{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T01:23:06Z","timestamp":1770513786203,"version":"3.49.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,9,4]],"date-time":"2018-09-04T00:00:00Z","timestamp":1536019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB877"],"award-info":[{"award-number":["SFB877"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Cluster of Excellence Inflammation at Interfaces"],"award-info":[{"award-number":["Cluster of Excellence Inflammation at Interfaces"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.celrep.2018.09.005","type":"journal-article","created":{"date-parts":[[2018,10,2]],"date-time":"2018-10-02T10:41:59Z","timestamp":1538476919000},"page":"10-18.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["Mutations in Craniosynostosis Patients Cause Defective Interleukin-11 Receptor Maturation and Drive Craniosynostosis-like Disease in Mice"],"prefix":"10.1016","volume":"25","author":[{"given":"Maria","family":"Agthe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Br\u00fcgge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvonne","family":"Garbers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marieke","family":"Wandel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birte","family":"Kespohl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Arnold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte M.","family":"Flynn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliane","family":"Lokau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samadhi","family":"Aparicio-Siegmund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Bretscher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Rose-John","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg H.","family":"Waetzig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracy","family":"Putoczki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Gr\u00f6tzinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4939-6950","authenticated-orcid":false,"given":"Christoph","family":"Garbers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2018.09.005_bib1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.placenta.2017.05.015","article-title":"Interleukin-11 classic but not trans-signaling is essential for fertility in mice","volume":"57","author":"Agthe","year":"2017","journal-title":"Placenta"},{"key":"10.1016\/j.celrep.2018.09.005_bib2","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1159\/000488044","article-title":"Two N-linked glycans differentially control maturation, trafficking and proteolysis, but not activity of the IL-11 receptor","volume":"45","author":"Agthe","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.celrep.2018.09.005_bib3","doi-asserted-by":"crossref","first-page":"20424","DOI":"10.1016\/S0021-9258(18)54940-1","article-title":"Interleukin-11 regulates the hepatic expression of the same plasma protein genes as interleukin-6","volume":"266","author":"Baumann","year":"1991","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2018.09.005_bib4","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/ajmg.a.38540","article-title":"Single suture craniosynostosis: Identification of rare variants in genes associated with syndromic forms","volume":"176","author":"Clarke","year":"2018","journal-title":"Am. J. Med. Genet. A."},{"key":"10.1016\/j.celrep.2018.09.005_bib5","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/stem.150119","article-title":"Expression of murine interleukin 11 and its receptor alpha-chain in adult and embryonic tissues","volume":"15","author":"Davidson","year":"1997","journal-title":"Stem Cells"},{"key":"10.1016\/j.celrep.2018.09.005_bib6","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1515\/hsz-2013-0166","article-title":"Interleukin-6 and interleukin-11: same same but different","volume":"394","author":"Garbers","year":"2013","journal-title":"Biol. Chem."},{"key":"10.1016\/j.celrep.2018.09.005_bib7","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.cytogfr.2012.04.001","article-title":"Plasticity and cross-talk of interleukin 6-type cytokines","volume":"23","author":"Garbers","year":"2012","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.celrep.2018.09.005_bib8","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/mgg3.28","article-title":"Mutations in the interleukin receptor IL11RA cause autosomal recessive Crouzon-like craniosynostosis","volume":"1","author":"Keupp","year":"2013","journal-title":"Mol. Genet. Genomic Med."},{"key":"10.1016\/j.celrep.2018.09.005_bib9","doi-asserted-by":"crossref","first-page":"1785021","DOI":"10.1155\/2016\/1785021","article-title":"Generation of soluble interleukin-11 and interleukin-6 receptors: a crucial function for proteases during inflammation","volume":"2016","author":"Lokau","year":"2016","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.celrep.2018.09.005_bib10","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/j.celrep.2016.01.053","article-title":"Proteolytic cleavage governs interleukin-11 trans-signaling","volume":"14","author":"Lokau","year":"2016","journal-title":"Cell Rep."},{"issue":"11 Pt B","key":"10.1016\/j.celrep.2018.09.005_bib11","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1016\/j.bbamcr.2017.06.008","article-title":"Proteolytic control of Interleukin-11 and Interleukin-6 biology","volume":"1864","author":"Lokau","year":"2017","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.celrep.2018.09.005_bib12","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.bbamcr.2017.12.003","article-title":"The SNP rs4252548 (R112H) which is associated with reduced human height compromises the stability of IL-11","volume":"1865","author":"Lokau","year":"2018","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.celrep.2018.09.005_bib13","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.celrep.2016.06.062","article-title":"Transcytosis of IL-11 and apical redirection of gp130 is mediated by IL-11\u03b1 receptor","volume":"16","author":"Monhasery","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2018.09.005_bib14","first-page":"637","article-title":"Growth of the normal skull vault and its alteration in craniosynostosis: insights from human genetics and experimental studies","volume":"207","author":"Morriss-Kay","year":"2005","journal-title":"J.\u00a0Anat."},{"key":"10.1016\/j.celrep.2018.09.005_bib15","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ajhg.2011.05.024","article-title":"Inactivation of IL11 signaling causes craniosynostosis, delayed tooth eruption, and supernumerary teeth","volume":"89","author":"Nieminen","year":"2011","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.celrep.2018.09.005_bib16","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.biochi.2015.11.005","article-title":"Modular organization of Interleukin-6 and Interleukin-11 \u03b1-receptors","volume":"119","author":"Nitz","year":"2015","journal-title":"Biochimie."},{"key":"10.1016\/j.celrep.2018.09.005_bib17","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.cytogfr.2014.04.007","article-title":"Who climbs the tryptophan ladder? On the structure and function of the WSXWS motif in cytokine receptors and thrombospondin repeats","volume":"25","author":"Olsen","year":"2014","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.celrep.2018.09.005_bib18","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1189\/jlb.0410226","article-title":"More than a sidekick: the IL-6 family cytokine IL-11 links inflammation to cancer","volume":"88","author":"Putoczki","year":"2010","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.celrep.2018.09.005_bib19","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.ccr.2013.06.017","article-title":"Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically","volume":"24","author":"Putoczki","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2018.09.005_bib20","doi-asserted-by":"crossref","first-page":"699","DOI":"10.2174\/156652405774641043","article-title":"Craniofacial anomalies: from development to molecular pathogenesis","volume":"5","author":"Rice","year":"2005","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.celrep.2018.09.005_bib21","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nature24676","article-title":"IL-11 is a crucial determinant of cardiovascular fibrosis","volume":"552","author":"Schafer","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2018.09.005_bib22","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1359\/JBMR.050209","article-title":"Interleukin-11 receptor signaling is required for normal bone remodeling","volume":"20","author":"Sims","year":"2005","journal-title":"J.\u00a0Bone Miner. Res."},{"key":"10.1016\/j.celrep.2018.09.005_bib23","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/S0022-2836(02)00184-5","article-title":"Sequence conservation in Ig-like domains: the role of highly conserved proline residues in the fibronectin type III superfamily","volume":"318","author":"Steward","year":"2002","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.celrep.2018.09.005_bib24","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1002\/j.1460-2075.1993.tb05815.x","article-title":"Structure-function analysis of human IL-6 receptor: dissociation of amino acid residues required for IL-6-binding and for IL-6 signal transduction through gp130","volume":"12","author":"Yawata","year":"1993","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2018.09.005_bib25","doi-asserted-by":"crossref","first-page":"11619","DOI":"10.1016\/S0021-9258(19)49956-0","article-title":"Mutations in the Trp-Ser-X-Trp-Ser motif of the erythropoietin receptor abolish processing, ligand binding, and activation of the receptor","volume":"267","author":"Yoshimura","year":"1992","journal-title":"J.\u00a0Biol. Chem."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124718314207?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124718314207?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T10:28:43Z","timestamp":1761906523000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124718314207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["S2211124718314207"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2018.09.005","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mutations in Craniosynostosis Patients Cause Defective Interleukin-11 Receptor Maturation and Drive Craniosynostosis-like Disease in Mice","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2018.09.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Author(s).","name":"copyright","label":"Copyright"}]}}