{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T04:16:22Z","timestamp":1778818582802,"version":"3.51.4"},"reference-count":39,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,4,14]],"date-time":"2014-04-14T00:00:00Z","timestamp":1397433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.celrep.2014.04.013","type":"journal-article","created":{"date-parts":[[2014,5,9]],"date-time":"2014-05-09T19:47:12Z","timestamp":1399664832000},"page":"951-960","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"title":["Cadm4 Restricts the Production of Cardiac Outflow Tract Progenitor Cells"],"prefix":"10.1016","volume":"7","author":[{"given":"Xin-Xin\u00a0I.","family":"Zeng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah","family":"Yelon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2014.04.013_bib1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ygeno.2005.08.017","article-title":"Bioinformatic characterization of the SynCAM family of immunoglobulin-like domain-containing adhesion molecules","volume":"87","author":"Biederer","year":"2006","journal-title":"Genomics"},{"key":"10.1016\/j.celrep.2014.04.013_bib2","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1126\/science.1072356","article-title":"SynCAM, a synaptic adhesion molecule that drives synapse assembly","volume":"297","author":"Biederer","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.celrep.2014.04.013_bib3","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/nrg1710","article-title":"Building the mammalian heart from two sources of myocardial cells","volume":"6","author":"Buckingham","year":"2005","journal-title":"Nat. Rev. Genet."},{"issue":"Suppl 1","key":"10.1016\/j.celrep.2014.04.013_bib4","doi-asserted-by":"crossref","first-page":"4570","DOI":"10.1073\/pnas.1000072107","article-title":"Epithelial cell proliferation in the developing zebrafish intestine is regulated by the Wnt pathway and microbial signaling via Myd88","volume":"108","author":"Cheesman","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2014.04.013_bib5","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1242\/dev.030924","article-title":"Distinct phases of cardiomyocyte differentiation regulate growth of the zebrafish heart","volume":"136","author":"de Pater","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.celrep.2014.04.013_bib6","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.ydbio.2009.10.009","article-title":"The role of secondary heart field in cardiac development","volume":"336","author":"Dyer","year":"2009","journal-title":"Dev. Biol."},{"key":"10.1016\/j.celrep.2014.04.013_bib7","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.ydbio.2009.03.028","article-title":"Sonic hedgehog maintains proliferation in secondary heart field progenitors and is required for normal arterial pole formation","volume":"330","author":"Dyer","year":"2009","journal-title":"Dev. Biol."},{"key":"10.1016\/j.celrep.2014.04.013_bib8","doi-asserted-by":"crossref","first-page":"3215","DOI":"10.1242\/dev.052225","article-title":"Hand2 ensures an appropriate environment for cardiac fusion by limiting Fibronectin function","volume":"137","author":"Garavito-Aguilar","year":"2010","journal-title":"Development"},{"key":"10.1016\/j.celrep.2014.04.013_bib9","doi-asserted-by":"crossref","first-page":"10950","DOI":"10.1523\/JNEUROSCI.0571-13.2013","article-title":"Genetic deletion of Cadm4 results in myelin abnormalities resembling Charcot-Marie-Tooth neuropathy","volume":"33","author":"Golan","year":"2013","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2014.04.013_bib10","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1242\/dev.088351","article-title":"Zebrafish second heart field development relies on progenitor specification in anterior lateral plate mesoderm and nkx2.5 function","volume":"140","author":"Guner-Ataman","year":"2013","journal-title":"Development"},{"key":"10.1016\/j.celrep.2014.04.013_bib11","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1242\/dev.061473","article-title":"Zebrafish cardiac development requires a conserved secondary heart field","volume":"138","author":"Hami","year":"2011","journal-title":"Development"},{"key":"10.1016\/j.celrep.2014.04.013_bib12","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1002\/dvdy.10356","article-title":"Germ-line transmission of a myocardium-specific GFP transgene reveals critical regulatory elements in the cardiac myosin light chain 2 promoter of zebrafish","volume":"228","author":"Huang","year":"2003","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.celrep.2014.04.013_bib13","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.1242\/dev.051565","article-title":"Arterial pole progenitors interpret opposing FGF\/BMP signals to proliferate or differentiate","volume":"137","author":"Hutson","year":"2010","journal-title":"Development"},{"key":"10.1016\/j.celrep.2014.04.013_bib14","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1242\/dev.02408","article-title":"Fgf8 is required for anterior heart field development","volume":"133","author":"Ilagan","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.celrep.2014.04.013_bib15","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/B978-0-12-387786-4.00002-6","article-title":"The second heart field","volume":"100","author":"Kelly","year":"2012","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.celrep.2014.04.013_bib16","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.ydbio.2011.03.028","article-title":"Mef2cb regulates late myocardial cell addition from a second heart field-like population of progenitors in zebrafish","volume":"354","author":"Lazic","year":"2011","journal-title":"Dev. Biol."},{"key":"10.1016\/j.celrep.2014.04.013_bib17","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1016\/j.cub.2003.11.055","article-title":"heart of glass regulates the concentric growth of the heart in zebrafish","volume":"13","author":"Mably","year":"2003","journal-title":"Curr. Biol."},{"key":"10.1016\/j.celrep.2014.04.013_bib18","doi-asserted-by":"crossref","first-page":"16621","DOI":"10.1523\/JNEUROSCI.4769-10.2010","article-title":"DeltaA\/DeltaD regulate multiple and temporally distinct phases of notch signaling during dopaminergic neurogenesis in zebrafish","volume":"30","author":"Mahler","year":"2010","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2014.04.013_bib19","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.ydbio.2008.06.033","article-title":"Reiterative roles for FGF signaling in the establishment of size and proportion of the zebrafish heart","volume":"321","author":"Marques","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.celrep.2014.04.013_bib20","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1242\/jcs.054312","article-title":"Adhesion molecules in the stem cell niche\u2014more than just staying in shape?","volume":"123","author":"Marthiens","year":"2010","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.celrep.2014.04.013_bib21","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1083\/jcb.200705132","article-title":"Nectin-like proteins mediate axon Schwann cell interactions along the internode and are essential for myelination","volume":"178","author":"Maurel","year":"2007","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.celrep.2014.04.013_bib22","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1002\/wdev.98","article-title":"Cardiac outflow tract anomalies","volume":"2","author":"Neeb","year":"2013","journal-title":"Wiley Interdiscip. Rev. Dev. Biol."},{"key":"10.1016\/j.celrep.2014.04.013_bib23","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1038\/ncb2862","article-title":"Heart field origin of great vessel precursors relies on nkx2.5-mediated vasculogenesis","volume":"15","author":"Paffett-Lugassy","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2014.04.013_bib24","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1242\/dev.02367","article-title":"Required, tissue-specific roles for Fgf8 in outflow tract formation and remodeling","volume":"133","author":"Park","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.celrep.2014.04.013_bib25","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1242\/dev.025437","article-title":"An FGF autocrine loop initiated in second heart field mesoderm regulates morphogenesis at the arterial pole of the heart","volume":"135","author":"Park","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.celrep.2014.04.013_bib26","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/dvdy.21397","article-title":"Six cadm\/SynCAM genes are expressed in the nervous system of developing zebrafish","volume":"237","author":"Pietri","year":"2008","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.celrep.2014.04.013_bib27","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.cell.2007.01.042","article-title":"An Nkx2-5\/Bmp2\/Smad1 negative feedback loop controls heart progenitor specification and proliferation","volume":"128","author":"Prall","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2014.04.013_bib28","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1242\/dev.127.2.225","article-title":"Induction and differentiation of the zebrafish heart requires fibroblast growth factor 8 (fgf8\/acerebellar)","volume":"127","author":"Reifers","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.celrep.2014.04.013_bib29","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1161\/CIRCRESAHA.109.194464","article-title":"Signaling pathways controlling second heart field development","volume":"104","author":"Rochais","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.celrep.2014.04.013_bib30","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1073\/pnas.0712344105","article-title":"Retinoic acid deficiency alters second heart field formation","volume":"105","author":"Ryckebusch","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2014.04.013_bib31","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1002\/dvdy.21570","article-title":"Retinoic acid controls heart anteroposterior patterning by down-regulating Isl1 through the Fgf8 pathway","volume":"237","author":"Sirbu","year":"2008","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.celrep.2014.04.013_bib32","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ydbio.2011.07.022","article-title":"Restraint of Fgf8 signaling by retinoic acid signaling is required for proper heart and forelimb formation","volume":"358","author":"Sorrell","year":"2011","journal-title":"Dev. Biol."},{"key":"10.1016\/j.celrep.2014.04.013_bib33","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/nn1915","article-title":"A central role for Necl4 (SynCAM4) in Schwann cell-axon interaction and myelination","volume":"10","author":"Spiegel","year":"2007","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2014.04.013_bib34","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/gtc.12056","article-title":"Interaction of Necl-4\/CADM4 with ErbB3 and integrin \u03b16 \u03b24 and inhibition of ErbB2\/ErbB3 signaling and hemidesmosome disassembly","volume":"18","author":"Sugiyama","year":"2013","journal-title":"Genes Cells"},{"key":"10.1016\/j.celrep.2014.04.013_bib35","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.1242\/dev.051649","article-title":"BMP-mediated inhibition of FGF signaling promotes cardiomyocyte differentiation of anterior heart field progenitors","volume":"137","author":"Tirosh-Finkel","year":"2010","journal-title":"Development"},{"key":"10.1016\/j.celrep.2014.04.013_bib36","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1161\/CIRCRESAHA.108.185843","article-title":"A caudal proliferating growth center contributes to both poles of the forming heart tube","volume":"104","author":"van den Berg","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.celrep.2014.04.013_bib37","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1161\/CIRCRESAHA.109.201665","article-title":"Role of mesodermal FGF8 and FGF10 overlaps in the development of the arterial pole of the heart and pharyngeal arch arteries","volume":"106","author":"Watanabe","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.celrep.2014.04.013_bib38","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.devcel.2012.06.005","article-title":"The LIM protein Ajuba restricts the second heart\u00a0field\u00a0progenitor pool by regulating Isl1 activity","volume":"23","author":"Witzel","year":"2012","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2014.04.013_bib39","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/nature10094","article-title":"Latent TGF-\u03b2 binding\u00a0protein 3 identifies a second heart field in zebrafish","volume":"474","author":"Zhou","year":"2011","journal-title":"Nature"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124714003003?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124714003003?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T09:30:35Z","timestamp":1761903035000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124714003003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["S2211124714003003"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2014.04.013","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cadm4 Restricts the Production of Cardiac Outflow Tract Progenitor Cells","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2014.04.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}