{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:39:30Z","timestamp":1790707170142,"version":"4.1.0"},"reference-count":69,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T00:00:00Z","timestamp":1494460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008478","name":"Wake Forest School of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019340","name":"Wake Forest Clinical and Translational Science Institute, Wake Forest School of Medicine","doi-asserted-by":"publisher","award":["UL1 TR001420"],"award-info":[{"award-number":["UL1 TR001420"]}],"id":[{"id":"10.13039\/100019340","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK105965"],"award-info":[{"award-number":["DK105965"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL109650"],"award-info":[{"award-number":["HL109650"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL119962"],"award-info":[{"award-number":["HL119962"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL48044"],"award-info":[{"award-number":["HL48044"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008308","name":"Comprehensive Cancer Center, City of Hope","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008308","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA121291-37"],"award-info":[{"award-number":["P30 CA121291-37"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.celrep.2017.05.032","type":"journal-article","created":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T12:19:34Z","timestamp":1496751574000},"page":"2116-2129","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Hepatocyte ABCA1 Deletion Impairs Liver Insulin Signaling and Lipogenesis"],"prefix":"10.1016","volume":"19","author":[{"given":"Chia-Chi C.","family":"Key","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Lisa","family":"Kurtz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soonkyu","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Boudyguina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy A.","family":"Dinh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Bashore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter E.","family":"Phelan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry I.","family":"Freedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy F.","family":"Osborne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuewei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen","family":"Sethupathy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudha B.","family":"Biddinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S.","family":"Parks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2017.05.032_bib1","first-page":"1697","article-title":"Overproduction of VLDL1 driven by hyperglycemia is a dominant feature of diabetic dyslipidemia","volume":"25","author":"Adiels","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.celrep.2017.05.032_bib2","first-page":"15628","article-title":"Selective binding of sterol regulatory element-binding protein isoforms and co-regulatory proteins to promoters for lipid metabolic genes in liver","volume":"283","author":"Bennett","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2017.05.032_bib3","first-page":"2288","article-title":"Liver ABCA1 deletion in LDLrKO mice does not impair macrophage reverse cholesterol transport or exacerbate atherogenesis","volume":"33","author":"Bi","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.celrep.2017.05.032_bib4","first-page":"E1","article-title":"Lipid rafts and insulin signaling","volume":"282","author":"Bickel","year":"2002","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.celrep.2017.05.032_bib5","first-page":"13793","article-title":"Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins","volume":"272","author":"Bickel","year":"1997","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2017.05.032_bib6","first-page":"123","article-title":"From mice to men: insights into the insulin resistance syndromes","volume":"68","author":"Biddinger","year":"2006","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.celrep.2017.05.032_bib7","first-page":"125","article-title":"Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis","volume":"7","author":"Biddinger","year":"2008","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2017.05.032_bib8","first-page":"440","article-title":"Improved method for the quantification of lysophospholipids including enol ether species by liquid chromatography-tandem mass spectrometry","volume":"51","author":"Bollinger","year":"2010","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.celrep.2017.05.032_bib9","first-page":"95","article-title":"Selective versus total insulin resistance: a pathogenic paradox","volume":"7","author":"Brown","year":"2008","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2017.05.032_bib10","first-page":"340","article-title":"Beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment","volume":"13","author":"Brunham","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2017.05.032_bib11","first-page":"329","article-title":"Islet \u03b1 cells and glucagon--critical regulators of energy homeostasis","volume":"11","author":"Campbell","year":"2015","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.celrep.2017.05.032_bib12","first-page":"1063","article-title":"kNOXing on the door of selective insulin resistance","volume":"32","author":"Cheng","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.celrep.2017.05.032_bib13","first-page":"12197","article-title":"Targeted deletion of hepatocyte ABCA1 leads to very low density lipoprotein triglyceride overproduction and low density lipoprotein hypercatabolism","volume":"285","author":"Chung","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2017.05.032_bib14","first-page":"205","article-title":"Association of the ABCA1 gene polymorphisms with type 2 DM in a Japanese population","volume":"329","author":"Daimon","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.celrep.2017.05.032_bib15","first-page":"10580","article-title":"Use of mutant 125I-perfringolysin O to probe transport and organization of cholesterol in membranes of animal cells","volume":"110","author":"Das","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2017.05.032_bib16","first-page":"e02882","article-title":"Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis","volume":"3","author":"Das","year":"2014","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2017.05.032_bib17","first-page":"516","article-title":"ABCA1 in adipocytes regulates adipose tissue lipid content, glucose tolerance, and insulin sensitivity","volume":"55","author":"de Haan","year":"2014","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.celrep.2017.05.032_bib18","first-page":"4076","article-title":"Hepatic ABCA1 expression improves \u03b2-cell function and glucose tolerance","volume":"63","author":"de Haan","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.celrep.2017.05.032_bib19","first-page":"1168","article-title":"Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis","volume":"113","author":"Engelking","year":"2004","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2017.05.032_bib20","first-page":"497","article-title":"A simple method for the isolation and purification of total lipides from animal tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2017.05.032_bib21","first-page":"88","article-title":"Cell-intrinsic adaptation of lipid composition to local crowding drives social behaviour","volume":"523","author":"Frechin","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2017.05.032_bib22","first-page":"161","article-title":"A century of cholesterol and coronaries: from plaques to genes to statins","volume":"161","author":"Goldstein","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2017.05.032_bib23","first-page":"873","article-title":"Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression","volume":"15","author":"Haas","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2017.05.032_bib24","first-page":"5987","article-title":"Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice","volume":"95","author":"Horton","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2017.05.032_bib25","first-page":"391","article-title":"Measurement of fatty acid oxidation rates in animal tissues and cell lines","volume":"542","author":"Huynh","year":"2014","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.celrep.2017.05.032_bib26","first-page":"e08009","article-title":"LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling","volume":"4","author":"Ito","year":"2015","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2017.05.032_bib27","first-page":"65","article-title":"SREBPs: metabolic integrators in physiology and metabolism","volume":"23","author":"Jeon","year":"2012","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.celrep.2017.05.032_bib28","first-page":"1113","article-title":"Simultaneous labeling of lipoprotein intracellular trafficking in pigeon monocyte-derived macrophages","volume":"150","author":"Jones","year":"1997","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.celrep.2017.05.032_bib29","first-page":"201","article-title":"Use of a low-speed, iso-density percoll centrifugation method to increase the viability of isolated rat hepatocyte preparations","volume":"22","author":"Kreamer","year":"1986","journal-title":"In\u00a0Vitro Cell. Dev. Biol."},{"key":"10.1016\/j.celrep.2017.05.032_bib30","first-page":"3186","article-title":"Islet cholesterol accumulation due to loss of ABCA1 leads to impaired exocytosis of insulin granules","volume":"60","author":"Kruit","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.celrep.2017.05.032_bib31","first-page":"36091","article-title":"ATP-binding cassette transporter A1 expression disrupts raft membrane microdomains through its ATPase-related functions","volume":"281","author":"Landry","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2017.05.032_bib32","first-page":"538","article-title":"Raft nanodomains contribute to Akt\/PKB plasma membrane recruitment and activation","volume":"4","author":"Lasserre","year":"2008","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.celrep.2017.05.032_bib33","first-page":"200","article-title":"Insulin signaling to hepatic lipid metabolism in health and disease","volume":"46","author":"Leavens","year":"2011","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"10.1016\/j.celrep.2017.05.032_bib34","first-page":"3441","article-title":"Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis","volume":"107","author":"Li","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2017.05.032_bib35","first-page":"1513","article-title":"Sphingomyelin synthase 2 activity and liver steatosis: an effect of ceramide-mediated peroxisome proliferator-activated receptor \u03b32 suppression","volume":"33","author":"Li","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.celrep.2017.05.032_bib36","first-page":"256","article-title":"Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP","volume":"494","author":"Miller","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2017.05.032_bib37","first-page":"4138","article-title":"ApoE regulates hematopoietic stem cell proliferation, monocytosis, and monocyte accumulation in atherosclerotic lesions in mice","volume":"121","author":"Murphy","year":"2011","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2017.05.032_bib38","first-page":"315","article-title":"Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes","volume":"102","author":"Nohturfft","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2017.05.032_bib39","first-page":"1031","article-title":"ATP-binding cassette cholesterol transporters and cardiovascular disease","volume":"99","author":"Oram","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.celrep.2017.05.032_bib40","first-page":"1874","article-title":"ABCA1 single nucleotide polymorphisms on high-density lipoprotein-cholesterol and overweight: the D.E.S.I.R. study","volume":"14","author":"Porchay","year":"2006","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.celrep.2017.05.032_bib41","first-page":"224","article-title":"SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth","volume":"8","author":"Porstmann","year":"2008","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2017.05.032_bib42","first-page":"512","article-title":"Switch-like control of SREBP-2 transport triggered by small changes in ER cholesterol: a delicate balance","volume":"8","author":"Radhakrishnan","year":"2008","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2017.05.032_bib43","first-page":"1007","article-title":"Abnormal processing of Golgi elements and lysosomes in Tangier disease","volume":"11","author":"Robenek","year":"1991","journal-title":"Arterioscler. Thromb."},{"key":"10.1016\/j.celrep.2017.05.032_bib44","first-page":"799","article-title":"Insulin signalling and the regulation of glucose and lipid metabolism","volume":"414","author":"Saltiel","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2017.05.032_bib45","first-page":"6305","article-title":"Tangier disease: a disorder of intracellular membrane traffic","volume":"82","author":"Schmitz","year":"1985","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2017.05.032_bib46","first-page":"31","article-title":"Lipid rafts and signal transduction","volume":"1","author":"Simons","year":"2000","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2017.05.032_bib47","first-page":"1890","article-title":"Nascent high density lipoproteins formed by ABCA1 resemble lipid rafts and are structurally organized by three apoA-I monomers","volume":"53","author":"Sorci-Thomas","year":"2012","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.celrep.2017.05.032_bib48","first-page":"27180","article-title":"Distinct endosomal compartments in early trafficking of low density lipoprotein-derived cholesterol","volume":"278","author":"Sugii","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2017.05.032_bib49","first-page":"4356","article-title":"Lysosomal-specific cholesterol reduction by biocleavable polyrotaxanes for ameliorating Niemann-Pick type C disease","volume":"4","author":"Tamura","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2017.05.032_bib50","first-page":"508","article-title":"The serine hydrolase ABHD6 is a critical regulator of the metabolic syndrome","volume":"5","author":"Thomas","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2017.05.032_bib51","first-page":"1333","article-title":"Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I","volume":"115","author":"Timmins","year":"2005","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2017.05.032_bib52","first-page":"7078","article-title":"Hepatic insulin signalling is dispensable for suppression of glucose output by insulin in\u00a0vivo","volume":"6","author":"Titchenell","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2017.05.032_bib53","first-page":"1154","article-title":"Direct hepatocyte insulin signaling is required for lipogenesis but is dispensable for the suppression of glucose production","volume":"23","author":"Titchenell","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2017.05.032_bib54","first-page":"95","article-title":"Dynamic association of human insulin receptor with lipid rafts in cells lacking caveolae","volume":"3","author":"Vainio","year":"2002","journal-title":"EMBO Rep."},{"key":"10.1016\/j.celrep.2017.05.032_bib55","first-page":"465","article-title":"Defective insulin receptor activation and altered lipid rafts in Niemann-Pick type C disease hepatocytes","volume":"391","author":"Vainio","year":"2005","journal-title":"Biochem. J."},{"key":"10.1016\/j.celrep.2017.05.032_bib56","first-page":"1881","article-title":"The ATP-binding cassette transporter A1 R230C variant affects HDL cholesterol levels and BMI in the Mexican population: association with obesity and obesity-related comorbidities","volume":"56","author":"Villarreal-Molina","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.celrep.2017.05.032_bib57","first-page":"509","article-title":"Association of the ATP-binding cassette transporter A1 R230C variant with early-onset type 2 diabetes in a Mexican population","volume":"57","author":"Villarreal-Molina","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.celrep.2017.05.032_bib58","first-page":"53","article-title":"SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis","volume":"77","author":"Wang","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2017.05.032_bib59","first-page":"1236","article-title":"NOX4 pathway as a source of selective insulin resistance and responsiveness","volume":"32","author":"Wu","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.celrep.2017.05.032_bib60","first-page":"12753","article-title":"Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins","volume":"99","author":"Yabe","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2017.05.032_bib61","first-page":"3155","article-title":"Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis","volume":"100","author":"Yabe","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2017.05.032_bib62","first-page":"23464","article-title":"Deficiency in the lipid exporter ABCA1 impairs retrograde sterol movement and disrupts sterol sensing at the endoplasmic reticulum","volume":"290","author":"Yamauchi","year":"2015","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2017.05.032_bib63","first-page":"1689","article-title":"ATP-binding cassette transporters and HDL suppress hematopoietic stem cell proliferation","volume":"328","author":"Yvan-Charvet","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.celrep.2017.05.032_bib64","first-page":"1775","article-title":"Functional implications of the influence of ABCA1 on lipid microenvironment at the plasma membrane: a biophysical study","volume":"23","author":"Zarubica","year":"2009","journal-title":"FASEB J."},{"key":"10.1016\/j.celrep.2017.05.032_bib65","first-page":"39476","article-title":"Endocytosis is enhanced in Tangier fibroblasts: possible role of ATP-binding cassette protein A1 in endosomal vesicular transport","volume":"276","author":"Zha","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2017.05.032_bib66","first-page":"10002","article-title":"Secretory vesicular transport from the Golgi is altered during ATP-binding cassette protein A1 (ABCA1)-mediated cholesterol efflux","volume":"278","author":"Zha","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2017.05.032_bib67","first-page":"22930","article-title":"Increased cellular free cholesterol in macrophage-specific Abca1 knock-out mice enhances pro-inflammatory response of macrophages","volume":"283","author":"Zhu","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2017.05.032_bib68","first-page":"3196","article-title":"Macrophage ABCA1 reduces MyD88-dependent Toll-like receptor trafficking to lipid rafts by reduction of lipid raft cholesterol","volume":"51","author":"Zhu","year":"2010","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.celrep.2017.05.032_bib69","first-page":"1398","article-title":"Myeloid cell-specific ABCA1 deletion protects mice from bacterial infection","volume":"111","author":"Zhu","year":"2012","journal-title":"Circ. Res."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124717306745?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124717306745?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T10:07:41Z","timestamp":1761905261000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124717306745"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":69,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["S2211124717306745"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2017.05.032","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.727692983.793539935","asserted-by":"object"}]},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepatocyte ABCA1 Deletion Impairs Liver Insulin Signaling and Lipogenesis","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2017.05.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Author(s).","name":"copyright","label":"Copyright"}]}}