{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:36:15Z","timestamp":1792283775206,"version":"4.4.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,5,4]],"date-time":"2018-05-04T00:00:00Z","timestamp":1525392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["309742"],"award-info":[{"award-number":["309742"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006942","name":"Medical University of South Carolina","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006942","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009318","name":"Helmholtz Association","doi-asserted-by":"publisher","award":["VH-NG-1123"],"award-info":[{"award-number":["VH-NG-1123"]}],"id":[{"id":"10.13039\/501100009318","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000654","name":"Marie Curie","doi-asserted-by":"publisher","award":["CIG304108"],"award-info":[{"award-number":["CIG304108"]}],"id":[{"id":"10.13039\/501100000654","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["C06 RR018823"],"award-info":[{"award-number":["C06 RR018823"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DE 2157\/2-1"],"award-info":[{"award-number":["DE 2157\/2-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MC-A070-5PSB0"],"award-info":[{"award-number":["MC-A070-5PSB0"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.celrep.2018.05.009","type":"journal-article","created":{"date-parts":[[2018,6,8]],"date-time":"2018-06-08T04:08:20Z","timestamp":1528430900000},"page":"2976-2988","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":343,"title":["The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC and Fly Models of Parkinson\u2019s Disease"],"prefix":"10.1016","volume":"23","author":[{"given":"David C.","family":"Sch\u00f6ndorf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina","family":"Ivanyuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Baden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro","family":"Sanchez-Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"De Cicco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Giunta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas K.","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Di Napoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasiliki","family":"Panagiotakopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigrun","family":"Nestel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Keatinge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Pruszak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Bandmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Heimrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Gasser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander J.","family":"Whitworth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Deleidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2018.05.009_bib1","doi-asserted-by":"crossref","first-page":"e1002472","DOI":"10.1371\/journal.pbio.1002472","article-title":"NMNAT2:HSP90 complex mediates proteostasis in proteinopathies","volume":"14","author":"Ali","year":"2016","journal-title":"PLoS Biol."},{"key":"10.1016\/j.celrep.2018.05.009_bib2","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1083\/jcb.201401070","article-title":"Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin","volume":"206","author":"Ashrafi","year":"2014","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.celrep.2018.05.009_bib3","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s00441-016-2463-1","article-title":"Mitochondrial lipids in neurodegeneration","volume":"367","author":"Aufschnaiter","year":"2017","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.celrep.2018.05.009_bib4","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0092-8674(04)00416-7","article-title":"Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans","volume":"117","author":"Bieganowski","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2018.05.009_bib5","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.tem.2013.12.001","article-title":"SIRT1 and other sirtuins in metabolism","volume":"25","author":"Chang","year":"2014","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.celrep.2018.05.009_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuint.2012.10.010","article-title":"Glucocerebrosidase inhibition causes mitochondrial dysfunction and free radical damage","volume":"62","author":"Cleeter","year":"2013","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.celrep.2018.05.009_bib7","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.1038\/emboj.2012.170","article-title":"Mitochondrial dysfunction in Parkinson\u2019s disease: molecular mechanisms and pathophysiological consequences","volume":"31","author":"Exner","year":"2012","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2018.05.009_bib8","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.stemcr.2016.01.013","article-title":"ER stress and autophagic perturbations lead to elevated extracellular \u03b1-synuclein in GBA-N370S Parkinson\u2019s iPSC-derived dopamine neurons","volume":"6","author":"Fernandes","year":"2016","journal-title":"Stem Cell Reports"},{"key":"10.1016\/j.celrep.2018.05.009_bib9","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1002\/mds.27119","article-title":"N370S-GBA1 mutation causes lysosomal cholesterol accumulation in Parkinson\u2019s disease","volume":"32","author":"Garc\u00eda-Sanz","year":"2017","journal-title":"Mov. Disord."},{"key":"10.1016\/j.celrep.2018.05.009_bib10","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/ana.23614","article-title":"Glucocerebrosidase deficiency in substantia nigra of Parkinson disease brains","volume":"72","author":"Gegg","year":"2012","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.celrep.2018.05.009_bib11","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.cmet.2011.08.012","article-title":"Imaging cytosolic NADH-NAD(+) redox state with a genetically encoded fluorescent biosensor","volume":"14","author":"Hung","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2018.05.009_bib12","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13059-017-1147-9","article-title":"Discovery and functional prioritization of Parkinson\u2019s disease candidate genes from large-scale whole exome sequencing","volume":"18","author":"Jansen","year":"2017","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2018.05.009_bib13","doi-asserted-by":"crossref","first-page":"34328","DOI":"10.1074\/jbc.M004345200","article-title":"alpha-Synuclein membrane interactions and lipid specificity","volume":"275","author":"Jo","year":"2000","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2018.05.009_bib14","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.15252\/embj.201797135","article-title":"Modulating NAD+ metabolism, from bench to bedside","volume":"36","author":"Katsyuba","year":"2017","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2018.05.009_bib15","doi-asserted-by":"crossref","first-page":"6640","DOI":"10.1093\/hmg\/ddv369","article-title":"Glucocerebrosidase 1 deficient Danio rerio mirror key pathological aspects of human Gaucher disease and provide evidence of early microglial activation preceding alpha-synuclein-independent neuronal cell death","volume":"24","author":"Keatinge","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.celrep.2018.05.009_bib16","first-page":"2313","article-title":"Impaired OMA1-dependent cleavage of\u00a0OPA1 and reduced DRP1 fission activity combine to prevent mitophagy in cells that are dependent on oxidative phosphorylation","volume":"127","author":"MacVicar","year":"2014","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.celrep.2018.05.009_bib17","doi-asserted-by":"crossref","first-page":"3432","DOI":"10.1093\/hmg\/ddw185","article-title":"Autophagic lysosome reformation dysfunction in glucocerebrosidase deficient cells: relevance to Parkinson disease","volume":"25","author":"Magalhaes","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.celrep.2018.05.009_bib18","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/1750-1172-8-140","article-title":"Unfolded protein response in Gaucher disease: from human to Drosophila","volume":"8","author":"Maor","year":"2013","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.celrep.2018.05.009_bib19","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cell.2011.06.001","article-title":"Gaucher disease glucocerebrosidase and \u03b1-synuclein form a bidirectional pathogenic loop in synucleinopathies","volume":"146","author":"Mazzulli","year":"2011","journal-title":"Cell"},{"issue":"Suppl 1","key":"10.1016\/j.celrep.2018.05.009_bib20","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/jnc.13385","article-title":"The relationship between glucocerebrosidase mutations and Parkinson disease","volume":"139","author":"Migdalska-Richards","year":"2016","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.celrep.2018.05.009_bib21","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1002\/ana.24790","article-title":"Ambroxol effects in glucocerebrosidase and \u03b1-synuclein transgenic mice","volume":"80","author":"Migdalska-Richards","year":"2016","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.celrep.2018.05.009_bib22","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.cell.2013.06.016","article-title":"The NAD(+)\/sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling","volume":"154","author":"Mouchiroud","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2018.05.009_bib23","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.cmet.2013.04.014","article-title":"Mitochondria and quality control defects in a mouse model of Gaucher disease: links to Parkinson\u2019s disease","volume":"17","author":"Osellame","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2018.05.009_bib24","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/cdd.2016.138","article-title":"SIRT1 protects the heart from ER stress-induced cell death through eIF2\u03b1 deacetylation","volume":"24","author":"Prola","year":"2017","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.celrep.2018.05.009_bib25","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.cmet.2018.02.011","article-title":"Therapeutic potential of NAD-boosting molecules: the in\u00a0vivo evidence","volume":"27","author":"Rajman","year":"2018","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2018.05.009_bib26","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1038\/nprot.2013.143","article-title":"Genome engineering using the CRISPR-Cas9 system","volume":"8","author":"Ran","year":"2013","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2018.05.009_bib27","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/acn3.177","article-title":"Progressive decline of glucocerebrosidase in aging and Parkinson\u2019s disease","volume":"2","author":"Rocha","year":"2015","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/j.celrep.2018.05.009_bib28","doi-asserted-by":"crossref","first-page":"31380","DOI":"10.1038\/srep31380","article-title":"Parkinson disease-linked GBA mutation effects reversed by molecular chaperones in human cell and fly models","volume":"6","author":"Sanchez-Martinez","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2018.05.009_bib29","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nature07006","article-title":"Essential role for Nix in autophagic maturation of erythroid cells","volume":"454","author":"Sandoval","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2018.05.009_bib30","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1021\/cb600187q","article-title":"Chemical chaperones and permissive temperatures alter localization of Gaucher disease associated glucocerebrosidase variants","volume":"1","author":"Sawkar","year":"2006","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.celrep.2018.05.009_bib31","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/S0140-6736(89)92366-0","article-title":"Mitochondrial complex I deficiency in Parkinson\u2019s disease","volume":"1","author":"Schapira","year":"1989","journal-title":"Lancet"},{"key":"10.1016\/j.celrep.2018.05.009_bib32","doi-asserted-by":"crossref","first-page":"4028","DOI":"10.1038\/ncomms5028","article-title":"iPSC-derived neurons from GBA1-associated Parkinson\u2019s disease patients show autophagic defects and impaired calcium homeostasis","volume":"5","author":"Sch\u00f6ndorf","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2018.05.009_bib33","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1056\/NEJMoa0901281","article-title":"Multicenter analysis of glucocerebrosidase mutations in Parkinson\u2019s disease","volume":"361","author":"Sidransky","year":"2009","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.celrep.2018.05.009_bib34","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1038\/nprot.2012.058","article-title":"Assessment of mitochondrial respiratory chain enzymatic activities on tissues and cultured cells","volume":"7","author":"Spinazzi","year":"2012","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2018.05.009_bib35","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.molcel.2004.08.029","article-title":"GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis","volume":"15","author":"Tessitore","year":"2004","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2018.05.009_bib36","doi-asserted-by":"crossref","first-page":"12948","DOI":"10.1038\/ncomms12948","article-title":"Nicotinamide riboside is uniquely and orally bioavailable in mice and humans","volume":"7","author":"Trammell","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2018.05.009_bib37","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/s11910-010-0102-x","article-title":"The role of glucocerebrosidase mutations in Parkinson disease and Lewy body disorders","volume":"10","author":"Velayati","year":"2010","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.celrep.2018.05.009_bib38","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/nature25486","article-title":"Mitochondria-lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis","volume":"554","author":"Wong","year":"2018","journal-title":"Nature"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124718307423?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124718307423?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T10:23:17Z","timestamp":1761906197000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124718307423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":38,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["S2211124718307423"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2018.05.009","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC and Fly Models of Parkinson\u2019s Disease","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2018.05.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors.","name":"copyright","label":"Copyright"}]}}