{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:48:37Z","timestamp":1792687717949,"version":"4.5.0"},"reference-count":62,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,5,6]],"date-time":"2016-05-06T00:00:00Z","timestamp":1462492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.celrep.2016.05.018","type":"journal-article","created":{"date-parts":[[2016,6,2]],"date-time":"2016-06-02T17:22:52Z","timestamp":1464888172000},"page":"2500-2509","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":181,"title":["The Long Non-coding RNA HIF1A-AS2 Facilitates the Maintenance of Mesenchymal Glioblastoma Stem-like Cells in Hypoxic Niches"],"prefix":"10.1016","volume":"15","author":[{"given":"Marco","family":"Mineo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz","family":"Ricklefs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun\u00a0K.","family":"Rooj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn\u00a0M.","family":"Lyons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Ivanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khairul\u00a0I.","family":"Ansari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Nakano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.\u00a0Antonio","family":"Chiocca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Godlewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Bronisz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2016.05.018_bib1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.ccr.2013.08.001","article-title":"Mesenchymal differentiation mediated by NF-\u03baB promotes radiation resistance in glioblastoma","volume":"24","author":"Bhat","year":"2013","journal-title":"Cancer Cell"},{"issue":"Suppl 3","key":"10.1016\/j.celrep.2016.05.018_bib2","first-page":"33","article-title":"Master regulators, regulatory networks, and pathways of glioblastoma subtypes","volume":"13","author":"Bozdag","year":"2014","journal-title":"Cancer Inform."},{"key":"10.1016\/j.celrep.2016.05.018_bib3","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1158\/0008-5472.CAN-03-2073","article-title":"Pseudopalisades in glioblastoma are hypoxic, express extracellular matrix proteases, and are formed by an actively migrating cell population","volume":"64","author":"Brat","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2016.05.018_bib4","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1158\/0008-5472.CAN-13-2650","article-title":"Extracellular vesicles modulate the glioblastoma microenvironment via a tumor suppression signaling network directed by miR-1","volume":"74","author":"Bronisz","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2016.05.018_bib5","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/nature08712","article-title":"The transcriptional network for mesenchymal transformation of brain tumours","volume":"463","author":"Carro","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2016.05.018_bib6","doi-asserted-by":"crossref","first-page":"e101239","DOI":"10.1371\/journal.pone.0101239","article-title":"Visualizing molecular profiles of glioblastoma with GBM-BioDP","volume":"9","author":"Celiku","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.celrep.2016.05.018_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2015.08.049","article-title":"Hypoxia-regulated lncRNAs in cancer","volume":"575","author":"Chang","year":"2016","journal-title":"Gene"},{"key":"10.1016\/j.celrep.2016.05.018_bib8","doi-asserted-by":"crossref","first-page":"11704","DOI":"10.1128\/JVI.01474-13","article-title":"A host YB-1 ribonucleoprotein complex is hijacked by hepatitis C virus for the control of NS3-dependent particle production","volume":"87","author":"Chatel-Chaix","year":"2013","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.celrep.2016.05.018_bib9","first-page":"2439","article-title":"High level expression of the HMGI (Y) gene during embryonic development","volume":"13","author":"Chiappetta","year":"1996","journal-title":"Oncogene"},{"key":"10.1016\/j.celrep.2016.05.018_bib10","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1016\/j.ajpath.2012.01.040","article-title":"The tumor microenvironment strongly impacts master transcriptional regulators and gene expression class of glioblastoma","volume":"180","author":"Cooper","year":"2012","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.celrep.2016.05.018_bib11","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/nsmb.2591","article-title":"Integrative genomic analyses reveal clinically relevant long noncoding RNAs in human cancer","volume":"20","author":"Du","year":"2013","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.celrep.2016.05.018_bib12","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nrg3606","article-title":"Long non-coding RNAs: new players in cell differentiation and development","volume":"15","author":"Fatica","year":"2014","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.celrep.2016.05.018_bib13","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.gde.2011.11.002","article-title":"Active chromatin and noncoding RNAs: an intimate relationship","volume":"22","author":"Flynn","year":"2012","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.celrep.2016.05.018_bib14","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1038\/ng.2734","article-title":"The integrated landscape of driver genomic alterations in glioblastoma","volume":"45","author":"Frattini","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2016.05.018_bib15","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1038\/nrc2271","article-title":"Roles of HMGA proteins in cancer","volume":"7","author":"Fusco","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.celrep.2016.05.018_bib16","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1093\/neuonc\/nou292","article-title":"Belonging to a network--microRNAs, extracellular vesicles, and the glioblastoma microenvironment","volume":"17","author":"Godlewski","year":"2015","journal-title":"Neuro-oncol."},{"key":"10.1016\/j.celrep.2016.05.018_bib17","doi-asserted-by":"crossref","first-page":"5248","DOI":"10.1073\/pnas.1321014111","article-title":"In\u00a0vivo radiation response of proneural glioma characterized by protective p53 transcriptional program and proneural-mesenchymal shift","volume":"111","author":"Halliday","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2016.05.018_bib18","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1038\/nm.3981","article-title":"The emerging role of lncRNAs in cancer","volume":"21","author":"Huarte","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2016.05.018_bib19","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1101\/gad.188292.112","article-title":"Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells","volume":"26","author":"Janiszewska","year":"2012","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2016.05.018_bib20","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s11060-011-0749-4","article-title":"Glioblastoma survival in the United States before and during the temozolomide era","volume":"107","author":"Johnson","year":"2012","journal-title":"J.\u00a0Neurooncol."},{"key":"10.1016\/j.celrep.2016.05.018_bib21","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrm2319","article-title":"No place like home: anatomy and function of the stem cell niche","volume":"9","author":"Jones","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2016.05.018_bib22","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.canlet.2015.01.010","article-title":"Hypoxia enhances migration and invasion in glioblastoma by promoting a mesenchymal shift mediated by the HIF1\u03b1-ZEB1 axis","volume":"359","author":"Joseph","year":"2015","journal-title":"Cancer Lett."},{"key":"10.1016\/j.celrep.2016.05.018_bib23","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.ccell.2016.01.005","article-title":"Serine\/Threonine Kinase MLK4 Determines Mesenchymal Identity in Glioma Stem Cells in an NF-\u03baB-dependent Manner","volume":"29","author":"Kim","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2016.05.018_bib24","doi-asserted-by":"crossref","first-page":"344","DOI":"10.3109\/10408363.2014.944299","article-title":"The decalog of long non-coding RNA involvement in cancer diagnosis and monitoring","volume":"51","author":"Kunej","year":"2014","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"key":"10.1016\/j.celrep.2016.05.018_bib25","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1101\/gad.261982.115","article-title":"Cancer stem cells in glioblastoma","volume":"29","author":"Lathia","year":"2015","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2016.05.018_bib26","doi-asserted-by":"crossref","first-page":"22798","DOI":"10.1074\/jbc.M114.568535","article-title":"Suppression of the DHX9 helicase induces premature senescence in human diploid fibroblasts in a p53-dependent manner","volume":"289","author":"Lee","year":"2014","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2016.05.018_bib27","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.ccr.2009.03.018","article-title":"Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells","volume":"15","author":"Li","year":"2009","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2016.05.018_bib28","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.prp.2015.05.004","article-title":"High mobility group A1 expression shows negative correlation with recurrence time in patients with glioblastoma multiforme","volume":"211","author":"Liu","year":"2015","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.celrep.2016.05.018_bib29","doi-asserted-by":"crossref","first-page":"8644","DOI":"10.1073\/pnas.1221478110","article-title":"Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3","volume":"110","author":"Mao","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2016.05.018_bib30","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/nmeth.2817","article-title":"A blooming genomic desert","volume":"11","author":"Marx","year":"2014","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2016.05.018_bib31","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1073\/pnas.1314341111","article-title":"miR-218 opposes a critical RTK-HIF pathway in mesenchymal glioblastoma","volume":"111","author":"Mathew","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2016.05.018_bib32","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/nature12624","article-title":"Tumour heterogeneity and cancer cell plasticity","volume":"501","author":"Meacham","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2016.05.018_bib33","doi-asserted-by":"crossref","first-page":"aab2276","DOI":"10.1126\/science.aab2276","article-title":"Chromosomes. A comprehensive Xist interactome reveals cohesin repulsion and an RNA-directed chromosome conformation","volume":"349","author":"Minajigi","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.celrep.2016.05.018_bib34","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s10456-011-9241-1","article-title":"Exosomes released by K562 chronic myeloid leukemia cells promote angiogenesis in a Src-dependent fashion","volume":"15","author":"Mineo","year":"2012","journal-title":"Angiogenesis"},{"key":"10.1016\/j.celrep.2016.05.018_bib35","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nprot.2014.012","article-title":"Mapping Argonaute and conventional RNA-binding protein interactions with RNA at single-nucleotide resolution using HITS-CLIP and CIMS analysis","volume":"9","author":"Moore","year":"2014","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2016.05.018_bib36","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.2217\/fon.14.86","article-title":"Proneural-mesenchymal transformation of glioma stem cells: do therapies cause evolution of target in glioblastoma?","volume":"10","author":"Nakano","year":"2014","journal-title":"Future Oncol."},{"key":"10.1016\/j.celrep.2016.05.018_bib37","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/nature11903","article-title":"Corrigendum: Comprehensive genomic characterization defines human glioblastoma genes and core pathways","volume":"494","author":"Network","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2016.05.018_bib38","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1016\/j.ajpath.2012.03.001","article-title":"Nature versus nurture in glioblastoma: microenvironment and genetics can both drive mesenchymal transcriptional signature","volume":"180","author":"Orr","year":"2012","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.celrep.2016.05.018_bib39","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1126\/science.1164382","article-title":"An integrated genomic analysis of human glioblastoma multiforme","volume":"321","author":"Parsons","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.celrep.2016.05.018_bib40","doi-asserted-by":"crossref","first-page":"8326","DOI":"10.1073\/pnas.1424220112","article-title":"The Bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation","volume":"112","author":"Pastori","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2016.05.018_bib41","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1126\/science.1254257","article-title":"Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma","volume":"344","author":"Patel","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.celrep.2016.05.018_bib42","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1093\/neuonc\/not055","article-title":"MicroRNA-128 coordinately targets Polycomb Repressor Complexes in glioma stem cells","volume":"15","author":"Peruzzi","year":"2013","journal-title":"Neuro-oncol."},{"key":"10.1016\/j.celrep.2016.05.018_bib43","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.ccr.2006.02.019","article-title":"Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis","volume":"9","author":"Phillips","year":"2006","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2016.05.018_bib44","doi-asserted-by":"crossref","first-page":"4392","DOI":"10.1158\/1078-0432.CCR-12-1557","article-title":"Acquired resistance to anti-VEGF therapy in glioblastoma is associated with a mesenchymal transition","volume":"19","author":"Piao","year":"2013","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.celrep.2016.05.018_bib45","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/nrn3234","article-title":"Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease","volume":"13","author":"Qureshi","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.celrep.2016.05.018_bib46","first-page":"471","article-title":"One size should not fit all: advancing toward personalized glioblastoma therapy","volume":"19","author":"Reardon","year":"2015","journal-title":"Discov. Med."},{"key":"10.1016\/j.celrep.2016.05.018_bib47","doi-asserted-by":"crossref","DOI":"10.1158\/0008-5472.CAN-15-3432","article-title":"Extracellular vesicles from high grade glioma exchange diverse pro-oncogenic signals that maintain intratumoral heterogeneity","author":"Ricklefs","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2016.05.018_bib48","doi-asserted-by":"crossref","first-page":"3664","DOI":"10.1172\/JCI67230","article-title":"HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations","volume":"123","author":"Semenza","year":"2013","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2016.05.018_bib49","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/nrm2354","article-title":"The role of oxygen availability in embryonic development and stem cell function","volume":"9","author":"Simon","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2016.05.018_bib50","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/nature03128","article-title":"Identification of human brain tumour initiating cells","volume":"432","author":"Singh","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2016.05.018_bib51","doi-asserted-by":"crossref","first-page":"7979","DOI":"10.1038\/srep07979","article-title":"The evidence of glioblastoma heterogeneity","volume":"5","author":"Soeda","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2016.05.018_bib52","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/978-3-319-16537-0_7","article-title":"Chemoresistance and chemotherapy targeting stem-like cells in malignant glioma","volume":"853","author":"S\u00f8rensen","year":"2015","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.celrep.2016.05.018_bib53","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.cell.2014.02.030","article-title":"Reconstructing and reprogramming the tumor-propagating potential of glioblastoma stem-like cells","volume":"157","author":"Suv\u00e0","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2016.05.018_bib54","doi-asserted-by":"crossref","first-page":"D447","DOI":"10.1093\/nar\/gku1003","article-title":"STRING v10: protein-protein interaction networks, integrated over the tree of life","volume":"43","author":"Szklarczyk","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2016.05.018_bib55","first-page":"1585","article-title":"Modulation of hypoxia-signaling pathways by extracellular linc-RoR","volume":"127","author":"Takahashi","year":"2014","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.celrep.2016.05.018_bib56","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1093\/jnci\/91.2.143","article-title":"aHIF: a natural antisense transcript overexpressed in human renal cancer and during hypoxia","volume":"91","author":"Thrash-Bingham","year":"1999","journal-title":"J.\u00a0Natl. Cancer Inst."},{"key":"10.1016\/j.celrep.2016.05.018_bib57","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.cell.2013.06.020","article-title":"lincRNAs: genomics, evolution, and mechanisms","volume":"154","author":"Ulitsky","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2016.05.018_bib58","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/onc.2015.61","article-title":"WIF1 re-expression in glioblastoma inhibits migration through attenuation of non-canonical WNT signaling by downregulating the lncRNA MALAT1","volume":"35","author":"Vassallo","year":"2016","journal-title":"Oncogene"},{"key":"10.1016\/j.celrep.2016.05.018_bib59","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.ccr.2009.12.020","article-title":"Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1","volume":"17","author":"Verhaak","year":"2010","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2016.05.018_bib60","doi-asserted-by":"crossref","first-page":"5510","DOI":"10.1073\/pnas.92.12.5510","article-title":"Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension","volume":"92","author":"Wang","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2016.05.018_bib61","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1093\/neuonc\/not131","article-title":"HOTAIR, a cell cycle-associated long noncoding RNA and a strong predictor of survival, is preferentially expressed in classical and mesenchymal glioma","volume":"15","author":"Zhang","year":"2013","journal-title":"Neuro-oncol."},{"key":"10.1016\/j.celrep.2016.05.018_bib62","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1093\/neuonc\/noq190","article-title":"DNA hypermethylation profiles associated with glioma subtypes and EZH2 and IGFBP2 mRNA expression","volume":"13","author":"Zheng","year":"2011","journal-title":"Neuro-oncol."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124716305861?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124716305861?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T09:53:38Z","timestamp":1761904418000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124716305861"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":62,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["S2211124716305861"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2016.05.018","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Long Non-coding RNA HIF1A-AS2 Facilitates the Maintenance of Mesenchymal Glioblastoma Stem-like Cells in Hypoxic Niches","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2016.05.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Author(s).","name":"copyright","label":"Copyright"}]}}