{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T12:27:15Z","timestamp":1785241635604,"version":"3.55.0"},"reference-count":65,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,5,27]],"date-time":"2016-05-27T00:00:00Z","timestamp":1464307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.celrep.2016.05.080","type":"journal-article","created":{"date-parts":[[2016,6,27]],"date-time":"2016-06-27T16:09:25Z","timestamp":1467043765000},"page":"106-119","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":67,"title":["Sustained Elevated Adenosine via ADORA2B Promotes Chronic Pain through Neuro-immune Interaction"],"prefix":"10.1016","volume":"16","author":[{"given":"Xia","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morayo G.","family":"Adebiyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialie","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiqi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanh-Thuy T.","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shushan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Karmouty-Quintana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aji","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan Edward","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleg L.","family":"Zaika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mykola","family":"Mamenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleh M.","family":"Pochynyuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney E.","family":"Kellems","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger K.","family":"Eltzschig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Blackburn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar T.","family":"Walters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongzhen","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2016.05.080_bib1","doi-asserted-by":"crossref","first-page":"7947","DOI":"10.1073\/pnas.1331358100","article-title":"Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2","volume":"100","author":"Abbadie","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2016.05.080_bib2","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1124\/jpet.103.056036","article-title":"Antinociceptive effects of novel A2B adenosine receptor antagonists","volume":"308","author":"Abo-Salem","year":"2004","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.celrep.2016.05.080_bib3","doi-asserted-by":"crossref","first-page":"8031","DOI":"10.1523\/JNEUROSCI.15-12-08031.1995","article-title":"Opioid and adenosine peripheral antinociception are subject to tolerance and withdrawal","volume":"15","author":"Aley","year":"1995","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2016.05.080_bib4","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.pain.2013.10.012","article-title":"\u2018Inhibition of IL-6 signaling: a novel therapeutic approach to treating spinal cord injury pain\u2019 by Guptarak et\u00a0al","volume":"155","author":"Baastrup","year":"2014","journal-title":"Pain"},{"key":"10.1016\/j.celrep.2016.05.080_bib5","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.cell.2009.09.028","article-title":"Cellular and molecular mechanisms of pain","volume":"139","author":"Basbaum","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2016.05.080_bib6","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0304-3940(02)00524-4","article-title":"Effects of A(1) and A(2A) adenosine receptor ligands in mouse acute models of pain","volume":"328","author":"Bastia","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.celrep.2016.05.080_bib7","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.4049\/jimmunol.1001567","article-title":"A2B adenosine receptor blockade enhances macrophage-mediated bacterial phagocytosis and improves polymicrobial sepsis survival in mice","volume":"186","author":"Belikoff","year":"2011","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2016.05.080_bib8","doi-asserted-by":"crossref","first-page":"32114","DOI":"10.1074\/jbc.M005153200","article-title":"The use of enzyme therapy to regulate the metabolic and phenotypic consequences of adenosine deaminase deficiency in mice. Differential impact on pulmonary and immunologic abnormalities","volume":"275","author":"Blackburn","year":"2000","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2016.05.080_bib9","doi-asserted-by":"crossref","first-page":"R140","DOI":"10.1186\/ar3079","article-title":"Differential effects of locally and systemically administered soluble glycoprotein 130 on pain and inflammation in experimental arthritis","volume":"12","author":"Boettger","year":"2010","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.celrep.2016.05.080_bib10","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1038\/nn.3144","article-title":"Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology","volume":"15","author":"Chiu","year":"2012","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2016.05.080_bib11","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1023\/A:1008942828960","article-title":"Conditional gene targeting in macrophages and granulocytes using LysMcre mice","volume":"8","author":"Clausen","year":"1999","journal-title":"Transgenic Res."},{"key":"10.1016\/j.celrep.2016.05.080_bib12","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1681\/ASN.2010080890","article-title":"A2B adenosine receptor-mediated induction of IL-6 promotes CKD","volume":"22","author":"Dai","year":"2011","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.celrep.2016.05.080_bib13","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.ejpain.2011.02.005","article-title":"Enhanced cytokine-induced mechanical hyperalgesia in skeletal muscle produced by a novel mechanism in rats exposed to unpredictable sound stress","volume":"15","author":"Dina","year":"2011","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.celrep.2016.05.080_bib14","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/1742-2094-10-55","article-title":"Bilateral elevation of interleukin-6 protein and mRNA in both lumbar and cervical dorsal root ganglia following unilateral chronic compression injury of the sciatic nerve","volume":"10","author":"Dubov\u00fd","year":"2013","journal-title":"J.\u00a0Neuroinflammation"},{"key":"10.1016\/j.celrep.2016.05.080_bib15","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.4049\/jimmunol.1100593","article-title":"Identification of hypoxia-inducible factor HIF-1A as transcriptional regulator of the A2B adenosine receptor during acute lung injury","volume":"192","author":"Eckle","year":"2014","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2016.05.080_bib16","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1056\/NEJMra0910283","article-title":"Hypoxia and inflammation","volume":"364","author":"Eltzschig","year":"2011","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.celrep.2016.05.080_bib17","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1084\/jem.20030891","article-title":"Coordinated adenine nucleotide phosphohydrolysis and nucleoside signaling in posthypoxic endothelium: role of ectonucleotidases and adenosine A2B receptors","volume":"198","author":"Eltzschig","year":"2003","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2016.05.080_bib18","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1182\/blood-2006-02-001016","article-title":"Endothelial catabolism of extracellular adenosine during hypoxia: the role of surface adenosine deaminase and CD26","volume":"108","author":"Eltzschig","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2016.05.080_bib19","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1097\/j.pain.0000000000000158","article-title":"Interleukin-6-mediated functional upregulation of TRPV1 receptors in dorsal root ganglion neurons through the activation of JAK\/PI3K signaling pathway: roles in the development of bone cancer pain in a rat model","volume":"156","author":"Fang","year":"2015","journal-title":"Pain"},{"key":"10.1016\/j.celrep.2016.05.080_bib20","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1172\/JCI118245","article-title":"Adenosine A2b receptors evoke interleukin-8 secretion in human mast cells. An enprofylline-sensitive mechanism with implications for asthma","volume":"96","author":"Feoktistov","year":"1995","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2016.05.080_bib21","doi-asserted-by":"crossref","first-page":"669","DOI":"10.2337\/db10-1070","article-title":"Links between insulin resistance, adenosine A2B receptors, and inflammatory markers in mice and humans","volume":"60","author":"Figler","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.celrep.2016.05.080_bib22","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1038\/sj.cdd.4402132","article-title":"Adenosine, an endogenous distress signal, modulates tissue damage and repair","volume":"14","author":"Fredholm","year":"2007","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.celrep.2016.05.080_bib23","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0031-6997(24)01511-4","article-title":"International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors","volume":"53","author":"Fredholm","year":"2001","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.celrep.2016.05.080_bib24","first-page":"1203","article-title":"A pain research agenda for the 21st century","volume":"15","author":"Gereau","year":"2014","journal-title":"J.\u00a0Pain"},{"key":"10.1016\/j.celrep.2016.05.080_bib25","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1038\/nm.2235","article-title":"Nociceptor sensitization in pain pathogenesis","volume":"16","author":"Gold","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2016.05.080_bib26","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1186\/1471-2458-11-770","article-title":"Pain as a global public health priority","volume":"11","author":"Goldberg","year":"2011","journal-title":"BMC Public Health"},{"key":"10.1016\/j.celrep.2016.05.080_bib27","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/nn.2562","article-title":"Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture","volume":"13","author":"Goldman","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2016.05.080_bib28","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/humu.1380050202","article-title":"PEG-ADA: an alternative to haploidentical bone marrow transplantation and an adjunct to gene therapy for adenosine deaminase deficiency","volume":"5","author":"Hershfield","year":"1995","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.celrep.2016.05.080_bib29","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/eji.200425738","article-title":"New insights into adenosine-receptor-mediated immunosuppression and the role of adenosine in causing the immunodeficiency associated with adenosine deaminase deficiency","volume":"35","author":"Hershfield","year":"2005","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.celrep.2016.05.080_bib30","doi-asserted-by":"crossref","first-page":"3376","DOI":"10.1182\/blood-2010-12-327429","article-title":"Transient receptor potential vanilloid 1 mediates pain in mice with severe sickle cell disease","volume":"118","author":"Hillery","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2016.05.080_bib31","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1161\/CIRCULATIONAHA.114.013740","article-title":"Elevated placental adenosine signaling contributes to the pathogenesis of preeclampsia","volume":"131","author":"Iriyama","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.celrep.2016.05.080_bib32","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0896-6273(02)00908-X","article-title":"p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia","volume":"36","author":"Ji","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2016.05.080_bib33","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/nrd4334","article-title":"Emerging targets in neuroinflammation-driven chronic pain","volume":"13","author":"Ji","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.celrep.2016.05.080_bib34","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1096\/fj.11-200907","article-title":"The A2B adenosine receptor modulates pulmonary hypertension associated with interstitial lung disease","volume":"26","author":"Karmouty-Quintana","year":"2012","journal-title":"FASEB J."},{"key":"10.1016\/j.celrep.2016.05.080_bib35","doi-asserted-by":"crossref","first-page":"6467","DOI":"10.1021\/jm3004834","article-title":"Orally active adenosine A(1) receptor agonists with antinociceptive effects in mice","volume":"55","author":"Korboukh","year":"2012","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.celrep.2016.05.080_bib36","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.bbadis.2015.09.017","article-title":"Bone marrow-derived macrophages and the CNS: An update on the use of experimental chimeric mouse models and bone marrow transplantation in neurological disorders","volume":"1862","author":"Larochelle","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.celrep.2016.05.080_bib37","doi-asserted-by":"crossref","first-page":"3755","DOI":"10.4049\/jimmunol.1302470","article-title":"Blockade of IL-6 Trans signaling attenuates pulmonary fibrosis","volume":"193","author":"Le","year":"2014","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2016.05.080_bib38","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1242\/jeb.203.12.1783","article-title":"The macrophage in acute neural injury: changes in cell numbers over time and levels of cytokine production in mammalian central and peripheral nervous systems","volume":"203","author":"Leskovar","year":"2000","journal-title":"J.\u00a0Exp. Biol."},{"key":"10.1016\/j.celrep.2016.05.080_bib39","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.neuroscience.2010.07.045","article-title":"Peripheral adenosine A2A receptors are involved in carrageenan-induced mechanical hyperalgesia in mice","volume":"170","author":"Li","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.celrep.2016.05.080_bib40","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.bbi.2013.06.004","article-title":"Intrathecal injection of adenosine 2A receptor agonists reversed neuropathic allodynia through protein kinase (PK)A\/PKC signaling","volume":"33","author":"Loram","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.celrep.2016.05.080_bib41","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nrn3946","article-title":"Crosstalk between the nociceptive and immune systems in host defence and disease","volume":"16","author":"McMahon","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.celrep.2016.05.080_bib42","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1172\/JCI33467","article-title":"Excess adenosine in murine penile erectile tissues contributes to priapism via A2B adenosine receptor signaling","volume":"118","author":"Mi","year":"2008","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2016.05.080_bib43","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.brainresrev.2005.11.004","article-title":"Immune and inflammatory mechanisms in neuropathic pain","volume":"51","author":"Moalem","year":"2006","journal-title":"Brain Res. Brain Res. Rev."},{"key":"10.1016\/j.celrep.2016.05.080_bib44","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1046\/j.1460-9568.1999.00641.x","article-title":"Endogenous interleukin-6 contributes to hypersensitivity to cutaneous stimuli and changes in neuropeptides associated with chronic nerve constriction in mice","volume":"11","author":"Murphy","year":"1999","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.celrep.2016.05.080_bib45","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1136\/ard.2008.092866","article-title":"Long-term safety and efficacy of tocilizumab, an anti-IL-6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis (the STREAM study): evidence of safety and efficacy in a 5-year extension study","volume":"68","author":"Nishimoto","year":"2009","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.celrep.2016.05.080_bib46","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1096\/fj.08-119701","article-title":"Adenosine and inflammation: CD39 and CD73 are critical mediators in LPS-induced PMN trafficking into the lungs","volume":"23","author":"Reutershan","year":"2009","journal-title":"FASEB J."},{"key":"10.1016\/j.celrep.2016.05.080_bib47","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.neulet.2008.03.003","article-title":"Caffeine and a selective adenosine A(2B) receptor antagonist but not imidazoline receptor antagonists modulate antinociception induced by diphenyl diselenide in mice","volume":"436","author":"Savegnago","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.celrep.2016.05.080_bib48","article-title":"Adenosine receptor targets for pain","author":"Sawynok","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.celrep.2016.05.080_bib49","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0301-0082(03)00050-9","article-title":"Adenosine in the spinal cord and periphery: release and regulation of pain","volume":"69","author":"Sawynok","year":"2003","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.celrep.2016.05.080_bib50","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0304-3959(97)00153-X","article-title":"Peripheral antinociceptive effect of an adenosine kinase inhibitor, with augmentation by an adenosine deaminase inhibitor, in the rat formalin test","volume":"74","author":"Sawynok","year":"1998","journal-title":"Pain"},{"key":"10.1016\/j.celrep.2016.05.080_bib51","doi-asserted-by":"crossref","first-page":"5271","DOI":"10.4049\/jimmunol.0903035","article-title":"Signaling through the A2B adenosine receptor dampens endotoxin-induced acute lung injury","volume":"184","author":"Schingnitz","year":"2010","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2016.05.080_bib52","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1744-8069-6-20","article-title":"Recombinant ecto-5\u2032-nucleotidase (CD73) has long lasting antinociceptive effects that are dependent on adenosine A1 receptor activation","volume":"6","author":"Sowa","year":"2010","journal-title":"Mol. Pain"},{"key":"10.1016\/j.celrep.2016.05.080_bib53","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1172\/JCI27303","article-title":"Role of A2B adenosine receptor signaling in adenosine-dependent pulmonary inflammation and injury","volume":"116","author":"Sun","year":"2006","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2016.05.080_bib54","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/0306-4522(90)90068-F","article-title":"Direct cutaneous hyperalgesia induced by adenosine","volume":"38","author":"Taiwo","year":"1990","journal-title":"Neuroscience"},{"key":"10.1016\/j.celrep.2016.05.080_bib55","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1182\/blood-2013-04-498105","article-title":"Mast cell activation contributes to sickle cell pathobiology and pain in mice","volume":"122","author":"Vincent","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2016.05.080_bib56","doi-asserted-by":"crossref","first-page":"5010","DOI":"10.1182\/blood-2010-06-290643","article-title":"Adenosine A2A receptors induced on iNKT and NK cells reduce pulmonary inflammation and injury in mice with sickle cell disease","volume":"116","author":"Wallace","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2016.05.080_bib57","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.expneurol.2014.02.001","article-title":"Neuroinflammatory contributions to pain after SCI: roles for central glial mechanisms and nociceptor-mediated host defense","volume":"258","author":"Walters","year":"2014","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.celrep.2016.05.080_bib58","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.expneurol.2012.12.007","article-title":"The up-regulation of IL-6 in DRG and spinal dorsal horn contributes to neuropathic pain following L5 ventral root transection","volume":"241","author":"Wei","year":"2013","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.celrep.2016.05.080_bib59","first-page":"496","article-title":"Monocytes\/Macrophages control resolution of transient inflammatory pain","volume":"15","author":"Willemen","year":"2014","journal-title":"J.\u00a0Pain"},{"key":"10.1016\/j.celrep.2016.05.080_bib60","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.pain.2004.11.020","article-title":"Increased nociceptive response in mice lacking the adenosine A1 receptor","volume":"113","author":"Wu","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.celrep.2016.05.080_bib61","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.neuroscience.2006.06.045","article-title":"Robust increase of cutaneous sensitivity, cytokine production and sympathetic sprouting in rats with localized inflammatory irritation of the spinal ganglia","volume":"142","author":"Xie","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.celrep.2016.05.080_bib62","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.micinf.2012.05.005","article-title":"Adenosine signaling in normal and sickle erythrocytes and beyond","volume":"14","author":"Zhang","year":"2012","journal-title":"Microbes Infect."},{"key":"10.1016\/j.celrep.2016.05.080_bib63","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/nm.2280","article-title":"Detrimental effects of adenosine signaling in sickle cell disease","volume":"17","author":"Zhang","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2016.05.080_bib64","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0022-3565(24)29400-3","article-title":"Adenosine-mediated mast cell degranulation in adenosine deaminase-deficient mice","volume":"298","author":"Zhong","year":"2001","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.celrep.2016.05.080_bib65","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.4049\/jimmunol.1002907","article-title":"Distinct roles for the A2B adenosine receptor in acute and chronic stages of bleomycin-induced lung injury","volume":"186","author":"Zhou","year":"2011","journal-title":"J.\u00a0Immunol."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124716306933?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124716306933?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T09:53:26Z","timestamp":1761904406000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124716306933"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":65,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["S2211124716306933"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2016.05.080","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sustained Elevated Adenosine via ADORA2B Promotes Chronic Pain through Neuro-immune Interaction","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2016.05.080","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Author(s).","name":"copyright","label":"Copyright"}]}}