{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T22:24:29Z","timestamp":1792275869425,"version":"4.4.0"},"reference-count":55,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,9,13]],"date-time":"2016-09-13T00:00:00Z","timestamp":1473724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.celrep.2016.09.033","type":"journal-article","created":{"date-parts":[[2016,10,11]],"date-time":"2016-10-11T12:00:55Z","timestamp":1476187255000},"page":"735-747","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":86,"title":["Astroglial-Mediated Remodeling of the Interhemispheric Midline Is Required for the Formation of the Corpus Callosum"],"prefix":"10.1016","volume":"17","author":[{"given":"Ilan","family":"Gobius","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Morcom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Su\u00e1rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Bunt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polina","family":"Bukshpun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Reardon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William\u00a0B.","family":"Dobyns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John\u00a0L.R.","family":"Rubenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.\u00a0James","family":"Barkovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliott\u00a0H.","family":"Sherr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda\u00a0J.","family":"Richards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2016.09.033_bib1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0896-6273(02)00561-5","article-title":"Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain","volume":"33","author":"Bagri","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2016.09.033_bib2","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1136\/jmg.32.8.636","article-title":"Developmental delay and dysmorphic features associated with a previously undescribed deletion on chromosome 1","volume":"32","author":"Barton","year":"1995","journal-title":"J.\u00a0Med. Genet."},{"key":"10.1016\/j.celrep.2016.09.033_bib3","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/89126","article-title":"In\u00a0vivo molecular target assessment of matrix metalloproteinase inhibition","volume":"7","author":"Bremer","year":"2001","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2016.09.033_bib4","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jneumeth.2012.03.016","article-title":"A method for stable transgenesis of radial glia lineage in rat neocortex by piggyBac mediated transposition","volume":"207","author":"Chen","year":"2012","journal-title":"J.\u00a0Neurosci. Methods"},{"key":"10.1016\/j.celrep.2016.09.033_bib5","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.tjog.2011.07.014","volume":"50","author":"Chen","year":"2011","journal-title":"Taiwan. J. Obstet. Gynecol."},{"key":"10.1016\/j.celrep.2016.09.033_bib6","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.neuron.2011.11.036","article-title":"A cascade of morphogenic signaling initiated by the meninges controls corpus callosum formation","volume":"73","author":"Choe","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2016.09.033_bib7","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/ejhg.2008.206","article-title":"Kallmann syndrome","volume":"17","author":"Dod\u00e9","year":"2009","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.celrep.2016.09.033_bib8","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/ng1122","article-title":"Loss-of-function mutations in FGFR1 cause autosomal dominant Kallmann syndrome","volume":"33","author":"Dod\u00e9","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2016.09.033_bib9","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1093\/brain\/awt358","article-title":"Clinical, genetic and imaging findings identify new causes for corpus callosum development syndromes","volume":"137","author":"Edwards","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.celrep.2016.09.033_bib10","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1093\/cercor\/bhs395","article-title":"Netrin-DCC signaling regulates corpus callosum formation through attraction of pioneering axons and by modulating Slit2-mediated repulsion","volume":"24","author":"Fothergill","year":"2014","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.celrep.2016.09.033_bib11","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/nrn1723","article-title":"Forty-five years of split-brain research and still going strong","volume":"6","author":"Gazzaniga","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.celrep.2016.09.033_bib12","doi-asserted-by":"crossref","first-page":"6029","DOI":"10.1523\/JNEUROSCI.22-14-06029.2002","article-title":"A critical function of the pial basement membrane in cortical histogenesis","volume":"22","author":"Halfter","year":"2002","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2016.09.033_bib13","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.2214\/AJR.05.0146","article-title":"Anomalies of the corpus callosum: an MR analysis of the phenotypic spectrum of associated malformations","volume":"187","author":"Hetts","year":"2006","journal-title":"AJR Am. J. Roentgenol."},{"key":"10.1016\/j.celrep.2016.09.033_bib14","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1126\/science.1165187","article-title":"Draxin, a repulsive guidance protein for spinal cord and forebrain commissures","volume":"323","author":"Islam","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.celrep.2016.09.033_bib15","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1002\/gene.20009","article-title":"Dorsal telencephalon-specific expression of Cre recombinase in PAC transgenic mice","volume":"38","author":"Iwasato","year":"2004","journal-title":"Genesis"},{"key":"10.1016\/j.celrep.2016.09.033_bib16","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.ejmg.2014.03.004","article-title":"Microdeletion of 1p32-p31 involving NFIA in a patient with hypoplastic corpus callosum, ventriculomegaly, seizures and urinary tract defects","volume":"57","author":"Ji","year":"2014","journal-title":"Eur. J. Med. Genet."},{"key":"10.1016\/j.celrep.2016.09.033_bib17","doi-asserted-by":"crossref","first-page":"5840","DOI":"10.1523\/JNEUROSCI.1175-06.2006","article-title":"The Wnt receptor Ryk is required for Wnt5a-mediated axon guidance on the contralateral side of the corpus callosum","volume":"26","author":"Keeble","year":"2006","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2016.09.033_bib18","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s00431-009-1057-2","article-title":"A novel 1p31.3p32.2 deletion involving the NFIA gene detected by array CGH in a patient with macrocephaly and hypoplasia of the corpus callosum","volume":"169","author":"Koehler","year":"2010","journal-title":"Eur. J. Pediatr."},{"key":"10.1016\/j.celrep.2016.09.033_bib19","doi-asserted-by":"crossref","first-page":"443","DOI":"10.3171\/jns.1999.90.3.0443","article-title":"Clinical variability in patients with Apert\u2019s syndrome","volume":"90","author":"Lajeunie","year":"1999","journal-title":"J.\u00a0Neurosurg."},{"key":"10.1016\/j.celrep.2016.09.033_bib20","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.neuron.2012.08.031","article-title":"MEK Is a key regulator of gliogenesis in the developing brain","volume":"75","author":"Li","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2016.09.033_bib21","doi-asserted-by":"crossref","first-page":"e80","DOI":"10.1371\/journal.pgen.0030080","article-title":"NFIA haploinsufficiency is associated with a CNS malformation syndrome and urinary tract defects","volume":"3","author":"Lu","year":"2007","journal-title":"PLoS Genet."},{"key":"10.1016\/j.celrep.2016.09.033_bib22","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nn.2467","article-title":"A robust and high-throughput Cre reporting and characterization system for the whole mouse brain","volume":"13","author":"Madisen","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2016.09.033_bib23","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1093\/cercor\/bhs303","article-title":"Gli3 controls corpus callosum formation by positioning midline guideposts during telencephalic patterning","volume":"24","author":"Magnani","year":"2014","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.celrep.2016.09.033_bib24","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/nrn2189","article-title":"Initiation to end point: the multiple roles of fibroblast growth factors in neural development","volume":"8","author":"Mason","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.celrep.2016.09.033_bib25","doi-asserted-by":"crossref","first-page":"E1709","DOI":"10.1210\/jc.2011-0454","article-title":"Novel FGF8 mutations associated with recessive holoprosencephaly, craniofacial defects, and hypothalamo-pituitary dysfunction","volume":"96","author":"McCabe","year":"2011","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.celrep.2016.09.033_bib26","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1523\/JNEUROSCI.3162-05.2006","article-title":"Multiple Eph receptors and B-class ephrins regulate midline crossing of corpus callosum fibers in the developing mouse forebrain","volume":"26","author":"Mendes","year":"2006","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2016.09.033_bib27","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/ng0298-136","article-title":"An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination","volume":"18","author":"Meyers","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2016.09.033_bib28","doi-asserted-by":"crossref","first-page":"3645","DOI":"10.1002\/cne.22445","article-title":"Molecular regulation of the developing commissural plate","volume":"518","author":"Moldrich","year":"2010","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.celrep.2016.09.033_bib29","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/glia.20350","article-title":"Inducible gene deletion in astroglia and radial glia--a valuable tool for functional and lineage analysis","volume":"54","author":"Mori","year":"2006","journal-title":"Glia"},{"key":"10.1016\/j.celrep.2016.09.033_bib30","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.devcel.2008.12.014","article-title":"Committed neuronal precursors confer astrocytic potential on residual neural precursor cells","volume":"16","author":"Namihira","year":"2009","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2016.09.033_bib31","doi-asserted-by":"crossref","first-page":"e1000230","DOI":"10.1371\/journal.pbio.1000230","article-title":"Transient neuronal populations are required to guide callosal axons: a role for semaphorin 3C","volume":"7","author":"Niquille","year":"2009","journal-title":"PLoS Biol."},{"key":"10.1016\/j.celrep.2016.09.033_bib32","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/nrn2107","article-title":"Agenesis of the corpus callosum: genetic, developmental and functional aspects of connectivity","volume":"8","author":"Paul","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.celrep.2016.09.033_bib33","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1749-8104-4-43","article-title":"Multiple non-cell-autonomous defects underlie neocortical callosal dysgenesis in Nfib-deficient mice","volume":"4","author":"Piper","year":"2009","journal-title":"Neural Dev."},{"issue":"Suppl 1","key":"10.1016\/j.celrep.2016.09.033_bib34","doi-asserted-by":"crossref","first-page":"i11","DOI":"10.1093\/cercor\/bhp027","article-title":"Neuropilin 1-Sema signaling regulates crossing of cingulate pioneering axons during development of the corpus callosum","volume":"19","author":"Piper","year":"2009","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.celrep.2016.09.033_bib35","doi-asserted-by":"crossref","first-page":"9127","DOI":"10.1523\/JNEUROSCI.6167-09.2010","article-title":"NFIA controls telencephalic progenitor cell differentiation through repression of the Notch effector Hes1","volume":"30","author":"Piper","year":"2010","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2016.09.033_bib36","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/BF02680175","article-title":"\u00dcber den Bau des balkenlosen Gro\u03b2hirns, sowie \u00fcber mikrogyrie und heterotypie der grauer substanz","volume":"34","author":"Probst","year":"1901","journal-title":"Arch. F. Psychiatr."},{"key":"10.1016\/j.celrep.2016.09.033_bib37","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/cne.901320103","article-title":"Development of the corpus callosum and cavum septi in man","volume":"132","author":"Rakic","year":"1968","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.celrep.2016.09.033_bib38","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ejmg.2013.12.011","article-title":"An intragenic deletion of the NFIA gene in a patient with a hypoplastic corpus callosum, craniofacial abnormalities and urinary tract defects","volume":"57","author":"Rao","year":"2014","journal-title":"Eur. J. Med. Genet."},{"key":"10.1016\/j.celrep.2016.09.033_bib39","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1007\/s00381-007-0474-7","article-title":"Brain malformation in syndromic craniosynostoses, a primary disorder of white matter: a review","volume":"23","author":"Raybaud","year":"2007","journal-title":"Childs Nerv. Syst."},{"key":"10.1016\/j.celrep.2016.09.033_bib40","doi-asserted-by":"crossref","first-page":"e1003823","DOI":"10.1371\/journal.pgen.1003823","article-title":"Both rare and de novo copy number variants are prevalent in agenesis of the corpus callosum but not in cerebellar hypoplasia or polymicrogyria","volume":"9","author":"Sajan","year":"2013","journal-title":"PLoS Genet."},{"key":"10.1016\/j.celrep.2016.09.033_bib41","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/dneu.20865","article-title":"Appropriate Bmp7 levels are required for the differentiation of midline guidepost cells involved in corpus callosum formation","volume":"71","author":"S\u00e1nchez-Camacho","year":"2011","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.celrep.2016.09.033_bib42","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1523\/JNEUROSCI.23-01-00203.2003","article-title":"Abnormal development of forebrain midline glia and commissural projections in Nfia knock-out mice","volume":"23","author":"Shu","year":"2003","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2016.09.033_bib43","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/neu.10252","article-title":"Development of midline glial populations at the corticoseptal boundary","volume":"57","author":"Shu","year":"2003","journal-title":"J.\u00a0Neurobiol."},{"key":"10.1016\/j.celrep.2016.09.033_bib44","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.gde.2010.12.005","article-title":"We have got you \u2018covered\u2019: how the meninges control brain development","volume":"21","author":"Siegenthaler","year":"2011","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.celrep.2016.09.033_bib45","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/cne.902100103","article-title":"Axonal guidance during development of the great cerebral commissures: descriptive and experimental studies, in\u00a0vivo, on the role of preformed glial pathways","volume":"210","author":"Silver","year":"1982","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.celrep.2016.09.033_bib46","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/cne.903280308","article-title":"Immunocytochemical demonstration of early appearing astroglial structures that form boundaries and pathways along axon tracts in the fetal brain","volume":"328","author":"Silver","year":"1993","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.celrep.2016.09.033_bib47","first-page":"507","article-title":"De novo interstitial deletion of chromosome 1p with absent corpus callosum--a case report","volume":"26","author":"Sivasankaran","year":"1997","journal-title":"Ann. Acad. Med. Singapore"},{"key":"10.1016\/j.celrep.2016.09.033_bib48","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/nn1705","article-title":"Midline radial glia translocation and corpus callosum formation require FGF signaling","volume":"9","author":"Smith","year":"2006","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2016.09.033_bib49","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1128\/MCB.25.2.685-698.2005","article-title":"The transcription factor gene Nfib is essential for both lung maturation and brain development","volume":"25","author":"Steele-Perkins","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.celrep.2016.09.033_bib50","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.brainres.2016.06.015","article-title":"Perinatal midline astrocyte development is impaired in fibroblast growth factor 8 hypomorphic mice","volume":"1646","author":"Stewart","year":"2016","journal-title":"Brain Res."},{"key":"10.1016\/j.celrep.2016.09.033_bib51","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1242\/dev.02324","article-title":"Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers","volume":"133","author":"Storm","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.celrep.2016.09.033_bib52","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.neuron.2014.04.040","article-title":"Balanced interhemispheric cortical activity is required for correct targeting of the corpus callosum","volume":"82","author":"Su\u00e1rez","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2016.09.033_bib53","doi-asserted-by":"crossref","first-page":"497","DOI":"10.3389\/fnhum.2014.00497","article-title":"Evolution and development of interhemispheric connections in the vertebrate forebrain","volume":"8","author":"Su\u00e1rez","year":"2014","journal-title":"Front. Hum. Neurosci."},{"key":"10.1016\/j.celrep.2016.09.033_bib54","first-page":"619","article-title":"Skull base and calvarial deformities: association with intracranial changes in craniofacial syndromes","volume":"17","author":"Tokumaru","year":"1996","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"10.1016\/j.celrep.2016.09.033_bib55","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/ng0295-165","article-title":"Apert syndrome results from localized mutations of FGFR2 and is allelic with Crouzon syndrome","volume":"9","author":"Wilkie","year":"1995","journal-title":"Nat. Genet."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124716312554?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124716312554?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T09:59:12Z","timestamp":1761904752000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124716312554"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":55,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["S2211124716312554"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2016.09.033","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Astroglial-Mediated Remodeling of the Interhemispheric Midline Is Required for the Formation of the Corpus Callosum","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2016.09.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors.","name":"copyright","label":"Copyright"}]}}