","key":"10.1016\/j.cellsig.2026.112941_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2024.167053","article-title":"Melatonin ameliorates retinal ganglion cell senescence and apoptosis in a SIRT1-dependent manner in an optic nerve injury model","volume":"1870","author":"Shi","year":"2024","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"issue":"5","key":"10.1016\/j.cellsig.2026.112941_bb0205","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.jgr.2025.04.006","article-title":"Ginsenoside Rb1 attenuates coronary microvascular inflammatory injury via NDUFS4-SIRT5-DUSP1-mediated mitochondrial quality control in a murine ischemia-reperfusion model","volume":"49","author":"Pu","year":"2025","journal-title":"J. Ginseng Res."},{"key":"10.1016\/j.cellsig.2026.112941_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156982","article-title":"Tanshinone IIA modulates Sirt5 and Metll3 interaction to govern mitochondria-endoplasmic reticulum unfolded protein response in coronary microvascular injury","volume":"145","author":"Pu","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.cellsig.2026.112941_bb0215","doi-asserted-by":"crossref","first-page":"41768","DOI":"10.1038\/srep41768","article-title":"Intranasal delivery of a novel amnion cell secretome prevents neuronal damage and preserves function in a mouse multiple sclerosis model","volume":"7","author":"Khan","year":"2017","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.cellsig.2026.112941_bb0220","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1042\/CS20210519","article-title":"Hormonal regulation of metabolism-recent lessons learned from insulin and estrogen","volume":"137","author":"Tao","year":"2023","journal-title":"Clin. Sci. (Lond.)"},{"issue":"4","key":"10.1016\/j.cellsig.2026.112941_bb0225","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1042\/BCJ20210777","article-title":"FoxO transcription factors in mitochondrial homeostasis","volume":"479","author":"Cheng","year":"2022","journal-title":"Biochem. J."},{"issue":"9","key":"10.1016\/j.cellsig.2026.112941_bb0230","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.tem.2019.07.009","article-title":"The FoxO-autophagy axis in health and disease","volume":"30","author":"Cheng","year":"2019","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.cellsig.2026.112941_bb0235","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mce.2015.06.007","article-title":"Activation of FoxO1\/ PGC-1\u03b1 prevents mitochondrial dysfunction and ameliorates mesangial cell injury in diabetic rats","volume":"413","author":"Wu","year":"2015","journal-title":"Mol. Cell. Endocrinol."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112941_bb0240","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1186\/s12967-016-1101-8","article-title":"Repressed SIRT1\/PGC-1\u03b1 pathway and mitochondrial disintegration in iPSC-derived RPE disease model of age-related macular degeneration","volume":"14","author":"Golestaneh","year":"2016","journal-title":"J. Transl. Med."},{"issue":"7","key":"10.1016\/j.cellsig.2026.112941_bb0245","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1016\/j.bbadis.2018.04.005","article-title":"FOXO1 inhibition potentiates endothelial angiogenic functions in diabetes via suppression of ROCK1\/Drp1-mediated mitochondrial fission","volume":"1864","author":"Shi","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"key":"10.1016\/j.cellsig.2026.112941_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2026.110887","article-title":"Astaxanthin protects retinal M\u00fcller cells against high glucose-induced oxidative stress through the sirtuin 1\/AMPK\/FOXO1 pathway","volume":"265","author":"Tew","year":"2026","journal-title":"Exp. Eye Res."},{"issue":"6642","key":"10.1016\/j.cellsig.2026.112941_bb0255","doi-asserted-by":"crossref","DOI":"10.1126\/science.abj5559","article-title":"Induction of lysosomal and mitochondrial biogenesis by AMPK phosphorylation of FNIP1","volume":"380","author":"Malik","year":"2023","journal-title":"Science"},{"issue":"10","key":"10.1016\/j.cellsig.2026.112941_bb0260","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-019-0327-y","article-title":"Oxidative stress-mediated TXNIP loss causes RPE dysfunction","volume":"51","author":"Ji Cho","year":"2019","journal-title":"Exp. Mol. Med."},{"issue":"2","key":"10.1016\/j.cellsig.2026.112941_bb0265","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.yexcr.2016.08.013","article-title":"Metformin activation of AMPK-dependent pathways is neuroprotective in human neural stem cells against amyloid-beta-induced mitochondrial dysfunction","volume":"347","author":"Chiang","year":"2016","journal-title":"Exp. Cell Res."},{"issue":"10","key":"10.1016\/j.cellsig.2026.112941_bb0270","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1007\/s12272-018-1059-6","article-title":"Paeoniflorin attenuates atRAL-induced oxidative stress, mitochondrial dysfunction and endoplasmic reticulum stress in retinal pigment epithelial cells via triggering Ca(2+)\/CaMKII-dependent activation of AMPK","volume":"41","author":"Zhu","year":"2018","journal-title":"Arch. Pharm. Res."},{"issue":"1","key":"10.1016\/j.cellsig.2026.112941_bb0275","doi-asserted-by":"crossref","first-page":"11497","DOI":"10.1038\/s41598-024-62262-1","article-title":"Upregulation of the AMPK-FOXO1-PDK4 pathway is a primary mechanism of pyruvate dehydrogenase activity reduction in tafazzin-deficient cells","volume":"14","author":"Liang","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cellsig.2026.112941_bb0280","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2019.00223","article-title":"Propofol alleviates DNA damage induced by oxygen glucose deprivation and reperfusion via FoxO1 nuclear translocation in H9c2 cells","volume":"10","author":"Zhou","year":"2019","journal-title":"Front. Physiol."}],"container-title":["Cellular Signalling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826006017?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0898656826006017?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T09:54:48Z","timestamp":1791971688000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0898656826006017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":56,"alternative-id":["S0898656826006017"],"URL":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112941","relation":{},"ISSN":["0898-6568"],"issn-type":[{"value":"0898-6568","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SIRT1 alleviates hypoxia-induced mitochondrial dysfunction and scleral remodeling in scleral fibroblasts by regulating AMPK via FOXO1","name":"articletitle","label":"Article Title"},{"value":"Cellular Signalling","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cellsig.2026.112941","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112941"}}