{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:29:25Z","timestamp":1791052165290,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,7,24]],"date-time":"2017-07-24T00:00:00Z","timestamp":1500854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["NS062798"],"award-info":[{"award-number":["NS062798"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["DK090065"],"award-info":[{"award-number":["DK090065"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["MH099647"],"award-info":[{"award-number":["MH099647"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HG005058"],"award-info":[{"award-number":["HG005058"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["F30MH106261"],"award-info":[{"award-number":["F30MH106261"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["T32GM007365"],"award-info":[{"award-number":["T32GM007365"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["MH099555-03"],"award-info":[{"award-number":["MH099555-03"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006312","name":"BrightFocus Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004410","name":"EMBO","doi-asserted-by":"publisher","award":["ALTF 413-2012"],"award-info":[{"award-number":["ALTF 413-2012"]}],"id":[{"id":"10.13039\/100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006312","name":"BrightFocus Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Science Foundation","award":["DGE-1147470"],"award-info":[{"award-number":["DGE-1147470"]}]},{"name":"Bio-X Stanford"},{"name":"Bio-X-Stanford"},{"name":"Packard"},{"name":"Stanford"},{"name":"Child Health Research Institute","award":["UL1-TR001085"],"award-info":[{"award-number":["UL1-TR001085"]}]},{"name":"NIMH BRAINS Award","award":["R01MH107800"],"award-info":[{"award-number":["R01MH107800"]}]},{"name":"MQ Fellow Award"},{"name":"Donald E. and Delia B. Baxter Foundation Award"},{"name":"Kwan Foundation"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1016\/j.celrep.2017.07.051","type":"journal-article","created":{"date-parts":[[2017,8,15]],"date-time":"2017-08-15T12:16:46Z","timestamp":1502799406000},"page":"1533-1542","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":114,"title":["MicroRNA-9 Couples Brain Neurogenesis and Angiogenesis"],"prefix":"10.1016","volume":"20","author":[{"given":"Romain","family":"Madelaine","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven A.","family":"Sloan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Huber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James H.","family":"Notwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis C.","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemini","family":"Skariah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Halluin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergiu P.","family":"Pa\u015fca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gill","family":"Bejerano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Krasnow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben A.","family":"Barres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Mourrain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2017.07.051_bib1","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nature09522","article-title":"Pericytes regulate the blood-brain barrier","volume":"468","author":"Armulik","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2017.07.051_bib2","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: target recognition and regulatory functions","volume":"136","author":"Bartel","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2017.07.051_bib3","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.devcel.2010.11.018","article-title":"MicroRNA-9 reveals regional diversity of neural progenitors along the anterior-posterior axis","volume":"20","author":"Bonev","year":"2011","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2017.07.051_bib4","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1523\/JNEUROSCI.5531-11.2012","article-title":"Astrocytes control the development of the migration-promoting vasculature scaffold in the postnatal brain via VEGF signaling","volume":"32","author":"Bozoyan","year":"2012","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2017.07.051_bib5","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1242\/dev.114.2.521","article-title":"Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation","volume":"114","author":"Breier","year":"1992","journal-title":"Development"},{"key":"10.1016\/j.celrep.2017.07.051_bib6","doi-asserted-by":"crossref","first-page":"7961","DOI":"10.1523\/JNEUROSCI.6170-09.2010","article-title":"Notch activity levels control the balance between quiescence and recruitment of adult neural stem cells","volume":"30","author":"Chapouton","year":"2010","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2017.07.051_bib7","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1101\/gad.1629408","article-title":"Foxn4 directly regulates tbx2b expression and atrioventricular canal formation","volume":"22","author":"Chi","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2017.07.051_bib8","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.devcel.2012.03.003","article-title":"miR-9 controls the timing of neurogenesis through the direct inhibition of antagonistic factors","volume":"22","author":"Coolen","year":"2012","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2017.07.051_bib9","doi-asserted-by":"crossref","first-page":"220","DOI":"10.3389\/fncel.2013.00220","article-title":"miR-9: a versatile regulator of neurogenesis","volume":"7","author":"Coolen","year":"2013","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.celrep.2017.07.051_bib10","doi-asserted-by":"crossref","first-page":"14","DOI":"10.2353\/ajpath.2007.070385","article-title":"Vascular endothelial cell growth factor-a: not just for endothelial cells anymore","volume":"171","author":"D\u2019Amore","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.celrep.2017.07.051_bib11","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/nature09513","article-title":"Pericytes are required for blood-brain barrier integrity during embryogenesis","volume":"468","author":"Daneman","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2017.07.051_bib12","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1165\/rcmb.2013-0417OC","article-title":"Nuclear localization of vascular endothelial growth factor-D and regulation of c-Myc-dependent transcripts in human lung fibroblasts","volume":"51","author":"El-Chemaly","year":"2014","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.celrep.2017.07.051_bib13","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/nature04483","article-title":"Angiogenesis as a therapeutic target","volume":"438","author":"Ferrara","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2017.07.051_bib14","first-page":"1453","article-title":"Expression of vascular endothelial growth factor in the human retina and in nonproliferative diabetic retinopathy","volume":"152","author":"Gerhardinger","year":"1998","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.celrep.2017.07.051_bib15","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1083\/jcb.200302047","article-title":"VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia","volume":"161","author":"Gerhardt","year":"2003","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.celrep.2017.07.051_bib16","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/aja.1002030302","article-title":"Stages of embryonic development of the zebrafish","volume":"203","author":"Kimmel","year":"1995","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.celrep.2017.07.051_bib17","doi-asserted-by":"crossref","first-page":"13552","DOI":"10.1074\/jbc.273.22.13552","article-title":"Isoforms of hepatocyte nuclear factor-6 differ in DNA-binding properties, contain a bifunctional homeodomain, and define the new ONECUT class of homeodomain proteins","volume":"273","author":"Lannoy","year":"1998","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2017.07.051_bib18","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S0092-8674(02)00757-2","article-title":"Sensory nerves determine the pattern of arterial differentiation and blood vessel branching in the skin","volume":"109","author":"Mukouyama","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2017.07.051_bib19","doi-asserted-by":"crossref","first-page":"11410","DOI":"10.1074\/jbc.M111085200","article-title":"Paracrine and autocrine functions of neuronal vascular endothelial growth factor (VEGF) in the central nervous system","volume":"277","author":"Ogunshola","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2017.07.051_bib20","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.3415","article-title":"Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture","volume":"12","author":"Pa\u015fca","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2017.07.051_bib21","doi-asserted-by":"crossref","first-page":"26932","DOI":"10.1074\/jbc.M601225200","article-title":"MicroRNA-9 controls the expression of Granuphilin\/Slp4 and the secretory response of insulin-producing cells","volume":"281","author":"Plaisance","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2017.07.051_bib22","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/ncb2001","article-title":"Orphan nuclear receptor TLX activates Wnt\/beta-catenin signalling to stimulate neural stem cell proliferation and self-renewal","volume":"12","author":"Qu","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2017.07.051_bib23","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/386671a0","article-title":"Mechanisms of angiogenesis","volume":"386","author":"Risau","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2017.07.051_bib24","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1007\/s00018-013-1277-5","article-title":"Neurovascular development and links to disease","volume":"70","author":"Ruhrberg","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.celrep.2017.07.051_bib25","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.1101\/gad.242002","article-title":"Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis","volume":"16","author":"Ruhrberg","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2017.07.051_bib26","doi-asserted-by":"crossref","first-page":"E4086","DOI":"10.1073\/pnas.1405354111","article-title":"Onecut1 and Onecut2 redundantly regulate early retinal cell fates during development","volume":"111","author":"Sapkota","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2017.07.051_bib27","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1749-8104-8-3","article-title":"Neurogenesis in zebrafish \u2013 from embryo to adult","volume":"8","author":"Schmidt","year":"2013","journal-title":"Neural Dev."},{"key":"10.1016\/j.celrep.2017.07.051_bib28","doi-asserted-by":"crossref","first-page":"e11863","DOI":"10.1371\/journal.pone.0011863","article-title":"Astrocyte-derived vascular endothelial growth factor stabilizes vessels in the developing retinal vasculature","volume":"5","author":"Scott","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1016\/j.celrep.2017.07.051_bib29","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/nature02211","article-title":"Expression and function of orphan nuclear receptor TLX in adult neural stem cells","volume":"427","author":"Shi","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2017.07.051_bib30","doi-asserted-by":"crossref","first-page":"3407","DOI":"10.1523\/JNEUROSCI.5085-10.2011","article-title":"MicroRNA-9 regulates neurogenesis in mouse telencephalon by targeting multiple transcription factors","volume":"31","author":"Shibata","year":"2011","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2017.07.051_bib31","first-page":"1334","article-title":"Cloning and mRNA expression of vascular endothelial growth factor in ischemic retinas of Macaca fascicularis","volume":"37","author":"Shima","year":"1996","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.celrep.2017.07.051_bib32","doi-asserted-by":"crossref","first-page":"4738","DOI":"10.1523\/JNEUROSCI.15-07-04738.1995","article-title":"Development of retinal vasculature is mediated by hypoxia-induced\u00a0vascular endothelial growth factor (VEGF) expression by neuroglia","volume":"15","author":"Stone","year":"1995","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2017.07.051_bib33","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.ydbio.2011.06.037","article-title":"Neurovascular development in the embryonic zebrafish hindbrain","volume":"357","author":"Ulrich","year":"2011","journal-title":"Dev. Biol."},{"key":"10.1016\/j.celrep.2017.07.051_bib34","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.neuron.2015.06.038","article-title":"Wiring the vascular network with neural cues: A CNS perspective","volume":"87","author":"W\u00e4lchli","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2017.07.051_bib35","doi-asserted-by":"crossref","first-page":"13991","DOI":"10.1038\/ncomms13991","article-title":"Neuronal sFlt1 and Vegfaa determine venous sprouting and spinal cord vascularization","volume":"8","author":"Wild","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2017.07.051_bib36","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1073\/pnas.050566897","article-title":"The orphan nuclear receptor Tlx regulates Pax2 and is essential for vision","volume":"97","author":"Yu","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2017.07.051_bib37","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.brainres.2015.02.046","article-title":"Interaction between Oc-1 and Lmx1a promotes ventral midbrain dopamine neural stem cells differentiation into dopamine neurons","volume":"1608","author":"Yuan","year":"2015","journal-title":"Brain Res."},{"key":"10.1016\/j.celrep.2017.07.051_bib38","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1158\/1535-7163.MCT-12-0001","article-title":"microRNA-9 targets matrix metalloproteinase 14 to inhibit invasion, metastasis, and angiogenesis of neuroblastoma cells","volume":"11","author":"Zhang","year":"2012","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.celrep.2017.07.051_bib39","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.neuron.2015.11.013","article-title":"Purification and characterization of progenitor and mature human astrocytes reveals transcriptional and functional differences with mouse","volume":"89","author":"Zhang","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2017.07.051_bib40","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/nsmb.1576","article-title":"A feedback regulatory loop involving microRNA-9 and nuclear receptor TLX in neural stem cell fate determination","volume":"16","author":"Zhao","year":"2009","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.celrep.2017.07.051_bib41","doi-asserted-by":"crossref","first-page":"3513","DOI":"10.1038\/emboj.2012.183","article-title":"Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway","volume":"31","author":"Zhuang","year":"2012","journal-title":"EMBO J."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124717310306?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124717310306?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T10:10:12Z","timestamp":1761905412000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124717310306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":41,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["S2211124717310306"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2017.07.051","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2017,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MicroRNA-9 Couples Brain Neurogenesis and Angiogenesis","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2017.07.051","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors.","name":"copyright","label":"Copyright"}]}}