{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T05:36:30Z","timestamp":1773898590703,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T00:00:00Z","timestamp":1506470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"National Science Foundation","award":["1144247"],"award-info":[{"award-number":["1144247"]}]},{"DOI":"10.13039\/100005280","name":"AAUW","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005280","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R37NS040929"],"award-info":[{"award-number":["R37NS040929"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R35NS097227"],"award-info":[{"award-number":["R35NS097227"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.celrep.2017.09.089","type":"journal-article","created":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T10:19:41Z","timestamp":1509013181000},"page":"859-866","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"title":["Phospholipid Homeostasis Regulates Dendrite Morphogenesis in Drosophila Sensory Neurons"],"prefix":"10.1016","volume":"21","author":[{"given":"Shan","family":"Meltzer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua A.","family":"Bagley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerardo Lopez","family":"Perez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caitlin E.","family":"O\u2019Brien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"DeVault","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanmeng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lily Yeh","family":"Jan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuh-Nung","family":"Jan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2017.09.089_bib1","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1001\/jama.1971.03190200047010","article-title":"From the gene to behavior","volume":"218","author":"Benzer","year":"1971","journal-title":"JAMA"},{"key":"10.1016\/j.celrep.2017.09.089_bib2","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1038\/ng.2714","article-title":"A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome","volume":"45","author":"Buchovecky","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2017.09.089_bib3","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1126\/science.1071124","article-title":"Regulation of SREBP processing and membrane lipid production by phospholipids in Drosophila","volume":"296","author":"Dobrosotskaya","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.celrep.2017.09.089_bib4","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1242\/dev.129.12.2867","article-title":"Tiling of the Drosophila epidermis by multidendritic sensory neurons","volume":"129","author":"Grueber","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.celrep.2017.09.089_bib5","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1242\/dev.02666","article-title":"Projections of Drosophila multidendritic neurons in the central\u00a0nervous system: links with peripheral dendrite morphology","volume":"134","author":"Grueber","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.celrep.2017.09.089_bib6","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1534\/genetics.104.036558","article-title":"Seizure suppression by gain-of-function escargot mutations","volume":"169","author":"Hekmat-Scafe","year":"2005","journal-title":"Genetics"},{"key":"10.1016\/j.celrep.2017.09.089_bib7","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1534\/genetics.109.109074","article-title":"Seizure sensitivity is ameliorated by targeted expression of K+-Cl- cotransporter function in the mushroom body of the Drosophila brain","volume":"184","author":"Hekmat-Scafe","year":"2010","journal-title":"Genetics"},{"key":"10.1016\/j.celrep.2017.09.089_bib8","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/nrn2836","article-title":"Branching out: mechanisms of dendritic arborization","volume":"11","author":"Jan","year":"2010","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.celrep.2017.09.089_bib9","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1007\/BF02535576","article-title":"Lipid composition of subcellular membranes from larvae and prepupae of Drosophila melanogaster","volume":"27","author":"Jones","year":"1992","journal-title":"Lipids"},{"key":"10.1016\/j.celrep.2017.09.089_bib10","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1126\/science.1234879","article-title":"Compartmentalized calcium transients trigger dendrite pruning in Drosophila sensory neurons","volume":"340","author":"Kanamori","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.celrep.2017.09.089_bib11","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1093\/cercor\/10.10.981","article-title":"Dendritic anomalies in disorders associated with mental retardation","volume":"10","author":"Kaufmann","year":"2000","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.celrep.2017.09.089_bib12","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1523\/JNEUROSCI.3553-03.2004","article-title":"Active zone localization of presynaptic calcium channels encoded by the cacophony locus of Drosophila","volume":"24","author":"Kawasaki","year":"2004","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2017.09.089_bib13","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1146\/annurev.bi.26.070157.001003","article-title":"Metabolism of lipides","volume":"26","author":"Kennedy","year":"1957","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.celrep.2017.09.089_bib14","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1039\/b927494d","article-title":"Structural mass spectrometry analysis of lipid changes in a Drosophila epilepsy model brain","volume":"6","author":"Kliman","year":"2010","journal-title":"Mol. Biosyst."},{"key":"10.1016\/j.celrep.2017.09.089_bib15","doi-asserted-by":"crossref","first-page":"3500","DOI":"10.1002\/cne.23364","article-title":"Rescue of easily shocked mutant seizure sensitivity in Drosophila adults","volume":"521","author":"Kroll","year":"2013","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.celrep.2017.09.089_bib16","doi-asserted-by":"crossref","first-page":"15230","DOI":"10.1073\/pnas.0507393102","article-title":"Dendrite-specific remodeling of Drosophila sensory neurons requires matrix metalloproteases, ubiquitin-proteasome, and ecdysone signaling","volume":"102","author":"Kuo","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2017.09.089_bib17","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1146\/annurev-cellbio-100913-013020","article-title":"Development of dendritic form and function","volume":"31","author":"Lefebvre","year":"2015","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.celrep.2017.09.089_bib18","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1101\/gad.1992411","article-title":"Phospholipid homeostasis regulates lipid metabolism and cardiac function through SREBP signaling in Drosophila","volume":"25","author":"Lim","year":"2011","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2017.09.089_bib19","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.cell.2014.12.019","article-title":"Glial lipid droplets and ROS induced by mitochondrial defects promote neurodegeneration","volume":"160","author":"Liu","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2017.09.089_bib20","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.neuron.2016.01.020","article-title":"Epidermis-Derived Semaphorin Promotes Dendrite Self-Avoidance by Regulating Dendrite-Substrate Adhesion in Drosophila Sensory Neurons","volume":"89","author":"Meltzer","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2017.09.089_bib21","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1023\/A:1012209030803","article-title":"Tissue-specific and developmental effects of the easily shocked mutation on ethanolamine kinase activity and phospholipid composition in Drosophila melanogaster","volume":"39","author":"Nyako","year":"2001","journal-title":"Biochem. Genet."},{"key":"10.1016\/j.celrep.2017.09.089_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-387003-2.00001-X","article-title":"Seizure and\u00a0epilepsy: studies of seizure disorders in Drosophila","volume":"99","author":"Parker","year":"2011","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.celrep.2017.09.089_bib23","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1101\/gad.1514507","article-title":"Polycomb genes interact with the tumor suppressor genes hippo and warts in the maintenance of Drosophila sensory neuron dendrites","volume":"21","author":"Parrish","year":"2007","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2017.09.089_bib24","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0092-8674(94)90397-2","article-title":"The Drosophila easily shocked gene: a mutation in a phospholipid synthetic pathway causes seizure, neuronal failure, and paralysis","volume":"79","author":"Pavlidis","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2017.09.089_bib25","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1523\/JNEUROSCI.4746-06.2007","article-title":"Drosophila cacophony channels: a major mediator of neuronal Ca2+ currents and a trigger for K+ channel homeostatic regulation","volume":"27","author":"Peng","year":"2007","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2017.09.089_bib26","doi-asserted-by":"crossref","first-page":"E2967","DOI":"10.1073\/pnas.1405500111","article-title":"Optimized CRISPR\/Cas tools for efficient germline and somatic genome engineering in Drosophila","volume":"111","author":"Port","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2017.09.089_bib27","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/nrm1174","article-title":"The SREBP pathway--insights from Insigs and insects","volume":"4","author":"Rawson","year":"2003","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2017.09.089_bib28","doi-asserted-by":"crossref","first-page":"e1005784","DOI":"10.1371\/journal.pgen.1005784","article-title":"Mutations of the Calcium Channel Gene cacophony Suppress Seizures in Drosophila","volume":"12","author":"Saras","year":"2016","journal-title":"PLoS Genet."},{"key":"10.1016\/j.celrep.2017.09.089_bib29","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.celrep.2014.08.060","article-title":"Control of lipid metabolism by tachykinin in Drosophila","volume":"9","author":"Song","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2017.09.089_bib30","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1159\/000323189","article-title":"The neurobiology of lipid metabolism in autism spectrum disorders","volume":"18","author":"Tamiji","year":"2010","journal-title":"Neurosignals"},{"key":"10.1016\/j.celrep.2017.09.089_bib31","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1056\/NEJM199401133300205","article-title":"Defective cholesterol biosynthesis associated with the Smith-Lemli-Opitz syndrome","volume":"330","author":"Tint","year":"1994","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.celrep.2017.09.089_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/tra.12230","article-title":"Phospholipid synthesis and transport in mammalian cells","volume":"16","author":"Vance","year":"2015","journal-title":"Traffic"},{"key":"10.1016\/j.celrep.2017.09.089_bib33","doi-asserted-by":"crossref","first-page":"3631","DOI":"10.1242\/dev.01928","article-title":"Cellular mechanisms of dendrite pruning in Drosophila: insights from in\u00a0vivo time-lapse of remodeling dendritic arborizing sensory neurons","volume":"132","author":"Williams","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.celrep.2017.09.089_bib34","series-title":"Comprehensive Guide to Autism","first-page":"1259","article-title":"Lipid signalling in the pathology of autism spectrum disorders","author":"Wong","year":"2014"},{"key":"10.1016\/j.celrep.2017.09.089_bib35","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1007\/s13238-014-0131-3","article-title":"Cholesterol metabolism and homeostasis in the brain","volume":"6","author":"Zhang","year":"2015","journal-title":"Protein Cell"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124717314092?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124717314092?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T10:11:56Z","timestamp":1761905516000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124717314092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["S2211124717314092"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2017.09.089","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phospholipid Homeostasis Regulates Dendrite Morphogenesis in Drosophila Sensory Neurons","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2017.09.089","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Author(s).","name":"copyright","label":"Copyright"}]}}