{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:05:48Z","timestamp":1790802348887,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,20]],"date-time":"2013-07-20T00:00:00Z","timestamp":1374278400000},"content-version":"vor","delay-in-days":322,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1016\/j.celrep.2012.08.012","type":"journal-article","created":{"date-parts":[[2012,9,13]],"date-time":"2012-09-13T11:24:29Z","timestamp":1347535469000},"page":"526-539","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":83,"title":["Cell Competition Time Line: Winners Kill Losers, which Are Extruded and Engulfed by Hemocytes"],"prefix":"10.1016","volume":"2","author":[{"given":"Fidel-Nicol\u00e1s","family":"Lolo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Casas-Tint\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2012.08.012_bib1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1242\/dev.117.1.29","article-title":"Programmed cell death during Drosophila embryogenesis","volume":"117","author":"Abrams","year":"1993","journal-title":"Development"},{"key":"10.1016\/j.celrep.2012.08.012_bib2","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s12079-009-0072-4","article-title":"SPARC: a matricellular regulator of tumorigenesis","volume":"3","author":"Arnold","year":"2009","journal-title":"J. Cell Commun. Signal."},{"key":"10.1016\/j.celrep.2012.08.012_bib3","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.cub.2004.04.001","article-title":"Engulfing action of glial cells is required for programmed axon pruning during Drosophila metamorphosis","volume":"14","author":"Awasaki","year":"2004","journal-title":"Curr. Biol."},{"key":"10.1016\/j.celrep.2012.08.012_bib4","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.neuron.2006.04.027","article-title":"Essential role of the apoptotic cell engulfment genes draper and ced-6 in programmed axon pruning during Drosophila metamorphosis","volume":"50","author":"Awasaki","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2012.08.012_bib5","doi-asserted-by":"crossref","first-page":"5505","DOI":"10.1158\/0008-5472.CAN-07-6348","article-title":"Cell competition and its possible relation to cancer","volume":"68","author":"Baker","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2012.08.012_bib6","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1172\/JCI16804","article-title":"Enhanced growth of tumors in SPARC null mice is associated with changes in the ECM","volume":"111","author":"Brekken","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.celrep.2012.08.012_bib7","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1471-2121-5-26","article-title":"The phosphatidylserine receptor from Hydra is a nuclear protein with potential Fe(II) dependent oxygenase activity","volume":"5","author":"Cikala","year":"2004","journal-title":"BMC Cell Biol."},{"key":"10.1016\/j.celrep.2012.08.012_bib8","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1002\/jcb.21688","article-title":"A prototypic matricellular protein in the\u00a0tumor microenvironment\u2014where there\u2019s SPARC, there\u2019s fire","volume":"104","author":"Clark","year":"2008","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.celrep.2012.08.012_bib9","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.devcel.2010.05.014","article-title":"Oncogenic Ras diverts a host TNF tumor suppressor activity into tumor promoter","volume":"18","author":"Cordero","year":"2010","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2012.08.012_bib10","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.yexcr.2003.09.023","article-title":"Nuclear localization of the phosphatidylserine receptor protein via multiple nuclear localization signals","volume":"293","author":"Cui","year":"2004","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.celrep.2012.08.012_bib11","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0092-8674(04)00214-4","article-title":"Drosophila myc regulates organ size by inducing cell competition","volume":"117","author":"de la Cova","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2012.08.012_bib12","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S1534-5807(03)00335-6","article-title":"Thicker than blood: conserved mechanisms in Drosophila and vertebrate hematopoiesis","volume":"5","author":"Evans","year":"2003","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2012.08.012_bib13","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.4049\/jimmunol.148.7.2207","article-title":"Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages","volume":"148","author":"Fadok","year":"1992","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2012.08.012_bib14","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/35011084","article-title":"A receptor for phosphatidylserine-specific clearance of apoptotic cells","volume":"405","author":"Fadok","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2012.08.012_bib15","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1002\/jcb.20091","article-title":"SPARC and tumor growth: where the seed meets the soil?","volume":"92","author":"Framson","year":"2004","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.celrep.2012.08.012_bib16","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S1074-7613(00)80410-0","article-title":"Croquemort, a novel Drosophila hemocyte\/macrophage receptor that recognizes apoptotic cells","volume":"4","author":"Franc","year":"1996","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2012.08.012_bib17","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1126\/science.284.5422.1991","article-title":"Requirement for croquemort in phagocytosis of apoptotic cells in Drosophila","volume":"284","author":"Franc","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.celrep.2012.08.012_bib18","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0952-7915(99)80009-0","article-title":"Phagocytosis and development: back to the future","volume":"11","author":"Franc","year":"1999","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.celrep.2012.08.012_bib19","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S0896-6273(03)00289-7","article-title":"Unwrapping glial biology: Gcm target genes regulating glial development, diversification, and function","volume":"38","author":"Freeman","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2012.08.012_bib20","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.1093\/emboj\/cdf306","article-title":"Eiger, a TNF superfamily ligand that triggers the Drosophila JNK pathway","volume":"21","author":"Igaki","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2012.08.012_bib21","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1242\/dev.02860","article-title":"The Drosophila homolog of the putative phosphatidylserine receptor functions to inhibit apoptosis","volume":"134","author":"Krieser","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.celrep.2012.08.012_bib22","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1073\/pnas.0436940100","article-title":"Hemese, a hemocyte-specific transmembrane protein, affects the cellular immune response in Drosophila","volume":"100","author":"Kurucz","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2012.08.012_bib23","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.cub.2007.02.041","article-title":"Nimrod, a putative phagocytosis receptor with EGF repeats in Drosophila plasmatocytes","volume":"17","author":"Kurucz","year":"2007","journal-title":"Curr. Biol."},{"key":"10.1016\/j.celrep.2012.08.012_bib24","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1126\/science.288.5463.146","article-title":"Specification of Drosophila hematopoietic lineage by conserved transcription factors","volume":"288","author":"Lebestky","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.celrep.2012.08.012_bib25","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/j.cell.2007.03.054","article-title":"Engulfment is required for cell competition","volume":"129","author":"Li","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2012.08.012_bib26","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.neuron.2006.04.028","article-title":"The Drosophila cell corpse engulfment receptor Draper mediates glial clearance of severed axons","volume":"50","author":"MacDonald","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2012.08.012_bib27","doi-asserted-by":"crossref","first-page":"48466","DOI":"10.1074\/jbc.M408597200","article-title":"Draper-mediated and phosphatidylserine-independent phagocytosis of apoptotic cells by Drosophila hemocytes\/macrophages","volume":"279","author":"Manaka","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2012.08.012_bib28","doi-asserted-by":"crossref","first-page":"3747","DOI":"10.1242\/dev.038406","article-title":"Cell competition, growth and size control in the Drosophila wing imaginal disc","volume":"136","author":"Mart\u00edn","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.celrep.2012.08.012_bib29","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1084\/jem.182.5.1545","article-title":"Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl","volume":"182","author":"Martin","year":"1995","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.celrep.2012.08.012_bib30","doi-asserted-by":"crossref","first-page":"5718","DOI":"10.1074\/jbc.M509775200","article-title":"The presumptive phosphatidylserine receptor is dispensable for innate anti-inflammatory recognition and clearance of apoptotic cells","volume":"281","author":"Mitchell","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.celrep.2012.08.012_bib31","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0012-1606(75)90330-9","article-title":"Minutes: mutants of drosophila autonomously affecting cell division rate","volume":"42","author":"Morata","year":"1975","journal-title":"Dev. Biol."},{"key":"10.1016\/j.celrep.2012.08.012_bib32","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0092-8674(04)00262-4","article-title":"dMyc transforms cells into super-competitors","volume":"117","author":"Moreno","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2012.08.012_bib33","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/416755a","article-title":"Cells compete for decapentaplegic survival factor to prevent apoptosis in Drosophila wing development","volume":"416","author":"Moreno","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2012.08.012_bib34","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/S0960-9822(02)00954-5","article-title":"Evolution of TNF signaling mechanisms: JNK-dependent apoptosis triggered by Eiger, the Drosophila homolog of the TNF superfamily","volume":"12","author":"Moreno","year":"2002","journal-title":"Curr. Biol."},{"key":"10.1016\/j.celrep.2012.08.012_bib35","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.devcel.2011.02.007","article-title":"Elimination of oncogenic neighbors by JNK-mediated engulfment in Drosophila","volume":"20","author":"Ohsawa","year":"2011","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2012.08.012_bib36","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1242\/dmm.000950","article-title":"An innate immune response of blood cells to tumors and tissue damage in Drosophila","volume":"1","author":"Pastor-Pareja","year":"2008","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.celrep.2012.08.012_bib37","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/S1286-4579(03)00157-6","article-title":"Identification of cytoskeletal regulatory proteins required for efficient phagocytosis in Drosophila","volume":"5","author":"Pearson","year":"2003","journal-title":"Microbes Infect."},{"key":"10.1016\/j.celrep.2012.08.012_bib38","doi-asserted-by":"crossref","first-page":"171","DOI":"10.4161\/cib.4.2.14232","article-title":"The expression of SPARC in\u00a0human tumors is consistent with its role during cell competition","volume":"4","author":"Petrova","year":"2011","journal-title":"Commun. Integr. Biol."},{"key":"10.1016\/j.celrep.2012.08.012_bib39","first-page":"553","article-title":"Flower-deficient mice have reduced susceptibility to skin papilloma formation","volume":"5","author":"Petrova","year":"2012","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.celrep.2012.08.012_bib40","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.devcel.2010.09.004","article-title":"Drosophila SPARC is a self-protective signal expressed by loser cells during cell competition","volume":"19","author":"Portela","year":"2010","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2012.08.012_bib41","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.devcel.2010.05.010","article-title":"Flower forms an extracellular code that reveals the fitness of a cell to its neighbors in Drosophila","volume":"18","author":"Rhiner","year":"2010","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2012.08.012_bib42","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1016\/S0960-9822(01)00587-5","article-title":"An epithelial cell destined for apoptosis signals its neighbors to extrude it by an actin- and myosin-dependent mechanism","volume":"11","author":"Rosenblatt","year":"2001","journal-title":"Curr. Biol."},{"key":"10.1016\/j.celrep.2012.08.012_bib43","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1084\/jem.20030202","article-title":"Leukocyte, rather than tumor-produced SPARC, determines stroma and collagen type IV deposition in mammary carcinoma","volume":"198","author":"Sangaletti","year":"2003","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.celrep.2012.08.012_bib44","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/0012-1606(79)90284-7","article-title":"Parameters of cell competition in the compartments of the wing disc of Drosophila","volume":"69","author":"Simpson","year":"1979","journal-title":"Dev. Biol."},{"key":"10.1016\/j.celrep.2012.08.012_bib45","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1242\/dev.120.7.1829","article-title":"Embryonic origin of hemocytes and their relationship to cell death in Drosophila","volume":"120","author":"Tepass","year":"1994","journal-title":"Development"},{"key":"10.1016\/j.celrep.2012.08.012_bib46","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/ncb1050","article-title":"Hippo promotes proliferation arrest and apoptosis in the Salvador\/Warts pathway","volume":"5","author":"Udan","year":"2003","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2012.08.012_bib47","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1023\/A:1009650917818","article-title":"Cell surface exposure of phosphatidylserine during apoptosis is phylogenetically conserved","volume":"3","author":"van den Eijnde","year":"1998","journal-title":"Apoptosis"},{"key":"10.1016\/j.celrep.2012.08.012_bib48","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1084\/jem.182.5.1597","article-title":"Mechanisms of phosphatidylserine exposure, a phagocyte recognition signal, on apoptotic T\u00a0lymphocytes","volume":"182","author":"Verhoven","year":"1995","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.celrep.2012.08.012_bib49","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0092-8674(01)00190-8","article-title":"CED-1 is a transmembrane receptor that mediates cell corpse engulfment in C. elegans","volume":"104","author":"Zhou","year":"2001","journal-title":"Cell"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124712002379?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124712002379?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T09:20:29Z","timestamp":1761902429000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124712002379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["S2211124712002379"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2012.08.012","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2012,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cell Competition Time Line: Winners Kill Losers, which Are Extruded and Engulfed by Hemocytes","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2012.08.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}