{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T16:05:17Z","timestamp":1792253117095,"version":"4.4.0"},"reference-count":71,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,8,8]],"date-time":"2018-08-08T00:00:00Z","timestamp":1533686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1045585"],"award-info":[{"award-number":["APP1045585"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Borella family"},{"name":"Reece Borella Medal Presentation Night"},{"name":"Victorian Government\u2019s Operational Infrastructure Support Program"},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1042095"],"award-info":[{"award-number":["1042095"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["586604"],"award-info":[{"award-number":["586604"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1078985"],"award-info":[{"award-number":["1078985"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["FT0001657"],"award-info":[{"award-number":["FT0001657"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008710","name":"Alzheimer's Australia Dementia Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008710","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Baker Heart and Diabetes Institute"},{"name":"Australian Postgraduate Award"},{"name":"Baker Heart and Diabetes Institute"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.celrep.2018.08.017","type":"journal-article","created":{"date-parts":[[2018,9,4]],"date-time":"2018-09-04T10:47:25Z","timestamp":1536058045000},"page":"2757-2772","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":75,"title":["Lipidomic Profiles of the Heart and Circulation in Response to Exercise versus Cardiac Pathology: A Resource of Potential Biomarkers and Drug Targets"],"prefix":"10.1016","volume":"24","author":[{"given":"Yow Keat","family":"Tham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca C.","family":"Bernardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Huynh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny Y.Y.","family":"Ooi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao Ming","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Kiriazis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corey","family":"Giles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Meikle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie R.","family":"McMullen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2018.08.017_bib1","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1161\/CIRCULATIONAHA.116.023233","article-title":"Plasma lipidomic profiles improve on traditional risk factors for the prediction of cardiovascular events in type 2 diabetes mellitus","volume":"134","author":"Alshehry","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.celrep.2018.08.017_bib2","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/j.1748-1716.2007.01755.x","article-title":"Effect of exercise duration on ceramide metabolism in the rat heart","volume":"192","author":"Baranowski","year":"2008","journal-title":"Acta Physiol. (Oxf.)"},{"key":"10.1016\/j.celrep.2018.08.017_bib3","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1748-1716.2011.02322.x","article-title":"Exercise increases plasma levels of sphingoid base-1 phosphates in humans","volume":"203","author":"Baranowski","year":"2011","journal-title":"Acta Physiol. (Oxf.)"},{"key":"10.1016\/j.celrep.2018.08.017_bib4","doi-asserted-by":"crossref","first-page":"E398","DOI":"10.1152\/ajpendo.00134.2015","article-title":"Serum sphingolipids: relationships to insulin sensitivity and changes with exercise in humans","volume":"309","author":"Bergman","year":"2015","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.celrep.2018.08.017_bib5","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.pharmthera.2010.04.005","article-title":"Molecular distinction between physiological and pathological cardiac hypertrophy: experimental findings and therapeutic strategies","volume":"128","author":"Bernardo","year":"2010","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.celrep.2018.08.017_bib6","doi-asserted-by":"crossref","first-page":"17615","DOI":"10.1073\/pnas.1206432109","article-title":"Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function","volume":"109","author":"Bernardo","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2018.08.017_bib7","doi-asserted-by":"crossref","first-page":"5097","DOI":"10.1096\/fj.14-253856","article-title":"Therapeutic silencing of miR-652 restores heart function and attenuates adverse remodeling in a setting of established pathological hypertrophy","volume":"28","author":"Bernardo","year":"2014","journal-title":"FASEB J."},{"key":"10.1016\/j.celrep.2018.08.017_bib8","doi-asserted-by":"crossref","first-page":"22442","DOI":"10.1038\/srep22442","article-title":"Inhibition of miR-154 protects against cardiac dysfunction and fibrosis in a mouse model of pressure overload","volume":"6","author":"Bernardo","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2018.08.017_bib9","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1152\/physrev.00043.2016","article-title":"Understanding key mechanisms of exercise-induced cardiac protection to mitigate disease: current knowledge and emerging concepts","volume":"98","author":"Bernardo","year":"2018","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.celrep.2018.08.017_bib10","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1042\/CS20171269","article-title":"Gene delivery of medium chain acyl-coenzyme A dehydrogenase induces physiological cardiac hypertrophy and protects against pathological remodelling","volume":"132","author":"Bernardo","year":"2018","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.celrep.2018.08.017_bib11","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0003-9861(84)90277-7","article-title":"Elevation of tissue coenzyme Q (ubiquinone) and cytochrome c concentrations by endurance exercise in the rat","volume":"234","author":"Beyer","year":"1984","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.celrep.2018.08.017_bib12","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.tem.2015.07.006","article-title":"Ceramides - lipotoxic inducers of metabolic disorders","volume":"26","author":"Chaurasia","year":"2015","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.celrep.2018.08.017_bib13","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.1161\/CIRCULATIONAHA.111.060889","article-title":"Ventricular assist device implantation corrects myocardial lipotoxicity, reverses insulin resistance, and normalizes cardiac metabolism in patients with advanced heart failure","volume":"125","author":"Chokshi","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.celrep.2018.08.017_bib14","doi-asserted-by":"crossref","first-page":"H58","DOI":"10.1152\/ajpheart.00157.2018","article-title":"Improving the quality of preclinical research echocardiography: observations, training, and guidelines for measurement","volume":"315","author":"Donner","year":"2018","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.celrep.2018.08.017_bib15","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0925-4439(95)00028-3","article-title":"Biochemical, physiological and medical aspects of ubiquinone function","volume":"1271","author":"Ernster","year":"1995","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.celrep.2018.08.017_bib16","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1194\/jlr.E400004-JLR200","article-title":"A comprehensive classification system for lipids","volume":"46","author":"Fahy","year":"2005","journal-title":"J.\u00a0Lipid Res."},{"issue":"Suppl","key":"10.1016\/j.celrep.2018.08.017_bib17","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1194\/jlr.R800095-JLR200","article-title":"Update of the LIPID MAPS comprehensive classification system for lipids","volume":"50","author":"Fahy","year":"2009","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.celrep.2018.08.017_bib18","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.1021\/acs.jproteome.6b00149","article-title":"Integrated omic analysis of a guinea pig model of heart failure and sudden cardiac death","volume":"15","author":"Foster","year":"2016","journal-title":"J.\u00a0Proteome Res."},{"key":"10.1016\/j.celrep.2018.08.017_bib19","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1161\/ATVBAHA.116.307497","article-title":"Circulating ceramides predict cardiovascular outcomes in the population-based FINRISK 2002 cohort","volume":"36","author":"Havulinna","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.celrep.2018.08.017_bib20","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1161\/CIRCULATIONAHA.111.075978","article-title":"Carnitine palmitoyltransferase-1b deficiency aggravates pressure overload-induced cardiac hypertrophy caused by lipotoxicity","volume":"126","author":"He","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.celrep.2018.08.017_bib21","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/S0003-4975(01)03621-9","article-title":"Disease-specific remodeling of cardiac mitochondria after a left ventricular assist device","volume":"73","author":"Heerdt","year":"2002","journal-title":"Ann. Thorac. Surg."},{"key":"10.1016\/j.celrep.2018.08.017_bib22","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1007\/s00125-012-2495-3","article-title":"Coenzyme Q10 attenuates diastolic dysfunction, cardiomyocyte hypertrophy and cardiac fibrosis in the db\/db mouse model of type 2 diabetes","volume":"55","author":"Huynh","year":"2012","journal-title":"Diabetologia"},{"key":"10.1016\/j.celrep.2018.08.017_bib23","doi-asserted-by":"crossref","first-page":"82922","DOI":"10.1172\/jci.insight.82922","article-title":"Increased de novo ceramide synthesis and accumulation in failing myocardium","volume":"2","author":"Ji","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.celrep.2018.08.017_bib24","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1586\/14779072.2014.934226","article-title":"Physiologic or pathologic hypertrophy: how can we know?","volume":"12","author":"Lai","year":"2014","journal-title":"Expert Rev. Cardiovasc. Ther."},{"key":"10.1016\/j.celrep.2018.08.017_bib25","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1161\/CIRCHEARTFAILURE.114.001469","article-title":"Energy metabolic reprogramming in the hypertrophied and early stage failing heart: a multisystems approach","volume":"7","author":"Lai","year":"2014","journal-title":"Circ. Heart Fail."},{"issue":"Suppl","key":"10.1016\/j.celrep.2018.08.017_bib26","doi-asserted-by":"crossref","first-page":"S145","DOI":"10.1016\/S0098-2997(97)00006-X","article-title":"Treatment of hypertrophic cardiomyopathy with coenzyme Q10","volume":"18","author":"Langsjoen","year":"1997","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.celrep.2018.08.017_bib27","doi-asserted-by":"crossref","first-page":"160015","DOI":"10.1038\/sdata.2016.15","article-title":"A large dataset of protein dynamics in the mammalian heart proteome","volume":"3","author":"Lau","year":"2016","journal-title":"Sci. Data"},{"key":"10.1016\/j.celrep.2018.08.017_bib28","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1161\/CIRCHEARTFAILURE.113.000744","article-title":"Delta-6-desaturase links polyunsaturated fatty acid metabolism with phospholipid remodeling and disease progression in heart failure","volume":"7","author":"Le","year":"2014","journal-title":"Circ. Heart Fail."},{"key":"10.1016\/j.celrep.2018.08.017_bib29","doi-asserted-by":"crossref","first-page":"33ra37","DOI":"10.1126\/scitranslmed.3001006","article-title":"Metabolic signatures of exercise in human plasma","volume":"2","author":"Lewis","year":"2010","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2018.08.017_bib30","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1194\/jlr.M033506","article-title":"Shorthand notation for lipid structures derived from mass spectrometry","volume":"54","author":"Liebisch","year":"2013","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.celrep.2018.08.017_bib31","doi-asserted-by":"crossref","first-page":"36312","DOI":"10.1074\/jbc.M109.049817","article-title":"DGAT1 expression increases heart triglyceride content but ameliorates lipotoxicity","volume":"284","author":"Liu","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2018.08.017_bib32","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.yjmcc.2013.02.008","article-title":"Global metabolomic analysis of heart tissue in a hamster model for dilated cardiomyopathy","volume":"59","author":"Maekawa","year":"2013","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.celrep.2018.08.017_bib33","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/dmrr.2488","article-title":"Changes in insulin sensitivity in response to different modalities of exercise: a review of the evidence","volume":"30","author":"Mann","year":"2014","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.celrep.2018.08.017_bib34","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1136\/bjsm.2008.054726","article-title":"Distinguishing hypertrophic cardiomyopathy from athlete\u2019s heart physiological remodelling: clinical significance, diagnostic strategies and implications for preparticipation screening","volume":"43","author":"Maron","year":"2009","journal-title":"Br. J. Sports Med."},{"key":"10.1016\/j.celrep.2018.08.017_bib35","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/j.celrep.2017.01.038","article-title":"Lipidomic adaptations in white and brown adipose tissue in response to exercise demonstrate molecular species-specific remodeling","volume":"18","author":"May","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2018.08.017_bib36","doi-asserted-by":"crossref","first-page":"12355","DOI":"10.1073\/pnas.1934654100","article-title":"Phosphoinositide 3-kinase(p110alpha) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy","volume":"100","author":"McMullen","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2018.08.017_bib37","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/nrendo.2016.169","article-title":"Sphingolipids and phospholipids in insulin resistance and related metabolic disorders","volume":"13","author":"Meikle","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.celrep.2018.08.017_bib38","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1161\/ATVBAHA.111.234096","article-title":"Plasma lipidomic analysis of stable and unstable coronary artery disease","volume":"31","author":"Meikle","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.celrep.2018.08.017_bib39","doi-asserted-by":"crossref","first-page":"e74341","DOI":"10.1371\/journal.pone.0074341","article-title":"Plasma lipid profiling shows similar associations with prediabetes and type 2 diabetes","volume":"8","author":"Meikle","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.celrep.2018.08.017_bib40","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.3945\/jn.115.210104","article-title":"Postprandial plasma phospholipids in men are influenced by the source of dietary fat","volume":"145","author":"Meikle","year":"2015","journal-title":"J.\u00a0Nutr."},{"key":"10.1016\/j.celrep.2018.08.017_bib41","doi-asserted-by":"crossref","first-page":"6387","DOI":"10.1021\/cr2002917","article-title":"Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics","volume":"111","author":"Merrill","year":"2011","journal-title":"Chem. Rev."},{"key":"10.1016\/j.celrep.2018.08.017_bib42","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.ijcard.2016.11.127","article-title":"A metabolomics-driven approach reveals metabolic responses and mechanisms in the rat heart following myocardial infarction","volume":"227","author":"Nam","year":"2017","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.celrep.2018.08.017_bib43","series-title":"The Cellular Basis of Cardiovascular Function in Health and Disease, P.K. Singal, V. Panagia, and G.N. Pierce","first-page":"179","article-title":"Changes in fatty acid compositions of myocardial lipids in rats with heart failure following myocardial infarction","author":"Nasa","year":"1997"},{"key":"10.1016\/j.celrep.2018.08.017_bib44","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.33549\/physiolres.931924","article-title":"Myocardial phospholipid remodeling under different types of load imposed during early postnatal development","volume":"58","author":"Nov\u00e1k","year":"2009","journal-title":"Physiol. Res."},{"key":"10.1016\/j.celrep.2018.08.017_bib45","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/eurheartj\/ehu180","article-title":"Genome-wide profiling of the cardiac transcriptome after myocardial infarction identifies novel heart-specific long non-coding RNAs","volume":"36","author":"Ounzain","year":"2015","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.celrep.2018.08.017_bib46","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1194\/jlr.M800147-JLR200","article-title":"Ceramide is a cardiotoxin in lipotoxic cardiomyopathy","volume":"49","author":"Park","year":"2008","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.celrep.2018.08.017_bib47","first-page":"H1","article-title":"Altered phospholipid metabolism in pressure-overload hypertrophied hearts","volume":"250","author":"Reibel","year":"1986","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.celrep.2018.08.017_bib48","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.cardfail.2006.03.007","article-title":"The impact of coenzyme Q10 on systolic function in patients with chronic heart failure","volume":"12","author":"Sander","year":"2006","journal-title":"J.\u00a0Card. Fail."},{"key":"10.1016\/j.celrep.2018.08.017_bib49","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1161\/CIRCHEARTFAILURE.114.001151","article-title":"Metabolomic analysis of pressure-overloaded and infarcted mouse hearts","volume":"7","author":"Sansbury","year":"2014","journal-title":"Circ. Heart Fail."},{"key":"10.1016\/j.celrep.2018.08.017_bib50","doi-asserted-by":"crossref","first-page":"5705","DOI":"10.1038\/ncomms6705","article-title":"The small-molecule BGP-15 protects against heart failure and atrial fibrillation in mice","volume":"5","author":"Sapra","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2018.08.017_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.orcp.2008.06.001","article-title":"Circulating levels of ganglioside GM3 in metabolic syndrome: A pilot study","volume":"2","author":"Sato","year":"2008","journal-title":"Obes. Res. Clin. Pract."},{"key":"10.1016\/j.celrep.2018.08.017_bib52","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1152\/physrev.00031.2009","article-title":"Pathophysiological mechanisms of atrial fibrillation: a translational appraisal","volume":"91","author":"Schotten","year":"2011","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.celrep.2018.08.017_bib53","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1161\/CIRCULATIONAHA.111.060368","article-title":"Metabolomic profiling for the identification of novel biomarkers and mechanisms related to common cardiovascular diseases: form and function","volume":"126","author":"Shah","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.celrep.2018.08.017_bib54","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1016\/j.amjcard.2004.07.121","article-title":"Effect of atorvastatin on left ventricular diastolic function and ability of coenzyme Q10 to reverse that dysfunction","volume":"94","author":"Silver","year":"2004","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.celrep.2018.08.017_bib55","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1194\/jlr.M500031-JLR200","article-title":"Quantitation of cardiolipin molecular species in spontaneously hypertensive heart failure rats using electrospray ionization mass spectrometry","volume":"46","author":"Sparagna","year":"2005","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.celrep.2018.08.017_bib56","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1194\/jlr.M600551-JLR200","article-title":"Loss of cardiac tetralinoleoyl cardiolipin in human and experimental heart failure","volume":"48","author":"Sparagna","year":"2007","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.celrep.2018.08.017_bib57","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/ejlt.200390101","article-title":"Editorial: what is lipidomics?","volume":"105","author":"Spener","year":"2003","journal-title":"Eur. J. Lipid Sci. Technol."},{"key":"10.1016\/j.celrep.2018.08.017_bib58","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.atherosclerosis.2016.01.003","article-title":"Decreased phosphatidylcholine plasmalogens--a putative novel lipid signature in patients with stable coronary artery disease and acute myocardial infarction","volume":"246","author":"Sutter","year":"2016","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.celrep.2018.08.017_bib59","doi-asserted-by":"crossref","first-page":"E45","DOI":"10.1210\/jc.2013-2559","article-title":"Molecular lipids identify cardiovascular risk and are efficiently lowered by simvastatin and PCSK9 deficiency","volume":"99","author":"Tarasov","year":"2014","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.celrep.2018.08.017_bib60","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1007\/s00204-015-1477-x","article-title":"Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets","volume":"89","author":"Tham","year":"2015","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.celrep.2018.08.017_bib61","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.bbalip.2017.12.003","article-title":"Distinct lipidomic profiles in models of physiological and pathological cardiac remodeling, and potential therapeutic strategies","volume":"1863","author":"Tham","year":"2018","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.celrep.2018.08.017_bib62","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1002\/oby.21448","article-title":"Skeletal muscle and plasma lipidomic signatures of insulin resistance and overweight\/obesity in humans","volume":"24","author":"Tonks","year":"2016","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.celrep.2018.08.017_bib63","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nrm2330","article-title":"Membrane lipids: where they are and how they behave","volume":"9","author":"van Meer","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2018.08.017_bib64","doi-asserted-by":"crossref","first-page":"e0129645","DOI":"10.1371\/journal.pone.0129645","article-title":"Identification of ganglioside GM3 molecular species in human serum associated with risk factors of metabolic syndrome","volume":"10","author":"Veillon","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.celrep.2018.08.017_bib65","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1161\/CIRCHEARTFAILURE.112.966622","article-title":"Phosphoinositide 3-kinase p110\u03b1 is a master regulator of exercise-induced cardioprotection and PI3K gene therapy rescues cardiac dysfunction","volume":"5","author":"Weeks","year":"2012","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.celrep.2018.08.017_bib66","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1194\/jlr.P035808","article-title":"Plasma lipid profiling in a large population-based cohort","volume":"54","author":"Weir","year":"2013","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.celrep.2018.08.017_bib67","doi-asserted-by":"crossref","first-page":"H1098","DOI":"10.1152\/ajpheart.00101.2017","article-title":"Glucose transporter 4-deficient hearts develop maladaptive hypertrophy in response to physiological or pathological stresses","volume":"313","author":"Wende","year":"2017","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.celrep.2018.08.017_bib68","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1210\/en.2007-1220","article-title":"Endogenous relaxin does not affect chronic pressure overload-induced cardiac hypertrophy and fibrosis","volume":"149","author":"Xu","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.celrep.2018.08.017_bib69","first-page":"357","article-title":"Ceramide is upregulated and associated with mortality in patients with chronic heart failure","volume":"31","author":"Yu","year":"2015","journal-title":"Can. J. Cardiol."},{"key":"10.1016\/j.celrep.2018.08.017_bib70","doi-asserted-by":"crossref","first-page":"153","DOI":"10.2217\/bmm.14.81","article-title":"Lipidomics applications for disease biomarker discovery in mammal models","volume":"9","author":"Zhao","year":"2015","journal-title":"Biomarkers Med."},{"key":"10.1016\/j.celrep.2018.08.017_bib71","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1007\/s00424-016-1867-9","article-title":"Endurance training increases the efficiency of rat skeletal muscle mitochondria","volume":"468","author":"Zoladz","year":"2016","journal-title":"Pflugers Arch."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124718312713?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124718312713?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T10:25:32Z","timestamp":1761906332000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124718312713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":71,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["S2211124718312713"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2018.08.017","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lipidomic Profiles of the Heart and Circulation in Response to Exercise versus Cardiac Pathology: A Resource of Potential Biomarkers and Drug Targets","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2018.08.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors.","name":"copyright","label":"Copyright"}]}}