{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:45:11Z","timestamp":1792457111290,"version":"4.5.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,1,24]],"date-time":"2014-01-24T00:00:00Z","timestamp":1390521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1016\/j.celrep.2014.01.031","type":"journal-article","created":{"date-parts":[[2014,2,27]],"date-time":"2014-02-27T12:16:23Z","timestamp":1393503383000},"page":"836-843","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":373,"title":["The SIRT1 Activator SRT1720 Extends Lifespan and Improves Health of Mice Fed a Standard Diet"],"prefix":"10.1016","volume":"6","author":[{"given":"Sarah\u00a0J.","family":"Mitchell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Martin-Montalvo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evi\u00a0M.","family":"Mercken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector\u00a0H.","family":"Palacios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa\u00a0M.","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gelareh","family":"Abulwerdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin\u00a0K.","family":"Minor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George\u00a0P.","family":"Vlasuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James\u00a0L.","family":"Ellis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David\u00a0A.","family":"Sinclair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Dawson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David\u00a0B.","family":"Allison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin\u00a0G.","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Bernier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"de\u00a0Cabo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2014.01.031_bib1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.cmet.2008.08.014","article-title":"SirT1 gain of function increases energy efficiency and prevents diabetes in mice","volume":"8","author":"Banks","year":"2008","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2014.01.031_bib2","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature05354","article-title":"Resveratrol improves health and survival of mice on a high-calorie diet","volume":"444","author":"Baur","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2014.01.031_bib3","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nrd3738","article-title":"Are sirtuins viable targets for improving healthspan and lifespan?","volume":"11","author":"Baur","year":"2012","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.celrep.2014.01.031_bib4","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.1073\/pnas.1214266110","article-title":"Pharmacological modulation of circadian rhythms by synthetic activators of the deacetylase SIRT1","volume":"110","author":"Bellet","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2014.01.031_bib5","doi-asserted-by":"crossref","first-page":"19270","DOI":"10.1074\/jbc.M110.200311","article-title":"Negative regulation of STAT3 protein-mediated cellular respiration by SIRT1 protein","volume":"286","author":"Bernier","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2014.01.031_bib6","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1111\/j.1365-2141.2011.08888.x","article-title":"Preclinical evaluation of a novel SIRT1 modulator SRT1720 in multiple myeloma cells","volume":"155","author":"Chauhan","year":"2011","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.celrep.2014.01.031_bib7","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S1525-1578(10)60455-2","article-title":"Analysis of microarray data using Z score transformation","volume":"5","author":"Cheadle","year":"2003","journal-title":"J.\u00a0Mol. Diagn."},{"key":"10.1016\/j.celrep.2014.01.031_bib8","doi-asserted-by":"crossref","first-page":"e25192","DOI":"10.1371\/journal.pone.0025192","article-title":"Anticancer effects of 15d-prostaglandin-J2 in wild-type and doxorubicin-resistant ovarian cancer cells: novel actions on SIRT1 and HDAC","volume":"6","author":"de Jong","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.celrep.2014.01.031_bib9","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1111\/j.1476-5381.2011.01716.x","article-title":"Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats","volume":"165","author":"Deblon","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.celrep.2014.01.031_bib10","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/978-1-62703-637-5_15","article-title":"In\u00a0vivo measurement of the acetylation state of sirtuin substrates as a proxy for sirtuin activity","volume":"1077","author":"Dominy","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.celrep.2014.01.031_bib11","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.cmet.2008.08.017","article-title":"Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation","volume":"8","author":"Feige","year":"2008","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2014.01.031_bib12","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1749-6632.2000.tb06651.x","article-title":"Inflamm-aging. An evolutionary perspective on immunosenescence","volume":"908","author":"Franceschi","year":"2000","journal-title":"Ann. N Y Acad. Sci."},{"key":"10.1016\/j.celrep.2014.01.031_bib13","first-page":"225","article-title":"Circadian rhythms, aging, and life span in mammals","volume":"26","author":"Froy","year":"2011","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.celrep.2014.01.031_bib14","doi-asserted-by":"crossref","first-page":"173","DOI":"10.2174\/138920011795016890","article-title":"Regulation of hepatic cytochromes p450 by lipids and cholesterol","volume":"12","author":"Hafner","year":"2011","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.celrep.2014.01.031_bib15","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/nature08221","article-title":"Rapamycin fed late in life extends lifespan in genetically heterogeneous mice","volume":"460","author":"Harrison","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2014.01.031_bib16","first-page":"622","article-title":"The mitochondrial ribosomal protein of the large subunit, Afo1p, determines cellular longevity through mitochondrial back-signaling via TOR1","volume":"1","author":"Heeren","year":"2009","journal-title":"Aging (Albany, N.Y. Online)"},{"key":"10.1016\/j.celrep.2014.01.031_bib17","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.2337\/db09-1324","article-title":"Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue","volume":"59","author":"Houde","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.celrep.2014.01.031_bib18","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/nature12188","article-title":"Mitonuclear protein imbalance as a conserved longevity mechanism","volume":"497","author":"Houtkooper","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2014.01.031_bib19","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1126\/science.1231097","article-title":"Evidence for a common mechanism of SIRT1 regulation by allosteric activators","volume":"339","author":"Hubbard","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.celrep.2014.01.031_bib20","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.4155\/fmc.10.257","article-title":"SIRT1-independent mechanisms of the putative sirtuin enzyme activators SRT1720 and SRT2183","volume":"2","author":"Huber","year":"2010","journal-title":"Future Med Chem"},{"key":"10.1016\/j.celrep.2014.01.031_bib21","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/j.1440-1843.2012.02284.x","article-title":"Sirtuin 1 activator SRT1720 suppresses inflammation in an ovalbumin-induced mouse model of asthma","volume":"18","author":"Ichikawa","year":"2013","journal-title":"Respirology"},{"key":"10.1016\/j.celrep.2014.01.031_bib22","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1038\/srep02116","article-title":"Location- and sex-specific differences in weight and motor coordination in two commonly used mouse strains","volume":"3","author":"Kov\u00e1cs","year":"2013","journal-title":"Sci Rep"},{"key":"10.1016\/j.celrep.2014.01.031_bib23","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1038\/ni1012","article-title":"Suppressors of cytokine signaling and immunity","volume":"4","author":"Kubo","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2014.01.031_bib24","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1126\/science.1215135","article-title":"Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity","volume":"335","author":"Lamming","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.celrep.2014.01.031_bib25","doi-asserted-by":"crossref","first-page":"124ra127","DOI":"10.1126\/scitranslmed.3003293","article-title":"Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy","volume":"4","author":"Lee","year":"2012","journal-title":"Sci. Translat. Med."},{"key":"10.1016\/j.celrep.2014.01.031_bib26","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1038\/ncomms3192","article-title":"Metformin improves healthspan and lifespan in mice","volume":"4","author":"Martin-Montalvo","year":"2013","journal-title":"Nat Commun"},{"key":"10.1016\/j.celrep.2014.01.031_bib27","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/nature06261","article-title":"Small molecule activators of\u00a0SIRT1 as therapeutics for the treatment of type 2 diabetes","volume":"450","author":"Milne","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2014.01.031_bib28","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/srep00070","article-title":"SRT1720 improves survival and healthspan of obese mice","volume":"1","author":"Minor","year":"2011","journal-title":"Sci Rep"},{"key":"10.1016\/j.celrep.2014.01.031_bib29","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1124\/mol.110.065961","article-title":"Amurensin G, a potent natural SIRT1 inhibitor, rescues doxorubicin responsiveness via down-regulation of multidrug resistance 1","volume":"78","author":"Oh","year":"2010","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.celrep.2014.01.031_bib30","doi-asserted-by":"crossref","first-page":"8340","DOI":"10.1074\/jbc.M109.088682","article-title":"SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1","volume":"285","author":"Pacholec","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2014.01.031_bib31","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.cmet.2008.06.011","article-title":"Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span","volume":"8","author":"Pearson","year":"2008","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2014.01.031_bib32","doi-asserted-by":"crossref","first-page":"9793","DOI":"10.1073\/pnas.0802917105","article-title":"Sirt1 protects against high-fat diet-induced metabolic damage","volume":"105","author":"Pfluger","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2014.01.031_bib33","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.cmet.2011.05.010","article-title":"Life span extension via eIF4G inhibition is mediated by posttranscriptional remodeling of stress response gene expression in C. elegans","volume":"14","author":"Rogers","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2014.01.031_bib34","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1093\/gerona\/gls070","article-title":"Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice","volume":"68","author":"Strong","year":"2013","journal-title":"J.\u00a0Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.celrep.2014.01.031_bib35","doi-asserted-by":"crossref","first-page":"603","DOI":"10.2307\/2532572","article-title":"Nonparametric estimation for the difference or ratio of median failure times","volume":"49","author":"Su","year":"1993","journal-title":"Biometrics"},{"key":"10.1016\/j.celrep.2014.01.031_bib36","first-page":"1726","article-title":"SRT1720, a SIRT1 activator, promotes tumor cell migration, and lung metastasis of breast cancer in mice","volume":"27","author":"Suzuki","year":"2012","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.celrep.2014.01.031_bib37","doi-asserted-by":"crossref","first-page":"4332","DOI":"10.1096\/fj.12-216473","article-title":"Impaired SIRT1 nucleocytoplasmic shuttling in the senescent heart during ischemic stress","volume":"27","author":"Tong","year":"2013","journal-title":"FASEB J."},{"key":"10.1016\/j.celrep.2014.01.031_bib38","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.mad.2004.07.003","article-title":"Statistical methods for testing effects on \u201cmaximum lifespan\u201d","volume":"125","author":"Wang","year":"2004","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.celrep.2014.01.031_bib39","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.exer.2005.01.024","article-title":"Age-related cataract progression in five mouse models for anti-oxidant protection or hormonal influence","volume":"81","author":"Wolf","year":"2005","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.celrep.2014.01.031_bib40","doi-asserted-by":"crossref","first-page":"E1179","DOI":"10.1152\/ajpendo.90997.2008","article-title":"Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice","volume":"297","author":"Yamazaki","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.celrep.2014.01.031_bib41","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1172\/JCI60132","article-title":"SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice","volume":"122","author":"Yao","year":"2012","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2014.01.031_bib42","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3892\/mmr.2013.1460","article-title":"SIRT1 prevents atherosclerosis via liver-X-receptor and NF-\u03baB signaling in a U937 cell model","volume":"8","author":"Zeng","year":"2013","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.celrep.2014.01.031_bib43","doi-asserted-by":"crossref","first-page":"e31431","DOI":"10.1371\/journal.pone.0031431","article-title":"Activating transcription factor 4 confers a multidrug resistance phenotype to gastric cancer cells through transactivation of SIRT1 expression","volume":"7","author":"Zhu","year":"2012","journal-title":"PLoS ONE"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124714000655?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124714000655?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T09:27:32Z","timestamp":1761902852000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124714000655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["S2211124714000655"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2014.01.031","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718293833.793515608","asserted-by":"object"}]},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The SIRT1 Activator SRT1720 Extends Lifespan and Improves Health of Mice Fed a Standard Diet","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2014.01.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}