{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:32:15Z","timestamp":1789014735644,"version":"build-2803163510"},"reference-count":74,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,1,20]],"date-time":"2018-01-20T00:00:00Z","timestamp":1516406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008527","name":"Dan L. Duncan Cancer Center, Baylor College of Medicine","doi-asserted-by":"publisher","award":["P30CA125123"],"award-info":[{"award-number":["P30CA125123"]}],"id":[{"id":"10.13039\/100008527","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["201607010202"],"award-info":[{"award-number":["201607010202"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["201605030012"],"award-info":[{"award-number":["201605030012"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2017YFC1001901"],"award-info":[{"award-number":["2017YFC1001901"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2017YFA0102801"],"award-info":[{"award-number":["2017YFA0102801"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007915","name":"Baylor College of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2015M580751"],"award-info":[{"award-number":["2015M580751"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2015B020228002"],"award-info":[{"award-number":["2015B020228002"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002402","name":"Sun Yat-sen University","doi-asserted-by":"publisher","award":["16lgpy32"],"award-info":[{"award-number":["16lgpy32"]}],"id":[{"id":"10.13039\/501100002402","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.celrep.2018.01.057","type":"journal-article","created":{"date-parts":[[2018,2,13]],"date-time":"2018-02-13T12:13:27Z","timestamp":1518524007000},"page":"1849-1860","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Shwachman-Diamond Syndrome Protein SBDS Maintains Human Telomeres by Regulating Telomerase Recruitment"],"prefix":"10.1016","volume":"22","author":[{"given":"Yi","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhao","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangxiu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Songyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2018.01.057_bib1","doi-asserted-by":"crossref","first-page":"2971","DOI":"10.1128\/MCB.00240-10","article-title":"TIN2-tethered TPP1 recruits human telomerase to telomeres in\u00a0vivo","volume":"30","author":"Abreu","year":"2010","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.celrep.2018.01.057_bib2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1677\/joe.0.1410033","article-title":"Adrenocortical dysplasia: a mouse model system for adrenocortical insufficiency","volume":"141","author":"Beamer","year":"1994","journal-title":"J.\u00a0Endocrinol."},{"key":"10.1016\/j.celrep.2018.01.057_bib3","doi-asserted-by":"crossref","first-page":"13021","DOI":"10.1073\/pnas.1605685113","article-title":"Structural and functional consequences of a disease mutation in the telomere protein TPP1","volume":"113","author":"Bisht","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2018.01.057_bib4","doi-asserted-by":"crossref","first-page":"7405","DOI":"10.1002\/anie.201002387","article-title":"Telomeres and telomerase: the means to the end (Nobel lecture)","volume":"49","author":"Blackburn","year":"2010","journal-title":"Angew. Chem. Int.Engl."},{"key":"10.1016\/j.celrep.2018.01.057_bib5","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/ng1062","article-title":"Mutations in SBDS are associated with Shwachman-Diamond syndrome","volume":"33","author":"Boocock","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2018.01.057_bib6","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1182\/blood.V97.4.895","article-title":"Telomere length in leukocyte subpopulations of patients with aplastic anemia","volume":"97","author":"Br\u00fcmmendorf","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2018.01.057_bib7","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1182\/blood-2007-03-080044","article-title":"Mutations in the SBDS gene in acquired aplastic anemia","volume":"110","author":"Calado","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2018.01.057_bib8","doi-asserted-by":"crossref","first-page":"e1006552","DOI":"10.1371\/journal.pgen.1006552","article-title":"SBDS-Deficient Cells Have an Altered Homeostatic Equilibrium due to Translational Inefficiency Which Explains their Reduced Fitness and Provides a Logical Framework for Intervention","volume":"13","author":"Calamita","year":"2017","journal-title":"PLoS Genet."},{"key":"10.1016\/j.celrep.2018.01.057_bib9","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1172\/JCI43578","article-title":"Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts","volume":"121","author":"Cao","year":"2011","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2018.01.057_bib10","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nature11269","article-title":"The human CST complex is a terminator of telomerase activity","volume":"488","author":"Chen","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2018.01.057_bib11","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1126\/science.1231143","article-title":"Multiplex genome engineering using CRISPR\/Cas systems","volume":"339","author":"Cong","year":"2013","journal-title":"Science"},{"issue":"6 Pt B","key":"10.1016\/j.celrep.2018.01.057_bib12","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/j.jmb.2015.01.008","article-title":"Contributions of the TEL-patch amino acid cluster on TPP1 to telomeric DNA synthesis by human telomerase","volume":"427","author":"Dalby","year":"2015","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.celrep.2018.01.057_bib13","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1101\/gad.1346005","article-title":"Shelterin: the protein complex that shapes and safeguards human telomeres","volume":"19","author":"de Lange","year":"2005","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2018.01.057_bib14","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.3324\/haematol.2010.025619","article-title":"Inherited bone marrow failure syndromes","volume":"95","author":"Dokal","year":"2010","journal-title":"Haematologica"},{"key":"10.1016\/j.celrep.2018.01.057_bib15","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1126\/science.7544491","article-title":"The RNA component of human telomerase","volume":"269","author":"Feng","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.celrep.2018.01.057_bib16","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1182\/blood-2007-02-075184","article-title":"The human Shwachman-Diamond syndrome protein, SBDS, associates with ribosomal RNA","volume":"110","author":"Ganapathi","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2018.01.057_bib17","doi-asserted-by":"crossref","first-page":"3742","DOI":"10.4161\/15384101.2014.965044","article-title":"Genome-wide analysis of in\u00a0vivo TRF1 binding to chromatin restricts its location exclusively to telomeric repeats","volume":"13","author":"Garrobo","year":"2014","journal-title":"Cell Cycle"},{"key":"10.1016\/j.celrep.2018.01.057_bib18","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/bjh.13442","article-title":"Unraveling the pathogenesis of Hoyeraal-Hreidarsson syndrome, a complex telomere biology disorder","volume":"170","author":"Glousker","year":"2015","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.celrep.2018.01.057_bib19","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/0092-8674(85)90170-9","article-title":"Identification of a specific telomere terminal transferase activity in Tetrahymena extracts","volume":"43","author":"Greider","year":"1985","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2018.01.057_bib20","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/345458a0","article-title":"Telomeres shorten during ageing of human fibroblasts","volume":"345","author":"Harley","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2018.01.057_bib21","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1038\/nprot.2006.239","article-title":"Nonradioactive detection of telomerase activity using the telomeric repeat amplification protocol","volume":"1","author":"Herbert","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2018.01.057_bib22","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1111\/gtc.12391","article-title":"NEK6-mediated phosphorylation of human TPP1 regulates telomere length through telomerase recruitment","volume":"21","author":"Hirai","year":"2016","journal-title":"Genes Cells"},{"key":"10.1016\/j.celrep.2018.01.057_bib23","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/nsmb.3083","article-title":"Control of telomerase action at human telomeres","volume":"22","author":"Hockemeyer","year":"2015","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.celrep.2018.01.057_bib24","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/nbt816","article-title":"Simultaneous visualization of multiple protein interactions in living cells using multicolor fluorescence complementation analysis","volume":"21","author":"Hu","year":"2003","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2018.01.057_bib25","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1097\/MOH.0b013e32834114a5","article-title":"Clinical spectrum and molecular pathophysiology of Shwachman-Diamond syndrome","volume":"18","author":"Huang","year":"2011","journal-title":"Curr. Opin. Hematol."},{"key":"10.1016\/j.celrep.2018.01.057_bib26","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/hmg\/ddi011","article-title":"Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd) mice is caused by a splicing mutation in a novel telomeric regulator","volume":"14","author":"Keegan","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.celrep.2018.01.057_bib27","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1126\/science.7605428","article-title":"Specific association of human telomerase activity with immortal cells and cancer","volume":"266","author":"Kim","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.celrep.2018.01.057_bib28","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1101\/gad.248567.114","article-title":"Hoyeraal-Hreidarsson syndrome caused by a germline mutation in the TEL patch of the telomere protein TPP1","volume":"28","author":"Kocak","year":"2014","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2018.01.057_bib29","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1038\/emboj.2009.409","article-title":"POT1-TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocation","volume":"29","author":"Latrick","year":"2010","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2018.01.057_bib30","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.M110.001628","article-title":"Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells","volume":"10","author":"Lee","year":"2011","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.celrep.2018.01.057_bib31","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/0022-2836(92)90096-3","article-title":"Telomere end-replication problem and cell aging","volume":"225","author":"Levy","year":"1992","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.celrep.2018.01.057_bib32","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1126\/science.aah6752","article-title":"TZAP: A telomere-associated protein involved in telomere length control","volume":"355","author":"Li","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.celrep.2018.01.057_bib33","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1126\/science.7545310","article-title":"Telomerase and DNA end replication: no longer a lagging strand problem?","volume":"269","author":"Lingner","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.celrep.2018.01.057_bib34","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1126\/science.276.5312.561","article-title":"Reverse transcriptase motifs in the catalytic subunit of telomerase","volume":"276","author":"Lingner","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.celrep.2018.01.057_bib35","doi-asserted-by":"crossref","first-page":"4583","DOI":"10.1182\/blood-2005-12-4831","article-title":"Ribosomes and marrow failure: coincidental association or molecular paradigm?","volume":"107","author":"Liu","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2018.01.057_bib36","doi-asserted-by":"crossref","first-page":"51338","DOI":"10.1074\/jbc.M409293200","article-title":"Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins","volume":"279","author":"Liu","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2018.01.057_bib37","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/ncb1142","article-title":"PTOP interacts with POT1 and regulates its localization to telomeres","volume":"6","author":"Liu","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2018.01.057_bib38","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"L\u00f3pez-Ot\u00edn","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2018.01.057_bib39","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.yexcr.2012.09.005","article-title":"Telomeres-structure, function, and regulation","volume":"319","author":"Lu","year":"2013","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.celrep.2018.01.057_bib40","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/978-1-61779-092-8_16","article-title":"Studying of telomeric protein-protein interactions by Bi-molecular fluorescence complementation (BiFC) and peptide array-based assays","volume":"735","author":"Ma","year":"2011","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.celrep.2018.01.057_bib41","doi-asserted-by":"crossref","first-page":"E64","DOI":"10.3390\/genes7090064","article-title":"Telomerase Regulation from Beginning to the End","volume":"7","author":"MacNeil","year":"2016","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.celrep.2018.01.057_bib42","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.tibs.2015.06.003","article-title":"Replicating through telomeres: a means to an end","volume":"40","author":"Mart\u00ednez","year":"2015","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.celrep.2018.01.057_bib43","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.15252\/embj.201490070","article-title":"Telomerase abrogates aneuploidy-induced telomere replication stress, senescence and cell depletion","volume":"34","author":"Meena","year":"2015","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2018.01.057_bib44","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/0092-8674(89)90035-4","article-title":"The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats","volume":"59","author":"Morin","year":"1989","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2018.01.057_bib45","series-title":"GeneReviews","article-title":"Shwachman-Diamond Syndrome","author":"Myers","year":"1993"},{"key":"10.1016\/j.celrep.2018.01.057_bib46","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.hoc.2012.10.003","article-title":"Clinical and molecular pathophysiology of Shwachman-Diamond syndrome: an update","volume":"27","author":"Myers","year":"2013","journal-title":"Hematol. Oncol. Clin. North Am."},{"key":"10.1016\/j.celrep.2018.01.057_bib47","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s00439-004-1081-2","article-title":"Novel SBDS mutations caused by gene conversion in Japanese patients with Shwachman-Diamond syndrome","volume":"114","author":"Nakashima","year":"2004","journal-title":"Hum. Genet."},{"key":"10.1016\/j.celrep.2018.01.057_bib48","doi-asserted-by":"crossref","first-page":"33171","DOI":"10.1074\/jbc.M113.518175","article-title":"Inhibition of telomerase recruitment and cancer cell death","volume":"288","author":"Nakashima","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2018.01.057_bib49","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/nrm3505","article-title":"Finding the end: recruitment of telomerase to telomeres","volume":"14","author":"Nandakumar","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2018.01.057_bib50","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/nature11648","article-title":"The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity","volume":"492","author":"Nandakumar","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2018.01.057_bib51","doi-asserted-by":"crossref","first-page":"11874","DOI":"10.1073\/pnas.0605303103","article-title":"A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly","volume":"103","author":"O\u2019Connor","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2018.01.057_bib52","doi-asserted-by":"crossref","first-page":"10072","DOI":"10.1074\/jbc.275.14.10072","article-title":"Subsenescent telomere lengths in fibroblasts immortalized by limiting amounts of telomerase","volume":"275","author":"Ouellette","year":"2000","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2018.01.057_bib53","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1146\/annurev.genet.41.110306.130350","article-title":"How shelterin protects mammalian telomeres","volume":"42","author":"Palm","year":"2008","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.celrep.2018.01.057_bib54","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/sj.ejhg.5200798","article-title":"Fine mapping of the locus for Shwachman-Diamond syndrome at 7q11, identification of shared disease haplotypes, and exclusion of TPST1 as a candidate gene","volume":"10","author":"Popovic","year":"2002","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.celrep.2018.01.057_bib55","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1016\/j.bbapap.2014.04.014","article-title":"Multiple facets of TPP1 in telomere maintenance","volume":"1844","author":"Rajavel","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.celrep.2018.01.057_bib56","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1101\/gad.263863.115","article-title":"Human telomerase: biogenesis, trafficking, recruitment, and activation","volume":"29","author":"Schmidt","year":"2015","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2018.01.057_bib57","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/j.cell.2016.07.033","article-title":"Live Cell Imaging Reveals the Dynamics of Telomerase Recruitment to Telomeres","volume":"166","author":"Schmidt","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2018.01.057_bib58","doi-asserted-by":"crossref","first-page":"34455","DOI":"10.1074\/jbc.M112.394767","article-title":"Specificity requirements for human telomere protein interaction with telomerase holoenzyme","volume":"287","author":"Sexton","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2018.01.057_bib59","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.molcel.2014.02.030","article-title":"Elucidation of the DNA end-replication problem in Saccharomyces cerevisiae","volume":"53","author":"Soudet","year":"2014","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2018.01.057_bib60","first-page":"331","article-title":"Disease mutant analysis identifies a new function of DAXX in telomerase regulation and telomere maintenance","volume":"128","author":"Tang","year":"2015","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.celrep.2018.01.057_bib61","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1046\/j.1365-2141.2002.03371.x","article-title":"Abnormal telomere shortening in leucocytes of children with Shwachman-Diamond syndrome","volume":"117","author":"Thornley","year":"2002","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.celrep.2018.01.057_bib62","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1091\/mbc.e05-09-0903","article-title":"Cell cycle-regulated trafficking of human telomerase to telomeres","volume":"17","author":"Tomlinson","year":"2006","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.celrep.2018.01.057_bib63","doi-asserted-by":"crossref","first-page":"e1005288","DOI":"10.1371\/journal.pgen.1005288","article-title":"In\u00a0Vivo Senescence in the Sbds-Deficient Murine Pancreas: Cell-Type Specific Consequences of Translation Insufficiency","volume":"11","author":"Tourlakis","year":"2015","journal-title":"PLoS Genet."},{"key":"10.1016\/j.celrep.2018.01.057_bib64","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/nature05454","article-title":"The POT1-TPP1 telomere complex is a telomerase processivity factor","volume":"445","author":"Wang","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2018.01.057_bib65","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/j.celrep.2012.10.007","article-title":"Human CST has independent functions during telomere duplex replication and C-strand fill-in","volume":"2","author":"Wang","year":"2012","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2018.01.057_bib66","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1146\/annurev-biochem-061516-045019","article-title":"Telomerase Mechanism of Telomere Synthesis","volume":"86","author":"Wu","year":"2017","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.celrep.2018.01.057_bib67","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nature05469","article-title":"TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase","volume":"445","author":"Xin","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2018.01.057_bib68","doi-asserted-by":"crossref","first-page":"23022","DOI":"10.1074\/jbc.M111.225870","article-title":"TIN2 protein dyskeratosis congenita missense mutants are defective in association with telomerase","volume":"286","author":"Yang","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2018.01.057_bib69","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1101\/gad.1215404","article-title":"POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2\/TRF1 complex","volume":"18","author":"Ye","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2018.01.057_bib70","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1101\/gad.1881810","article-title":"Functional interaction between telomere protein TPP1 and telomerase","volume":"24","author":"Zaug","year":"2010","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2018.01.057_bib71","doi-asserted-by":"crossref","first-page":"5457","DOI":"10.1073\/pnas.1217733110","article-title":"Phosphorylation of TPP1 regulates cell cycle-dependent telomerase recruitment","volume":"110","author":"Zhang","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2018.01.057_bib72","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.cell.2009.05.026","article-title":"Telomere extension occurs at most chromosome ends and is uncoupled from fill-in in human cancer cells","volume":"138","author":"Zhao","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2018.01.057_bib73","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.molcel.2011.03.020","article-title":"Processive and distributive extension of human telomeres by telomerase under homeostatic and nonequilibrium conditions","volume":"42","author":"Zhao","year":"2011","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2018.01.057_bib74","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.cell.2012.07.012","article-title":"TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends","volume":"150","author":"Zhong","year":"2012","journal-title":"Cell"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124718301062?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124718301062?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T10:19:17Z","timestamp":1761905957000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124718301062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":74,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["S2211124718301062"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2018.01.057","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Shwachman-Diamond Syndrome Protein SBDS Maintains Human Telomeres by Regulating Telomerase Recruitment","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2018.01.057","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Author(s).","name":"copyright","label":"Copyright"}]}}