{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T17:26:08Z","timestamp":1791134768453,"version":"4.1.0"},"reference-count":74,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,20]],"date-time":"2013-07-20T00:00:00Z","timestamp":1374278400000},"content-version":"vor","delay-in-days":506,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1016\/j.celrep.2012.01.006","type":"journal-article","created":{"date-parts":[[2012,3,8]],"date-time":"2012-03-08T17:31:09Z","timestamp":1331227869000},"page":"241-250","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"title":["Mechanoprotection by Polycystins against Apoptosis Is Mediated through the Opening of Stretch-Activated K2P Channels"],"prefix":"10.1016","volume":"1","author":[{"given":"R\u00e9mi","family":"Peyronnet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Sharif-Naeini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost\u00a0H.A.","family":"Folgering","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malika","family":"Arhatte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Jodar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charbel","family":"El\u00a0Boustany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Gallian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Tauc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Duranton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Rubera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Lesage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"York","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorien\u00a0J.M.","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Somlo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick","family":"Sachs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Honor\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Duprat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2012.01.006_bib1","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1038\/emboj.2008.70","article-title":"Activation of TRPP2 through mDia1-dependent voltage gating","volume":"27","author":"Bai","year":"2008","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2012.01.006_bib2","doi-asserted-by":"crossref","first-page":"17412","DOI":"10.1074\/jbc.M000445200","article-title":"TREK-2, a new member of the mechanosensitive tandem-pore K+ channel family","volume":"275","author":"Bang","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2012.01.006_bib3","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1085\/jgp.200308820","article-title":"Role of TASK2 potassium channels regarding volume regulation in primary cultures of mouse proximal tubules","volume":"122","author":"Barriere","year":"2003","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.celrep.2012.01.006_bib4","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1113\/jphysiol.1990.sp018108","article-title":"Cell swelling, co-transport activation and potassium conductance in isolated perfused rabbit kidney proximal tubules","volume":"425","author":"Beck","year":"1990","journal-title":"J. Physiol."},{"key":"10.1016\/j.celrep.2012.01.006_bib5","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1161\/CIRCRESAHA.107.154443","article-title":"Polyunsaturated fatty acids are cerebral vasodilators via the TREK-1 potassium channel","volume":"101","author":"Blondeau","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.celrep.2012.01.006_bib6","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1681\/ASN.2005050534","article-title":"Polycystin-1 induces resistance to apoptosis through the phosphatidylinositol 3-kinase\/Akt signaling pathway","volume":"17","author":"Boca","year":"2006","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.celrep.2012.01.006_bib7","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/S1097-2765(00)00123-4","article-title":"Polycystin-1, the gene product of PKD1, induces resistance to apoptosis and spontaneous tubulogenesis in MDCK cells","volume":"6","author":"Boletta","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2012.01.006_bib8","first-page":"F697","article-title":"Substrate activation of mechanosensitive, whole cell currents in renal proximal tubule","volume":"264","author":"Cemerikic","year":"1993","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.celrep.2012.01.006_bib9","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nrm2595","article-title":"Neurosensory mechanotransduction","volume":"10","author":"Chalfie","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2012.01.006_bib10","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1006\/bbrc.2001.4720","article-title":"Transport function of the naturally occurring pathogenic polycystin-2 mutant, R742X","volume":"282","author":"Chen","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"Suppl 1","key":"10.1016\/j.celrep.2012.01.006_bib11","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1007\/s00247-007-0585-z","article-title":"Chronic partial ureteral obstruction and the developing kidney","volume":"38","author":"Chevalier","year":"2008","journal-title":"Pediatr. Radiol."},{"key":"10.1016\/j.celrep.2012.01.006_bib12","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.cell.2004.07.007","article-title":"Polycystins: from mechanosensation to gene regulation","volume":"118","author":"Delmas","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2012.01.006_bib13","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1464-410X.1982.tb13525.x","article-title":"Hydrostatic pressure within renal cysts","volume":"54","author":"Derezic","year":"1982","journal-title":"Br. J. Urol."},{"key":"10.1016\/j.celrep.2012.01.006_bib14","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.4161\/cc.4.11.2185","article-title":"What is the role of tubular epithelial cell apoptosis in polycystic kidney disease (PKD)?","volume":"4","author":"Edelstein","year":"2005","journal-title":"Cell Cycle"},{"key":"10.1016\/j.celrep.2012.01.006_bib15","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1146\/annurev.neuro.20.1.567","article-title":"The molecules of mechanosensation","volume":"20","author":"Garcia-Anoveros","year":"1997","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.celrep.2012.01.006_bib16","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/sj.embor.7400916","article-title":"Altered acetylcholine, bradykinin and cutaneous pressure-induced vasodilation in mice lacking the TREK1 potassium channel: the endothelial link","volume":"8","author":"Garry","year":"2007","journal-title":"EMBO Rep."},{"key":"10.1016\/j.celrep.2012.01.006_bib17","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/j.bbadis.2011.01.006","article-title":"Apoptosis in polycystic kidney disease","volume":"1812","author":"Goilav","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.celrep.2012.01.006_bib18","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/nrneph.2011.109","article-title":"Why kidneys fail in autosomal dominant polycystic kidney disease","volume":"7","author":"Grantham","year":"2011","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.celrep.2012.01.006_bib19","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1523\/JNEUROSCI.5764-08.2009","article-title":"Glucose inhibition persists in hypothalamic neurons lacking tandem-pore K+ channels","volume":"29","author":"Guyon","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.celrep.2012.01.006_bib20","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/nrm2596","article-title":"Mechanotransduction in vascular physiology and atherogenesis","volume":"10","author":"Hahn","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2012.01.006_bib21","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev.med.60.101707.125712","article-title":"Polycystic kidney disease","volume":"60","author":"Harris","year":"2009","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.celrep.2012.01.006_bib22","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nrn2117","article-title":"The neuronal background K2P channels: focus on TREK1","volume":"8","author":"Honor\u00e9","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.celrep.2012.01.006_bib23","doi-asserted-by":"crossref","first-page":"2968","DOI":"10.1093\/emboj\/cdf288","article-title":"An intracellular proton sensor commands lipid- and mechano-gating of the K(+) channel TREK-1","volume":"21","author":"Honor\u00e9","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2012.01.006_bib24","doi-asserted-by":"crossref","first-page":"6859","DOI":"10.1073\/pnas.0600463103","article-title":"Desensitization of mechano-gated K2P channels","volume":"103","author":"Honor\u00e9","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2012.01.006_bib25","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/nrm2597","article-title":"Mechanotransduction gone awry","volume":"10","author":"Jaalouk","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2012.01.006_bib26","doi-asserted-by":"crossref","first-page":"21998","DOI":"10.1074\/jbc.M200715200","article-title":"Cell death and mechanoprotection by filamin a in connective tissues after challenge by applied tensile forces","volume":"277","author":"Kainulainen","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2012.01.006_bib27","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/nature03896","article-title":"A possible unifying principle for mechanosensation","volume":"436","author":"Kung","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2012.01.006_bib28","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1093\/hmg\/ddh336","article-title":"Lowering of Pkd1 expression is sufficient to cause polycystic kidney disease","volume":"13","author":"Lantinga-van Leeuwen","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.celrep.2012.01.006_bib29","doi-asserted-by":"crossref","first-page":"32068","DOI":"10.1074\/jbc.M302631200","article-title":"K+-dependent cerebellar granule neuron apoptosis. Role of task leak K+ channels","volume":"278","author":"Lauritzen","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2012.01.006_bib30","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/sj.embor.7400449","article-title":"Cross-talk between the mechano-gated K2P channel TREK-1 and the actin cytoskeleton","volume":"6","author":"Lauritzen","year":"2005","journal-title":"EMBO Rep."},{"key":"10.1016\/j.celrep.2012.01.006_bib31","doi-asserted-by":"crossref","first-page":"28398","DOI":"10.1074\/jbc.M002822200","article-title":"Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors","volume":"275","author":"Lesage","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2012.01.006_bib32","doi-asserted-by":"crossref","first-page":"36692","DOI":"10.1074\/jbc.M703933200","article-title":"Role of TASK2 in the control of apoptotic volume decrease in proximal kidney cells","volume":"282","author":"L'Hoste","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2012.01.006_bib33","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1038\/nature05662","article-title":"Mechanisms of sensory transduction in the skin","volume":"445","author":"Lumpkin","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2012.01.006_bib34","doi-asserted-by":"crossref","first-page":"8285","DOI":"10.1128\/MCB.25.18.8285-8298.2005","article-title":"PKD2 functions as an epidermal growth factor-activated plasma membrane channel","volume":"25","author":"Ma","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.celrep.2012.01.006_bib35","doi-asserted-by":"crossref","first-page":"26691","DOI":"10.1074\/jbc.274.38.26691","article-title":"Mechano- or acid stimulation, two interactive modes of activation of the TREK-1 potassium channel","volume":"274","author":"Maingret","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2012.01.006_bib36","first-page":"105","article-title":"Small artery remodeling and significance in the development of hypertension","volume":"17","author":"Mulvany","year":"2002","journal-title":"News Physiol. Sci."},{"key":"10.1016\/j.celrep.2012.01.006_bib37","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/ng1076","article-title":"Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells","volume":"33","author":"Nauli","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2012.01.006_bib38","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1161\/CIRCULATIONAHA.107.710111","article-title":"Endothelial cilia are fluid shear sensors that regulate calcium signaling and nitric oxide production through polycystin-1","volume":"117","author":"Nauli","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.celrep.2012.01.006_bib39","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/nrneph.2010.97","article-title":"Polycystins and renovascular mechanosensory transduction","volume":"6","author":"Patel","year":"2010","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.celrep.2012.01.006_bib40","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s00424-004-1255-8","article-title":"The 2P-domain K+ channels: role in apoptosis and tumorigenesis","volume":"448","author":"Patel","year":"2004","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.celrep.2012.01.006_bib41","doi-asserted-by":"crossref","first-page":"4283","DOI":"10.1093\/emboj\/17.15.4283","article-title":"A mammalian two pore domain mechano-gated S-like K+ channel","volume":"17","author":"Patel","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2012.01.006_bib42","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0076-6879(07)28010-3","article-title":"Transient receptor potential channels in mechanosensing and cell volume regulation","volume":"428","author":"Pedersen","year":"2007","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.celrep.2012.01.006_bib43","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S1471-4914(01)01953-0","article-title":"A \u201ctwo-hit\u201d model of cystogenesis in autosomal dominant polycystic kidney disease?","volume":"7","author":"Pei","year":"2001","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.celrep.2012.01.006_bib44","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1097\/01.ju.0000091106.61065.e3","article-title":"Mechanical deformation induced apoptosis in human proximal renal tubular epithelial cells is caspase dependent","volume":"171","author":"Power","year":"2004","journal-title":"J. Urol."},{"key":"10.1016\/j.celrep.2012.01.006_bib45","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/S0092-8674(00)81793-6","article-title":"The molecular basis of focal cyst formation in human autosomal dominant polycystic kidney disease type I","volume":"87","author":"Qian","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2012.01.006_bib46","doi-asserted-by":"crossref","first-page":"F1","DOI":"10.1152\/ajprenal.00576.2007","article-title":"Exploring mechanisms involved in renal tubular sensing of mechanical stretch following ureteric obstruction","volume":"295","author":"Quinlan","year":"2008","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.celrep.2012.01.006_bib47","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1097\/MNH.0b013e32833327f3","article-title":"Intratubular hydrodynamic forces influence tubulointerstitial fibrosis in the kidney","volume":"19","author":"Rohatgi","year":"2010","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"10.1016\/j.celrep.2012.01.006_bib48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BFb0004985","article-title":"Mechanosensitive ion channels in nonspecialized cells","volume":"132","author":"Sachs","year":"1998","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"key":"10.1016\/j.celrep.2012.01.006_bib49","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1073\/pnas.86.5.1731","article-title":"A stretch-activated K+ channel sensitive to cell volume","volume":"86","author":"Sackin","year":"1989","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2012.01.006_bib50","doi-asserted-by":"crossref","first-page":"18794","DOI":"10.1074\/jbc.M109.090662","article-title":"Polycystin-2 activation by inositol 1,4,5-trisphosphate-induced Ca2+ release requires its direct association with the inositol 1,4,5-trisphosphate receptor in a signaling microdomain","volume":"285","author":"Sammels","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2012.01.006_bib51","doi-asserted-by":"crossref","first-page":"14628","DOI":"10.1073\/pnas.0906267106","article-title":"Extracellular acidification exerts opposite actions on TREK1 and TREK2 potassium channels via a single conserved histidine residue","volume":"106","author":"Sandoz","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2012.01.006_bib52","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.cell.2009.08.045","article-title":"Polycystin-1 and -2 dosage regulates pressure sensing","volume":"139","author":"Sharif-Naeini","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2012.01.006_bib53","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1046\/j.1523-1755.2002.00689.x","article-title":"Atubular glomeruli in a rat model of polycystic kidney disease","volume":"62","author":"Tanner","year":"2002","journal-title":"Kidney Int."},{"key":"10.1016\/j.celrep.2012.01.006_bib54","doi-asserted-by":"crossref","first-page":"6954","DOI":"10.1073\/pnas.0408518102","article-title":"Caspase inhibition reduces tubular apoptosis and proliferation and slows disease progression in polycystic kidney disease","volume":"102","author":"Tao","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2012.01.006_bib55","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1161\/hh1601.094979","article-title":"A TREK-1-like potassium channel in atrial cells inhibited by beta-adrenergic stimulation and activated by volatile anesthetics","volume":"89","author":"Terrenoire","year":"2001","journal-title":"Circ. Res."},{"key":"10.1016\/j.celrep.2012.01.006_bib56","doi-asserted-by":"crossref","first-page":"3934","DOI":"10.1073\/pnas.96.7.3934","article-title":"Specific association of the gene product of PKD2 with the TRPC1 channel","volume":"96","author":"Tsiokas","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2012.01.006_bib57","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1038\/ki.2008.395","article-title":"Neutrophil gelatinase-associated lipocalin suppresses cyst growth by Pkd1 null cells in\u00a0vitro and in\u00a0vivo","volume":"74","author":"Wei","year":"2008","journal-title":"Kidney Int."},{"key":"10.1016\/j.celrep.2012.01.006_bib58","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1056\/NEJMra022161","article-title":"Polycystic kidney disease","volume":"350","author":"Wilson","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.celrep.2012.01.006_bib59","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1056\/NEJM199507063330104","article-title":"Apoptosis and loss of renal tissue in polycystic kidney diseases","volume":"333","author":"Woo","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.celrep.2012.01.006_bib60","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nrm2592","article-title":"Mechanotransduction in development: a growing role for contractility","volume":"10","author":"Wozniak","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2012.01.006_bib61","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0092-8674(00)81570-6","article-title":"Somatic inactivation of Pkd2 results in polycystic kidney disease","volume":"93","author":"Wu","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2012.01.006_bib62","first-page":"430","article-title":"Mechanical factors and tissue stresses in chronic hydronephrosis","volume":"18","author":"Wyker","year":"1981","journal-title":"Invest. Urol."},{"key":"10.1016\/j.celrep.2012.01.006_bib63","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1146\/annurev.physiol.70.113006.100621","article-title":"Polycystins and primary cilia: primers for cell cycle progression","volume":"71","author":"Zhou","year":"2009","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.celrep.2012.01.006_bib64","doi-asserted-by":"crossref","unstructured":"Fink, M., Duprat, F., Lesage, F., Reyes, R., Romey, G., Heurteaux, C., and Lazdunski, M. (1996). Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel. EMBO J. 15, 6854\u20136862.","DOI":"10.1002\/j.1460-2075.1996.tb01077.x"},{"key":"10.1016\/j.celrep.2012.01.006_bib65","doi-asserted-by":"crossref","unstructured":"Guyon, A., Tardy, M.P., Rov\u00e8re, C., Nahon, J.L., Barhanin, J., and Lesage, F. (2009). Glucose inhibition persists in hypothalamic neurons lacking tandem-pore K+ channels. J. Neurosci. 29, 2528\u20132533.","DOI":"10.1523\/JNEUROSCI.5764-08.2009"},{"key":"10.1016\/j.celrep.2012.01.006_bib66","doi-asserted-by":"crossref","unstructured":"Lantinga-van Leeuwen, I.S., Leonhard, W.N., van der Wal, A., Breuning, M.H., de Heer, E., and Peters, D.J. (2007). Kidney-specific inactivation of the Pkd1 gene induces rapid cyst formation in developing kidneys and a slow onset of disease in adult mice. Hum. Mol. Genet. 16, 3188\u20133196.","DOI":"10.1093\/hmg\/ddm299"},{"key":"10.1016\/j.celrep.2012.01.006_bib67","doi-asserted-by":"crossref","unstructured":"Power, R.E., Doyle, B.T., Higgins, D., Brady, H.R., Fitzpatrick, J.M., and Watson, R.W. (2004). Mechanical deformation induced apoptosis in human proximal renal tubular epithelial cells is caspase dependent. J. Urol. 171, 457\u2013461.","DOI":"10.1097\/01.ju.0000091106.61065.e3"},{"key":"10.1016\/j.celrep.2012.01.006_bib68","doi-asserted-by":"crossref","unstructured":"Qian, F., Germino, F.J., Cai, Y., Zhang, X., Somlo, S., and Germino, G.G. (1997). PKD1 interacts with PKD2 through a probable coiled-coil domain. Nat. Genet. 16, 179\u2013183.","DOI":"10.1038\/ng0697-179"},{"key":"10.1016\/j.celrep.2012.01.006_bib69","doi-asserted-by":"crossref","unstructured":"Quinlan, M.R., Docherty, N.G., Watson, R.W., and Fitzpatrick, J.M. (2008). Exploring mechanisms involved in renal tubular sensing of mechanical stretch following ureteric obstruction. Am. J. Physiol. Renal Physiol. 295, F1\u2013F11.","DOI":"10.1152\/ajprenal.00576.2007"},{"key":"10.1016\/j.celrep.2012.01.006_bib70","doi-asserted-by":"crossref","unstructured":"Rawicz, W., Smith, B.A., McIntosh, T.J., Simon, S.A., and Evans, E. (2008). Elasticity, strength, and water permeability of bilayers that contain raft microdomain-forming lipids. Biophys. J. 94, 4725\u20134736.","DOI":"10.1529\/biophysj.107.121731"},{"key":"10.1016\/j.celrep.2012.01.006_bib71","doi-asserted-by":"crossref","unstructured":"Sachs, F., and Morris, C.E. (1998). Mechanosensitive ion channels in nonspecialized cells. Rev. Physiol. Biochem. Pharmacol. 132, 1\u201377.","DOI":"10.1007\/BFb0004985"},{"key":"10.1016\/j.celrep.2012.01.006_bib72","doi-asserted-by":"crossref","unstructured":"Sharif-Naeini, R., Folgering, J.H., Bichet, D., Duprat, F., Lauritzen, I., Arhatte, M., Jodar, M., Dedman, A., Chatelain, F.C., Schulte, U., et\u00a0al. (2009). Polycystin-1 and -2 dosage regulates pressure sensing. Cell 139, 587\u2013596.","DOI":"10.1016\/j.cell.2009.08.045"},{"key":"10.1016\/j.celrep.2012.01.006_bib73","doi-asserted-by":"crossref","unstructured":"Wei, F., Karihaloo, A., Yu, Z., Marlier, A., Seth, P., Shibazaki, S., Wang, T., Sukhatme, V.P., Somlo, S., and Cantley, L.G. (2008). Neutrophil gelatinase-associated lipocalin suppresses cyst growth by Pkd1 null cells in\u00a0vitro and in\u00a0vivo. Kidney Int. 74, 1310\u20131318.","DOI":"10.1038\/ki.2008.395"},{"key":"10.1016\/j.celrep.2012.01.006_bib74","unstructured":"Wyker, A.T., Ritter, R.C., Marion, D., and Gillenwater, J.Y. (1981). Mechanical factors and tissue stresses in chronic hydronephrosis. Invest. Urol. 18, 430\u2013436."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124712000423?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124712000423?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T09:19:19Z","timestamp":1761902359000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124712000423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":74,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["S2211124712000423"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2012.01.006","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2012,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanoprotection by Polycystins against Apoptosis Is Mediated through the Opening of Stretch-Activated K2P Channels","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2012.01.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}