{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:06:51Z","timestamp":1790395611217,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,2,18]],"date-time":"2016-02-18T00:00:00Z","timestamp":1455753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1016\/j.celrep.2016.02.051","type":"journal-article","created":{"date-parts":[[2016,3,10]],"date-time":"2016-03-10T12:25:28Z","timestamp":1457612728000},"page":"2554-2561","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Pharmacological Bypass of Cockayne Syndrome B Function in Neuronal Differentiation"],"prefix":"10.1016","volume":"14","author":[{"given":"Yuming","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jace","family":"Jones-Tabah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Probir","family":"Chakravarty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aengus","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alysson","family":"Muotri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca\u00a0R.","family":"Laposa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper\u00a0Q.","family":"Svejstrup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2016.02.051_bib1","doi-asserted-by":"crossref","first-page":"1239882","DOI":"10.1126\/science.1239882","article-title":"Development-inspired reprogramming of the mammalian central nervous system","volume":"343","author":"Amamoto","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.celrep.2016.02.051_bib2","doi-asserted-by":"crossref","first-page":"3825","DOI":"10.1093\/hmg\/dds211","article-title":"Evidence for premature aging due to oxidative stress in iPSCs from Cockayne syndrome","volume":"21","author":"Andrade","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.celrep.2016.02.051_bib3","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.dnarep.2012.02.004","article-title":"The conserved Cockayne syndrome B-piggyBac fusion protein (CSB-PGBD3) affects DNA repair and induces both interferon-like and innate antiviral responses in CSB-null cells","volume":"11","author":"Bailey","year":"2012","journal-title":"DNA Repair (Amst.)"},{"key":"10.1016\/j.celrep.2016.02.051_bib4","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature09915","article-title":"Modelling schizophrenia using human induced pluripotent stem cells","volume":"473","author":"Brennand","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2016.02.051_bib5","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.dnarep.2013.04.018","article-title":"Blinded by the UV light: how the focus on transcription-coupled NER has distracted from understanding the mechanisms of Cockayne syndrome neurologic disease","volume":"12","author":"Brooks","year":"2013","journal-title":"DNA Repair (Amst.)"},{"key":"10.1016\/j.celrep.2016.02.051_bib6","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1006\/mcne.1997.0641","article-title":"Reduced size of retinal ganglion cell axons and hypomyelination in mice lacking brain-derived neurotrophic factor","volume":"9","author":"Cellerino","year":"1997","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.celrep.2016.02.051_bib7","doi-asserted-by":"crossref","first-page":"e1268","DOI":"10.1038\/cddis.2014.228","article-title":"The cockayne syndrome B protein is essential for neuronal differentiation and neuritogenesis","volume":"5","author":"Ciaffardini","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.celrep.2016.02.051_bib8","doi-asserted-by":"crossref","first-page":"11844","DOI":"10.1074\/jbc.273.19.11844","article-title":"Biochemical and biological characterization of wild-type and ATPase-deficient Cockayne syndrome B repair protein","volume":"273","author":"Citterio","year":"1998","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2016.02.051_bib9","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1074\/jbc.M114.588608","article-title":"Amitriptyline improves motor function via enhanced neurotrophin signaling and mitochondrial functions in the murine N171-82Q Huntington disease model","volume":"290","author":"Cong","year":"2015","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2016.02.051_bib10","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1091\/mbc.e11-08-0707","article-title":"Axonal and dendritic synaptotagmin isoforms revealed by a pHluorin-syt functional screen","volume":"23","author":"Dean","year":"2012","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.celrep.2016.02.051_bib11","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1126\/science.1158799","article-title":"Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons","volume":"321","author":"Dimos","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.celrep.2016.02.051_bib12","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1046\/j.1471-4159.2000.0750991.x","article-title":"Sequential treatment of SH-SY5Y cells with retinoic acid and brain-derived neurotrophic factor gives rise to fully differentiated, neurotrophic factor-dependent, human neuron-like cells","volume":"75","author":"Encinas","year":"2000","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.celrep.2016.02.051_bib13","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/368147a0","article-title":"Mice lacking brain-derived neurotrophic factor develop with sensory deficits","volume":"368","author":"Ernfors","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2016.02.051_bib14","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1093\/nar\/gku1279","article-title":"CSB interacts with SNM1A and promotes DNA interstrand crosslink processing","volume":"43","author":"Iyama","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2016.02.051_bib15","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1073\/pnas.0913572107","article-title":"A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone","volume":"107","author":"Jang","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2016.02.051_bib16","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1093\/hmg\/ddt098","article-title":"Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington\u2019s disease","volume":"22","author":"Jiang","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.celrep.2016.02.051_bib17","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/0092-8674(94)90377-8","article-title":"Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development","volume":"76","author":"Jones","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2016.02.051_bib18","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1007\/s11940-014-0326-1","article-title":"Treatment of pediatric migraine","volume":"17","author":"O\u2019Brien","year":"2015","journal-title":"Curr. Treat. Options Neurol."},{"key":"10.1016\/j.celrep.2016.02.051_bib19","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nrn3379","article-title":"Neurotrophin regulation of neural circuit development and function","volume":"14","author":"Park","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.celrep.2016.02.051_bib20","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.cell.2014.03.048","article-title":"RECQL5 controls transcript elongation and suppresses genome instability associated with transcription stress","volume":"157","author":"Saponaro","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2016.02.051_bib21","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.mad.2013.02.007","article-title":"Mitochondrial deficiency in Cockayne syndrome","volume":"134","author":"Scheibye-Knudsen","year":"2013","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.celrep.2016.02.051_bib22","series-title":"Bioinformatics and Computational Biology Solutions using R and Bioconductor","first-page":"397","article-title":"Limma: linear models for microarray data","author":"Smyth","year":"2005"},{"key":"10.1016\/j.celrep.2016.02.051_bib23","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.mrfmmm.2005.03.017","article-title":"UV-sensitive syndrome","volume":"577","author":"Spivak","year":"2005","journal-title":"Mutat. Res."},{"key":"10.1016\/j.celrep.2016.02.051_bib24","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.ceb.2012.12.007","article-title":"MicroRNAs: regulators of neuronal fate","volume":"25","author":"Sun","year":"2013","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.celrep.2016.02.051_bib25","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/0092-8674(92)90390-X","article-title":"ERCC6, a member of a subfamily of putative helicases, is involved in Cockayne\u2019s syndrome and preferential repair of active genes","volume":"71","author":"Troelstra","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2016.02.051_bib26","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0092-8674(00)80223-8","article-title":"Defective transcription-coupled repair in Cockayne syndrome B mice is associated with skin cancer predisposition","volume":"89","author":"van der Horst","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2016.02.051_bib27","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.mad.2013.03.004","article-title":"Cockayne syndrome group B (CSB) protein: at the crossroads of transcriptional networks","volume":"134","author":"V\u00e9lez-Cruz","year":"2013","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.celrep.2016.02.051_bib28","doi-asserted-by":"crossref","first-page":"a012625","DOI":"10.1101\/cshperspect.a012625","article-title":"Mammalian transcription-coupled excision repair","volume":"5","author":"Vermeulen","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.celrep.2016.02.051_bib29","doi-asserted-by":"crossref","DOI":"10.1093\/hmg\/ddw008","article-title":"Cockayne Syndrome-derived neurons display reduced synapse density and altered neural network synchrony","author":"Vessoni","year":"2016","journal-title":"Hum Mol Genet."},{"key":"10.1016\/j.celrep.2016.02.051_bib30","doi-asserted-by":"crossref","first-page":"14454","DOI":"10.1073\/pnas.1412569111","article-title":"Dysregulation of gene expression as a cause of Cockayne syndrome neurological disease","volume":"111","author":"Wang","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2016.02.051_bib31","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.mad.2009.07.006","article-title":"Neuropathology of Cockayne syndrome: Evidence for impaired development, premature aging, and neurodegeneration","volume":"130","author":"Weidenheim","year":"2009","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.celrep.2016.02.051_bib32","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.neuron.2007.05.004","article-title":"Synaptotagmin-1, -2, and -9: Ca(2+) sensors for fast release that specify distinct presynaptic properties in subsets of neurons","volume":"54","author":"Xu","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2016.02.051_bib33","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/nature10323","article-title":"MicroRNA-mediated conversion of human fibroblasts to neurons","volume":"476","author":"Yoo","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2016.02.051_bib34","article-title":"The role of 7,8-dihydroxyflavone in preventing dendrite degeneration in cortex after moderate traumatic brain injury","author":"Zhao","year":"2015","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.celrep.2016.02.051_bib35","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.bbrc.2007.07.083","article-title":"Synaptotagmin I and IX function redundantly in controlling fusion pore of large dense core vesicles","volume":"361","author":"Zhu","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124716301723?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124716301723?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T09:52:27Z","timestamp":1761904347000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124716301723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":35,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["S2211124716301723"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2016.02.051","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmacological Bypass of Cockayne Syndrome B Function in Neuronal Differentiation","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2016.02.051","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}