{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:16:12Z","timestamp":1790460972236,"version":"4.1.0"},"reference-count":55,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T00:00:00Z","timestamp":1518134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS064273"],"award-info":[{"award-number":["NS064273"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS095795"],"award-info":[{"award-number":["NS095795"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.celrep.2018.02.036","type":"journal-article","created":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T15:38:39Z","timestamp":1520350719000},"page":"2575-2583","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"title":["Glia Modulate a Neuronal Circuit for Locomotion Suppression during Sleep in C.\u00a0elegans"],"prefix":"10.1016","volume":"22","author":[{"given":"Menachem","family":"Katz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Corson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shachar","family":"Iwanir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Biron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shai","family":"Shaham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2018.02.036_bib1","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1038\/npp.2015.26","article-title":"Astroglial glutamate transporter deficiency increases synaptic excitability and leads to pathological repetitive behaviors in mice","volume":"40","author":"Aida","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.celrep.2018.02.036_bib2","doi-asserted-by":"crossref","first-page":"14336","DOI":"10.1038\/ncomms14336","article-title":"Astrocyte deletion of Bmal1 alters daily locomotor activity and cognitive functions via GABA signalling","volume":"8","author":"Barca-Mayo","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2018.02.036_bib3","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1016\/j.neuron.2017.02.030","article-title":"Astrocytes Control Circadian Timekeeping in the Suprachiasmatic Nucleus via Glutamatergic Signaling","volume":"93","author":"Brancaccio","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2018.02.036_bib4","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1152\/physrev.00032.2011","article-title":"Control of sleep and wakefulness","volume":"92","author":"Brown","year":"2012","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.celrep.2018.02.036_bib5","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1523\/JNEUROSCI.05-04-00956.1985","article-title":"The neural circuit for touch sensitivity in Caenorhabditis elegans","volume":"5","author":"Chalfie","year":"1985","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2018.02.036_bib6","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1073\/pnas.0610877104","article-title":"Targeted cell killing by reconstituted caspases","volume":"104","author":"Chelur","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2018.02.036_bib7","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.cell.2013.11.036","article-title":"Multilevel modulation of a sensory motor circuit during C. elegans sleep and arousal","volume":"156","author":"Cho","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2018.02.036_bib8","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.neuron.2013.04.002","article-title":"Analysis of NPR-1 reveals a circuit mechanism for behavioral quiescence in C. elegans","volume":"78","author":"Choi","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2018.02.036_bib9","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/nmeth1075","article-title":"Microfluidics for in\u00a0vivo imaging of neuronal and behavioral activity in Caenorhabditis elegans","volume":"4","author":"Chronis","year":"2007","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2018.02.036_bib10","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1126\/science.1143762","article-title":"Glia promote local synaptogenesis through UNC-6 (netrin) signaling in C. elegans","volume":"318","author":"Col\u00f3n-Ramos","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.celrep.2018.02.036_bib11","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.brainresrev.2004.03.003","article-title":"GABA transporters in the mammalian cerebral cortex: localization, development and pathological implications","volume":"45","author":"Conti","year":"2004","journal-title":"Brain Res. Brain Res. Rev."},{"key":"10.1016\/j.celrep.2018.02.036_bib12","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nature09612","article-title":"Regulation of synaptic connectivity by glia","volume":"468","author":"Eroglu","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2018.02.036_bib13","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.neuron.2007.11.030","article-title":"GFP Reconstitution Across Synaptic Partners (GRASP) defines cell contacts and synapses in living nervous systems","volume":"57","author":"Feinberg","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2018.02.036_bib14","doi-asserted-by":"crossref","first-page":"5579","DOI":"10.1038\/ncomms6579","article-title":"VAV-1 acts in a single interneuron to inhibit motor circuit activity in Caenorhabditis elegans","volume":"5","author":"Fry","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2018.02.036_bib15","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/S0896-6273(02)01093-0","article-title":"Regulation of body size and behavioral state of C. elegans by sensory perception and the EGL-4 cGMP-dependent protein kinase","volume":"36","author":"Fujiwara","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2018.02.036_bib16","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.tins.2007.06.008","article-title":"Cajal\u2019s contributions to glia research","volume":"30","author":"Garc\u00eda-Mar\u00edn","year":"2007","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.celrep.2018.02.036_bib17","doi-asserted-by":"crossref","first-page":"e17686","DOI":"10.7554\/eLife.17686","article-title":"A cellular and regulatory map of the GABAergic nervous system of C. elegans","volume":"5","author":"Gendrel","year":"2016","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2018.02.036_bib18","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.molmed.2006.12.005","article-title":"The tripartite synapse: roles for gliotransmission in health and disease","volume":"13","author":"Halassa","year":"2007","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.celrep.2018.02.036_bib19","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.neuron.2008.11.024","article-title":"Astrocytic modulation of sleep homeostasis and cognitive consequences of sleep loss","volume":"61","author":"Halassa","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2018.02.036_bib20","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1016\/j.cub.2014.08.040","article-title":"Cellular stress induces a protective sleep-like state in C. elegans","volume":"24","author":"Hill","year":"2014","journal-title":"Curr. Biol."},{"key":"10.1016\/j.celrep.2018.02.036_bib21","doi-asserted-by":"crossref","first-page":"385","DOI":"10.5665\/sleep.2456","article-title":"The microarchitecture of C. elegans behavior during lethargus: homeostatic bout dynamics, a typical body posture, and regulation by a central neuron","volume":"36","author":"Iwanir","year":"2013","journal-title":"Sleep (Basel)"},{"key":"10.1016\/j.celrep.2018.02.036_bib22","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1126\/science.286.5442.1141","article-title":"Similarity of the C. elegans developmental timing protein LIN-42 to circadian rhythm proteins","volume":"286","author":"Jeon","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.celrep.2018.02.036_bib23","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.cell.2015.09.034","article-title":"Global brain dynamics embed the motor command sequence of Caenorhabditis elegans","volume":"163","author":"Kato","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2018.02.036_bib24","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.neuron.2011.09.005","article-title":"An imbalancing act: gap junctions reduce the backward motor circuit activity to bias C. elegans for forward locomotion","volume":"72","author":"Kawano","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2018.02.036_bib25","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1038\/nrn2521","article-title":"Sleep as a fundamental property of neuronal assemblies","volume":"9","author":"Krueger","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.celrep.2018.02.036_bib26","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1016\/j.cub.2011.10.054","article-title":"LIN-42\/PERIOD controls cyclical and developmental progression of C. elegans molts","volume":"21","author":"Monsalve","year":"2011","journal-title":"Curr. Biol."},{"key":"10.1016\/j.celrep.2018.02.036_bib27","doi-asserted-by":"crossref","first-page":"e04380","DOI":"10.7554\/eLife.04380","article-title":"Homeostasis in C. elegans sleep is characterized by two behaviorally and genetically distinct mechanisms","volume":"3","author":"Nagy","year":"2014","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2018.02.036_bib28","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1016\/j.cub.2016.07.048","article-title":"C.\u00a0elegans Stress-Induced Sleep Emerges from the Collective Action of Multiple Neuropeptides","volume":"26","author":"Nath","year":"2016","journal-title":"Curr. Biol."},{"key":"10.1016\/j.celrep.2018.02.036_bib29","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.1038\/ncomms3846","article-title":"The neuropeptide NLP-22 regulates a sleep-like state in Caenorhabditis elegans","volume":"4","author":"Nelson","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2018.02.036_bib30","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1016\/j.cub.2014.08.037","article-title":"FMRFamide-like FLP-13 neuropeptides promote quiescence following heat stress in Caenorhabditis elegans","volume":"24","author":"Nelson","year":"2014","journal-title":"Curr. Biol."},{"key":"10.1016\/j.celrep.2018.02.036_bib31","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.cub.2011.03.027","article-title":"Glial cells physiologically modulate clock neurons and circadian behavior in a calcium-dependent manner","volume":"21","author":"Ng","year":"2011","journal-title":"Curr. Biol."},{"key":"10.1016\/j.celrep.2018.02.036_bib32","doi-asserted-by":"crossref","first-page":"eaam6851","DOI":"10.1126\/science.aam6851","article-title":"A global brain state underlies C. elegans sleep behavior","volume":"356","author":"Nichols","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.celrep.2018.02.036_bib33","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1152\/jn.01029.2010","article-title":"Neuronal plasticity regulated by the insulin-like signaling pathway underlies salt chemotaxis learning in Caenorhabditis elegans","volume":"106","author":"Oda","year":"2011","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.celrep.2018.02.036_bib34","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0306-4522(02)00041-6","article-title":"Structural and quantitative analysis of astrocytes in the mouse hippocampus","volume":"113","author":"Ogata","year":"2002","journal-title":"Neuroscience"},{"key":"10.1016\/j.celrep.2018.02.036_bib35","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1111\/ejn.13074","article-title":"Optogenetic stimulation of astrocytes in the posterior hypothalamus increases sleep at night in C57BL\/6J mice","volume":"43","author":"Pelluru","year":"2016","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.celrep.2018.02.036_bib36","doi-asserted-by":"crossref","first-page":"e12432","DOI":"10.7554\/eLife.12432","article-title":"A\u00a0cellular and regulatory map of the cholinergic nervous system of C. elegans","volume":"4","author":"Pereira","year":"2015","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2018.02.036_bib37","doi-asserted-by":"crossref","first-page":"E2675","DOI":"10.1073\/pnas.1520759113","article-title":"Astrocytes regulate cortical state switching in\u00a0vivo","volume":"113","author":"Poskanzer","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2018.02.036_bib38","doi-asserted-by":"crossref","first-page":"3361","DOI":"10.1242\/dev.127.15.3361","article-title":"The homeodomain protein CePHOX2\/CEH-17 controls antero-posterior axonal growth in C. elegans","volume":"127","author":"Pujol","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.celrep.2018.02.036_bib39","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/nature06535","article-title":"Lethargus is a Caenorhabditis elegans sleep-like state","volume":"451","author":"Raizen","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2018.02.036_bib40","series-title":"Algunas conjeturas sobre el mecanismo anat\u00f3mico de la ideaci\u00f3n, asociaci\u00f3n y atenci\u00f3n","author":"Ram\u00f3n y Cajal","year":"1895"},{"key":"10.1016\/j.celrep.2018.02.036_bib41","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1038\/nn.4630","article-title":"Glia initiate brain assembly through noncanonical Chimaerin-Furin axon guidance in C. elegans","volume":"20","author":"Rapti","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2018.02.036_bib42","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0896-6273(00)80086-0","article-title":"Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate","volume":"16","author":"Rothstein","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2018.02.036_bib43","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1038\/nature04284","article-title":"Hypothalamic regulation of sleep and circadian rhythms","volume":"437","author":"Saper","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2018.02.036_bib44","doi-asserted-by":"crossref","first-page":"R983","DOI":"10.1016\/j.cub.2011.10.046","article-title":"Reduced activity of a sensory neuron during a sleep-like state in Caenorhabditis elegans","volume":"21","author":"Schwarz","year":"2011","journal-title":"Curr. Biol."},{"key":"10.1016\/j.celrep.2018.02.036_bib45","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.cub.2011.04.001","article-title":"Notch signaling modulates sleep homeostasis and learning after sleep deprivation in Drosophila","volume":"21","author":"Seugnet","year":"2011","journal-title":"Curr. Biol."},{"key":"10.1016\/j.celrep.2018.02.036_bib46","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.neuron.2013.07.029","article-title":"Short neuropeptide F is a sleep-promoting inhibitory modulator","volume":"80","author":"Shang","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2018.02.036_bib47","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.cub.2011.04.010","article-title":"C.\u00a0elegans Notch signaling regulates adult chemosensory response and larval molting quiescence","volume":"21","author":"Singh","year":"2011","journal-title":"Curr. Biol."},{"key":"10.1016\/j.celrep.2018.02.036_bib48","doi-asserted-by":"crossref","first-page":"14571","DOI":"10.1523\/JNEUROSCI.1369-15.2015","article-title":"Distinct Mechanisms Underlie Quiescence during Two Caenorhabditis elegans Sleep-Like States","volume":"35","author":"Trojanowski","year":"2015","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2018.02.036_bib49","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.cub.2017.02.037","article-title":"Astrocytes Regulate Daily Rhythms in the Suprachiasmatic Nucleus and Behavior","volume":"27","author":"Tso","year":"2017","journal-title":"Curr. Biol."},{"key":"10.1016\/j.celrep.2018.02.036_bib50","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1016\/j.cub.2013.09.028","article-title":"An AP2 transcription factor is required for a sleep-active neuron to induce sleep-like quiescence in C. elegans","volume":"23","author":"Turek","year":"2013","journal-title":"Curr. Biol."},{"key":"10.1016\/j.celrep.2018.02.036_bib51","doi-asserted-by":"crossref","first-page":"e12499","DOI":"10.7554\/eLife.12499","article-title":"Sleep-active neuron specification and sleep induction require FLP-11 neuropeptides to systemically induce sleep","volume":"5","author":"Turek","year":"2016","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2018.02.036_bib52","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1038\/nn1981","article-title":"Epidermal growth factor signaling induces behavioral quiescence in Caenorhabditis elegans","volume":"10","author":"Van Buskirk","year":"2007","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2018.02.036_bib53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1098\/rstb.1986.0056","article-title":"The structure of the nervous system of the nematode Caenorhabditis elegans","volume":"314","author":"White","year":"1986","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.celrep.2018.02.036_bib54","doi-asserted-by":"crossref","first-page":"11929","DOI":"10.1523\/JNEUROSCI.1860-14.2014","article-title":"An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex","volume":"34","author":"Zhang","year":"2014","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2018.02.036_bib55","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.tins.2008.05.001","article-title":"Conservation of sleep: insights from non-mammalian model systems","volume":"31","author":"Zimmerman","year":"2008","journal-title":"Trends Neurosci."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124718302171?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124718302171?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T10:20:41Z","timestamp":1761906041000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124718302171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":55,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["S2211124718302171"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2018.02.036","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glia Modulate a Neuronal Circuit for Locomotion Suppression during Sleep in C.\u00a0elegans","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2018.02.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors.","name":"copyright","label":"Copyright"}]}}