{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:21:10Z","timestamp":1790742070909,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T00:00:00Z","timestamp":1471478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.celrep.2016.08.057","type":"journal-article","created":{"date-parts":[[2016,9,20]],"date-time":"2016-09-20T14:32:31Z","timestamp":1474381951000},"page":"3232-3246","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"title":["IL-4 Induces Metallothionein 3- and SLC30A4-Dependent Increase in Intracellular Zn2+ that Promotes Pathogen Persistence in Macrophages"],"prefix":"10.1016","volume":"16","author":[{"given":"Kavitha","family":"Subramanian Vignesh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio A.","family":"Landero Figueroa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksey","family":"Porollo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senad","family":"Divanovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"Caruso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"George S.","family":"Deepe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2016.08.057_bib1","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1128\/iai.65.7.2564-2569.1997","article-title":"Intrapulmonary response to Histoplasma capsulatum in gamma interferon knockout mice","volume":"65","author":"Allendoerfer","year":"1997","journal-title":"Infect. Immun."},{"key":"10.1016\/j.celrep.2016.08.057_bib2","doi-asserted-by":"crossref","first-page":"4199","DOI":"10.1182\/blood-2011-01-328906","article-title":"Alternative activation of macrophages by IL-4 enhances the proteolytic capacity of their phagosomes through synergistic mechanisms","volume":"118","author":"Balce","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2016.08.057_bib3","doi-asserted-by":"crossref","first-page":"e1002777","DOI":"10.1371\/journal.ppat.1002777","article-title":"Candida albicans scavenges host zinc via Pra1 during endothelial invasion","volume":"8","author":"Citiulo","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.celrep.2016.08.057_bib4","doi-asserted-by":"crossref","first-page":"2912","DOI":"10.1111\/j.1742-4658.2010.07716.x","article-title":"Neuronal growth-inhibitory factor (metallothionein-3): structure-function relationships","volume":"277","author":"Ding","year":"2010","journal-title":"FEBS J."},{"key":"10.1016\/j.celrep.2016.08.057_bib5","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.imbio.2010.05.031","article-title":"Interleukin-4 induced interferon regulatory factor (Irf) 4 participates in the regulation of alternative macrophage priming","volume":"215","author":"El Chartouni","year":"2010","journal-title":"Immunobiology"},{"key":"10.1016\/j.celrep.2016.08.057_bib6","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1039\/C3MT00283G","article-title":"Selectivity and specificity of small molecule fluorescent dyes\/probes used for the detection of Zn2+ and Ca2+ in cells","volume":"6","author":"Figueroa","year":"2014","journal-title":"Metallomics"},{"key":"10.1016\/j.celrep.2016.08.057_bib7","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1101\/gad.1874010","article-title":"IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion","volume":"24","author":"Gocheva","year":"2010","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2016.08.057_bib8","first-page":"661","article-title":"Zinc deficiency adversely influences interleukin-4 and interleukin-6 signaling","volume":"27","author":"Gruber","year":"2013","journal-title":"J.\u00a0Biol. Regul. Homeost. Agents"},{"key":"10.1016\/j.celrep.2016.08.057_bib9","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/biof.1114","article-title":"Zinc signals and immune function","volume":"40","author":"Haase","year":"2014","journal-title":"Biofactors"},{"key":"10.1016\/j.celrep.2016.08.057_bib10","doi-asserted-by":"crossref","first-page":"6491","DOI":"10.4049\/jimmunol.181.9.6491","article-title":"Zinc signals are essential for lipopolysaccharide-induced signal transduction in monocytes","volume":"181","author":"Haase","year":"2008","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2016.08.057_bib11","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.immuni.2007.07.022","article-title":"T helper 2 cytokines inhibit autophagic control of intracellular Mycobacterium tuberculosis","volume":"27","author":"Harris","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2016.08.057_bib12","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1002\/jcp.24992","article-title":"TNF\u03b1 Post-Translationally Targets ZnT2 to Accumulate Zinc in Lysosomes","volume":"230","author":"Hennigar","year":"2015","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.celrep.2016.08.057_bib13","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nrmicro2836","article-title":"Nutritional immunity: transition metals at the pathogen-host interface","volume":"10","author":"Hood","year":"2012","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.celrep.2016.08.057_bib14","doi-asserted-by":"crossref","first-page":"3489","DOI":"10.1073\/pnas.95.7.3489","article-title":"Control of zinc transfer between thionein, metallothionein, and zinc proteins","volume":"95","author":"Jacob","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.celrep.2016.08.057_bib15","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/eji.200535496","article-title":"Alternative activation deprives macrophages of a coordinated defense program to Mycobacterium tuberculosis","volume":"36","author":"Kahnert","year":"2006","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.celrep.2016.08.057_bib16","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1756-6606-3-30","article-title":"Roles of zinc and metallothionein-3 in oxidative stress-induced lysosomal dysfunction, cell death, and autophagy in neurons and astrocytes","volume":"3","author":"Lee","year":"2010","journal-title":"Mol. Brain"},{"key":"10.1016\/j.celrep.2016.08.057_bib17","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1038\/mi.2014.65","article-title":"Classical versus alternative macrophage activation: the Ying and the Yang in host defense against pulmonary fungal infections","volume":"7","author":"Leopold Wager","year":"2014","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.celrep.2016.08.057_bib18","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1039\/b802220h","article-title":"Human metallothionein metallomics","volume":"23","author":"Li","year":"2008","journal-title":"J.\u00a0Anal. At. Spectrom."},{"key":"10.1016\/j.celrep.2016.08.057_bib19","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.chom.2012.01.017","article-title":"Zinc sequestration by the neutrophil protein calprotectin enhances Salmonella growth in the inflamed gut","volume":"11","author":"Liu","year":"2012","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.celrep.2016.08.057_bib20","doi-asserted-by":"crossref","first-page":"C291","DOI":"10.1152\/ajpcell.00443.2011","article-title":"ZnT4 provides zinc to zinc-dependent proteins in the trans-Golgi network critical for cell function and Zn export in mammary epithelial cells","volume":"303","author":"McCormick","year":"2012","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.celrep.2016.08.057_bib21","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0041-008X(92)90152-I","article-title":"In\u00a0vitro degradation of apo-, zinc-, and cadmium-metallothionein by cathepsins B, C, and D","volume":"116","author":"McKim","year":"1992","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.celrep.2016.08.057_bib22","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1189\/jlb.0602325","article-title":"The many faces of macrophage activation","volume":"73","author":"Mosser","year":"2003","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.celrep.2016.08.057_bib23","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/nri2448","article-title":"Exploring the full spectrum of macrophage activation","volume":"8","author":"Mosser","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2016.08.057_bib24","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1096\/fj.13-232272","article-title":"The endolysosomal cysteine cathepsins L and K are involved in macrophage-mediated clearance of Staphylococcus aureus and the concomitant cytokine induction","volume":"28","author":"M\u00fcller","year":"2014","journal-title":"FASEB J."},{"key":"10.1016\/j.celrep.2016.08.057_bib25","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.immuni.2014.06.008","article-title":"Macrophage activation and polarization: nomenclature and experimental guidelines","volume":"41","author":"Murray","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2016.08.057_bib26","doi-asserted-by":"crossref","first-page":"4593","DOI":"10.1128\/iai.60.11.4593-4597.1992","article-title":"Colony-stimulating factors activate human macrophages to inhibit intracellular growth of Histoplasma capsulatum yeasts","volume":"60","author":"Newman","year":"1992","journal-title":"Infect. Immun."},{"key":"10.1016\/j.celrep.2016.08.057_bib27","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1007\/s00424-003-1070-7","article-title":"Efflux and compartmentalization of zinc by members of the SLC30 family of solute carriers","volume":"447","author":"Palmiter","year":"2004","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.celrep.2016.08.057_bib28","doi-asserted-by":"crossref","first-page":"5712","DOI":"10.1128\/IAI.72.10.5712-5721.2004","article-title":"The down-regulation of cathepsin G in THP-1 monocytes after infection with Mycobacterium tuberculosis is associated with increased intracellular survival of bacilli","volume":"72","author":"Rivera-Marrero","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.celrep.2016.08.057_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2016.02.020","article-title":"Immunological orchestration of zinc homeostasis: The battle between host mechanisms and pathogen defenses","author":"Subramanian Vignesh","year":"2016","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.celrep.2016.08.057_bib30","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.immuni.2013.09.006","article-title":"Granulocyte macrophage-colony stimulating factor induced Zn sequestration enhances macrophage superoxide and limits intracellular pathogen survival","volume":"39","author":"Subramanian Vignesh","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2016.08.057_bib31","doi-asserted-by":"crossref","first-page":"e1003815","DOI":"10.1371\/journal.ppat.1003815","article-title":"Zinc sequestration: arming phagocyte defense against fungal attack","volume":"9","author":"Subramanian Vignesh","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.celrep.2016.08.057_bib32","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.4049\/jimmunol.0901316","article-title":"The CCL7-CCL2-CCR2 axis regulates IL-4 production in lungs and fungal immunity","volume":"183","author":"Szymczak","year":"2009","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2016.08.057_bib33","doi-asserted-by":"crossref","first-page":"13462","DOI":"10.1016\/S0021-9258(18)98862-9","article-title":"Calcium-dependent complex assembly of the myeloic differentiation proteins MRP-8 and MRP-14","volume":"266","author":"Teigelkamp","year":"1991","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2016.08.057_bib34","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/mi.2014.75","article-title":"Type II cytokines impair host defense against an intracellular fungal pathogen by amplifying macrophage generation of IL-33","volume":"8","author":"Verma","year":"2015","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.celrep.2016.08.057_bib35","doi-asserted-by":"crossref","first-page":"420","DOI":"10.4049\/jimmunol.158.1.420","article-title":"Pathways for the regulation of macrophage iron metabolism by the anti-inflammatory cytokines IL-4 and IL-13","volume":"158","author":"Weiss","year":"1997","journal-title":"J.\u00a0Immunol."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221112471631138X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221112471631138X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T09:57:49Z","timestamp":1761904669000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221112471631138X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":35,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["S221112471631138X"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2016.08.057","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IL-4 Induces Metallothionein 3- and SLC30A4-Dependent Increase in Intracellular Zn2+ that Promotes Pathogen Persistence in Macrophages","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2016.08.057","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"name":"copyright","label":"Copyright"}]}}