{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T01:56:42Z","timestamp":1792202202988,"version":"4.4.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,6,6]],"date-time":"2018-06-06T00:00:00Z","timestamp":1528243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM111987"],"award-info":[{"award-number":["GM111987"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.celrep.2018.06.023","type":"journal-article","created":{"date-parts":[[2018,7,3]],"date-time":"2018-07-03T10:52:56Z","timestamp":1530615176000},"page":"66-78.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"title":["Spatial Fold Change of FGF Signaling Encodes Positional Information for Segmental Determination in Zebrafish"],"prefix":"10.1016","volume":"24","author":[{"given":"M. Fethullah","family":"Simsek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ertu\u011frul M.","family":"\u00d6zbudak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2018.06.023_bib1","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1242\/dev.098905","article-title":"An\u00a0anterior limit of FGF\/Erk signal activity marks the earliest future somite boundary in zebrafish","volume":"141","author":"Akiyama","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.celrep.2018.06.023_bib2","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S1534-5807(03)00055-8","article-title":"Wnt3a plays a major role in the segmentation clock controlling somitogenesis","volume":"4","author":"Aulehla","year":"2003","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2018.06.023_bib3","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/ncb1679","article-title":"A beta-catenin gradient links the clock and wavefront systems in mouse embryo segmentation","volume":"10","author":"Aulehla","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2018.06.023_bib4","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1242\/dev.093435","article-title":"Wnt-regulated dynamics of positional information in zebrafish somitogenesis","volume":"141","author":"Bajard","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.celrep.2018.06.023_bib5","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ydbio.2004.03.033","article-title":"Beyond the neckless phenotype: influence of reduced retinoic acid signaling on motor neuron development in the zebrafish hindbrain","volume":"271","author":"Begemann","year":"2004","journal-title":"Dev. Biol."},{"key":"10.1016\/j.celrep.2018.06.023_bib6","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1038\/nature07059","article-title":"Scaling of the BMP activation gradient in Xenopus embryos","volume":"453","author":"Ben-Zvi","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2018.06.023_bib7","doi-asserted-by":"crossref","first-page":"aaa5838","DOI":"10.1126\/science.aaa5838","article-title":"Embryo development. BMP gradients: a paradigm for morphogen-mediated developmental patterning","volume":"348","author":"Bier","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.celrep.2018.06.023_bib8","first-page":"1368","article-title":"Dynamic visualization of transcription and RNA subcellular localization in zebrafish","volume":"142","author":"Campbell","year":"2015","journal-title":"Development"},{"key":"10.1016\/j.celrep.2018.06.023_bib9","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.molcel.2009.11.025","article-title":"Dynamics and variability of ERK2 response to EGF in individual living cells","volume":"36","author":"Cohen-Saidon","year":"2009","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2018.06.023_bib10","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/254196a0","article-title":"Control of somite number during morphogenesis of a vertebrate, Xenopus laevis","volume":"254","author":"Cooke","year":"1975","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2018.06.023_bib11","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S0022-5193(76)80131-2","article-title":"A clock and wavefront model for control of the number of repeated structures during animal morphogenesis","volume":"58","author":"Cooke","year":"1976","journal-title":"J.\u00a0Theor. Biol."},{"key":"10.1016\/j.celrep.2018.06.023_bib12","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.cels.2015.10.002","article-title":"A local, self-organizing reaction-diffusion model can explain somite patterning in embryos","volume":"1","author":"Cotterell","year":"2015","journal-title":"Cell Syst."},{"key":"10.1016\/j.celrep.2018.06.023_bib13","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.mod.2017.04.005","article-title":"A framework for understanding morphogenesis and migration of the zebrafish posterior Lateral Line primordium","volume":"148","author":"Dalle Nogare","year":"2017","journal-title":"Mech. Dev."},{"key":"10.1016\/j.celrep.2018.06.023_bib14","doi-asserted-by":"crossref","first-page":"e04379","DOI":"10.7554\/eLife.04379","article-title":"Hox genes control vertebrate body elongation by collinear Wnt repression","volume":"4","author":"Denans","year":"2015","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2018.06.023_bib15","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/nature06347","article-title":"Interpretation of the sonic hedgehog morphogen gradient by a temporal adaptation mechanism","volume":"450","author":"Dessaud","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2018.06.023_bib16","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0896-6273(03)00565-8","article-title":"Opposing FGF and retinoid pathways control ventral neural pattern, neuronal differentiation, and segmentation during body axis extension","volume":"40","author":"Diez del Corral","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2018.06.023_bib17","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/nature02216","article-title":"fgf8 mRNA decay establishes a gradient that couples axial elongation to patterning in the vertebrate embryo","volume":"427","author":"Dubrulle","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2018.06.023_bib18","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0092-8674(01)00437-8","article-title":"FGF signaling controls somite boundary position and regulates segmentation clock control of spatiotemporal Hox gene activation","volume":"106","author":"Dubrulle","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2018.06.023_bib19","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3389\/fnana.2017.00064","article-title":"Midbrain-hindbrain boundary morphogenesis: at the intersection of Wnt and Fgf signaling","volume":"11","author":"Gibbs","year":"2017","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.celrep.2018.06.023_bib20","doi-asserted-by":"crossref","first-page":"e150","DOI":"10.1371\/journal.pbio.0050150","article-title":"Setting the tempo in development: an investigation of the zebrafish somite clock mechanism","volume":"5","author":"Giudicelli","year":"2007","journal-title":"PLoS Biol."},{"key":"10.1016\/j.celrep.2018.06.023_bib21","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.molcel.2009.11.017","article-title":"Evidence that fold-change, and not absolute level, of beta-catenin dictates Wnt signaling","volume":"36","author":"Goentoro","year":"2009","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2018.06.023_bib22","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nature07020","article-title":"Control of segment number in vertebrate embryos","volume":"454","author":"Gomez","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2018.06.023_bib23","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1016\/j.cub.2010.09.063","article-title":"WNT5A\/JNK and FGF\/MAPK pathways regulate the cellular events shaping the vertebrate limb bud","volume":"20","author":"Gros","year":"2010","journal-title":"Curr. Biol."},{"key":"10.1016\/j.celrep.2018.06.023_bib24","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.cell.2013.05.004","article-title":"Scaling of dorsal-ventral patterning by embryo size-dependent degradation of Spemann\u2019s organizer signals","volume":"153","author":"Inomata","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2018.06.023_bib25","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/nature03512","article-title":"Retinoic acid signalling links left-right asymmetric patterning and bilaterally symmetric somitogenesis in the zebrafish embryo","volume":"435","author":"Kawakami","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2018.06.023_bib26","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.cell.2011.03.009","article-title":"Pattern, growth, and control","volume":"144","author":"Lander","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2018.06.023_bib27","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nature11804","article-title":"Scaling of embryonic patterning based on phase-gradient encoding","volume":"493","author":"Lauschke","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2018.06.023_bib28","doi-asserted-by":"crossref","first-page":"5173","DOI":"10.1242\/dev.02101","article-title":"Fgf signaling instructs position-dependent growth rate during zebrafish fin regeneration","volume":"132","author":"Lee","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.celrep.2018.06.023_bib29","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1242\/dev.01007","article-title":"Reiterated Wnt signaling during zebrafish neural crest development","volume":"131","author":"Lewis","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.celrep.2018.06.023_bib30","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/nchembio.190","article-title":"Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages","volume":"5","author":"Molina","year":"2009","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.celrep.2018.06.023_bib31","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1101\/gad.2035311","article-title":"Different types of oscillations in Notch and Fgf signaling regulate the spatiotemporal periodicity of somitogenesis","volume":"25","author":"Niwa","year":"2011","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2018.06.023_bib32","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0092-8674(00)80451-1","article-title":"Avian hairy gene expression identifies a molecular clock linked to vertebrate segmentation and somitogenesis","volume":"91","author":"Palmeirim","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2018.06.023_bib33","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.cell.2011.05.011","article-title":"Vertebrate segmentation: from cyclic gene networks to scoliosis","volume":"145","author":"Pourqui\u00e9","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2018.06.023_bib34","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.cell.2005.08.030","article-title":"Regulation of cell proliferation by a morphogen gradient","volume":"123","author":"Rogulja","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2018.06.023_bib35","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.devcel.2008.06.003","article-title":"Morphogen control of wing growth through the Fat signaling pathway","volume":"15","author":"Rogulja","year":"2008","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2018.06.023_bib36","doi-asserted-by":"crossref","first-page":"4873","DOI":"10.1242\/dev.128.23.4873","article-title":"Fgf\/MAPK signalling is a crucial positional cue in somite boundary formation","volume":"128","author":"Sawada","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.celrep.2018.06.023_bib37","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat Methods"},{"key":"10.1016\/j.celrep.2018.06.023_bib38","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1016\/j.cub.2004.09.084","article-title":"Endocytosis controls spreading and effective signaling range of Fgf8 protein","volume":"14","author":"Scholpp","year":"2004","journal-title":"Curr. Biol."},{"key":"10.1016\/j.celrep.2018.06.023_bib39","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1126\/science.1253089","article-title":"Genetic oscillations. A Doppler effect in embryonic pattern formation","volume":"345","author":"Soroldoni","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.celrep.2018.06.023_bib40","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1242\/dev.001123","article-title":"Distinct Wnt signaling pathways have opposing roles in appendage regeneration","volume":"134","author":"Stoick-Cooper","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.celrep.2018.06.023_bib41","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.1242\/dev.023176","article-title":"Wnt and FGF signals interact to coordinate growth with cell fate specification during limb development","volume":"135","author":"ten Berge","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.celrep.2018.06.023_bib42","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nprot.2007.514","article-title":"High-resolution in\u00a0situ hybridization to whole-mount zebrafish embryos","volume":"3","author":"Thisse","year":"2008","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2018.06.023_bib43","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1002\/dvdy.24234","article-title":"Wnt and FGF mediated epithelial-mesenchymal crosstalk during lung development","volume":"244","author":"Volckaert","year":"2015","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.celrep.2018.06.023_bib44","doi-asserted-by":"crossref","first-page":"4033","DOI":"10.1242\/dev.009167","article-title":"FGF signaling acts upstream of the NOTCH and WNT signaling pathways to control segmentation clock oscillations in mouse somitogenesis","volume":"134","author":"Wahl","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.celrep.2018.06.023_bib45","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1126\/science.1200037","article-title":"Dynamics of Dpp signaling and proliferation control","volume":"331","author":"Wartlick","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.celrep.2018.06.023_bib46","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1242\/dev.127.8.1553","article-title":"Retinoid signaling is essential for patterning the endoderm of the third and fourth pharyngeal arches","volume":"127","author":"Wendling","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.celrep.2018.06.023_bib47","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/nature08391","article-title":"Fgf8 morphogen gradient forms by a source-sink mechanism with freely diffusing molecules","volume":"461","author":"Yu","year":"2009","journal-title":"Nature"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124718309185?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124718309185?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T10:25:09Z","timestamp":1761906309000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124718309185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["S2211124718309185"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2018.06.023","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Spatial Fold Change of FGF Signaling Encodes Positional Information for Segmental Determination in Zebrafish","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2018.06.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Author(s).","name":"copyright","label":"Copyright"}]}}