{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T05:21:54Z","timestamp":1788931314695,"version":"build-2803163510"},"reference-count":29,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,3,27]],"date-time":"2017-03-27T00:00:00Z","timestamp":1490572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"ERC Starting Grant"},{"name":"Spanish Ministry of Economy and Competitiveness","award":["SAF2013-48535-P"],"award-info":[{"award-number":["SAF2013-48535-P"]}]},{"name":"Spanish Ministry of Economy and Competitiveness","award":["SAF2016-80412-P"],"award-info":[{"award-number":["SAF2016-80412-P"]}]},{"name":"Spanish Ministry of Economy and Competitiveness"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.celrep.2017.03.065","type":"journal-article","created":{"date-parts":[[2017,4,19]],"date-time":"2017-04-19T13:16:57Z","timestamp":1492607817000},"page":"471-478","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"title":["Physiological Plasticity of Neural-Crest-Derived Stem Cells in the Adult Mammalian Carotid Body"],"prefix":"10.1016","volume":"19","author":[{"given":"Valentina","family":"Annese","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Navarro-Guerrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismael","family":"Rodr\u00edguez-Prieto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Pardal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2017.03.065_bib1","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0046-8177(76)80052-4","article-title":"Chief cell hyperplasia in the human carotid body at high altitudes; physiologic and pathologic significance","volume":"7","author":"Arias-Stella","year":"1976","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.celrep.2017.03.065_bib2","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1182\/blood-2003-04-1284","article-title":"Erythropoietin regulates endothelial progenitor cells","volume":"103","author":"Bahlmann","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2017.03.065_bib3","doi-asserted-by":"crossref","first-page":"L1257","DOI":"10.1152\/ajplung.00419.2006","article-title":"Effect of the endothelin receptor antagonist bosentan on chronic hypoxia-induced morphological and physiological changes in rat carotid body","volume":"292","author":"Chen","year":"2007","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.celrep.2017.03.065_bib4","doi-asserted-by":"crossref","first-page":"25875","DOI":"10.1074\/jbc.M701988200","article-title":"Endogenous erythropoietin signaling is required for normal neural progenitor cell proliferation","volume":"282","author":"Chen","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2017.03.065_bib5","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.cell.2013.02.021","article-title":"Glioblastoma stem cells generate vascular pericytes to support vessel function and tumor growth","volume":"153","author":"Cheng","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2017.03.065_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/path.1711040102","article-title":"The carotid body in emphysema and left ventricular hypertrophy","volume":"104","author":"Edwards","year":"1971","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.celrep.2017.03.065_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0034-5687(95)00013-4","article-title":"Hypoxia-inducible gene expression","volume":"101","author":"Fandrey","year":"1995","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.celrep.2017.03.065_bib8","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1182\/blood-2013-01-478065","article-title":"Erythrocytosis: The HIF pathway in control","volume":"122","author":"Franke","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2017.03.065_bib9","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/978-1-4615-5891-0_47","article-title":"Expression and localization of enkephalin, substance P, and substance P receptor genes in the rat carotid body","volume":"410","author":"Gauda","year":"1996","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.celrep.2017.03.065_bib10","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1111\/j.1471-4159.1993.tb13401.x","article-title":"Opioid peptides in the rabbit carotid body: Identification and evidence for co-utilization and interactions with dopamine","volume":"60","author":"Gonz\u00e1lez-Guerrero","year":"1993","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.celrep.2017.03.065_bib11","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/path.1711380203","article-title":"Hyperplasia of the carotid body","volume":"138","author":"Heath","year":"1982","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.celrep.2017.03.065_bib12","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1182\/blood-2003-01-0223","article-title":"Erythropoietin is a potent physiologic stimulus for endothelial progenitor cell mobilization","volume":"102","author":"Heeschen","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2017.03.065_bib13","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1161\/CIRCRESAHA.109.199299","article-title":"Concurrent vasculogenesis and neurogenesis from adult neural stem cells","volume":"105","author":"Ii","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.celrep.2017.03.065_bib14","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/978-90-481-2259-2_24","article-title":"Upregulation of erythropoietin and its receptor expression in the rat carotid body during chronic and intermittent hypoxia","volume":"648","author":"Lam","year":"2009","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.celrep.2017.03.065_bib15","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.4161\/cc.7.8.5641","article-title":"The stem cells of the neural crest","volume":"7","author":"Le Douarin","year":"2008","journal-title":"Cell Cycle"},{"key":"10.1016\/j.celrep.2017.03.065_bib16","doi-asserted-by":"crossref","first-page":"39273","DOI":"10.1074\/jbc.M509446200","article-title":"Erythropoietin promotes MCF-7 breast cancer cell migration by an ERK\/mitogen-activated protein kinase-dependent pathway and is primarily responsible for the increase in migration observed in hypoxia","volume":"280","author":"Lester","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2017.03.065_bib17","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1146\/annurev.physiol.63.1.259","article-title":"Cellular mechanism of oxygen sensing","volume":"63","author":"L\u00f3pez-Barneo","year":"2001","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.celrep.2017.03.065_bib18","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S0896-6273(03)00116-8","article-title":"Neuronal or glial progeny: Regional differences in radial glia fate","volume":"37","author":"Malatesta","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2017.03.065_bib19","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1002\/stem.2331","article-title":"Gene Expression Profiling Supports the Neural Crest Origin of Adult Rodent Carotid Body Stem Cells and Identifies CD10 as a Marker for Mesectoderm-Committed Progenitors","volume":"34","author":"Navarro-Guerrero","year":"2016","journal-title":"Stem Cells"},{"key":"10.1016\/j.celrep.2017.03.065_bib20","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.cell.2007.07.043","article-title":"Glia-like stem cells sustain physiologic neurogenesis in the adult mammalian carotid body","volume":"131","author":"Pardal","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2017.03.065_bib21","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1038\/cr.2011.38","article-title":"Oct-4+\/Tenascin C+ neuroblastoma cells serve as progenitors of tumor-derived endothelial cells","volume":"21","author":"Pezzolo","year":"2011","journal-title":"Cell Res."},{"key":"10.1016\/j.celrep.2017.03.065_bib22","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.cell.2013.12.013","article-title":"An O2-sensitive glomus cell-stem cell synapse induces carotid body growth in chronic hypoxia","volume":"156","author":"Platero-Luengo","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2017.03.065_bib23","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1038\/nature09557","article-title":"Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells","volume":"468","author":"Ricci-Vitiani","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2017.03.065_bib24","doi-asserted-by":"crossref","first-page":"9733","DOI":"10.1523\/JNEUROSCI.21-24-09733.2001","article-title":"Erythropoietin regulates the in\u00a0vitro and in\u00a0vivo production of neuronal progenitors by mammalian forebrain neural stem cells","volume":"21","author":"Shingo","year":"2001","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2017.03.065_bib25","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1083\/jcb.99.6.2034","article-title":"Identification and isolation of endothelial cells based on their increased uptake of acetylated-low density lipoprotein","volume":"99","author":"Voyta","year":"1984","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.celrep.2017.03.065_bib26","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/jemt.10191","article-title":"Chronic hypoxia-induced morphological and neurochemical changes in the carotid body","volume":"59","author":"Wang","year":"2002","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.celrep.2017.03.065_bib27","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1161\/01.STR.0000132196.49028.a4","article-title":"Treatment of\u00a0stroke with erythropoietin enhances neurogenesis and angiogenesis and improves neurological function in rats","volume":"35","author":"Wang","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.celrep.2017.03.065_bib28","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nature09624","article-title":"Glioblastoma stem-like cells give rise to tumour endothelium","volume":"468","author":"Wang","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2017.03.065_bib29","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/nature02604","article-title":"Cell fusion-independent differentiation of neural stem cells to the endothelial lineage","volume":"430","author":"Wurmser","year":"2004","journal-title":"Nature"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124717304266?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124717304266?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T10:05:31Z","timestamp":1761905131000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124717304266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["S2211124717304266"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2017.03.065","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Physiological Plasticity of Neural-Crest-Derived Stem Cells in the Adult Mammalian Carotid Body","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2017.03.065","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Author(s).","name":"copyright","label":"Copyright"}]}}