{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:48:22Z","timestamp":1791355702772,"version":"4.3.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,10,2]],"date-time":"2014-10-02T00:00:00Z","timestamp":1412208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1016\/j.celrep.2014.10.004","type":"journal-article","created":{"date-parts":[[2014,10,30]],"date-time":"2014-10-30T13:02:07Z","timestamp":1414674127000},"page":"918-929","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":114,"title":["Tumor Suppressor p53 Alters Host Cell Metabolism to Limit Chlamydia trachomatis Infection"],"prefix":"10.1016","volume":"9","author":[{"given":"Christine","family":"Siegl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhupesh\u00a0K.","family":"Prusty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karthika","family":"Karunakaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Wischhusen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Rudel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2014.10.004_bib1","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1054\/bjoc.2001.2128","article-title":"Activation and activities of the p53 tumour suppressor protein","volume":"85","author":"B\u00e1lint","year":"2001","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.celrep.2014.10.004_bib2","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cell.2006.05.036","article-title":"TIGAR, a p53-inducible regulator of glycolysis and apoptosis","volume":"126","author":"Bensaad","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2014.10.004_bib3","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.chom.2012.01.013","article-title":"Calpain activation by the Shigella flexneri effector VirA regulates key steps in the formation and life of the bacterium\u2019s epithelial niche","volume":"11","author":"Bergounioux","year":"2012","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.celrep.2014.10.004_bib4","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1111\/j.1462-5822.2010.01473.x","article-title":"Chlamydia trachomatis-infected host cells resist dsRNA-induced apoptosis","volume":"12","author":"B\u00f6hme","year":"2010","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.celrep.2014.10.004_bib5","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1128\/IAI.00725-09","article-title":"Production of reactive oxygen species is turned on and rapidly shut down in epithelial cells infected with Chlamydia trachomatis","volume":"78","author":"Boncompain","year":"2010","journal-title":"Infect. Immun."},{"key":"10.1016\/j.celrep.2014.10.004_bib6","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1126\/science.282.5393.1497","article-title":"Requirement for p53 and p21 to sustain G2 arrest after DNA damage","volume":"282","author":"Bunz","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.celrep.2014.10.004_bib7","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.chom.2013.05.010","article-title":"Chlamydia infection promotes host DNA damage and proliferation but impairs the DNA damage response","volume":"13","author":"Chumduri","year":"2013","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.celrep.2014.10.004_bib8","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/BF00203619","article-title":"Increased induction of apoptosis in mononuclear cells of a glucose-6-phosphate dehydrogenase deficient patient","volume":"73","author":"Efferth","year":"1995","journal-title":"J.\u00a0Mol. Med."},{"key":"10.1016\/j.celrep.2014.10.004_bib9","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3389\/fcimb.2013.00024","article-title":"Metabolic host responses to infection by intracellular bacterial pathogens","volume":"3","author":"Eisenreich","year":"2013","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.celrep.2014.10.004_bib10","doi-asserted-by":"crossref","first-page":"4385","DOI":"10.1007\/s00018-013-1392-3","article-title":"The opportunistic pathogen Pseudomonas aeruginosa activates the DNA double-strand break signaling and repair pathway in infected cells","volume":"70","author":"Elsen","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.celrep.2014.10.004_bib11","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1084\/jem.187.4.487","article-title":"Inhibition of apoptosis in chlamydia-infected cells: blockade of mitochondrial cytochrome c release and caspase activation","volume":"187","author":"Fan","year":"1998","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2014.10.004_bib12","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1038\/nature07986","article-title":"Cytoplasmic functions of the tumour suppressor p53","volume":"458","author":"Green","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2014.10.004_bib13","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/ncb2172","article-title":"p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase","volume":"13","author":"Jiang","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2014.10.004_bib14","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/nrc2723","article-title":"The first 30 years of p53: growing ever more complex","volume":"9","author":"Levine","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.celrep.2014.10.004_bib15","doi-asserted-by":"crossref","first-page":"948","DOI":"10.18632\/oncotarget.389","article-title":"Regulation of glucose metabolism by p53: emerging new roles for the tumor suppressor","volume":"2","author":"Madan","year":"2011","journal-title":"Oncotarget"},{"key":"10.1016\/j.celrep.2014.10.004_bib16","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/75586","article-title":"A common polymorphism acts as an intragenic modifier of mutant p53 behaviour","volume":"25","author":"Marin","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2014.10.004_bib17","first-page":"1815","article-title":"DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways","volume":"14","author":"Nelson","year":"1994","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.celrep.2014.10.004_bib18","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1126\/science.1127059","article-title":"Escherichia coli induces DNA double-strand breaks in eukaryotic cells","volume":"313","author":"Nougayr\u00e8de","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.celrep.2014.10.004_bib19","doi-asserted-by":"crossref","first-page":"21843","DOI":"10.1074\/jbc.M109745200","article-title":"Akt enhances Mdm2-mediated ubiquitination and degradation of p53","volume":"277","author":"Ogawara","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2014.10.004_bib20","doi-asserted-by":"crossref","first-page":"19781","DOI":"10.1073\/pnas.1212831109","article-title":"Developmental stage-specific metabolic and transcriptional activity of Chlamydia trachomatis in an axenic medium","volume":"109","author":"Omsland","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2014.10.004_bib21","doi-asserted-by":"crossref","first-page":"5209","DOI":"10.1002\/j.1460-2075.1995.tb00205.x","article-title":"Targeted disruption of the housekeeping gene encoding glucose 6-phosphate dehydrogenase (G6PD): G6PD is dispensable for pentose synthesis but essential for defense against oxidative stress","volume":"14","author":"Pandolfi","year":"1995","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2014.10.004_bib22","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/humu.20495","article-title":"Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database","volume":"28","author":"Petitjean","year":"2007","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.celrep.2014.10.004_bib23","doi-asserted-by":"crossref","first-page":"e47427","DOI":"10.1371\/journal.pone.0047427","article-title":"Imbalanced oxidative stress causes chlamydial persistence during non-productive human herpes virus co-infection","volume":"7","author":"Prusty","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.celrep.2014.10.004_bib24","doi-asserted-by":"crossref","first-page":"e1004033","DOI":"10.1371\/journal.pgen.1004033","article-title":"Reactivation of chromosomally integrated human herpesvirus-6 by telomeric circle formation","volume":"9","author":"Prusty","year":"2013","journal-title":"PLoS Genet."},{"key":"10.1016\/j.celrep.2014.10.004_bib25","doi-asserted-by":"crossref","first-page":"e3102","DOI":"10.1371\/journal.pone.0003102","article-title":"Mcl-1 is a key regulator of apoptosis resistance in Chlamydia trachomatis-infected cells","volume":"3","author":"Rajalingam","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1016\/j.celrep.2014.10.004_bib26","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.mib.2009.11.002","article-title":"Acquisition of nutrients by Chlamydiae: unique challenges of living in an intracellular compartment","volume":"13","author":"Saka","year":"2010","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.celrep.2014.10.004_bib27","doi-asserted-by":"crossref","first-page":"5148","DOI":"10.1038\/sj.onc.1202898","article-title":"Telomere shortening triggers a p53-dependent cell cycle arrest via accumulation of G-rich single stranded DNA fragments","volume":"18","author":"Saretzki","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.celrep.2014.10.004_bib28","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1158\/0008-5472.CAN-03-0846","article-title":"The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression","volume":"64","author":"Schwartzenberg-Bar-Yoseph","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2014.10.004_bib29","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1007\/s10096-012-1570-5","article-title":"Viral and bacterial aetiologies of epithelial ovarian cancer","volume":"31","author":"Shanmughapriya","year":"2012","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"10.1016\/j.celrep.2014.10.004_bib30","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1126\/science.282.5389.754","article-title":"Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis","volume":"282","author":"Stephens","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.celrep.2014.10.004_bib31","doi-asserted-by":"crossref","first-page":"14944","DOI":"10.1073\/pnas.1100959108","article-title":"Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells","volume":"108","author":"Toller","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2014.10.004_bib32","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1667\/0033-7587(2000)153[0781:GPDATO]2.0.CO;2","article-title":"Glucose-6-phosphate dehydrogenase and the oxidative pentose phosphate cycle protect cells against apoptosis induced by low doses of ionizing radiation","volume":"153","author":"Tuttle","year":"2000","journal-title":"Radiat. Res."},{"key":"10.1016\/j.celrep.2014.10.004_bib33","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.4161\/cc.10.10.15519","article-title":"Mechanism-specific signatures for small-molecule p53 activators","volume":"10","author":"van Leeuwen","year":"2011","journal-title":"Cell Cycle"},{"key":"10.1016\/j.celrep.2014.10.004_bib34","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1371\/journal.ppat.0020045","article-title":"Recruitment of BAD by the Chlamydia trachomatis vacuole correlates with host-cell survival","volume":"2","author":"Verbeke","year":"2006","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.celrep.2014.10.004_bib35","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1242\/jcs.117721","article-title":"Neisseria gonorrhoeae infection causes DNA damage and affects the expression of p21, p27 and p53 in non-tumor epithelial cells","volume":"126","author":"Vielfort","year":"2013","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.celrep.2014.10.004_bib36","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.cell.2009.04.037","article-title":"Blinded by the light: the growing complexity of p53","volume":"137","author":"Vousden","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2014.10.004_bib37","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/nrc2715","article-title":"p53 and metabolism","volume":"9","author":"Vousden","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.celrep.2014.10.004_bib38","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.cell.2004.10.011","article-title":"Homologous recombination generates T-loop-sized deletions at human telomeres","volume":"119","author":"Wang","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2014.10.004_bib39","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1126\/science.124.3215.269","article-title":"On respiratory impairment in cancer cells","volume":"124","author":"Warburg","year":"1956","journal-title":"Science"},{"key":"10.1016\/j.celrep.2014.10.004_bib40","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1053\/j.gastro.2010.06.018","article-title":"Regulation of p53 tumor suppressor by Helicobacter pylori in gastric epithelial cells","volume":"139","author":"Wei","year":"2010","journal-title":"Gastroenterology"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124714008444?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124714008444?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T09:32:16Z","timestamp":1761903136000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124714008444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["S2211124714008444"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2014.10.004","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tumor Suppressor p53 Alters Host Cell Metabolism to Limit Chlamydia trachomatis Infection","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2014.10.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}