{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:06:14Z","timestamp":1792058774781,"version":"4.4.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,4,28]],"date-time":"2018-04-28T00:00:00Z","timestamp":1524873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["K08-DK114527-01"],"award-info":[{"award-number":["K08-DK114527-01"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001445","name":"Alex's Lemonade Stand Foundation for Childhood Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001445","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA163647"],"award-info":[{"award-number":["R01CA163647"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.celrep.2018.04.116","type":"journal-article","created":{"date-parts":[[2018,6,8]],"date-time":"2018-06-08T04:08:12Z","timestamp":1528430892000},"page":"3091-3101","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":119,"title":["Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28"],"prefix":"10.1016","volume":"23","author":[{"given":"Longfei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Grant","family":"Rowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Jaimes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxiao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunsun","family":"Nam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S.","family":"Pearson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Marion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory J.","family":"Heffron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George Q.","family":"Daley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6522-0835","authenticated-orcid":false,"given":"Piotr","family":"Sliz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2018.04.116_bib1","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1126\/science.6494891","article-title":"Heterochronic mutants of the nematode Caenorhabditis elegans","volume":"226","author":"Ambros","year":"1984","journal-title":"Science"},{"key":"10.1016\/j.celrep.2018.04.116_bib2","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1182\/blood-2012-01-401760","article-title":"Enforced expression of Lin28b leads to impaired T-cell development, release of inflammatory cytokines, and peripheral T-cell lymphoma","volume":"120","author":"Beachy","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2018.04.116_bib3","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/nature12119","article-title":"A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway","volume":"497","author":"Chang","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2018.04.116_bib4","unstructured":"DeLano, W.L. (2002). PyMOL: an open-source molecular graphics tool. CCP4 Newsletter on Protein Crystallography, March (40), http:\/\/www.ccp4.ac.uk\/newsletters\/newsletter40\/11_pymol.pdf."},{"key":"10.1016\/j.celrep.2018.04.116_bib5","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/jcb.21613","article-title":"Zinc depletion efficiently inhibits pancreatic cancer cell growth by increasing the ratio of antiproliferative\/proliferative genes","volume":"104","author":"Donadelli","year":"2008","journal-title":"J.\u00a0Cell. Biochem."},{"key":"10.1016\/j.celrep.2018.04.116_bib6","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1038\/nsmb.1676","article-title":"Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells","volume":"16","author":"Hagan","year":"2009","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.celrep.2018.04.116_bib7","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.bbrc.2012.04.014","article-title":"Pancreatic stellate cells enhance stem cell-like phenotypes in pancreatic cancer cells","volume":"421","author":"Hamada","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.celrep.2018.04.116_bib8","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.molcel.2008.09.014","article-title":"Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA","volume":"32","author":"Heo","year":"2008","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2018.04.116_bib9","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2009.10.014","article-title":"An epigenetic switch involving NF-kappaB, Lin28, Let-7 microRNA, and IL6 links inflammation to cell transformation","volume":"139","author":"Iliopoulos","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2018.04.116_bib10","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1038\/bjc.2014.529","article-title":"Interrogation of gossypol therapy in glioblastoma implementing cell line and patient-derived tumour models","volume":"111","author":"Jarzabek","year":"2014","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.celrep.2018.04.116_bib11","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1016\/j.molonc.2015.03.014","article-title":"Natural product (\u2013)-gossypol inhibits colon cancer cell growth by targeting RNA-binding protein Musashi-1","volume":"9","author":"Lan","year":"2015","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.celrep.2018.04.116_bib12","doi-asserted-by":"crossref","first-page":"10208","DOI":"10.1039\/C6OB01945E","article-title":"Identification of small molecule inhibitors of the Lin28-mediated blockage of pre-let-7g processing","volume":"14","author":"Lightfoot","year":"2016","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.celrep.2018.04.116_bib13","doi-asserted-by":"crossref","first-page":"13630","DOI":"10.1021\/jacs.6b06965","article-title":"Discovery of a small-molecule inhibitor of protein-microRNA interaction using binding assay with a site-specifically labeled Lin28","volume":"138","author":"Lim","year":"2016","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.celrep.2018.04.116_bib14","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/nsmb.2202","article-title":"Structural basis of pre-let-7 miRNA recognition by the zinc knuckles of pluripotency factor Lin28","volume":"19","author":"Loughlin","year":"2011","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.celrep.2018.04.116_bib15","doi-asserted-by":"crossref","first-page":"7492","DOI":"10.1093\/nar\/gks355","article-title":"The Lin28 cold-shock domain remodels pre-let-7 microRNA","volume":"40","author":"Mayr","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2018.04.116_bib16","first-page":"101","article-title":"Chelation of intracellular zinc triggers apoptosis in mature thymocytes","volume":"69","author":"McCabe","year":"1993","journal-title":"Lab. Invest."},{"key":"10.1016\/j.celrep.2018.04.116_bib17","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/ng.2436","article-title":"LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression","volume":"44","author":"Molenaar","year":"2012","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2018.04.116_bib18","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.cell.2011.10.020","article-title":"Molecular basis for interaction of let-7 microRNAs with Lin28","volume":"147","author":"Nam","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2018.04.116_bib19","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.ccr.2014.06.018","article-title":"Lin28b is sufficient to drive liver cancer and necessary for its maintenance in murine models","volume":"26","author":"Nguyen","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2018.04.116_bib20","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1158\/1535-7163.23.4.1","article-title":"(\u2013)-Gossypol acts directly on the mitochondria to overcome Bcl-2- and Bcl-X(L)-mediated apoptosis resistance","volume":"4","author":"Oliver","year":"2005","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.celrep.2018.04.116_bib21","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1021\/acschembio.6b00232","article-title":"A small-molecule inhibitor of Lin28","volume":"11","author":"Roos","year":"2016","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.celrep.2018.04.116_bib22","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1084\/jem.20151912","article-title":"Developmental regulation of myeloerythroid progenitor function by the Lin28b-let-7-Hmga2 axis","volume":"213","author":"Rowe","year":"2016","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2018.04.116_bib23","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1038\/ncb1759","article-title":"A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment","volume":"10","author":"Rybak","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2018.04.116_bib24","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.3892\/ijo.2014.2652","article-title":"Gossypol induces apoptosis in multiple myeloma cells by inhibition of interleukin-6 signaling and Bcl-2\/Mcl-1 pathway","volume":"45","author":"Sadahira","year":"2014","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.celrep.2018.04.116_bib25","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1107\/S1399004714026662","article-title":"Structure calculation, refinement and validation using CcpNmr Analysis","volume":"71","author":"Skinner","year":"2015","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.celrep.2018.04.116_bib26","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/ncb3453","article-title":"LIN28 phosphorylation by MAPK\/ERK couples signalling to the post-transcriptional control of pluripotency","volume":"19","author":"Tsanov","year":"2017","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2018.04.116_bib27","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1101\/gad.256693.114","article-title":"LIN28 cooperates with WNT signaling to drive invasive intestinal and colorectal adenocarcinoma in mice and humans","volume":"29","author":"Tu","year":"2015","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2018.04.116_bib28","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1101\/gad.237149.113","article-title":"Lin28 sustains early renal progenitors and induces Wilms tumor","volume":"28","author":"Urbach","year":"2014","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2018.04.116_bib29","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1126\/science.1154040","article-title":"Selective blockade of microRNA processing by Lin28","volume":"320","author":"Viswanathan","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.celrep.2018.04.116_bib30","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/ng.392","article-title":"Lin28 promotes transformation and is associated with advanced human malignancies","volume":"41","author":"Viswanathan","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2018.04.116_bib31","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1158\/1535-7163.MCT-09-0507","article-title":"Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells","volume":"9","author":"Volate","year":"2010","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.celrep.2018.04.116_bib32","doi-asserted-by":"crossref","first-page":"e82","DOI":"10.1093\/nar\/gng082","article-title":"General plasmids for producing RNA in\u00a0vitro transcripts with homogeneous ends","volume":"31","author":"Walker","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2018.04.116_bib33","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.1016\/j.celrep.2017.02.044","article-title":"LIN28 zinc knuckle domain is required and sufficient to induce let-7 oligouridylation","volume":"18","author":"Wang","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2018.04.116_bib34","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1177\/2472555217731983","article-title":"MightyScreen: an open-source visualization application for screening data analysis","volume":"23","author":"Wang","year":"2018","journal-title":"SLAS Discov."},{"key":"10.1016\/j.celrep.2018.04.116_bib35","doi-asserted-by":"crossref","first-page":"9463","DOI":"10.1158\/0008-5472.CAN-10-2388","article-title":"Double-negative feedback loop between reprogramming factor LIN28 and microRNA let-7 regulates aldehyde dehydrogenase 1-positive cancer stem cells","volume":"70","author":"Yang","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2018.04.116_bib36","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nature06968","article-title":"The ground state of embryonic stem cell self-renewal","volume":"453","author":"Ying","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2018.04.116_bib37","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.biocel.2013.02.006","article-title":"LIN28\/LIN28B: an emerging oncogenic driver in cancer stem cells","volume":"45","author":"Zhou","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124718307162?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124718307162?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T10:23:49Z","timestamp":1761906229000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124718307162"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":37,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["S2211124718307162"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2018.04.116","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2018.04.116","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors.","name":"copyright","label":"Copyright"}]}}