{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:54:08Z","timestamp":1790301248127,"version":"4.1.0"},"reference-count":62,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T00:00:00Z","timestamp":1537142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"NIH\/NHLBI","award":["R01HL131652"],"award-info":[{"award-number":["R01HL131652"]}]},{"name":"NIH\/NHLBI","award":["R01HL133216"],"award-info":[{"award-number":["R01HL133216"]}]},{"name":"NIH\/NHLBI","award":["R01HL122578"],"award-info":[{"award-number":["R01HL122578"]}]},{"name":"NIH\/NICHH","award":["R01HD081534"],"award-info":[{"award-number":["R01HD081534"]}]},{"name":"Oklahoma Center for Adult Stem Cell Research"},{"DOI":"10.13039\/100015309","name":"TSET","doi-asserted-by":"crossref","award":["4340"],"award-info":[{"award-number":["4340"]}],"id":[{"id":"10.13039\/100015309","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NIH\/NIGMS COBRE","award":["P20 GM103441"],"award-info":[{"award-number":["P20 GM103441"]}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["15BGIA25710032"],"award-info":[{"award-number":["15BGIA25710032"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["15POST25080182"],"award-info":[{"award-number":["15POST25080182"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["16PRE31190025"],"award-info":[{"award-number":["16PRE31190025"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2016R1E1A1A01943544"],"award-info":[{"award-number":["NRF-2016R1E1A1A01943544"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.celrep.2018.09.049","type":"journal-article","created":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T17:29:22Z","timestamp":1539710962000},"page":"571-584.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":74,"title":["Complementary Wnt Sources Regulate Lymphatic Vascular Development via PROX1-Dependent Wnt\/\u03b2-Catenin Signaling"],"prefix":"10.1016","volume":"25","author":[{"given":"Boksik","family":"Cha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Riaj","family":"Mahamud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny Y.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wantae","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eek-hoon","family":"Jho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeunhee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongwon","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Brandon","family":"Dixon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Kwon","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorin","family":"Olson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Hoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley J.","family":"Merrill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4465-3340","authenticated-orcid":false,"given":"R. Sathish","family":"Srinivasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2018.09.049_bib1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.devcel.2009.06.017","article-title":"Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis","volume":"17","author":"Bazigou","year":"2009","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2018.09.049_bib2","doi-asserted-by":"crossref","first-page":"3232","DOI":"10.1101\/gad.1751908","article-title":"Master and commander: continued expression of Prox1 prevents the dedifferentiation of lymphatic endothelial cells","volume":"22","author":"Bixel","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2018.09.049_bib3","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1242\/dev.128.8.1253","article-title":"Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development","volume":"128","author":"Brault","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.celrep.2018.09.049_bib4","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1002\/dvg.20651","article-title":"Generation of mice with a conditional null allele for Wntless","volume":"48","author":"Carpenter","year":"2010","journal-title":"Genesis"},{"key":"10.1016\/j.celrep.2018.09.049_bib5","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1038\/onc.2010.610","article-title":"Methylation by protein arginine methyltransferase 1 increases stability of Axin, a negative regulator of Wnt signaling","volume":"30","author":"Cha","year":"2011","journal-title":"Oncogene"},{"key":"10.1016\/j.celrep.2018.09.049_bib6","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1101\/gad.282400.116","article-title":"Mechanotransduction activates canonical Wnt\/\u03b2-catenin signaling to promote lymphatic vascular patterning and the development of lymphatic and lymphovenous valves","volume":"30","author":"Cha","year":"2016","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2018.09.049_bib7","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1158\/0008-5472.CAN-15-1199","article-title":"Aberrant Activation of Notch Signaling Inhibits PROX1 Activity to Enhance the Malignant Behavior of Thyroid Cancer Cells","volume":"76","author":"Choi","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2018.09.049_bib8","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1172\/JCI87442","article-title":"Laminar flow downregulates Notch activity to promote lymphatic sprouting","volume":"127","author":"Choi","year":"2017","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2018.09.049_bib9","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.09073","article-title":"An ancient Pygo-dependent Wnt enhanceosome integrated by Chip\/LDB-SSDP","volume":"4","author":"Fiedler","year":"2015","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2018.09.049_bib10","doi-asserted-by":"crossref","first-page":"e07727","DOI":"10.7554\/eLife.07727","article-title":"Non-canonical Wnt signalling modulates the endothelial shear stress flow sensor in vascular remodelling","volume":"5","author":"Franco","year":"2016","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2018.09.049_bib11","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.ydbio.2015.10.022","article-title":"Multiple mouse models of primary lymphedema exhibit distinct defects in lymphovenous valve development","volume":"409","author":"Geng","year":"2016","journal-title":"Dev. Biol."},{"key":"10.1016\/j.celrep.2018.09.049_bib12","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1242\/dmm.030825","article-title":"Intraluminal valves: development, function and disease","volume":"10","author":"Geng","year":"2017","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.celrep.2018.09.049_bib13","doi-asserted-by":"crossref","first-page":"5954","DOI":"10.1073\/pnas.1017496108","article-title":"An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt\/wingless signaling pathway","volume":"108","author":"Gonsalves","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2018.09.049_bib14","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1038\/ng1642","article-title":"Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity","volume":"37","author":"Harvey","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2018.09.049_bib15","doi-asserted-by":"crossref","first-page":"7142","DOI":"10.1073\/pnas.102650499","article-title":"Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure","volume":"99","author":"Holtwick","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2018.09.049_bib16","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s00441-003-0747-8","article-title":"Prox1, master regulator of the lymphatic vasculature phenotype","volume":"314","author":"Hong","year":"2003","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.celrep.2018.09.049_bib17","doi-asserted-by":"crossref","first-page":"4193","DOI":"10.1172\/JCI92852","article-title":"Hdac3 regulates lymphovenous and lymphatic valve formation","volume":"127","author":"Janardhan","year":"2017","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2018.09.049_bib18","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.ydbio.2011.08.020","article-title":"Lrp5 and Lrp6 redundantly control skeletal development in the mouse embryo","volume":"359","author":"Joeng","year":"2011","journal-title":"Dev. Biol."},{"key":"10.1016\/j.celrep.2018.09.049_bib19","doi-asserted-by":"crossref","first-page":"3282","DOI":"10.1101\/gad.1727208","article-title":"Lymphatic endothelial cell identity is reversible and its maintenance requires Prox1 activity","volume":"22","author":"Johnson","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2018.09.049_bib20","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1242\/dev.104976","article-title":"Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts","volume":"141","author":"Kabiri","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.celrep.2018.09.049_bib21","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ydbio.2015.06.004","article-title":"Combining Foxc2 and Connexin37 deletions in mice leads to severe defects in lymphatic vascular growth and remodeling","volume":"405","author":"Kanady","year":"2015","journal-title":"Dev. Biol."},{"key":"10.1016\/j.celrep.2018.09.049_bib22","doi-asserted-by":"crossref","first-page":"e40497","DOI":"10.1371\/journal.pone.0040497","article-title":"In\u00a0vitro assays using primary embryonic mouse lymphatic endothelial cells uncover key roles for FGFR1 signalling in lymphangiogenesis","volume":"7","author":"Kazenwadel","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.celrep.2018.09.049_bib23","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.1172\/JCI78888","article-title":"GATA2 is required for lymphatic vessel valve development and maintenance","volume":"125","author":"Kazenwadel","year":"2015","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2018.09.049_bib24","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1006\/dbio.2000.0106","article-title":"Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in\u00a0vivo","volume":"230","author":"Kisanuki","year":"2001","journal-title":"Dev. Biol."},{"key":"10.1016\/j.celrep.2018.09.049_bib25","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1016\/j.celrep.2015.10.055","article-title":"Vegfc Regulates Bipotential Precursor Division and Prox1 Expression to Promote Lymphatic Identity in Zebrafish","volume":"13","author":"Koltowska","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2018.09.049_bib26","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1126\/science.275.5307.1784","article-title":"Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-\/- colon carcinoma","volume":"275","author":"Korinek","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.celrep.2018.09.049_bib27","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1172\/JCI89607","article-title":"RASA1 regulates the function of lymphatic vessel valves in mice","volume":"127","author":"Lapinski","year":"2017","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2018.09.049_bib28","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1161\/ATVBAHA.114.303345","article-title":"Shear stress-activated Wnt-angiopoietin-2 signaling recapitulates vascular repair in zebrafish embryos","volume":"34","author":"Li","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.celrep.2018.09.049_bib29","doi-asserted-by":"crossref","first-page":"20224","DOI":"10.1073\/pnas.1314239110","article-title":"Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974","volume":"110","author":"Liu","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2018.09.049_bib30","doi-asserted-by":"crossref","first-page":"5524","DOI":"10.1038\/onc.2015.7","article-title":"PROX1 promotes hepatocellular carcinoma proliferation and sorafenib resistance by enhancing \u03b2-catenin expression and nuclear translocation","volume":"34","author":"Liu","year":"2015","journal-title":"Oncogene"},{"key":"10.1016\/j.celrep.2018.09.049_bib31","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1016\/j.celrep.2016.11.008","article-title":"Semaphorin 3G Provides a Repulsive Guidance Cue to Lymphatic Endothelial Cells via Neuropilin-2\/PlexinD1","volume":"17","author":"Liu","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2018.09.049_bib32","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1146\/annurev.cellbio.20.010403.113126","article-title":"The Wnt signaling pathway in development and disease","volume":"20","author":"Logan","year":"2004","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.celrep.2018.09.049_bib33","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/nm.1960","article-title":"Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism","volume":"15","author":"Machnik","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2018.09.049_bib34","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nn.2467","article-title":"A robust and high-throughput Cre reporting and characterization system for the whole mouse brain","volume":"13","author":"Madisen","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2018.09.049_bib35","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/35077108","article-title":"LDL-receptor-related protein 6 is a receptor for Dickkopf proteins","volume":"411","author":"Mao","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2018.09.049_bib36","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1007\/s00018-010-0329-3","article-title":"Regulation of Lrp6 phosphorylation","volume":"67","author":"Niehrs","year":"2010","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.celrep.2018.09.049_bib37","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1083\/jcb.200901104","article-title":"FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1","volume":"185","author":"Norrm\u00e9n","year":"2009","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.celrep.2018.09.049_bib38","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.cell.2006.02.046","article-title":"Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination","volume":"125","author":"Olson","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2018.09.049_bib39","doi-asserted-by":"crossref","first-page":"4593","DOI":"10.1093\/emboj\/cdf470","article-title":"Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor","volume":"21","author":"Petrova","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2018.09.049_bib40","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1038\/nm1094","article-title":"Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis","volume":"10","author":"Petrova","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2018.09.049_bib41","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1084\/jem.20091619","article-title":"Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning","volume":"207","author":"Pham","year":"2010","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2018.09.049_bib42","doi-asserted-by":"crossref","first-page":"R233","DOI":"10.1016\/j.cub.2007.02.030","article-title":"On the use of the word \u2018epigenetic\u2019","volume":"17","author":"Ptashne","year":"2007","journal-title":"Curr. Biol."},{"key":"10.1016\/j.celrep.2018.09.049_bib43","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1128\/MCB.00325-13","article-title":"Wnt7a regulates multiple steps of neurogenesis","volume":"33","author":"Qu","year":"2013","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.celrep.2018.09.049_bib44","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1016\/j.yexcr.2009.06.021","article-title":"Genomic response to Wnt signalling is highly context-dependent--evidence from DNA microarray and chromatin immunoprecipitation screens of Wnt\/TCF targets","volume":"315","author":"Railo","year":"2009","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.celrep.2018.09.049_bib45","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.cell.2014.10.010","article-title":"iDISCO: a simple, rapid method to immunolabel large tissue samples for volume imaging","volume":"159","author":"Renier","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2018.09.049_bib46","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1067\/mjd.2002.120909","article-title":"Lymphedema: an immunologically vulnerable site for development of neoplasms","volume":"47","author":"Ruocco","year":"2002","journal-title":"J.\u00a0Am. Acad. Dermatol."},{"key":"10.1016\/j.celrep.2018.09.049_bib47","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.devcel.2011.12.020","article-title":"Mechanotransduction, PROX1, and FOXC2 cooperate to control connexin37 and calcineurin during lymphatic-valve formation","volume":"22","author":"Sabine","year":"2012","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2018.09.049_bib48","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nm979","article-title":"Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor","volume":"10","author":"Sato","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2018.09.049_bib49","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nature09637","article-title":"Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts","volume":"469","author":"Sato","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2018.09.049_bib50","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/embj.201385358","article-title":"Wnt-induced transcriptional activation is exclusively mediated by TCF\/LEF","volume":"33","author":"Schuijers","year":"2014","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2018.09.049_bib51","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1101\/gad.16974811","article-title":"Prox1 dosage controls the number of lymphatic endothelial cell progenitors and the formation of the lymphovenous valves","volume":"25","author":"Srinivasan","year":"2011","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2018.09.049_bib52","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1101\/gad.1859310","article-title":"The nuclear hormone receptor Coup-TFII is required for the initiation and early maintenance of Prox1 expression in lymphatic endothelial cells","volume":"24","author":"Srinivasan","year":"2010","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2018.09.049_bib53","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1101\/gad.216226.113","article-title":"The Prox1-Vegfr3 feedback loop maintains the identity and the number of lymphatic endothelial cell progenitors","volume":"28","author":"Srinivasan","year":"2014","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2018.09.049_bib54","doi-asserted-by":"crossref","first-page":"3526","DOI":"10.1128\/MCB.01986-07","article-title":"Cell-type-specific function of BCL9 involves a transcriptional activation domain that synergizes with beta-catenin","volume":"28","author":"Sustmann","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.celrep.2018.09.049_bib55","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1172\/JCI79386","article-title":"Lymph flow regulates collecting lymphatic vessel maturation in\u00a0vivo","volume":"125","author":"Sweet","year":"2015","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2018.09.049_bib56","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.cell.2010.01.045","article-title":"Lymphangiogenesis: Molecular mechanisms and future promise","volume":"140","author":"Tammela","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2018.09.049_bib57","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.devcel.2013.05.015","article-title":"Planar cell polarity protein Celsr1 regulates endothelial adherens junctions and directed cell rearrangements during valve morphogenesis","volume":"26","author":"Tatin","year":"2013","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2018.09.049_bib58","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.ydbio.2014.05.006","article-title":"Integrin-\u03b15\u03b21 is not required for mural cell functions during development of blood vessels but is required for lymphatic-blood vessel separation and lymphovenous valve formation","volume":"392","author":"Turner","year":"2014","journal-title":"Dev. Biol."},{"key":"10.1016\/j.celrep.2018.09.049_bib59","doi-asserted-by":"crossref","first-page":"e1000246","DOI":"10.1371\/journal.pbio.1000246","article-title":"Reversing blood flows act through klf2a to ensure normal valvulogenesis in the developing heart","volume":"7","author":"Vermot","year":"2009","journal-title":"PLoS Biol."},{"key":"10.1016\/j.celrep.2018.09.049_bib60","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nature21028","article-title":"The role of fatty acid \u03b2-oxidation in lymphangiogenesis","volume":"542","author":"Wong","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2018.09.049_bib61","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1242\/dev.076067","article-title":"Function of Wnt\/\u03b2-catenin in counteracting Tcf3 repression through the Tcf3-\u03b2-catenin interaction","volume":"139","author":"Wu","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.celrep.2018.09.049_bib62","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1242\/jcs.083998","article-title":"Ets family members induce lymphangiogenesis through physical and functional interaction with Prox1","volume":"124","author":"Yoshimatsu","year":"2011","journal-title":"J.\u00a0Cell Sci."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124718314943?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124718314943?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T10:29:35Z","timestamp":1761906575000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124718314943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":62,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["S2211124718314943"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2018.09.049","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Complementary Wnt Sources Regulate Lymphatic Vascular Development via PROX1-Dependent Wnt\/\u03b2-Catenin Signaling","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2018.09.049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Author(s).","name":"copyright","label":"Copyright"}]}}