{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:46:55Z","timestamp":1790621215947,"version":"4.1.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,7,6]],"date-time":"2018-07-06T00:00:00Z","timestamp":1530835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000735","name":"University of Cambridge","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00c3\u00a5det","doi-asserted-by":"publisher","award":["K2014-62X-22527-01-3"],"award-info":[{"award-number":["K2014-62X-22527-01-3"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00c3\u00a5det","doi-asserted-by":"publisher","award":["K2014-62X-20404-08-5"],"award-info":[{"award-number":["K2014-62X-20404-08-5"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001729","name":"Stiftelsen f\u00c3\u00b6r\u00c2\u00a0Strategisk Forskning","doi-asserted-by":"publisher","award":["FFL12-0074"],"award-info":[{"award-number":["FFL12-0074"]}],"id":[{"id":"10.13039\/501100001729","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.celrep.2018.07.017","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T11:27:46Z","timestamp":1533641266000},"page":"1397-1406","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":95,"title":["Huntingtin Aggregation Impairs Autophagy, Leading to Argonaute-2 Accumulation and Global MicroRNA Dysregulation"],"prefix":"10.1016","volume":"24","author":[{"given":"Karolina","family":"Pircs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Petri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Madsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per Ludvik","family":"Bratt\u00e5s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romina","family":"Vuono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniella R.","family":"Ottosson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"St-Amour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bob A.","family":"Hersbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Matusiak-Br\u00fcckner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia Hult","family":"Lundh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5sa","family":"Peters\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"D\u00e9glon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien S.","family":"H\u00e9bert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malin","family":"Parmar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger A.","family":"Barker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Jakobsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2018.07.017_bib1","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.05005","article-title":"Predicting effective microRNA target sites in mammalian mRNAs","volume":"4","author":"Agarwal","year":"2015","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2018.07.017_bib2","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1083\/jcb.200512082","article-title":"RNA granules","volume":"172","author":"Anderson","year":"2006","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.celrep.2018.07.017_bib3","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/cr.2010.83","article-title":"A new twist in the microRNA pathway: Not Dicer but Argonaute is required for a microRNA production","volume":"20","author":"Boss\u00e9","year":"2010","journal-title":"Cell Res."},{"key":"10.1016\/j.celrep.2018.07.017_bib4","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.biocel.2014.10.029","article-title":"Age-dependent neuron loss is associated with impaired adult neurogenesis in forebrain neuron-specific Dicer conditional knockout mice","volume":"57","author":"Cheng","year":"2014","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.celrep.2018.07.017_bib5","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.drudis.2014.02.014","article-title":"The many faces of autophagy dysfunction in Huntington\u2019s disease: from mechanism to therapy","volume":"19","author":"Cortes","year":"2014","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.celrep.2018.07.017_bib6","doi-asserted-by":"crossref","first-page":"3473","DOI":"10.1523\/JNEUROSCI.22-09-03473.2002","article-title":"Lentiviral-mediated delivery of mutant huntingtin in the striatum of rats induces a selective neuropathology modulated by polyglutamine repeat size, huntingtin expression levels, and protein length","volume":"22","author":"de Almeida","year":"2002","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2018.07.017_bib7","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.cell.2007.10.032","article-title":"Dual role for argonautes in microRNA processing and posttranscriptional regulation of microRNA expression","volume":"131","author":"Diederichs","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2018.07.017_bib8","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1126\/science.277.5334.1990","article-title":"Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain","volume":"277","author":"DiFiglia","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.celrep.2018.07.017_bib9","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/nrm3716","article-title":"The return of the nucleus: transcriptional and epigenetic control of autophagy","volume":"15","author":"F\u00fcllgrabe","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2018.07.017_bib10","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1038\/ncb2611","article-title":"Selective autophagy degrades DICER and AGO2 and regulates miRNA activity","volume":"14","author":"Gibbings","year":"2012","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2018.07.017_bib11","doi-asserted-by":"crossref","first-page":"6182","DOI":"10.1523\/JNEUROSCI.0857-08.2008","article-title":"Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice","volume":"28","author":"Gray","year":"2008","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2018.07.017_bib12","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.neuron.2011.11.010","article-title":"Cell-type-based analysis of microRNA profiles in the mouse brain","volume":"73","author":"He","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2018.07.017_bib13","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/1756-6606-7-46","article-title":"microRNA-128a dysregulation in transgenic Huntington\u2019s disease monkeys","volume":"7","author":"Kocerha","year":"2014","journal-title":"Mol. Brain"},{"key":"10.1016\/j.celrep.2018.07.017_bib14","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.expneurol.2010.10.012","article-title":"Altered microRNA regulation in Huntington\u2019s disease models","volume":"227","author":"Lee","year":"2011","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.celrep.2018.07.017_bib15","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/978-1-4614-5107-5_10","article-title":"Quantifying Argonaute proteins in and out of GW\/P-bodies: implications in microRNA activities","volume":"768","author":"Leung","year":"2013","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.celrep.2018.07.017_bib16","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3389\/fncel.2013.00265","article-title":"The involvement of microRNAs in neurodegenerative diseases","volume":"7","author":"Maciotta","year":"2013","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.celrep.2018.07.017_bib17","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.tins.2014.09.003","article-title":"Autophagy in Huntington disease and huntingtin in autophagy","volume":"38","author":"Martin","year":"2015","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.celrep.2018.07.017_bib18","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.mcn.2013.10.009","article-title":"Dicer expression is essential for adult midbrain dopaminergic neuron maintenance and survival","volume":"58","author":"Pang","year":"2014","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.celrep.2018.07.017_bib19","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.yexcr.2013.09.022","article-title":"miRNAs in brain development","volume":"321","author":"Petri","year":"2014","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.celrep.2018.07.017_bib20","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.15252\/embj.201695235","article-title":"let-7 regulates radial migration of new-born neurons through positive regulation of autophagy","volume":"36","author":"Petri","year":"2017","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2018.07.017_bib21","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nature07186","article-title":"Prolyl 4-hydroxylation regulates Argonaute 2 stability","volume":"455","author":"Qi","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2018.07.017_bib22","doi-asserted-by":"crossref","first-page":"10820","DOI":"10.1073\/pnas.0800658105","article-title":"Huntington\u2019s disease protein contributes to RNA-mediated gene silencing through association with Argonaute and P bodies","volume":"105","author":"Savas","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2018.07.017_bib23","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1084\/jem.20070823","article-title":"Cerebellar neurodegeneration in the absence of microRNAs","volume":"204","author":"Schaefer","year":"2007","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2018.07.017_bib24","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1126\/science.1244193","article-title":"MicroRNA-128 governs neuronal excitability and motor behavior in mice","volume":"342","author":"Tan","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.celrep.2018.07.017_bib25","doi-asserted-by":"crossref","first-page":"4760","DOI":"10.1128\/MCB.05776-11","article-title":"Hypoxia potentiates microRNA-mediated gene silencing through posttranslational modification of Argonaute2","volume":"31","author":"Wu","year":"2011","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.celrep.2018.07.017_bib26","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1146\/annurev-neuro-071013-014149","article-title":"Autophagy and its normal and pathogenic states in the brain","volume":"37","author":"Yamamoto","year":"2014","journal-title":"Annu. Rev. Neurosci."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124718311070?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124718311070?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T10:25:49Z","timestamp":1761906349000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124718311070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["S2211124718311070"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2018.07.017","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Huntingtin Aggregation Impairs Autophagy, Leading to Argonaute-2 Accumulation and Global MicroRNA Dysregulation","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2018.07.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Author(s).","name":"copyright","label":"Copyright"}]}}