{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:50:06Z","timestamp":1791179406740,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,26]],"date-time":"2013-07-26T00:00:00Z","timestamp":1374796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1016\/j.celrep.2013.07.021","type":"journal-article","created":{"date-parts":[[2013,8,15]],"date-time":"2013-08-15T13:59:29Z","timestamp":1376575169000},"page":"709-723","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":96,"title":["The Calcineurin-NFAT-Angiopoietin-2 Signaling Axis in Lung Endothelium Is Critical for the Establishment of Lung Metastases"],"prefix":"10.1016","volume":"4","author":[{"given":"Takashi","family":"Minami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuying","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keri","family":"Schadler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-ichi","family":"Suehiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Osawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Oike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Miura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Naito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuhiko","family":"Kodama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Ryeom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2013.07.021_bib1","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1038\/nature08062","article-title":"Down\u2019s syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1","volume":"459","author":"Baek","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2013.07.021_bib2","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/nrc2442","article-title":"Modes of resistance to anti-angiogenic therapy","volume":"8","author":"Bergers","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.celrep.2013.07.021_bib3","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/nm871","article-title":"Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells","volume":"9","author":"De Palma","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2013.07.021_bib4","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ccr.2005.08.002","article-title":"Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors","volume":"8","author":"De Palma","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2013.07.021_bib5","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.yexcr.2013.03.011","article-title":"Angiopoietin signaling in the vasculature","volume":"319","author":"Eklund","year":"2013","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.celrep.2013.07.021_bib6","doi-asserted-by":"crossref","first-page":"e34172","DOI":"10.1371\/journal.pone.0034172","article-title":"A cell permeable peptide inhibitor of NFAT inhibits macrophage cytokine expression and ameliorates experimental colitis","volume":"7","author":"Elloumi","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.celrep.2013.07.021_bib7","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ccr.2008.11.012","article-title":"Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche","volume":"15","author":"Erler","year":"2009","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2013.07.021_bib8","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1182\/blood-2012-02-404475","article-title":"NFAT control of innate immunity","volume":"120","author":"Fric","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2013.07.021_bib9","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1158\/0008-5472.CAN-12-4697","article-title":"Angiopoietin-2: an attractive target for improved antiangiogenic tumor therapy","volume":"73","author":"Gerald","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2013.07.021_bib10","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1161\/01.ATV.0000140819.81839.0e","article-title":"Expression of angiopoietin-2 in endothelial cells is controlled by positive and negative regulatory promoter elements","volume":"24","author":"Hegen","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.celrep.2013.07.021_bib11","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1182\/blood-2004-01-0273","article-title":"Down syndrome critical region protein 1 (DSCR1), a novel VEGF target gene that regulates expression of inflammatory markers on activated endothelial cells","volume":"104","author":"Hesser","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2013.07.021_bib12","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1038\/ncb1794","article-title":"The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase","volume":"10","author":"Hiratsuka","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2013.07.021_bib13","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1126\/science.284.5422.1994","article-title":"Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF","volume":"284","author":"Holash","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.celrep.2013.07.021_bib14","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1038\/emboj.2011.173","article-title":"Epigenetically coordinated GATA2 binding is necessary for endothelium-specific endomucin expression","volume":"30","author":"Kanki","year":"2011","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2013.07.021_bib15","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/nature04186","article-title":"VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche","volume":"438","author":"Kaplan","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2013.07.021_bib16","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1161\/01.ATV.0000089326.63053.9A","article-title":"Ets motifs are necessary for endothelial cell-specific expression of a 723-bp Tie-2 promoter\/enhancer in Hprt targeted transgenic mice","volume":"23","author":"Minami","year":"2003","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.celrep.2013.07.021_bib17","doi-asserted-by":"crossref","first-page":"50537","DOI":"10.1074\/jbc.M406454200","article-title":"Vascular endothelial growth factor- and thrombin-induced termination factor, Down syndrome critical region-1, attenuates endothelial cell proliferation and angiogenesis","volume":"279","author":"Minami","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2013.07.021_bib18","doi-asserted-by":"crossref","first-page":"20503","DOI":"10.1074\/jbc.M513112200","article-title":"Thrombin-induced autoinhibitory factor, Down syndrome critical region-1, attenuates NFAT-dependent vascular cell adhesion molecule-1 expression and inflammation in the endothelium","volume":"281","author":"Minami","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2013.07.021_bib19","first-page":"2257","article-title":"The Down syndrome critical region gene 1 short variant promoters direct vascular bed-specific gene expression during inflammation in mice","volume":"119","author":"Minami","year":"2009","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2013.07.021_bib20","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1038\/ni966","article-title":"The threshold pattern of calcineurin-dependent gene expression is altered by loss of the endogenous inhibitor calcipressin","volume":"4","author":"Ryeom","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2013.07.021_bib21","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.ccr.2008.02.018","article-title":"Targeted deletion of the calcineurin inhibitor DSCR1 suppresses tumor growth","volume":"13","author":"Ryeom","year":"2008","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2013.07.021_bib22","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1172\/JCI58196","article-title":"The yin, the yang, and the angiopoietin-1","volume":"121","author":"Saharinen","year":"2011","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2013.07.021_bib23","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.molmed.2011.01.015","article-title":"VEGF and angiopoietin signaling in tumor angiogenesis and metastasis","volume":"17","author":"Saharinen","year":"2011","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.celrep.2013.07.021_bib24","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1002\/jcp.21558","article-title":"The angiopoietin-2 gene of endothelial cells is up-regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA-2 and Ets-1","volume":"217","author":"Simon","year":"2008","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.celrep.2013.07.021_bib25","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.cell.2011.09.024","article-title":"Tumor metastasis: molecular insights and evolving paradigms","volume":"147","author":"Valastyan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2013.07.021_bib26","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1172\/JCI44562","article-title":"TIE2-expressing macrophages limit the therapeutic efficacy of the vascular-disrupting agent combretastatin A4 phosphate in mice","volume":"121","author":"Welford","year":"2011","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2013.07.021_bib27","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1517\/17460441.2012.695774","article-title":"Anti-angiogenic drug discovery: lessons from the past and thoughts for the future","volume":"7","author":"Wu","year":"2012","journal-title":"Expert Opin. Drug Discov."},{"key":"10.1016\/j.celrep.2013.07.021_bib28","first-page":"28","article-title":"Fitting a mixture model by expectation maximization to discover motifs in biopolymers","volume":"2","author":"Bailey","year":"1994","journal-title":"Proc. Int. Conf. Intell. Syst. Mol. Biol."},{"key":"10.1016\/j.celrep.2013.07.021_bib29","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.1093\/nar\/gkp1012","article-title":"Sole-Search: an integrated analysis program for peak detection and functional annotation using ChIP-seq data","volume":"38","author":"Blahnik","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2013.07.021_bib30","doi-asserted-by":"crossref","first-page":"R24","DOI":"10.1186\/gb-2007-8-2-r24","article-title":"Quantifying similarity between motifs","volume":"8","author":"Gupta","year":"2007","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2013.07.021_bib31","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nmeth.1246","article-title":"Genome-wide analysis of transcription factor binding sites based on ChIP-Seq data","volume":"5","author":"Valouev","year":"2008","journal-title":"Nat. Methods"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124713003835?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124713003835?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T09:24:32Z","timestamp":1761902672000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124713003835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["S2211124713003835"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2013.07.021","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2013,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Calcineurin-NFAT-Angiopoietin-2 Signaling Axis in Lung Endothelium Is Critical for the Establishment of Lung Metastases","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2013.07.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2013.07.034","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}