{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:47:05Z","timestamp":1791341225547,"version":"4.3.1"},"reference-count":68,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,9,10]],"date-time":"2015-09-10T00:00:00Z","timestamp":1441843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.celrep.2015.09.023","type":"journal-article","created":{"date-parts":[[2015,10,18]],"date-time":"2015-10-18T19:37:22Z","timestamp":1445197042000},"page":"533-545","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":266,"title":["Lethal Cardiomyopathy in Mice Lacking Transferrin Receptor in the Heart"],"prefix":"10.1016","volume":"13","author":[{"given":"Wenjing","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasa","family":"Barrientos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard\u00a0A.","family":"Rockman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony\u00a0A.","family":"Sauve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy\u00a0C.","family":"Andrews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2015.09.023_bib1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1172\/JCI119509","article-title":"Gene recombination in postmitotic cells. Targeted expression of Cre recombinase provokes cardiac-restricted, site-specific rearrangement in adult ventricular muscle in\u00a0vivo","volume":"100","author":"Agah","year":"1997","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2015.09.023_bib2","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.cmet.2005.03.002","article-title":"Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle","volume":"1","author":"Arany","year":"2005","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2015.09.023_bib3","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1172\/JCI9056","article-title":"Deactivation of peroxisome proliferator-activated receptor-alpha during cardiac hypertrophic growth","volume":"105","author":"Barger","year":"2000","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2015.09.023_bib4","doi-asserted-by":"crossref","first-page":"12079","DOI":"10.1073\/pnas.96.21.12079","article-title":"Selective expression of the large neutral amino acid transporter at the blood-brain barrier","volume":"96","author":"Boado","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2015.09.023_bib5","doi-asserted-by":"crossref","first-page":"9082","DOI":"10.1073\/pnas.97.16.9082","article-title":"Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia","volume":"97","author":"Bruick","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2015.09.023_bib6","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.cmet.2012.04.022","article-title":"The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity","volume":"15","author":"Cant\u00f3","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2015.09.023_bib7","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.cmet.2014.04.001","article-title":"NAD(+)-dependent activation of Sirt1 corrects the phenotype in a mouse model of mitochondrial disease","volume":"19","author":"Cerutti","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2015.09.023_bib8","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/emboj.2009.369","article-title":"Antagonism of\u00a0Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1","volume":"29","author":"Chang","year":"2010","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2015.09.023_bib9","doi-asserted-by":"crossref","first-page":"11714","DOI":"10.1073\/pnas.1511701112","article-title":"Noncanonical role of transferrin receptor 1 is essential for intestinal homeostasis","volume":"112","author":"Chen","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2015.09.023_bib10","first-page":"657","article-title":"Nicotinamide riboside, a trace nutrient in foods, is a vitamin B3 with effects on energy metabolism and neuroprotection","volume":"16","author":"Chi","year":"2013","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"10.1016\/j.celrep.2015.09.023_bib11","doi-asserted-by":"crossref","first-page":"15504","DOI":"10.1073\/pnas.2533374100","article-title":"Structural basis for PAS domain heterodimerization in the basic helix--loop--helix-PAS transcription factor hypoxia-inducible factor","volume":"100","author":"Erbel","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2015.09.023_bib12","doi-asserted-by":"crossref","first-page":"14088","DOI":"10.1074\/jbc.M111.305342","article-title":"Chronic expression of RCAN1-1L protein induces mitochondrial autophagy and metabolic shift from oxidative phosphorylation to glycolysis in neuronal cells","volume":"287","author":"Ermak","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2015.09.023_bib13","doi-asserted-by":"crossref","first-page":"H3101","DOI":"10.1152\/ajpheart.2000.279.6.H3101","article-title":"Cellular and functional defects in a mouse model of heart failure","volume":"279","author":"Esposito","year":"2000","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.celrep.2015.09.023_bib14","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.cell.2014.03.026","article-title":"Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)\/SIRT1 reduction","volume":"157","author":"Fang","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2015.09.023_bib15","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.cmet.2006.08.005","article-title":"Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha\/PPARalpha regulatory pathway","volume":"4","author":"Finck","year":"2006","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2015.09.023_bib16","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1083\/jcb.200711112","article-title":"Quantitative analysis of autophagy-related protein stoichiometry by fluorescence microscopy","volume":"182","author":"Geng","year":"2008","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.celrep.2015.09.023_bib17","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1016\/j.cell.2013.11.037","article-title":"Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging","volume":"155","author":"Gomes","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2015.09.023_bib18","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1097\/CRD.0b013e3182a67805","article-title":"Cardiac involvement in hemochromatosis","volume":"22","author":"Gulati","year":"2014","journal-title":"Cardiol. Rev."},{"key":"10.1016\/j.celrep.2015.09.023_bib19","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0092-8674(04)00343-5","article-title":"Balancing acts: molecular control of mammalian iron metabolism","volume":"117","author":"Hentze","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2015.09.023_bib20","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0736-5748(03)00089-3","article-title":"Bcl-2 family members make different contributions to cell death in hypoxia and\/or hyperoxia in rat cerebral cortex","volume":"21","author":"Hu","year":"2003","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.celrep.2015.09.023_bib21","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/S0305-4179(03)00204-3","article-title":"Roles of ischemia and hypoxia and the molecular pathogenesis of post-burn cardiac shock","volume":"29","author":"Huang","year":"2003","journal-title":"Burns"},{"key":"10.1016\/j.celrep.2015.09.023_bib22","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1172\/JCI25049","article-title":"A mouse model of juvenile hemochromatosis","volume":"115","author":"Huang","year":"2005","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2015.09.023_bib23","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nm.1910","article-title":"Coordination of PGC-1beta and iron uptake in mitochondrial biogenesis and osteoclast activation","volume":"15","author":"Ishii","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2015.09.023_bib24","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1373\/clinchem.2006.078873","article-title":"Spectrophotometric assay for complex I of the respiratory chain in tissue samples and cultured fibroblasts","volume":"53","author":"Janssen","year":"2007","journal-title":"Clin. Chem."},{"key":"10.1016\/j.celrep.2015.09.023_bib25","series-title":"Methods in Hematology","first-page":"104","article-title":"Tissue iron stores","author":"Torrance","year":"1980"},{"key":"10.1016\/j.celrep.2015.09.023_bib26","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1111\/bph.12477","article-title":"Autophagy and mitophagy in the myocardium: therapeutic potential and concerns","volume":"171","author":"Jimenez","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.celrep.2015.09.023_bib27","doi-asserted-by":"crossref","first-page":"e844","DOI":"10.1371\/journal.pone.0000844","article-title":"The N-Myc down regulated Gene1 (NDRG1) Is a Rab4a effector involved in vesicular recycling of E-cadherin","volume":"2","author":"Kachhap","year":"2007","journal-title":"PLoS ONE"},{"key":"10.1016\/j.celrep.2015.09.023_bib28","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.molcel.2008.04.009","article-title":"Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway","volume":"30","author":"Kaelin","year":"2008","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2015.09.023_bib29","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.cmet.2013.07.002","article-title":"Mitochondrial complex I deficiency increases protein acetylation and accelerates heart failure","volume":"18","author":"Karamanlidis","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2015.09.023_bib30","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1002\/emmm.201403943","article-title":"Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3","volume":"6","author":"Khan","year":"2014","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.celrep.2015.09.023_bib31","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0091-679X(06)80004-X","article-title":"Biochemical assays of respiratory chain complex activity","volume":"80","author":"Kirby","year":"2007","journal-title":"Methods Cell Biol."},{"key":"10.1016\/j.celrep.2015.09.023_bib32","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1515\/bchm2.1932.210.1-2.33","article-title":"Untersuchungen \u00fcber die Harnstoffbildung im Tierk\u00f6rper","volume":"210","author":"Krebs","year":"1932","journal-title":"Hoppe Seylers Z. Physiol. Chem."},{"key":"10.1016\/j.celrep.2015.09.023_bib33","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1182\/blood-2004-05-1866","article-title":"Iron chelators with high antiproliferative activity up-regulate the expression of a growth inhibitory and metastasis suppressor gene: a link between iron metabolism and proliferation","volume":"104","author":"Le","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2015.09.023_bib34","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1172\/JCI10268","article-title":"Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis","volume":"106","author":"Lehman","year":"2000","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2015.09.023_bib35","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/7727","article-title":"Transferrin receptor is necessary for development of erythrocytes and the nervous system","volume":"21","author":"Levy","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2015.09.023_bib36","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/ncb2422","article-title":"Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells","volume":"14","author":"Liu","year":"2012","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2015.09.023_bib37","doi-asserted-by":"crossref","first-page":"370","DOI":"10.3181\/00379727-218-44306","article-title":"Dietary iron deficiency results in cardiac eccentric hypertrophy in rats","volume":"218","author":"Medeiros","year":"1998","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.celrep.2015.09.023_bib38","doi-asserted-by":"crossref","first-page":"15851","DOI":"10.1074\/jbc.M111431200","article-title":"A zinc-finger protein, PLAGL2, induces the expression of a proapoptotic protein Nip3, leading to cellular apoptosis","volume":"277","author":"Mizutani","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2015.09.023_bib39","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/ng1180","article-title":"PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes","volume":"34","author":"Mootha","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2015.09.023_bib40","doi-asserted-by":"crossref","first-page":"3711","DOI":"10.1182\/blood-2003-04-1086","article-title":"Transferrin receptor 1 is differentially required in lymphocyte development","volume":"102","author":"Ned","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2015.09.023_bib41","doi-asserted-by":"crossref","first-page":"39517","DOI":"10.1074\/jbc.M300550200","article-title":"The mouse APG10 homologue, an E2-like enzyme for Apg12p conjugation, facilitates MAP-LC3 modification","volume":"278","author":"Nemoto","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2015.09.023_bib42","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/embor.2009.256","article-title":"Nix is a selective autophagy receptor for mitochondrial clearance","volume":"11","author":"Novak","year":"2010","journal-title":"EMBO Rep."},{"key":"10.1016\/j.celrep.2015.09.023_bib43","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.cell.2012.02.035","article-title":"Mitochondria: in sickness and in health","volume":"148","author":"Nunnari","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2015.09.023_bib44","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1128\/MCB.26.6.2373-2386.2006","article-title":"Activation of transferrin receptor 1 by c-Myc enhances cellular proliferation and tumorigenesis","volume":"26","author":"O\u2019Donnell","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.celrep.2015.09.023_bib45","doi-asserted-by":"crossref","first-page":"75","DOI":"10.2164\/jandrol.109.008052","article-title":"Histone demethylase JHDM2A is involved in male infertility and obesity","volume":"31","author":"Okada","year":"2010","journal-title":"J.\u00a0Androl."},{"key":"10.1016\/j.celrep.2015.09.023_bib46","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1159\/000177592","article-title":"Iron deficiency in growing male rats: a cause of development of cardiomyopathy","volume":"34","author":"Petering","year":"1990","journal-title":"Ann. Nutr. Metab."},{"key":"10.1016\/j.celrep.2015.09.023_bib47","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/84818","article-title":"Mouse models for Friedreich ataxia exhibit cardiomyopathy, sensory nerve defect and Fe-S enzyme deficiency followed by intramitochondrial iron deposits","volume":"27","author":"Puccio","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2015.09.023_bib48","doi-asserted-by":"crossref","first-page":"182","DOI":"10.4161\/auto.27174","article-title":"ATG16L1 meets ATG9 in recycling endosomes: additional roles for the plasma membrane and endocytosis in autophagosome biogenesis","volume":"10","author":"Puri","year":"2014","journal-title":"Autophagy"},{"key":"10.1016\/j.celrep.2015.09.023_bib49","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1161\/01.RES.0000029232.42227.16","article-title":"Inducible expression of BNIP3 provokes mitochondrial defects and hypoxia-mediated cell death of ventricular myocytes","volume":"91","author":"Regula","year":"2002","journal-title":"Circ. Res."},{"key":"10.1016\/j.celrep.2015.09.023_bib50","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.celrep.2012.11.029","article-title":"Complementary RNA and protein profiling identifies iron as a key regulator of mitochondrial biogenesis","volume":"3","author":"Rensvold","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2015.09.023_bib51","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.molcel.2013.12.019","article-title":"Hexokinase-II positively regulates glucose starvation-induced autophagy through TORC1 inhibition","volume":"53","author":"Roberts","year":"2014","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2015.09.023_bib52","doi-asserted-by":"crossref","first-page":"9692","DOI":"10.1074\/jbc.M113.529511","article-title":"The metastasis suppressor, N-myc downstream-regulated gene 1 (NDRG1), inhibits stress-induced autophagy in cancer cells","volume":"289","author":"Sahni","year":"2014","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2015.09.023_bib53","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.mito.2011.07.006","article-title":"Optimization of respiratory chain enzymatic assays in muscle for the diagnosis of mitochondrial disorders","volume":"11","author":"Spinazzi","year":"2011","journal-title":"Mitochondrion"},{"key":"10.1016\/j.celrep.2015.09.023_bib54","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.cmet.2013.06.015","article-title":"Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins","volume":"18","author":"Stehling","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2015.09.023_bib55","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2015.09.023_bib56","doi-asserted-by":"crossref","first-page":"47704","DOI":"10.1074\/jbc.M407016200","article-title":"Human light chain 3\/MAP1LC3B is cleaved at its carboxyl-terminal Met121 to expose Gly120 for lipidation and targeting to autophagosomal membranes","volume":"279","author":"Tanida","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2015.09.023_bib57","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1182\/blood.V96.3.1113","article-title":"The molecular defect in hypotransferrinemic mice","volume":"96","author":"Trenor","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2015.09.023_bib58","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1038\/ncb2589","article-title":"Autophagy receptors link myosin VI to autophagosomes to mediate Tom1-dependent autophagosome maturation and fusion with the lysosome","volume":"14","author":"Tumbarello","year":"2012","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2015.09.023_bib59","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s004240050739","article-title":"Transcriptional regulation of metabolic processes: implications for cardiac metabolism","volume":"437","author":"van Bilsen","year":"1998","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.celrep.2015.09.023_bib60","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1038\/emboj.2010.74","article-title":"LC3 and GATE-16\/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis","volume":"29","author":"Weidberg","year":"2010","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2015.09.023_bib61","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1126\/science.283.5402.676","article-title":"Coordinated regulation of iron-controlling genes, H-ferritin and IRP2, by c-MYC","volume":"283","author":"Wu","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.celrep.2015.09.023_bib62","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0092-8674(00)80611-X","article-title":"Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1","volume":"98","author":"Wu","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2015.09.023_bib63","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1002\/embr.201438501","article-title":"ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy","volume":"15","author":"Wu","year":"2014","journal-title":"EMBO Rep."},{"key":"10.1016\/j.celrep.2015.09.023_bib64","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.cmet.2013.02.004","article-title":"Iron and copper in mitochondrial diseases","volume":"17","author":"Xu","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2015.09.023_bib65","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.cell.2006.03.027","article-title":"JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor","volume":"125","author":"Yamane","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2015.09.023_bib66","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1097\/FJC.0000000000000121","article-title":"Regulator of calcineurin 1-1L protects cardiomyocytes against hypoxia-induced apoptosis via mitophagy","volume":"64","author":"Yan","year":"2014","journal-title":"J.\u00a0Cardiovasc. Pharmacol."},{"key":"10.1016\/j.celrep.2015.09.023_bib67","doi-asserted-by":"crossref","first-page":"6458","DOI":"10.1021\/jm701001c","article-title":"Syntheses of nicotinamide riboside and derivatives: effective agents for increasing nicotinamide adenine dinucleotide concentrations in mammalian cells","volume":"50","author":"Yang","year":"2007","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.celrep.2015.09.023_bib68","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.cmet.2014.05.003","article-title":"Lipin-1 regulates autophagy clearance and intersects with statin drug effects in skeletal muscle","volume":"20","author":"Zhang","year":"2014","journal-title":"Cell Metab."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124715010347?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124715010347?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T09:45:32Z","timestamp":1761903932000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124715010347"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":68,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["S2211124715010347"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2015.09.023","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lethal Cardiomyopathy in Mice Lacking Transferrin Receptor in the Heart","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2015.09.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}