{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T12:27:24Z","timestamp":1790512044034,"version":"4.1.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T00:00:00Z","timestamp":1539820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HHSN272201400058C"],"award-info":[{"award-number":["HHSN272201400058C"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000185","name":"Defense Advanced Research Projects Agency","doi-asserted-by":"publisher","award":["W31P4Q-15-1-0003"],"award-info":[{"award-number":["W31P4Q-15-1-0003"]}],"id":[{"id":"10.13039\/100000185","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006441","name":"Center for Outcomes Research and Evaluation, Yale School of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006441","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.celrep.2018.10.062","type":"journal-article","created":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T10:44:25Z","timestamp":1542105865000},"page":"1982-1993.e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"title":["In\u00a0Vivo Delivery of Synthetic Human DNA-Encoded Monoclonal Antibodies Protect against Ebolavirus Infection in a Mouse Model"],"prefix":"10.1016","volume":"25","author":[{"given":"Ami","family":"Patel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel H.","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl W.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor R.F.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Tierney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aubrey","family":"Bryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar","family":"Davidson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trina","family":"Racine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Reed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marguerite E.","family":"Gorman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan C.","family":"Wise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah T.C.","family":"Elliott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rianne","family":"Esquivel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kar","family":"Muthumani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin J.","family":"Doranz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica Ollmann","family":"Saphire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Crowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate E.","family":"Broderick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary P.","family":"Kobinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihua","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangguo","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darwyn","family":"Kobasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Humeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niranjan Y.","family":"Sardesai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafi","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Weiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2018.10.062_bib1","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1089\/hgtb.2015.020","article-title":"Skin transfection patterns and expression kinetics of electroporation-enhanced plasmid delivery using the CELLECTRA-3P, a portable next-generation dermal electroporation device","volume":"26","author":"Amante","year":"2015","journal-title":"Hum. Gene Ther. Methods"},{"key":"10.1016\/j.celrep.2018.10.062_bib2","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.omtm.2017.09.003","article-title":"In\u00a0vivo production of monoclonal antibodies by gene transfer via electroporation protects against lethal influenza and Ebola infections","volume":"7","author":"Andrews","year":"2017","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"10.1016\/j.celrep.2018.10.062_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/jmbi.1998.1843","article-title":"Anatomy of hot spots in protein interfaces","volume":"280","author":"Bogan","year":"1998","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.celrep.2018.10.062_bib4","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1126\/science.aad5788","article-title":"Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak","volume":"351","author":"Bornholdt","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.celrep.2018.10.062_bib5","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1086\/515386","article-title":"A mouse model for evaluation of prophylaxis and therapy of Ebola hemorrhagic fever","volume":"178","author":"Bray","year":"1998","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.celrep.2018.10.062_bib6","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1586\/14760584.2015.990890","article-title":"Electroporation-enhanced delivery of nucleic acid vaccines","volume":"14","author":"Broderick","year":"2015","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.celrep.2018.10.062_bib7","doi-asserted-by":"crossref","first-page":"5640","DOI":"10.1182\/blood-2012-01-380121","article-title":"Properties of mouse and human IgG receptors and their contribution to disease models","volume":"119","author":"Bruhns","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2018.10.062_bib8","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1126\/science.aad5224","article-title":"Protective monotherapy against lethal Ebola virus infection by a potently neutralizing antibody","volume":"351","author":"Corti","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.celrep.2018.10.062_bib9","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1056\/NEJMoa1604330","article-title":"A randomized, controlled trial of ZMapp for Ebola virus infection","volume":"375","author":"Davey","year":"2016","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.celrep.2018.10.062_bib10","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/imm.12323","article-title":"A high-throughput shotgun mutagenesis approach to mapping B-cell antibody epitopes","volume":"143","author":"Davidson","year":"2014","journal-title":"Immunology"},{"key":"10.1016\/j.celrep.2018.10.062_bib11","doi-asserted-by":"crossref","first-page":"10982","DOI":"10.1128\/JVI.01490-15","article-title":"Mechanism of binding to Ebola virus glycoprotein by the ZMapp, ZMAb, and MB-003 cocktail antibodies","volume":"89","author":"Davidson","year":"2015","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.celrep.2018.10.062_bib12","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1080\/19420862.2017.1323159","article-title":"Affinity of human IgG subclasses to mouse Fc gamma receptors","volume":"9","author":"Dekkers","year":"2017","journal-title":"MAbs"},{"key":"10.1016\/j.celrep.2018.10.062_bib13","doi-asserted-by":"crossref","first-page":"10991","DOI":"10.1128\/JVI.75.22.10991-11001.2001","article-title":"Multiple effects of codon usage optimization on expression and immunogenicity of DNA candidate vaccines encoding the human immunodeficiency virus type 1 Gag protein","volume":"75","author":"Deml","year":"2001","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.celrep.2018.10.062_bib14","first-page":"4","article-title":"Making it to manufacturing. The potential success of broadly neutralizing monoclonal antibodies for HIV prevention, treatment, and possibly even a cure could come at a cost","volume":"18","author":"Dumiak","year":"2014","journal-title":"IAVI Rep."},{"issue":"W1","key":"10.1016\/j.celrep.2018.10.062_bib15","doi-asserted-by":"crossref","first-page":"W474","DOI":"10.1093\/nar\/gkw361","article-title":"SAbPred: a structure-based antibody prediction server","volume":"44","author":"Dunbar","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2018.10.062_bib16","first-page":"737","article-title":"IMGT\/DomainGapAlign: IMGT standardized analysis of amino acid sequences of variable, constant, and groove domains (IG, TR, MH, IgSF, MhSF)","volume":"2011","author":"Ehrenmann","year":"2011","journal-title":"Cold Spring Harb. Protoc."},{"key":"10.1016\/j.celrep.2018.10.062_bib17","doi-asserted-by":"crossref","first-page":"D301","DOI":"10.1093\/nar\/gkp946","article-title":"IMGT\/3Dstructure-DB and IMGT\/DomainGapAlign: a database and a tool for immunoglobulins or antibodies, T\u00a0cell receptors, MHC, IgSF and MhcSF","volume":"38","author":"Ehrenmann","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2018.10.062_bib18","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41541-017-0020-x","article-title":"DMAb inoculation of synthetic cross reactive antibodies protects against lethal influenza A and B infections","volume":"2","author":"Elliott","year":"2017","journal-title":"NPJ Vaccines"},{"key":"10.1016\/j.celrep.2018.10.062_bib19","doi-asserted-by":"crossref","first-page":"12616","DOI":"10.1038\/srep12616","article-title":"Protection against dengue disease by synthetic nucleic acid antibody prophylaxis\/immunotherapy","volume":"5","author":"Flingai","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2018.10.062_bib20","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.cell.2015.12.022","article-title":"Cross-reactive and potent neutralizing antibody responses in human survivors of natural Ebolavirus infection","volume":"164","author":"Flyak","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2018.10.062_bib21","first-page":"197","article-title":"Codon-optimized genes that enable increased heterologous expression in mammalian cells and elicit efficient immune responses in mice after vaccination of naked DNA","volume":"94","author":"Graf","year":"2004","journal-title":"Methods Mol. Med."},{"key":"10.1016\/j.celrep.2018.10.062_bib22","doi-asserted-by":"crossref","first-page":"4231","DOI":"10.4049\/jimmunol.165.8.4231","article-title":"Depletion of CD4 and CD8\u00a0T lymphocytes in mice in\u00a0vivo enhances 1,25-dihydroxyvitamin D3-stimulated osteoclast-like cell formation in\u00a0vitro by a mechanism that is dependent on prostaglandin synthesis","volume":"165","author":"Grcevi\u0107","year":"2000","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2018.10.062_bib23","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ymeth.2005.01.001","article-title":"Immunogenicity of engineered antibodies","volume":"36","author":"Hwang","year":"2005","journal-title":"Methods"},{"key":"10.1016\/j.celrep.2018.10.062_bib24","doi-asserted-by":"crossref","first-page":"35409","DOI":"10.1074\/jbc.M112.404483","article-title":"Variable region identical immunoglobulins differing in isotype express different paratopes","volume":"287","author":"Janda","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2018.10.062_bib25","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3389\/fmicb.2016.00022","article-title":"Ig constant region effects on variable region structure and function","volume":"7","author":"Janda","year":"2016","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.celrep.2018.10.062_bib26","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.cell.2014.08.026","article-title":"The RAG recombinase dictates functional heterogeneity and cellular fitness in natural killer cells","volume":"159","author":"Karo","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2018.10.062_bib27","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1016\/j.celrep.2015.08.038","article-title":"Emergence of Ebola virus escape variants in infected nonhuman primates treated with the MB-003 antibody cocktail","volume":"12","author":"Kugelman","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2018.10.062_bib28","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1093\/molbev\/msw054","article-title":"MEGA7: molecular evolutionary genetics analysis version 7.0 for bigger datasets","volume":"33","author":"Kumar","year":"2016","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.celrep.2018.10.062_bib29","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.1007\/s00253-016-7388-9","article-title":"Advances in recombinant antibody manufacturing","volume":"100","author":"Kunert","year":"2016","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.celrep.2018.10.062_bib30","doi-asserted-by":"crossref","first-page":"4.1.1","DOI":"10.1002\/0471142735.im0401s113","article-title":"In\u00a0vivo depletion of T lymphocytes","volume":"113","author":"Laky","year":"2016","journal-title":"Curr. Protoc. Immunol."},{"key":"10.1016\/j.celrep.2018.10.062_bib31","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1002\/jps.22758","article-title":"Developability index: a rapid in\u00a0silico tool for the screening of antibody aggregation propensity","volume":"101","author":"Lauer","year":"2012","journal-title":"J.\u00a0Pharm. Sci."},{"key":"10.1016\/j.celrep.2018.10.062_bib32","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/nar\/29.1.207","article-title":"IMGT, the international ImMunoGeneTics database","volume":"29","author":"Lefranc","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2018.10.062_bib33","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1093\/infdis\/jiw460","article-title":"Adeno-associated virus serotype 9-expressed ZMapp in mice confers protection against systemic and airway-acquired Ebola virus infection","volume":"214","author":"Limberis","year":"2016","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.celrep.2018.10.062_bib34","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1006\/jmbi.1998.2439","article-title":"). The atomic structure of protein-protein recognition sites","volume":"285","author":"Lo Conte","year":"1999","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.celrep.2018.10.062_bib35","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1038\/sj.gt.3301522","article-title":"Optimisation of electrotransfer of plasmid into skeletal muscle by pretreatment with hyaluronidase -- increased expression with reduced muscle damage","volume":"8","author":"McMahon","year":"2001","journal-title":"Gene Ther."},{"key":"10.1016\/j.celrep.2018.10.062_bib36","doi-asserted-by":"crossref","first-page":"e1674","DOI":"10.7717\/peerj.1674","article-title":"Initiating a watch list for Ebola virus antibody escape mutations","volume":"4","author":"Miller","year":"2016","journal-title":"PeerJ"},{"key":"10.1016\/j.celrep.2018.10.062_bib37","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1093\/infdis\/jiw111","article-title":"Rapid and long-term immunity elicited by DNA-encoded antibody prophylaxis and DNA vaccination against chikungunya virus","volume":"214","author":"Muthumani","year":"2016","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.celrep.2018.10.062_bib38","doi-asserted-by":"crossref","first-page":"3430","DOI":"10.4049\/jimmunol.1200356","article-title":"Crosstalk between human IgG isotypes and murine effector cells","volume":"189","author":"Overdijk","year":"2012","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2018.10.062_bib39","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/s41467-017-00576-7","article-title":"An engineered bispecific DNA-encoded IgG antibody protects against Pseudomonas aeruginosa in a pneumonia challenge model","volume":"8","author":"Patel","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2018.10.062_bib40","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1186\/s12879-015-1169-4","article-title":"Ebola virus disease complicated with viral interstitial pneumonia: a\u00a0case report","volume":"15","author":"Petrosillo","year":"2015","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.celrep.2018.10.062_bib41","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ymeth.2013.07.005","article-title":"Humanized FcRn mouse models for\u00a0evaluating pharmacokinetics of human IgG antibodies","volume":"65","author":"Proetzel","year":"2014","journal-title":"Methods"},{"key":"10.1016\/j.celrep.2018.10.062_bib42","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.clim.2011.08.008","article-title":"Characterization of Zaire ebolavirus glycoprotein-specific monoclonal antibodies","volume":"141","author":"Qiu","year":"2011","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.celrep.2018.10.062_bib43","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1080\/07853890802698842","article-title":"Challenges in monoclonal antibody-based therapies","volume":"41","author":"Samaranayake","year":"2009","journal-title":"Ann. Med."},{"key":"10.1016\/j.celrep.2018.10.062_bib44","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1159\/000019115","article-title":"Protein displays of the human immunoglobulin heavy, kappa and lambda variable and joining regions","volume":"16","author":"Scaviner","year":"1999","journal-title":"Exp. Clin. Immunogenet."},{"key":"10.1016\/j.celrep.2018.10.062_bib45","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1080\/19420862.2015.1017695","article-title":"Boosting antibody developability through rational sequence optimization","volume":"7","author":"Seeliger","year":"2015","journal-title":"MAbs"},{"key":"10.1016\/j.celrep.2018.10.062_bib46","doi-asserted-by":"crossref","first-page":"18601","DOI":"10.1073\/pnas.1421779112","article-title":"In silico selection of therapeutic antibodies for development: viscosity, clearance, and chemical stability","volume":"111","author":"Sharma","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2018.10.062_bib47","doi-asserted-by":"crossref","first-page":"6181","DOI":"10.1073\/pnas.1203954109","article-title":"Mouse model recapitulating human Fc\u03b3 receptor structural and functional diversity","volume":"109","author":"Smith","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2018.10.062_bib48","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.jcv.2016.11.005","article-title":"Ebola virus disease: an update on current prevention and management strategies","volume":"86","author":"Trad","year":"2017","journal-title":"J.\u00a0Clin. Virol."},{"key":"10.1016\/j.celrep.2018.10.062_bib49","doi-asserted-by":"crossref","first-page":"12680","DOI":"10.1073\/pnas.1200024109","article-title":"Isotype modulates epitope specificity, affinity, and antiviral activities of anti-HIV-1 human broadly neutralizing 2F5 antibody","volume":"109","author":"Tudor","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2018.10.062_bib50","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1126\/science.287.5458.1664","article-title":"Epitopes involved in antibody-mediated protection from Ebola virus","volume":"287","author":"Wilson","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.celrep.2018.10.062_bib51","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1080\/19420862.2017.1367074","article-title":"IgG cooperativity\u2014is there allostery? Implications for antibody functions and therapeutic antibody development","volume":"9","author":"Yang","year":"2017","journal-title":"MAbs"},{"key":"10.1016\/j.celrep.2018.10.062_bib52","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/nature18615","article-title":"Toremifene interacts with and destabilizes the Ebola virus glycoprotein","volume":"535","author":"Zhao","year":"2016","journal-title":"Nature"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124718316516?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124718316516?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T01:40:35Z","timestamp":1775266835000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124718316516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":52,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["S2211124718316516"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2018.10.062","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In\u00a0Vivo Delivery of Synthetic Human DNA-Encoded Monoclonal Antibodies Protect against Ebolavirus Infection in a Mouse Model","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2018.10.062","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors.","name":"copyright","label":"Copyright"}]}}