{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:30:00Z","timestamp":1790267400384,"version":"4.1.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,3,17]],"date-time":"2018-03-17T00:00:00Z","timestamp":1521244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015250","name":"NIHR Bristol Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015250","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19AI 082630"],"award-info":[{"award-number":["U19AI 082630"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["WT091663MA"],"award-info":[{"award-number":["WT091663MA"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["109965MA"],"award-info":[{"award-number":["109965MA"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014653","name":"Manchester Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014653","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.celrep.2018.03.074","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T11:39:22Z","timestamp":1523965162000},"page":"768-782","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":68,"title":["Induction and Maintenance of CX3CR1-Intermediate Peripheral Memory CD8+ T Cells by Persistent Viruses and Vaccines"],"prefix":"10.1016","volume":"23","author":[{"given":"Claire Louse","family":"Gordon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian Ni","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo","family":"Swadling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Hutchings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeleine","family":"Zinser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew John","family":"Highton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Capone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Folgori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleanor","family":"Barnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Klenerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2018.03.074_bib1","doi-asserted-by":"crossref","first-page":"115ra1","DOI":"10.1126\/scitranslmed.3003155","article-title":"Novel adenovirus-based vaccines induce broad and sustained T\u00a0cell responses to HCV in man","volume":"4","author":"Barnes","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2018.03.074_bib2","doi-asserted-by":"crossref","first-page":"4162","DOI":"10.4049\/jimmunol.1202665","article-title":"A new model for CD8+ T\u00a0cell memory inflation based upon a recombinant adenoviral vector","volume":"190","author":"Bolinger","year":"2013","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2018.03.074_bib3","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1016\/j.celrep.2015.10.034","article-title":"Adenoviral vector vaccination induces a conserved program of CD8(+) T\u00a0cell memory differentiation in mouse and man","volume":"13","author":"Bolinger","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2018.03.074_bib4","doi-asserted-by":"crossref","first-page":"8306","DOI":"10.1038\/ncomms9306","article-title":"Functional classification of memory CD8(+) T\u00a0cells by CX3CR1 expression","volume":"6","author":"B\u00f6ttcher","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2018.03.074_bib5","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.chom.2014.02.002","article-title":"Cytomegalovirus hijacks CX3CR1(hi) patrolling monocytes as immune-privileged vehicles for dissemination in mice","volume":"15","author":"Daley-Bauer","year":"2014","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.celrep.2018.03.074_bib6","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1016\/j.immuni.2016.10.018","article-title":"The chemokine receptor CX3CR1 defines three antigen-experienced CD8 T\u00a0cell subsets with distinct roles in immune surveillance and homeostasis","volume":"45","author":"Gerlach","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2018.03.074_bib7","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nature10003","article-title":"Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine","volume":"473","author":"Hansen","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2018.03.074_bib8","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1126\/science.aac9475","article-title":"Broadly targeted CD8+ T\u00a0cell responses restricted by major histocompatibility complex E","volume":"351","author":"Hansen","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.celrep.2018.03.074_bib9","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.4049\/jimmunol.151.5.2426","article-title":"Regulation of CD27 expression on subsets of mature T-lymphocytes","volume":"151","author":"Hintzen","year":"1993","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2018.03.074_bib10","doi-asserted-by":"crossref","first-page":"4106","DOI":"10.1128\/MCB.20.11.4106-4114.2000","article-title":"Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion","volume":"20","author":"Jung","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.celrep.2018.03.074_bib11","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.4049\/jimmunol.170.4.2022","article-title":"Memory inflation: continuous accumulation of antiviral CD8+ T\u00a0cells over time","volume":"170","author":"Karrer","year":"2003","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2018.03.074_bib12","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.tim.2008.08.011","article-title":"Loss of CD127 expression links immune activation and CD4(+) T\u00a0cell loss in HIV infection","volume":"16","author":"Kiazyk","year":"2008","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.celrep.2018.03.074_bib13","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nri.2016.38","article-title":"T cell responses to cytomegalovirus","volume":"16","author":"Klenerman","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2018.03.074_bib14","doi-asserted-by":"crossref","first-page":"e1006782","DOI":"10.1371\/journal.ppat.1006782","article-title":"Adenoviral vaccine induction of CD8+ T\u00a0cell memory inflation: Impact of co-infection and infection order","volume":"13","author":"Lee","year":"2017","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.celrep.2018.03.074_bib15","doi-asserted-by":"crossref","first-page":"eaaj1996","DOI":"10.1126\/sciimmunol.aaj1996","article-title":"Up-regulation of LFA-1 allows liver-resident memory T\u00a0cells to patrol and remain in the hepatic sinusoids","volume":"2","author":"McNamara","year":"2017","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.celrep.2018.03.074_bib16","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/nri.2015.3","article-title":"Tissue-resident memory T\u00a0cells: local specialists in immune defence","volume":"16","author":"Mueller","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2018.03.074_bib17","doi-asserted-by":"crossref","first-page":"5214","DOI":"10.4049\/jimmunol.1302806","article-title":"Longitudinal requirement for CD4+ T\u00a0cell help for adenovirus vector-elicited CD8+ T\u00a0cell responses","volume":"192","author":"Provine","year":"2014","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2018.03.074_bib18","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/44385","article-title":"Two subsets of memory T lymphocytes with distinct homing potentials and effector functions","volume":"401","author":"Sallusto","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2018.03.074_bib19","doi-asserted-by":"crossref","first-page":"e1004233","DOI":"10.1371\/journal.ppat.1004233","article-title":"Systemic hematogenous maintenance of memory inflation by MCMV infection","volume":"10","author":"Smith","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.celrep.2018.03.074_bib20","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.celrep.2015.09.076","article-title":"Murine CMV infection induces the continuous production of mucosal resident T\u00a0cells","volume":"13","author":"Smith","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2018.03.074_bib21","doi-asserted-by":"crossref","first-page":"3932","DOI":"10.4049\/jimmunol.0900227","article-title":"CD4+ T\u00a0cell help has an epitope-dependent impact on CD8+ T\u00a0cell memory inflation during murine cytomegalovirus infection","volume":"183","author":"Snyder","year":"2009","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2018.03.074_bib22","doi-asserted-by":"crossref","first-page":"261ra153","DOI":"10.1126\/scitranslmed.3009185","article-title":"A human vaccine strategy based on chimpanzee adenoviral and MVA vectors that primes, boosts, and sustains functional HCV-specific T\u00a0cell memory","volume":"6","author":"Swadling","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2018.03.074_bib23","doi-asserted-by":"crossref","first-page":"e1002313","DOI":"10.1371\/journal.ppat.1002313","article-title":"Non-hematopoietic cells in lymph nodes drive memory CD8 T\u00a0cell inflation during murine cytomegalovirus infection","volume":"7","author":"Torti","year":"2011","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.celrep.2018.03.074_bib24","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.virusres.2003.08.009","article-title":"Improved detection and quantification of mouse cytomegalovirus by real-time PCR","volume":"98","author":"Vliegen","year":"2003","journal-title":"Virus Res."},{"key":"10.1016\/j.celrep.2018.03.074_bib25","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/ni889","article-title":"Lineage relationship and protective immunity of memory CD8 T\u00a0cell subsets","volume":"4","author":"Wherry","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2018.03.074_bib26","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.immuni.2016.07.007","article-title":"A high-dimensional atlas of human T\u00a0cell diversity reveals tissue-specific trafficking and cytokine signatures","volume":"45","author":"Wong","year":"2016","journal-title":"Immunity"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124718304352?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124718304352?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T10:21:24Z","timestamp":1761906084000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124718304352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["S2211124718304352"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2018.03.074","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Induction and Maintenance of CX3CR1-Intermediate Peripheral Memory CD8+ T Cells by Persistent Viruses and Vaccines","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2018.03.074","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Author(s).","name":"copyright","label":"Copyright"}]}}