{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:38:52Z","timestamp":1791639532278,"version":"4.3.4"},"reference-count":42,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,3,29]],"date-time":"2017-03-29T00:00:00Z","timestamp":1490745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.celrep.2017.03.071","type":"journal-article","created":{"date-parts":[[2017,4,19]],"date-time":"2017-04-19T13:17:54Z","timestamp":1492607874000},"page":"451-460","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":78,"title":["The Natural Product Cavinafungin Selectively Interferes with Zika and Dengue Virus Replication by Inhibition of the Host Signal Peptidase"],"prefix":"10.1016","volume":"19","author":[{"given":"David","family":"Estoppey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia Min","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Janoschke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boon Heng","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kah Fei","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongping","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Mathys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ireos","family":"Filipuzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Schuhmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Riedl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Aust","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Galuba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"McAllister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Russ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Spiess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tewis","family":"Bouwmeester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghislain M.C.","family":"Bonamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic","family":"Hoepfner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2017.03.071_bib1","doi-asserted-by":"crossref","first-page":"18965","DOI":"10.1074\/jbc.274.27.18965","article-title":"Mechanism of endoplasmic reticulum retention of mutant vasopressin precursor caused by a signal peptide truncation associated with diabetes insipidus","volume":"274","author":"Beuret","year":"1999","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2017.03.071_bib2","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature12060","article-title":"The global distribution and burden of dengue","volume":"496","author":"Bhatt","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2017.03.071_bib3","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1083\/jcb.106.4.1035","article-title":"SEC11 is required for signal peptide processing and yeast cell growth","volume":"106","author":"B\u00f6hni","year":"1988","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.celrep.2017.03.071_bib4","doi-asserted-by":"crossref","first-page":"e1760","DOI":"10.1371\/journal.pntd.0001760","article-title":"Refining the global spatial limits of dengue virus transmission by evidence-based consensus","volume":"6","author":"Brady","year":"2012","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.celrep.2017.03.071_bib5","doi-asserted-by":"crossref","first-page":"4761","DOI":"10.1016\/j.bmcl.2015.07.072","article-title":"The inhibition of type I bacterial signal peptidase: Biological consequences and therapeutic potential","volume":"25","author":"Craney","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.celrep.2017.03.071_bib6","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nature18296","article-title":"The Brazilian Zika virus strain causes birth defects in experimental models","volume":"534","author":"Cugola","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2017.03.071_bib7","doi-asserted-by":"crossref","first-page":"28131","DOI":"10.1074\/jbc.M115.692350","article-title":"Competitive inhibition of the endoplasmic reticulum signal peptidase by non-cleavable mutant preprotein cargos","volume":"290","author":"Cui","year":"2015","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2017.03.071_bib8","doi-asserted-by":"crossref","first-page":"42728","DOI":"10.1038\/srep42728","article-title":"Identification of a novel NAMPT inhibitor by CRISPR\/Cas9 chemogenomic profiling in mammalian cells","volume":"7","author":"Estoppey","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2017.03.071_bib9","doi-asserted-by":"crossref","first-page":"13152","DOI":"10.1074\/jbc.272.20.13152","article-title":"In addition to SEC11, a newly identified gene, SPC3, is essential for signal peptidase activity in the yeast endoplasmic reticulum","volume":"272","author":"Fang","year":"1997","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2017.03.071_bib10","doi-asserted-by":"crossref","first-page":"19441","DOI":"10.1074\/jbc.M310249200","article-title":"Degradation of wild-type vasopressin precursor and pathogenic mutants by the proteasome","volume":"279","author":"Friberg","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2017.03.071_bib11","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1083\/jcb.136.4.789","article-title":"COPI-independent anterograde transport: cargo-selective ER to Golgi protein transport in yeast COPI mutants","volume":"136","author":"Gaynor","year":"1997","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.celrep.2017.03.071_bib12","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/6791","article-title":"Genomic profiling of drug sensitivities via induced haploinsufficiency","volume":"21","author":"Giaever","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2017.03.071_bib13","doi-asserted-by":"crossref","first-page":"4501","DOI":"10.1021\/cr000033x","article-title":"Serine protease mechanism and specificity","volume":"102","author":"Hedstrom","year":"2002","journal-title":"Chem. Rev."},{"key":"10.1016\/j.celrep.2017.03.071_bib14","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0005-2736(99)00168-6","article-title":"Structural, mechanistic and clinical aspects of MRP1","volume":"1461","author":"Hipfner","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.celrep.2017.03.071_bib15","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.chom.2012.04.015","article-title":"Selective\u00a0and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin","volume":"11","author":"Hoepfner","year":"2012","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.celrep.2017.03.071_bib16","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.micres.2013.11.004","article-title":"High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions","volume":"169","author":"Hoepfner","year":"2014","journal-title":"Microbiol. Res."},{"key":"10.1016\/j.celrep.2017.03.071_bib17","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/nchembio.100","article-title":"An integrated platform of genomic assays reveals small-molecule bioactivities","volume":"4","author":"Hoon","year":"2008","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.celrep.2017.03.071_bib18","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.celrep.2013.01.019","article-title":"A functional variomics tool for discovering drug-resistance genes and drug targets","volume":"3","author":"Huang","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2017.03.071_bib19","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0006-2952(98)00346-3","article-title":"Free radical modulation of insulin release in INS-1 cells exposed to alloxan","volume":"57","author":"Janjic","year":"1999","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.celrep.2017.03.071_bib20","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1086\/383043","article-title":"Localization of dengue virus in naturally infected human tissues, by immunohistochemistry and in\u00a0situ hybridization","volume":"189","author":"Jessie","year":"2004","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.celrep.2017.03.071_bib21","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1016\/j.bcp.2010.07.038","article-title":"Identification of a \u03ba-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis","volume":"80","author":"Jones","year":"2010","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.celrep.2017.03.071_bib22","first-page":"1217","article-title":"Decatransin, a new\u00a0natural product inhibiting protein translocation at the Sec61\/SecYEG translocon","volume":"128","author":"Junne","year":"2015","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.celrep.2017.03.071_bib23","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/nmeth1089","article-title":"A probability-based approach for the analysis of large-scale RNAi screens","volume":"4","author":"K\u00f6nig","year":"2007","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2017.03.071_bib24","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1126\/science.1250217","article-title":"Mapping the cellular response to small molecules using chemogenomic fitness signatures","volume":"344","author":"Lee","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.celrep.2017.03.071_bib25","series-title":"Lippincott, Williams & Wilkins","first-page":"1101","article-title":"Flaviviridae: the viruses and their replication","author":"Lindenbach","year":"2007"},{"key":"10.1016\/j.celrep.2017.03.071_bib26","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.celrep.2015.06.049","article-title":"A CRISPR-based screen identifies genes essential for West-Nile-virus-induced cell death","volume":"12","author":"Ma","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2017.03.071_bib27","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nature18631","article-title":"Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens","volume":"535","author":"Marceau","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2017.03.071_bib28","doi-asserted-by":"crossref","first-page":"13159","DOI":"10.1074\/jbc.272.20.13159","article-title":"The yeast SPC22\/23 homolog Spc3p\u00a0is essential for signal peptidase activity","volume":"272","author":"Meyer","year":"1997","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2017.03.071_bib29","doi-asserted-by":"crossref","first-page":"29094","DOI":"10.1074\/jbc.271.46.29094","article-title":"Structurally related Spc1p and Spc2p of yeast signal peptidase complex are functionally distinct","volume":"271","author":"Mullins","year":"1996","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2017.03.071_bib30","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1021\/np500854j","article-title":"Cyclic colisporifungin and linear cavinafungins, antifungal lipopeptides isolated from Colispora cavincola","volume":"78","author":"Ort\u00edz-L\u00f3pez","year":"2015","journal-title":"J.\u00a0Nat. Prod."},{"key":"10.1016\/j.celrep.2017.03.071_bib31","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1099\/vir.0.000097","article-title":"Post-translational regulation and modifications of flavivirus structural proteins","volume":"96","author":"Roby","year":"2015","journal-title":"J.\u00a0Gen. Virol."},{"key":"10.1016\/j.celrep.2017.03.071_bib32","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.celrep.2016.06.028","article-title":"Identification of Zika virus and dengue virus dependency factors using\u00a0functional genomics","volume":"16","author":"Savidis","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2017.03.071_bib33","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/0092-8674(90)90698-E","article-title":"ERD2, a yeast gene required for the receptor-mediated retrieval of luminal ER proteins from the secretory pathway","volume":"61","author":"Semenza","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2017.03.071_bib34","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.chom.2016.05.004","article-title":"An infectious cDNA clone of Zika virus to study viral virulence, mosquito transmission, and antiviral inhibitors","volume":"19","author":"Shan","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.celrep.2017.03.071_bib35","doi-asserted-by":"crossref","first-page":"5201","DOI":"10.1016\/S0021-9258(18)53520-1","article-title":"Membrane topology and\u00a0biogenesis of eukaryotic signal peptidase","volume":"268","author":"Shelness","year":"1993","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2017.03.071_bib36","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1089\/vbz.2006.6.325","article-title":"Infectious clones of Chikungunya virus (La\u00a0R\u00e9union isolate) for vector competence studies","volume":"6","author":"Tsetsarkin","year":"2006","journal-title":"Vector Borne Zoonotic Dis."},{"key":"10.1016\/j.celrep.2017.03.071_bib37","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/BF01868635","article-title":"The signal peptide","volume":"115","author":"von Heijne","year":"1990","journal-title":"J.\u00a0Membr. Biol."},{"key":"10.1016\/j.celrep.2017.03.071_bib38","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.virol.2013.12.025","article-title":"Generation and characterization of mouse monoclonal antibodies against NS4B protein of dengue virus","volume":"450-451","author":"Xie","year":"2014","journal-title":"Virology"},{"key":"10.1016\/j.celrep.2017.03.071_bib39","doi-asserted-by":"crossref","first-page":"256","DOI":"10.7150\/ijms.10735","article-title":"Upregulation of heat shock proteins (HSPA12A, HSP90B1, HSPA4, HSPA5 and HSPA6) in tumour tissues is associated with poor outcomes from HBV-related early-stage hepatocellular carcinoma","volume":"12","author":"Yang","year":"2015","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.celrep.2017.03.071_bib40","doi-asserted-by":"crossref","first-page":"20435","DOI":"10.1073\/pnas.0907010106","article-title":"An adenosine nucleoside inhibitor of dengue virus","volume":"106","author":"Yin","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2017.03.071_bib41","doi-asserted-by":"crossref","first-page":"e99135","DOI":"10.1371\/journal.pone.0099135","article-title":"Structure and activity of Streptococcus pyogenes SipA: a signal peptidase-like protein essential for pilus polymerisation","volume":"9","author":"Young","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.celrep.2017.03.071_bib42","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/nature18625","article-title":"A CRISPR screen defines a signal peptide processing pathway required by flaviviruses","volume":"535","author":"Zhang","year":"2016","journal-title":"Nature"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124717304485?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124717304485?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T10:04:43Z","timestamp":1761905083000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124717304485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["S2211124717304485"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2017.03.071","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Natural Product Cavinafungin Selectively Interferes with Zika and Dengue Virus Replication by Inhibition of the Host Signal Peptidase","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2017.03.071","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Author(s).","name":"copyright","label":"Copyright"}]}}