{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:04:52Z","timestamp":1791320692503,"version":"4.3.1"},"reference-count":33,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,10,13]],"date-time":"2014-10-13T00:00:00Z","timestamp":1413158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1016\/j.celrep.2014.10.019","type":"journal-article","created":{"date-parts":[[2014,11,6]],"date-time":"2014-11-06T13:52:08Z","timestamp":1415281928000},"page":"1281-1291","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":324,"title":["Sestrins Inhibit mTORC1 Kinase Activation through the GATOR Complex"],"prefix":"10.1016","volume":"9","author":[{"given":"Anita","family":"Parmigiani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aida","family":"Nourbakhsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boxiao","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young\u00a0Chul","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin","family":"Akopiants","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun-Liang","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Karin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei\u00a0V.","family":"Budanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2014.10.019_bib1","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.M114.039388","article-title":"Molecular architecture and function of the SEA complex, a modulator of the TORC1 pathway","author":"Algret","year":"2014","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.celrep.2014.10.019_bib2","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.cmet.2012.12.002","article-title":"Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage","volume":"17","author":"Bae","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2014.10.019_bib3","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.tcb.2014.03.003","article-title":"Regulation of mTORC1 by amino acids","volume":"24","author":"Bar-Peled","year":"2014","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.celrep.2014.10.019_bib4","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1126\/science.1232044","article-title":"A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1","volume":"340","author":"Bar-Peled","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.celrep.2014.10.019_bib5","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/cdd.2012.157","article-title":"Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death","volume":"20","author":"Ben-Sahra","year":"2013","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.celrep.2014.10.019_bib6","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1089\/ars.2010.3530","article-title":"Stress-responsive sestrins link p53 with redox regulation and mammalian target of rapamycin signaling","volume":"15","author":"Budanov","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.celrep.2014.10.019_bib7","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.cell.2008.06.028","article-title":"p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling","volume":"134","author":"Budanov","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2014.10.019_bib8","doi-asserted-by":"crossref","first-page":"6017","DOI":"10.1038\/sj.onc.1205877","article-title":"Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability","volume":"21","author":"Budanov","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.celrep.2014.10.019_bib9","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1126\/science.1095569","article-title":"Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD","volume":"304","author":"Budanov","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.celrep.2014.10.019_bib10","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/emmm.201000097","article-title":"Stressin\u2019 Sestrins take an aging fight","volume":"2","author":"Budanov","year":"2010","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.celrep.2014.10.019_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.celrep.2014.09.014","article-title":"The sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1","volume":"9","author":"Chantranupong","year":"2014","journal-title":"Cell Rep"},{"key":"10.1016\/j.celrep.2014.10.019_bib12","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.molmed.2007.04.002","article-title":"mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer","volume":"13","author":"Dann","year":"2007","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.celrep.2014.10.019_bib13","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/ncb2763","article-title":"Signal integration by mTORC1 coordinates nutrient input with biosynthetic output","volume":"15","author":"Dibble","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2014.10.019_bib14","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/nature11745","article-title":"Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival","volume":"493","author":"Efeyan","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2014.10.019_bib15","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.molcel.2008.03.003","article-title":"AMPK phosphorylation of raptor mediates a metabolic checkpoint","volume":"30","author":"Gwinn","year":"2008","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2014.10.019_bib16","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nrm3311","article-title":"AMPK: a nutrient and energy sensor that maintains energy homeostasis","volume":"13","author":"Hardie","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2014.10.019_bib17","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1101\/gad.1212704","article-title":"Upstream and downstream of mTOR","volume":"18","author":"Hay","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2014.10.019_bib18","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0092-8674(03)00929-2","article-title":"TSC2 mediates cellular energy response to control cell growth and survival","volume":"115","author":"Inoki","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2014.10.019_bib19","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.cmet.2010.03.014","article-title":"Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner","volume":"11","author":"Kalender","year":"2010","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2014.10.019_bib20","doi-asserted-by":"crossref","first-page":"4241","DOI":"10.1038\/ncomms5241","article-title":"Rag GTPases are cardioprotective by regulating lysosomal function","volume":"5","author":"Kim","year":"2014","journal-title":"Nat Commun"},{"key":"10.1016\/j.celrep.2014.10.019_bib21","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.cell.2012.03.017","article-title":"mTOR signaling in growth control and disease","volume":"149","author":"Laplante","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2014.10.019_bib22","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1126\/science.1182228","article-title":"Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies","volume":"327","author":"Lee","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.celrep.2014.10.019_bib23","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.cmet.2012.08.004","article-title":"Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3","volume":"16","author":"Lee","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2014.10.019_bib24","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.cmet.2013.08.018","article-title":"Sestrins orchestrate cellular metabolism to attenuate aging","volume":"18","author":"Lee","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2014.10.019_bib25","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0092-8674(00)81871-1","article-title":"p53, the cellular gatekeeper for growth and division","volume":"88","author":"Levine","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2014.10.019_bib26","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.cell.2013.11.049","article-title":"Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome","volume":"156","author":"Menon","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2014.10.019_bib27","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/ncb2329","article-title":"The AMPK signalling pathway coordinates cell growth, autophagy and metabolism","volume":"13","author":"Mihaylova","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2014.10.019_bib28","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1074\/jbc.M113.528505","article-title":"Amino acids activate mammalian target of rapamycin (mTOR) complex 1 without changing Rag GTPase guanyl nucleotide charging","volume":"289","author":"Oshiro","year":"2014","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2014.10.019_bib29","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.cell.2014.08.038","article-title":"Sestrins Function as Guanine Nucleotide Dissociation Inhibitors for Rag GTPases to Control mTORC1 Signaling","volume":"159","author":"Peng","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2014.10.019_bib30","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1038\/nm1320","article-title":"The antioxidant function of the p53 tumor suppressor","volume":"11","author":"Sablina","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2014.10.019_bib31","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1126\/science.1157535","article-title":"The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1","volume":"320","author":"Sancak","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.celrep.2014.10.019_bib32","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.cell.2006.01.016","article-title":"TOR signaling in growth and metabolism","volume":"124","author":"Wullschleger","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2014.10.019_bib33","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/s13238-011-1018-1","article-title":"Structure and function of WD40 domain proteins","volume":"2","author":"Xu","year":"2011","journal-title":"Protein Cell"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124714008730?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124714008730?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T09:33:56Z","timestamp":1761903236000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124714008730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["S2211124714008730"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2014.10.019","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sestrins Inhibit mTORC1 Kinase Activation through the GATOR Complex","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2014.10.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}